Clinical trials: Tourette Syndrome
Tourette Syndrome
Washed Microbiota Transplantation for Tourette's Syndrome
This study aimed to evaluate the efficacy of washed microbiota transplantation in the treatment of Tourette's syndrome (TS).
- Trial name
- WMT (NCT03764748)
- Testing
- Washed Microbiota Transplantation
- Where
- 2 sites in China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Nanjing Medical University
Tourette Syndrome in Children
The Findings of Magnetic Resonance Imaging in Subtypes of Tics-related Disorders
The findings of resting-state functional magnetic resonance imaging and diffusion spectrum imaging in subtypes of tics-related disorders
- Trial name
- NCT05566496
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Tourette Syndrome, Tic Disorders
Investigating Distress Tolerance in Adults With Tourette Syndrome
Although behavior therapy is recognized as a first-line intervention for Tourette's Disorder (TD), less than 40% of adults with TD respond to this evidence-based treatment.
- Conditions
- Tourette Syndrome, Tic Disorders, Tics
- Trial name
- NCT05047705
- Testing
- Distress Tolerance Skills Training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Johns Hopkins University
Obsessive-Compulsive Disorder, Tic Disorders
Effects of Ondansetron in Obsessive-compulsive and Tic Disorders
This project investigates the use of 4 weeks of 24 mg/day ondansetron as compared to placebo on symptoms and brain functioning in patients with obsessive-compulsive disorder (OCD) and tic disorders (TD).
- Conditions
- Obsessive-Compulsive Disorder, Tic Disorders, Tourette Syndrome
- Trial name
- NCT03239210
- Testing
- Ondansetron
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- NYU Langone Health
Tourette Syndrome
Combined CBIT and rTMS to Improve Tourette's Syndrome
The investigator will apply 16 sessions of repetitive transcranial magnetic stimulation (rTMS) over 4 consecutive days for adult patients suffering from Tourette's Syndrome.
- Trial name
- STOP-TIC (NCT04795908)
- Testing
- Transcranial Magnetic Stimulation, Comprehensive behavioral intervention
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Tourette Syndrome, Persistent Tic Disorder
Online Mindfulness-based Tic Reduction (Phase Two)
Tourette Syndrome (TS) and Persistent Tic Disorder (PTD) are chronic and potentially disabling neurobiological conditions. Although a range of pharmacological and psychosocial treatments exists, a significant number of…
- Trial name
- NCT03771235
- Testing
- Mindfulness-based Intervention for Tics, Tic Information and Coping Strategies
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Bowdoin College
Tics, Tic Disorders
Clinical Characteristics and Temporal Properties of Individual Tics in Persistent Tic Disorder
The goal of this clinical study is to learn more about the timing of tics (sudden, fast movements and sounds that people do and make without meaning to) in people who have multiple tics that have been going on for more than one…
- Conditions
- Tics, Tic Disorders, Vocal Tic, Motor Tic
- Trial name
- PTD (NCT06385535)
- Testing
- Habit Reversal Training (HRT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Tourette Syndrome in Children, Food Intolerance
Peripheral Mechanisms of Humoral Immune Effector-mediated Tourette's Syndrome and the Role of Tuina Intervention
Tourette syndrome is a refractory type of tic disorder. Previous clinical studies have confirmed that Tuina has a good effect on TS, but the mechanism of action is still uncertain.
- Conditions
- Tourette Syndrome in Children, Food Intolerance, Inflammatory Response
- Trial name
- NCT06379373
- Testing
- Spine manipulation; westren medicine
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Tourette Syndrome
Response Inhibition in Tourette Syndrome
Tics are the hallmark symptoms in Tourette Syndrome. Patients with Tourette Syndrome have difficulties controlling unwanted movements.
- Trial name
- NCT03628703
- Testing
- Repetitive TMS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Tourette's Syndrome
Exploring DBS Efficacy in Treatment-refractory Tourette's Syndrome
The primary purpose of this study is to investigate the effect of deep brain stimulation (DBS) in patients with Treatment-refractory Tourette's syndrome (TR-TS) implantation targeting the Antero-medial globus pallidus interna…
- Trial name
- NCT06361004
- Testing
- Deep Brain Stimulation (DBS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Gilles de la Tourette Syndrome, Tourette Syndrome
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 1: Simultaneous PET and 3T MRI
Gilles de la Tourette syndrome (GTS; also known as Tourette syndrome) is a congenital neuropsychiatric disorder. Characteristic symptoms are so-called tics-rapid, repetitive movements (motor tics) or vocalizations (vocal tics)…
- Trial name
- NCT05232955
- Testing
- PET/MR scanner
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Gilles de la Tourette Syndrome, Tourette Syndrome
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 2: 7T MRI
Gilles de la Tourette syndrome (GTS; also known as Tourette syndrome) is a congenital neuropsychiatric disorder. Characteristic symptoms are so-called tics-rapid, repetitive movements (motor tics) or vocalizations (vocal tics)…
- Trial name
- NCT05233306
- Testing
- MRI scanner (7 Tesla)
- Where
- Germany
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Tourette Syndrome, Chronic Tic Disorder
Internet-based Behavior Therapy for Adults With Tourette Syndrome
This study protocol outlines a parallel-group, randomized controlled trial (RCT) designed to evaluate the effectiveness of Internet-delivered behavior therapy (BT) based on exposure with response prevention (ERP) for adults with…
- Trial name
- TICNET (NCT06271083)
- Testing
- Exposure with response prevention, Brief psychoeducation with general psychological support
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Karolinska Institutet
Tourette Syndrome in Children, Tourette Syndrome in Adolescence
Ecopipam Tablets to Study Tourette Syndrome in Children and Adolescents - Open Label Extension
This study was an international, multicenter, open-label, long term extension study evaluating the safety of ecopipam tablets for the treatment of children and adolescent subjects with Tourette Syndrome.
- Trial name
- NCT04114539
- Testing
- Ecopipam
- Where
- 65 sites in United States, Canada and 3 more
- Volunteers
- 124 people
- Sponsor
- Emalex Biosciences Inc.
Tourette Syndrome
Atomoxetine in Patients With Tourette's Syndrome
The purpose of this pilot study is to evaluate the effects of Atomoxetine, a selective noradrenaline reuptake inhibitor, on impulsivity in patients with Tourette's syndrome.
- Trial name
- ATO-TS (NCT04354103)
- Testing
- Atomoxetine
- Where
- 3 sites in France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Tourette's Disorder
Investigating Circadian Rhythms in Youth With Persistent Tic Disorders
This study examines circadian rhythms and morningness-eveningness preference in youth with Persistent Tic Disorders (PTDs), including Tourette's Disorder (TD); and assesses the effects of wearable short wavelength light therapy…
- Trial name
- NCT03508245
- Testing
- Wearable short wavelength light therapy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Los Angeles
Tourette Syndrome, Tourette's Disorder
Assessment of Children With Tic Onset in the Past 6 Months
The purpose of this research is to study why most children who have tics never develop Tourette syndrome but some do. In other words, we aim to find features that may predict whose tics will go away and whose tics will continue…
- Conditions
- Tourette Syndrome, Tourette's Disorder, Chronic Motor or Vocal Tic Disorder, Transient Tic Disorder
- Trial name
- NewTics (NCT01177774)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Washington University School of Medicine
Tourette Syndrome, Habit Reversal Training
Extinction Learning in Adults With Tourette Syndrome
Aversive sensory phenomena such as premonitory urges play a central role in the behavioral treatment model of tics. Extinction learning and extinction recall are learning processes implicated within this model, but are still…
- Conditions
- Tourette Syndrome, Habit Reversal Training, Tic Disorders, Tics
- Trial name
- NCT04498364
- Testing
- Habit Reversal Training
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tourette Syndrome, Tic Disorders
Median Nerve Stimulation Pilot
Results from the University of Nottingham suggested that rhythmic median nerve stimulation (MNS) improves tic symptoms in Tourette syndrome (TS).
- Conditions
- Tourette Syndrome, Tic Disorders, Tic Disorder, Chronic Motor or Vocal
- Trial name
- MNS (NCT04731714)
- Testing
- Rhythmic median nerve stimulation, Arrhythmic median nerve stimulation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Washington University School of Medicine
Tourette Syndrome, Tic Disorder, Chronic Motor or Vocal
Open-label MNS for Tourette Syndrome
A recent report (Morera Maiquez et al 2020) described reduced tic severity in people with Tourette syndrome during 1-minute epochs of median nerve stimulation (MNS) at 10 Hz.
- Trial name
- NCT05016765
- Testing
- Active, self-directed electrical stimulation of the median nerve
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine