Clinical trials: Trabeculectomy
Open-angle Glaucoma (OAG), Ocular Hypertension (OHT)
Direct vs Standard SLT for Glaucoma: A Noninferiority Trial
This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss.
- Trial name
- NCT07408154
- Testing
- Direct Selective laser Trabeculoplasty
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Medical University of South Carolina
Glaucoma, Open-Angle, Ocular Hypertension
Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension
This study will evaluate the intraocular pressure (IOP)-lowering effect and safety of bimatoprost SR compared with selective laser trabeculoplasty in patients with open-angle glaucoma or ocular hypertension who are not adequately…
- Trial name
- NCT02507687
- Testing
- Bimatoprost SR, Selective Laser Trabeculoplasty
- Where
- 95 sites in United States, Australia and 10 more
- Volunteers
- 240 people
- Sponsor
- AbbVie
Open Angle Glaucoma
Effects of Selective Laser Trabeculoplasty on Aqueous Humor Dynamics
This study will compare aqueous humor dynamics in adults with primary open angle glaucoma that receive Selective Laser Trabeculoplasty (SLT).
- Trial name
- NCT01342406
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- University of Nebraska
Glaucoma, Choroidal Effusions
Triamcinolone Injections for Persistent Choroidal Effusions Post Glaucoma Surgery
During glaucoma surgery, a new opening is created that allows fluid to drain out of the eye, bypassing the clogged drainage channels that are malfunctioning in patients with glaucoma.
- Trial name
- TRICEPS (NCT02917564)
- Testing
- Triamcinolone Acetonide 1 ml of 40 mg/mL suspension
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Glaucoma, Cataracts
Intraocular Pressure Control Following One Site Versus Two Site Combined Phacoemulsification/IOL And Trabeculectomy
The purpose of this study is to compare the safety \& effectiveness of the two types of cataract and glaucoma surgeries. Results from this study may improve the surgical and post surgical management and long term management of…
- Trial name
- NCT00695747
- Testing
- 2 Site procedure- Phacoemulsification/IOL and Trabeculectomy
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Lahey Clinic
Primary Open-angle Glaucoma
SIGHT Study: Cost-effectiveness of InnFocus Microshunt Implantation vs. Trabeculectomy.
The standard surgical treatment for glaucoma is trabeculectomy. The PRESERFLO™ (formerly InnFocus) Microshunt (IMS) is a new, minimally invasive drainage device which has been suggested to result in similar IOP lowering, but with…
- Trial name
- SIGHT (NCT03931564)
- Testing
- PRESERFLO Microshunt implantation, Trabeculectomy
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Primary Open Angle Glaucoma, Ocular Hypertension
Direct Selective Laser Trabeculoplasty in Ethnic Chinese Population
The objective of this study is to evaluate the safety and effectiveness of Direct Selective Laser Trabeculoplasty (DSLT) in ethnic Chinese participants with Primary Open Angle Glaucoma (POAG), Ocular Hypertension (OHT), or Normal…
- Conditions
- Primary Open Angle Glaucoma, Ocular Hypertension, Normal Tension Glaucoma
- Trial name
- Zhuiguangzhe (NCT05902871)
- Testing
- External Automatic Glaucoma Laser, Direct Selective Laser Trabeculoplasty
- Where
- 2 sites in China, Singapore
- Volunteers
- 40 people
- Sponsor
- BelkinVision
OCTA
Conjunctival Vascularity Changes Usnig OCTA After Trabeculectomy
Reduce the trauma and the time taken for patient rehabilitation. The prevailing trend is to perform a mitomycin- C (MMC)-augmented trabeculectomy and trabeculectomy with ologen implants in a trial to decrease bleb failure as a…
- Trial name
- NCT04493073
- Testing
- Trabectulectomy, Mitomycin, Ologen Collagen Implant
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Asmaa Ahmed Ali Youssif
Glaucoma
Will the Use of Triesence During Glaucoma Surgery Provide Lower Eye Pressure and Improve the Results of the Surgery?
The investigators hypothesize that intracameral Triesence during glaucoma surgery will provide lower intraocular pressure through better control of ocular inflammation, thus leading to a more successful filtering procedure.
- Trial name
- NCT00853905
- Testing
- Triesence, balanced salt solution BSS
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Wills Eye
Primary Open Angle Glaucoma
Results of Ocular Compression and Suture Release in Trabeculectomy and Combined Surgery
The use of ocular compression and suture release have helped to improve the safety and decrease the risks of glaucoma filtering surgery.
- Trial name
- NCT00327405
- Where
- United States
- Sponsor
- University of Cincinnati
Angle Closure Glaucoma, Glaucoma
Anterior Segment Changes by Optical Coherence Tomography (OCT) in Phaco- Trabeculectomy
1. Develop a measurement protocol by OCT imaging and characterization of the anterior chamber change in glaucoma patients before and after surgery. 2. Show the effect of combined surgery in control of intra ocular pressure.
- Conditions
- Angle Closure Glaucoma, Glaucoma, Cataract Secondary
- Trial name
- NCT03626675
- Testing
- phaco- trabeculectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Glaucoma, Trabeculectomy
Innovative Tube Trabeculectomy for Advanced and Refractory Glaucoma: A Randomized Controlled Trial
This study aims to compare the efficacy and safety of a novel surgical technique, Innovative Tube Trabeculectomy (ITT), against conventional trabeculectomy in patients with advanced and refractory glaucoma.
- Conditions
- Glaucoma, Trabeculectomy, Innovative Procedures
- Trial name
- ITT-RCT (NCT07755761)
- Testing
- Innovative Tube Trabeculectomy, Conventional Trabeculectomy
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Benha University
Glaucoma
Effects of Selective Laser Trabeculoplasty
Primary objective is to evaluate the effect of selective laser trabeculoplasty (SLT) on the diurnal intraocular pressure variation in open-angle glaucoma patients (OAG).
- Trial name
- SLT (NCT00986141)
- Testing
- Surgery, Selective Laser Trabeculoplasty
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kentucky
Glaucoma, Ocular Hypertension
Efficacy of Selective Laser Trabeculoplasty in Pseudophakic Patients
Retrospective analysis of efficacy of selective laser trabeculoplasty in pseudophakic patients compared to phakic patients is performed.
- Trial name
- NCT01467388
- Testing
- selective laser trabeculoplasty (SLT)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Glaucoma, Primary
Biomechanical Changes After Trabeculectomy
Corneal biomechanics are studied in glaucoma patients prior and at least 6 month after trabeculectomy.
- Trial name
- TE-biomech (NCT02287545)
- Testing
- trabeculectomy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technische Universität Dresden
Pediatric Aphakic Glaucoma
Trabeculectomy With MMC Versus Ahmed Glaucoma Implant for Treatment of Pediatric Aphakic Glaucoma
In this randomized clinical trial we compare trabeculectomy with mitomycin-C (T+MMC) and Ahmed glaucoma implant (AGI) in treatment of aphakic glaucoma in children under 16 years of age.Complete and qualified success were defined…
- Trial name
- NCT00371072
- Testing
- trabeculectomy with mitomycin-C
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Eye Diseases, Optic Nerve Damage
Comparison of Efficacy and Safety of Mitomycin and Aflibercept Used to Support Primary Trabeculectomy.
Comparison of efficacy and safety of Mitomycin and Aflibercept used to support primary trabeculectomy - a prospective, randomized trial in patients with open-angle glaucoma undergoing surgery.
- Conditions
- Eye Diseases, Optic Nerve Damage, Glaucoma Surgery
- Trial name
- NCT03766425
- Testing
- Aflibercept, Mitomycin
- Where
- Poland
- Volunteers
- 64 people
- Sponsor
- Medical University of Lublin
Glaucoma
Express Implant Versus Trabeculectomy After Late Failure Trabeculectomy
To compare between outcome of Express implant and subscleral trabeculectomy (SST) in management of glaucoma after previous trabeculectomy with a fibrotic bleb.
- Trial name
- NCT04417920
- Testing
- Express implant device
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Menoufia University
Glaucoma Patients Scheduled for Trabeculectomy
Comparison of Two Method Antimetabolites Application on Corneal Function in Trabeculectomy Surgery
Application of antimetabolite agents such as mitomycin_c has improved trabeculectomy results and better control of intraocular pressure complications such as corneal endothelial cell loss.
- Trial name
- NCT01297803
- Testing
- Mitomycin_c
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Glaucoma
Study of PGA Suture in Ophthalmology
To evaluate the safety and efficacy of polyglycolic acid suture in ophthalmic surgical procedures
- Trial name
- NCT00351429
- Testing
- Polyglycolic acid suture
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Aurolab