Clinical trials: Toxicity, open to volunteers
Lymphoma, Cancer
Feasibility of Intermittent Fasting During Chemotherapy
The goal of this randomized controlled parallel group trial is to examine if fasting before and after chemotherapy is safe, feasible and acceptable.
- Conditions
- Lymphoma, Cancer, Fasting
- Trial name
- FasteStudien (NCT06645093)
- Testing
- Fasting
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- University of Oslo
Head and Neck Cancer
Outcome Prediction in Head&Neck Cancer Patients After Radiotherapy
The primary and general objective of the clinical introduction of the Standard Follow-up Program (SFP) as the current standard of care is to improve the quality of radiotherapy for head and neck cancer patients by reducing…
- Trial name
- OutcomeH&N (NCT01985984)
- Testing
- Radiation alone, Radiation in combination with systemic therapy
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Maastricht Radiation Oncology
EGFR Inhibitor-associated Rash
A Study to Evaluate Topical ATR04-484 for EGFRi-Associated Dermal Toxicity
The goal of this randomized clinical trial is to learn if topical treatment with ATR04-484 can treat skin rash in patients undergoing EGFR inhibitor (EGFRi) therapy.
- Trial name
- NCT06830863
- Testing
- ATR04-484, Vehicle
- Where
- 6 sites in United States
- Volunteers
- 32 people
- Sponsor
- Azitra Inc.
Esophageal Cancer
Standard Follow-Up Program (SFP) for Patients With Esophageal Cancer
Motive: In order to improve the treatment technique, a comprehensive follow-up program is needed to obtain all relevant patient, treatment and toxicity data from esophageal cancer patients.
- Trial name
- SFP OES (NCT02454790)
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- University Medical Center Groningen
Cancer, Toxicity Due to Chemotherapy
Dose Optimization and Efficacy Assessment of a Fluoropyrimidine Antidote
Fluoropyrimidines (FLU) are drugs widely used in chemotherapy for various tumors, such as breast, colon, rectal, and gastric cancers.
- Trial name
- ARCTURUS (NCT07032142)
- Testing
- I-01/23
- Where
- 5 sites in Brazil
- Volunteers
- 66 people
- Sponsor
- D'Or Institute for Research and Education
Ofloxacin, Bone and Joint Infection
Ofloxacin Concentration-toxicity Relationship in the Elderly
Ofloxacin is a gold standard antibiotic for the treatment of bone and joint infections due to sensible staphylococcus strains. However, in the elderly, inter-individual variability of the pharmacokinetics may reduce the efficacy…
- Conditions
- Ofloxacin, Bone and Joint Infection, Therapeutic Drug Monitoring, Adverse Drug Reactions
- Trial name
- ROSCO (NCT04496024)
- Testing
- ofloxacin, questionnaire, Ofloxacin Serum concentration
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Solid Cancers
Monitoring of Immunological Mechanisms and Biomarkers Underlying Efficacy and Toxicity of Cancer Immunotherapy
This is a translational, open-label, multi-site, prospective cohort study aiming to identify and to monitor immunological biomarkers associated with therapeutic response to immune checkpoints blockade (ICB), in patients with…
- Trial name
- MINER (NCT03514368)
- Testing
- Patients treated with immune checkpoint blockade
- Where
- 3 sites in France
- Volunteers
- 770 people
- Sponsor
- Institut Claudius Regaud
Head and Neck Squamous Cell Carcinoma, Locally Advanced Rectal Cancer
GALENOS 1 in Head and Neck, Lung, and Rectal Cancer Patients
GALENOS 1 is a prospective observational study designed to explore longitudinal changes in nutritional status and body composition in patients with head and neck squamous cell carcinoma, locally advanced rectal cancer, and lung…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Locally Advanced Rectal Cancer, Lung Cancer
- Trial name
- GALENOS 1 (NCT07511413)
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Radiation Proctitis, Gastrointestinal Hemorrhage
A Study of Chlorophyllin or Placebo With Standard Treatment for Late Radiation Induced Luminal Gastrointestinal Tract Bleeding
This multicenter, randomized, double-blind, placebo-controlled Phase III clinical trial will evaluate whether oral sodium copper chlorophyllin (CHL) is effective and safe for treating late radiation-induced gastrointestinal (GI)…
- Conditions
- Radiation Proctitis, Gastrointestinal Hemorrhage, Radiation Injuries
- Trial name
- NCT07837713
- Testing
- Chlorophyllin, Sodium Copper Complex
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Centre
Acute Myeloid Leukemia
ONC-LEUK-2406: The Impact of Systematic Financial Navigation in Acute Myeloid Leukemia
The purpose of this research is to see how personal financial burden (financial toxicity) related to cancer affects the overall health and quality of life by evaluating the impact of systematic financial navigation in addition to…
- Trial name
- NCT06945042
- Testing
- Arm A, Arm B
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Wake Forest University Health Sciences
Prostate Cancer
A Trial Evaluating Toxicity of SBRT and LDRB in Localized Prostate Cancer.
The goal of this clinical trial is to compare SBRT (Stereotactic Body RadioTherapy) to LDRB (Low-Dose Rate Brachytherapy with Iodine-125 seed implant) in patients with low and favourable intermediate-risk prostate cancer.
- Trial name
- NCT06052683
- Testing
- Low-Dose Rate Brachytherapy to the prostate using Iodine-125 seed implant, Stereotactic Body Radiation Therapy to the prostate
- Where
- Canada
- Volunteers
- 208 people
- Sponsor
- CHU de Quebec-Universite Laval
Melanoma
Dose Ranging, Toxicity Seeking, Phase 1 Trial of Oncolytic Adenoviral Therapy for Melanoma Intracranial and Extracranial Metastases
The goal of this clinical research study is to find the recommended dose level and recommended number of injections of the study agent DNX-2401 that can be given to patients with metastatic melanoma that have intracranial and/or…
- Trial name
- NCT07444606
- Testing
- DNX-2401
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Male Erectile Disorder, Prostate Cancer
Focal Therapy for Prostate Cancer Using HIFU
RATIONALE: Prospective trials using hemi-ablation with high intensity focused ultrasound (HIFU) (Sonablate 500) have demonstrated feasibility, safety, and encouraging functional outcomes and early cancer control with 90% of men…
- Conditions
- Male Erectile Disorder, Prostate Cancer, Therapy-related Toxicity, Urinary Incontinence
- Trial name
- INDEX (NCT01194648)
- Testing
- questionnaire administration, assessment of therapy complications, high-intensity focused ultrasound ablation
- Where
- United Kingdom
- Volunteers
- 354 people
- Sponsor
- University College, London
Seminoma
PRISTINE Trial: PRoton Beam Therapy In Seminoma - Toxicity INvestigation and Evaluation of Outcome
Stage II seminoma is a type of cancer that is usually highly curable and most often affects young men. Radiotherapy is an effective treatment, but it can sometimes cause side effects in the long term and, rarely, increase the…
- Trial name
- PRISTINE (NCT07601672)
- Testing
- protontherapy
- Volunteers
- 20 people
- Sponsor
- Istituto Clinico Humanitas
Oncology
Understanding immunE-related toXicities by multifACeT Profiling
A prospective observational cohort study of patients undergoing CPI therapy in which translational research is the fundamental aspect of the study.
- Trial name
- EXACT (NCT05331066)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Breast Cancer, Capsular Contracture Associated With Breast Implant
Predictive Toxicity Test Linked to Radiotherapy After Mastectomy and Immediate Implant Reconstruction
This study evaluates the capacity of the NovaGray RILA Breast® test to predict the toxicity linked to radiotherapy and the impact of implant breast reconstruction.
- Trial name
- PRETORIA (NCT04342546)
- Testing
- NovaGray RILA Breast® test
- Where
- 9 sites in France
- Volunteers
- 250 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Myocarditis, Cardiomyopathies
JOint Use of Database to Identify Risk Factors of CARDio-vascular Toxicity Induced by Immune Checkpoint Inhibitors
Immune checkpoint inhibitors (ICIs) might induce high grade immune-related adverse events (irAEs) involving the cardio-vascular system.
- Conditions
- Myocarditis, Cardiomyopathies, Heart Diseases, Cardiovascular Diseases
- Trial name
- JOCARDITE (NCT04294771)
- Testing
- ICI
- Where
- France
- Volunteers
- 500,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Neurological Cancer
Standard Follow-up Program Neuro-oncology Patients (SFP Neuro-Oncology)
Standardised evaluation of baseline data regarding tumor-, patient- and treatment-characteristics as well as follow-up data regarding tumor- and clinical-outcome of neuro-oncology patients treated with radical/curative…
- Trial name
- NCT06528912
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- University Medical Center Groningen
Cancer, Immune System or Toxicities Suspected
Exploration of Adaptive Antitumoral Immune Cells Through Lymphapheresis in Cancer Patients : ALCYTA
The study will evaluate the detection of tumor-antigen specific immune cells in cancer patients in whom the role of the immune system is suspected.
- Trial name
- ALCYTA (NCT05354765)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Institut Curie
Colorectal Cancer, Sarcopenia
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.
- Trial name
- M&M (NCT03998202)
- Where
- 147 sites in United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences