Clinical trials: Tracheal Stenosis
Idiopathic Subglottic Tracheal Stenosis
Voice Quality Analysis of Patients With Laryngotracheal Stenosis
The investigators previously demonstrated that voice changes are common in patients with Laryngotracheal Stenosis (LTS), and patients typically report an improvement in voice outcomes following endoscopic dilation.
- Trial name
- NCT06161077
- Testing
- Voice Biomarker Screening Too
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Tracheal Stenosis
Office-based Radial Expansion Balloon Dilation of the Esophagus and Trachea
Retrospective chart review of UCDMC patients who have undergone esophageal or tracheal balloon dilation to record data including age, gender, diagnosis pre-and post-procedure eating assessment tool, esophagoscopy findings…
- Trial name
- NCT00583960
- Sponsor
- University of California, Davis
Tracheal Stenosis, Laryngeal Stenosis
Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells
The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis
- Conditions
- Tracheal Stenosis, Laryngeal Stenosis, Mesenchymal Stem Cells
- Trial name
- NCT03130374
- Testing
- Olfactory mucosa-derived mesenchymal stem cells
- Where
- 2 sites in Belarus
- Volunteers
- 12 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Tracheomalacia, Tracheal Stenosis
A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells
This is a phase I study to evaluate the safety, efficacy and tolerability of a novel tracheal replacement therapy using cadaveric de-cellularised tracheal scaffold and patients' own mesenchymal cells isolated from a sample of…
- Trial name
- NCT02949414
- Testing
- Cadaveric decellularised tracheal scaffold seeded with autologous mesenchymal cells
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- Cell Therapy Catapult
Tracheal Stenosis
DilAtation Versus Endoscopic Laser Resection in Simple Benign trAcheal sTEnosis
Multicenter randomized controlled trial comparing endoscopic laser resection vs dilatation in benign tracheal stenosis.
- Trial name
- AERATE (NCT04719845)
- Testing
- Endoscopic laser resection, Dilatation
- Where
- 4 sites in Canada, France
- Volunteers
- 108 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Apnea+Hypopnea, Tracheal Dilatation
Tracheal Dilatation in Pediatric Patients With Acquired Tracheal Stenosis, and the Effects of Apneic Oxygenation
The study presents an alternative method of tracheal dilatation in pediatric patients with acquired tracheal stenosis. Dilatation is performed by the use of balloon catheter connected with manometer, that is bronchoscopic guided…
- Conditions
- Apnea+Hypopnea, Tracheal Dilatation, Igel, Tracheal Stenosis
- Trial name
- NCT05028023
- Testing
- Apneic oxygenation - supplemental high flow oxygen administration by an apneic way
- Where
- Greece
- Volunteers
- 5 people
- Sponsor
- Aristotle University Of Thessaloniki
Respiratory Disease, Tracheal Stenosis
Total Intravenous Anesthesia for Rigid Bronchoscopy Using Remimazolam
Rigid bronchoscopy usually requires deep general anesthesia, but the duration of the procedure is relatively short. Remimazolam, a recently developed anesthetics, showed faster recovery from anesthesia and stable hemodynamics…
- Conditions
- Respiratory Disease, Tracheal Stenosis, Endobronchial Mass
- Trial name
- NCT05835713
- Testing
- Remimazolam besylate, Propofol
- Sponsor
- Samsung Medical Center
Idiopathic Subglottic Tracheal Stenosis
Everolimus Trial in Laryngotracheal Stenosis
Subglottic stenosis (obstructing scar in the larynx and trachea) occurs in patients spontaneously (idiopathic), with autoimmune disease, and after long-term breathing tube placement and can result in communication disability and…
- Trial name
- NCT05153668
- Testing
- Everolimus Oral Tablet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Johns Hopkins University
Idiopathic Subglottic Stenosis (iSGS)
Treatment Alternatives in iSGS (NoAAC PR-02 Study)
The study is aimed at answering the questions; (1) How well do the most commonly used treatments in iSGS work? and (2) What quality-of-life trade-offs are associated with each approach? With the results of this trial, the…
- Trial name
- NoAAC PR-02 (NCT02481817)
- Testing
- Endoscopic dilation of subglottic stenosis, Endoscopic resection of the stenosis, Tracheal Resection
- Where
- 42 sites in United States, Australia and 2 more
- Volunteers
- 1,239 people
- Sponsor
- Vanderbilt University Medical Center
Anomalies of Pulmonary Artery, Congenital
Relationship Between Tracheal and Left Pulmonary Artery Stenosis Index and Prognosis of PA Sling With Tracheal Stenosis
Pulmonary artery sling is a rare congenital pulmonary vascular malformation, often associated with tracheal or bronchial stenosis.
- Trial name
- NCT04383184
- Testing
- tracheoplasty
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Fudan University
Barrett Esophagus, Esophageal Dysplasia
trūFreeze® Spray Cryotherapy Patient Registry
To collect efficacy and outcomes data related to the use of trūFreeze® spray cryotherapy for the treatment of unwanted tissue in the pulmonary and gastrointestinal settings.
- Conditions
- Barrett Esophagus, Esophageal Dysplasia, Esophageal Neoplasm, Esophageal Stenosis
- Trial name
- NCT01802203
- Testing
- truFreeze Spray Cryotherapy
- Where
- 16 sites in United States
- Volunteers
- 275 people
- Sponsor
- US Endoscopy Group Inc.
Chronic Obstructive Pulmonary Disease
Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing
This study is aimed to determine factors leading to obstructive granulation tissue formation after placement of Self-Expandable Metallic Stent (SEMS) in patients with benign tracheal diseases.
- Trial name
- NCT01006200
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- Chang Gung Memorial Hospital
Tracheal Stenosis
Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision
Some people develop a narrowing of their windpipe (trachea), called benign tracheal stenosis, which can make it hard to breathe.
- Trial name
- NCT07463742
- Testing
- Bronchoscopy, carbon dioxide (CO2) laser wedge resection, Radial incision with dilation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Esophageal Diseases
Post Market Clinical Study - Evolution® Esophageal Stent Systems, Europe: Fully and Partially Covered
The aim of this post-market clinical follow-up study is to evaluate the continued safety and performance of the marketed Evolution® Esophageal Stent System (Partially- and Fully Covered).
- Trial name
- NCT05182255
- Testing
- Evolution® Esophageal Stent Systems, Europe: Fully and Partially Covered
- Where
- 5 sites in Germany, Spain and 1 more
- Volunteers
- 127 people
- Sponsor
- Cook Research Incorporated
Disorder of Upper Respiratory System, Laryngostenosis
Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants
This study aims to test a new groundbreaking treatment for narrowing of the voicebox and upper windpipe, which can be due to injury, inflammatory disease or cancer treatment.
- Conditions
- Disorder of Upper Respiratory System, Laryngostenosis, Tracheal Stenosis
- Trial name
- RegenVOX (NCT01977911)
- Testing
- Stem cell based tissue engineered partial laryngeal implants
- Where
- United Kingdom
- Sponsor
- University College, London
Stenosis Trachea
Cryospray Therapy for Benign Airway Stenosis
This is a clinical evaluation to assess the effectiveness of cryospray therapy used in addition to current standard of care endoscopic therapies in preventing short term recurrent airway stenosis with a multicentric outcome…
- Trial name
- CRYOSTASIS (NCT06085209)
- Testing
- The truFreeze Spray Cryotherapy, Ballon dilation, Radial Incision
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Foreign Bodies, Tumor
High-flow Nasal Oxygen During Rigid Bronchoscopy Under General Anesthesia: a Randomized Controlled Trial
The aim of this study is to evaluate the effect of high-flow nasal cannula oxygen administration on apnea in patients undergoing general anesthesia with rigid bronchoscopy compared with standard anesthesia methods.
- Conditions
- Foreign Bodies, Tumor, Stenosis Trachea, Bronchus Tumour
- Trial name
- NCT03892408
- Testing
- Optiflow ™
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Tracheal Stenosis, COVID-19
Relationship Between Post-Intubation Tracheal Stenosis and Covid-19
Tracheal stenosis (TS) is a serious complication that occurs in approximately 6-22% of patients due to prolonged endotracheal intubation.
- Conditions
- Tracheal Stenosis, COVID-19, Post-Intubation Subglottic Stenosis, Intensive Care Unit
- Trial name
- NCT05682651
- Testing
- tracheal stenosis follow-up file
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Ankara City Hospital Bilkent
Trachea Diseases, Tracheal Stenosis
Feasibility of Tracheobronchial Reconstruction Using Allogenic Aortic Patch in Children
Feasibility and safety of repairing tracheal and bronchial defects in infants and children using cryopreserved donor aortic patches.
- Conditions
- Trachea Diseases, Tracheal Stenosis, Tuberculosis; Tracheitis, Airway Disease
- Trial name
- NCT07240259
- Testing
- Cryopreserved aorta
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Tracheal Stenosis, Intensive Care Unit
Long-term Outcomes of Post-intubation Tracheal Stenosis; 7-year Follow-up
This retrospective, observational, cohort study evaluates the treatment management, long-term outcomes and survival analyses in patients hospitalized in the Intensive Care Unit with a diagnosis of Post-Intubation Tracheal…
- Trial name
- NCT06121024
- Testing
- Interventional Bronchoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital