Clinical trials: Toxicity, Drug
Toxicity, Drug
Neoadjuvant CRT Combined With Camrelizumab and Nimotuzumab for Initially Inoperable Patients With Esophageal Carcinoma
Neoadjuvant chemoradiotherapy followed by surgery has been the standard modality for locally advance esophageal carcinoma. According to CROSS study, the pathological complete remission rate achieved by paclitaxel and carboplatin…
- Trial name
- NCT05355168
- Testing
- neoadjuvant chemoradiotherapy combined with Camrelizumab and Nimotuzumab followed by surgery
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Anhui Provincial Hospital
Sepsis, Critical Illness
Optimizing Vancomycin Therapy in Children
The purpose of Opt Vanc is to evaluate the feasibility of Bayesian dose adaptation, based on a previously-developed population pharmacokinetic (PK) model and a single optimally timed PK sample, to predict vancomycin area under…
- Conditions
- Sepsis, Critical Illness, Infections, Drug Toxicity
- Trial name
- Opt Vanc (NCT05691309)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Children's Hospital of Philadelphia
Drug Toxicity
GHB Poisoning and Poisoning Induced by Others
Patients with suspected GHB poisoning presenting to Oslo Accident and Emergency Outpatient Clinic (Oslo Legevakt) or a hospital in Oslo (Oslo University Hospital Ullevål, Diakonhjemmet, Lovisenberg) will be included.
- Trial name
- NCT03651778
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Odd Martin Vallersnes
Toxicity, Drug, Progression, Disease
Real-World Clinical Outcomes and Toxicity in Metastatic Breast Cancer Patients Treated With First or Second Line CDK 4/6 Inhibitors and Endocrine Therapy
To assess CDK4/6i toxicity and effect on PFS in the Egyptian population
- Trial name
- NCT06558084
- Testing
- CDK4/6 Inhibitor
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Cancer, Drug Toxicity
Atrial Fibrillation in Active Cancer Patients
Atrial fibrillation is a common complication of both cancer and anticancer drugs but the consequences of such events remain poorly known and are not adressed in both phase III oncological trials and cardiological guidelines.
- Conditions
- Cancer, Drug Toxicity, Atrial Fibrillation, Cardiovascular Complication
- Trial name
- AFIB-CANCER (NCT04696081)
- Testing
- occurence of atrial fibrillation
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Caen
Effect of Drug, Drug
Apatinib With Ifosfamide Plus Etoposide for Relapsed or Refractory Osteosarcoma (OAIE)
Apatinib has led to positive responses in the treatment of osteosarcoma refractory to first-line chemotherapy. However, apatinib demonstrates only short-lived activity, and the disease control of musculoskeletal lesions is worse…
- Conditions
- Effect of Drug, Drug, Toxicity
- Trial name
- OAIE (NCT05277480)
- Testing
- Apatinib+IE, IE
- Where
- 5 sites in China
- Volunteers
- 81 people
- Sponsor
- Peking University People's Hospital
Drug Toxicity
Double-Blind Randomized Crossover Trial to Access Electrocardiogram Effects of HPN-100
Arm 1: Primary Objective: To determine the safety and tolerability of multiple ascending, supratherapeutic doses of HPN-100. Arm 2: Primary Objective: To assess the effects of steady-state levels of HPN-100 metabolites (4…
- Trial name
- NCT01135680
- Testing
- HPN-100, Moxifloxacin
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Amgen
Malnutrition Severe, Dementia
Drug Burden Index is Associated With Malnutrition in Community-dwelling Dementia Patients
Malnutrition leads to poor clinical outcomes in dementia patients. The investigator aimed to examine the association between drug burden index (DBI) and anticholinergic burden (ACB) scores with nutrition status in…
- Conditions
- Malnutrition Severe, Dementia, Drug Use, Anticholinergic Toxicity
- Trial name
- NCT06447259
- Where
- Turkey (Türkiye)
- Volunteers
- 415 people
- Sponsor
- Sultan Keskin Demircan
Effect of Drug, Toxicity, Drug
Apatinib Plus IE Chemotherapy (Ifosfamide and Etoposide) for Relapsed or Refractory Osteosarcoma
Apatinib has led to positive responses in the treatment of osteosarcoma refractory to first-line chemotherapy. However, apatinib demonstrates only short-lived activity, and the disease control of musculoskeletal lesions is worse…
- Trial name
- AIEO (NCT04824352)
- Testing
- apatinib
- Where
- 2 sites in China
- Volunteers
- 44 people
- Sponsor
- Peking University People's Hospital
Diffuse Large B-Cell Lymphoma, Drug Toxicity
Reduction of MTX Levels After Glucarpidase Treatment in DLBCL Patients at Risk of CNS
Diffuse large B-cell lymphoma (DLBCL) is an aggressive subset of non-Hodgkin's lymphoma (NHL). Central nervous system (CNS) involvement in patients with NHL is a serious complication.
- Trial name
- NCT05022797
- Testing
- Glucarpidase 1000 UNT [Voraxaze]
- Where
- 2 sites in Spain
- Volunteers
- 3 people
- Sponsor
- Fundacion CRIS de Investigación para Vencer el Cáncer
Acute Kidney Injury, Drug Toxicity
Retrospective Registry Study of Patients With Cancer Treated With High-dose Methotrexate
This retrospective observational study will evaluate high-dose methotrexate patterns of use, supportive care measures used during high-dose methotrexate chemotherapy, along with the incidence of delayed elimination of…
- Trial name
- NCT05899751
- Testing
- High-dose methotrexate, Glucarpidase
- Where
- 5 sites in France, Italy and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Protherics Medicines Development Limited
Liver Toxicity, Chemically-Induced
Livertoxcicity in Acute Leukemia Patients During Chemotherapy Treatment
Detection of hepatotoxcicity in acute leukemia and study the outcome of acute leukemia patients that suffer from hepatic toxiciyt
- Trial name
- NCT06383325
- Testing
- Chemotherapy
- Volunteers
- 70 people
- Sponsor
- Assiut University
Drug Toxicity, Platelet Dysfunction
The Influence of Tramadol on Platelet Function
The aim of this ex-vivo study is to quantify the effect of tramadol on platelet aggregation.
- Conditions
- Drug Toxicity, Platelet Dysfunction, Clotting Disorder
- Trial name
- NCT05237492
- Testing
- Tramadol
- Where
- Austria
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Toxicity, Drug, Adverse Drug Event
TIL and Anti-PD1 in Metastatic Melanoma
The ACTME study is an investigator initiated, single center phase I/II clinical trial for patients with progressive unresectable stage III or stage IV melanoma.
- Conditions
- Toxicity, Drug, Adverse Drug Event, Effects of Immunotherapy
- Trial name
- ACTME (NCT03638375)
- Testing
- Nivolumab & Tumor Infiltrating Lymphocytes with/without Interferon-Alpha
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Leiden University
Toxicity, Drug
Observation Study of the Pharmacokinetics of Adductor Canal Block
With the aging of the population, osteoarthritis of knees and hips become major orthopedic problems worldwide. Osteoarthritis of the knees and hips is associated with a significant pain problem and functional disability.
- Trial name
- NCT04916392
- Testing
- Liposomal bupivacaine
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- The University of Hong Kong
Antipsychotic Drug- Toxicity
Pattern of Acute Antipsychotic Drug- Toxicity in Children
Pattern of Acute Antipsychotic Drug- Toxicity in Children at Assiut University Children Hospital. Determine the pattern and outcome of acute antipsychotic drug- toxicity of children who are admitted to The emergency department of…
- Trial name
- NCT06125275
- Volunteers
- 50 people
- Sponsor
- Assiut University
Drug Toxicity
Role of N-Acetylcysteine for Prevention of Cisplatin-induced Nephrotoxicity
Cisplatin is one of the first-line drugs used against many malignancies, such as lung cancer, head and neck cancer, esophageal cancer, gastric cancer, colorectal cancer, urothelial cancer, bladder cancer and testicular cancer.
- Trial name
- NCT06019520
- Testing
- N-Acetylcysteine, Chemotherapy
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Foundation University Islamabad
Mesenchymal Stromal Cells, Psoriasis
Safety and Efficacy of Expanded Allogeneic AD-MSCs in Patients With Moderate to Severe Psoriasis
The purpose of this study is to evaluate the safety and efficacy of Adipose-derived Mesenchymal Stem Cells (AD-MSCs) with moderate to severe psoriasis. Any adverse events related to AD-MSCs infusion will be monitored.
- Conditions
- Mesenchymal Stromal Cells, Psoriasis, Drug Toxicity, Drug Effect
- Trial name
- ADMSP (NCT03265613)
- Testing
- adipose-derived multipotent mesenchymal stem cells
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Mesenchymal Stromal Cells, Psoriasis
Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment in Patients With Moderate to Severe Psoriasis
The purpose of this study is to evaluate the efficacy and safety of Adipose derived Mesenchymal Stem Cells (AD-MSCs) plus Calpocitriol Ointment with moderate to severe psoriasis.
- Conditions
- Mesenchymal Stromal Cells, Psoriasis, Drug Effect, Drug Toxicity
- Trial name
- NCT03392311
- Testing
- Calcipotriol ointment, adipose-derived multipotent mesenchymal stem cells
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Mesenchymal Stromal Cells, Psoriasis
Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment and PSORI-CM01 Granule in Psoriasis Patients
The purpose of this study is to evaluate the efficacy and safety of Adipose derived Mesenchymal Stem Cells (AD-MSCs) plus Calpocitriol Ointment and PSORI-CM01 Granule with moderate to severe psoriasis.
- Conditions
- Mesenchymal Stromal Cells, Psoriasis, Drug Effect, Drug Toxicity
- Trial name
- NCT04275024
- Testing
- Calcipotriol ointment, PSORI-CM01 Granule, adipose-derived multipotent mesenchymal stem cells
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine