Clinical trials: Tracheostomy Patients
Delayed Tracheostoma Healing Following Decannulation in Long-term Tracheostomy Patients
Predictive Model for Stoma Healing After Tracheostomy Decannulation in Patients With Prolonged Tracheostomy
Prolonged tracheostomy is prone to induce chronic airway mucosal injury and tracheal cartilage degeneration, which not only elevates the risks of post-decannulation complications such as persistent fistula non-healing, airway…
- Trial name
- STOMA-PRED (NCT07747844)
- Testing
- No intervention
- Where
- China
- Volunteers
- 219 people
- Sponsor
- Capital Medical University
Neuromuscular Diseases, Respiration, Artificial
Quality of Life in Ventilator-dependant Neuromuscular Patients
This study aims at evaluating the quality of life of patients with slowly progressive neuromuscular disorders who are dependant on mechanical ventilation (daily usage ≥ 16h).
- Conditions
- Neuromuscular Diseases, Respiration, Artificial, Tracheostomy, Noninvasive Ventilation
- Trial name
- EqualVENT (NCT04652401)
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
ICU Patients, Healthy Lung
Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Respiratory Distress Syndrome
PEEP titration is a recommended during invasive mechanical ventilation of ICU patients. However, little is known about the right way to conduct this titration.
- Conditions
- ICU Patients, Healthy Lung, Positive End-Expiratory Pressure, ARDS
- Trial name
- PEEP-Réa (NCT04503876)
- Testing
- Increasing PEEP setting, Decreasing PEEP setting
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
ICU Patients, Tracheotomy Required
Electric Impedance Tomography Before and After Dilatative Tracheotomy
The changes of local pulmonary ventilation should be registered with an electric impedance tomography (EIT) before and after a dilatative tracheotomy.
- Trial name
- NCT02161328
- Testing
- EIT belt
- Where
- 2 sites in Germany
- Volunteers
- 29 people
- Sponsor
- Stefan Kluge
Critical Care, Oxygen Therapy
Comparison of Physiological Effects of Two Types of High-Flow Oxygen Therapy in Tracheostomized Patients
High-flow nasal oxygen therapy offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function.
- Conditions
- Critical Care, Oxygen Therapy, Tracheostomy
- Trial name
- NCT06816745
- Testing
- Modified high flow tracheal oxygen, Standard high flow tracheal oxygen
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jian-Xin Zhou
Spinal Cord Injury Cervical
Randomized Controlled Study on T-PEP Versus IPV Method for Lower Respiratory Airways Clearance in Tetraplegic Tracheotomized Spinal Cord Injured Patients
In tetraplegic patients with complete cervical spinal cord injury, respiratory complications are very frequent, especially in the sub-acute phase: the lungs often become obstructed due to the accumulation of secretions and the…
- Trial name
- T-PEP (NCT04142814)
- Testing
- T-PEP, IPV
- Where
- Italy
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative
Peri-operative BiPAP to Prevent Tracheostomy in High-Risk Bilateral Vocal-Cord Paralysis (BVCP)
Why: After thyroid or neck surgery, some patients can lose movement of both vocal cords (bilateral vocal-cord paralysis, BVCP). This can make breathing difficult and often leads to an emergency or preventive tracheostomy…
- Conditions
- Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative, Thyroid Neoplasms, Sleep Apnea, Obstructive
- Trial name
- BVCP-BiPAP (NCT07042971)
- Testing
- Pre-operative BiPAP Training, Post-extubation BiPAP Support, Standard Peri-operative Care
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Fujian Medical University
ICU Patients, Intubation
Pulmonary and Ventilatory Effects of Trigger Modulation in Intubated ICU
Pressure support ventilation allows intubated ICU patients to breathe spontaneously. Among specific settings, the adjustment of the trigger value (or threshold for triggering the ventilator) has not been explored to date.
- Conditions
- ICU Patients, Intubation, Spontaneously Breathing, Pulmonary Function
- Trial name
- Trigger (NCT04041817)
- Testing
- Trigger setting of pressure support ventilation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiratory Failure, Speech
Early Speech With One-Way Speaking Valve in Tracheostomy Patients
Patients with tracheostomy who are on and off of mechanical ventilation initially lose the ability to speak, and the use of one-way speaking valves (OWSV) is one method of restoring speech in these patients.
- Conditions
- Respiratory Failure, Speech, Aphonia
- Trial name
- NCT03008174
- Testing
- Early one-way speaking valve (OWSV) assessment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Tracheostomy, Cough
Objective Evaluation of Cough Effort in Tracheotomized Patients (LOST Study)
This study aims to evaluate how well tracheotomized patients can cough before and after their tracheostomy tube is removed. Cough strength is measured using two different tools-Peak Flow and Lorio.
- Conditions
- Tracheostomy, Cough, Weaning, Respiratory Function Tests
- Trial name
- NCT07061561
- Testing
- Peak Expiratory Flow Measurement Using Peak Flow Meter and Lorio Device
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Tracheostomy Decannulation
The Effect of Speaking Valve on Physiological Parameters With Wearable Devices
To explore the effect of speaking valves on physiological parameters of tracheostomized patients with wearable devices.
- Trial name
- Effect of SV (NCT07422350)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jingyi Ge
Stroke, Tracheotomy Patients
Study on the Correlation Mechanism and Application of Genetic Susceptibility, Hemoglobin Adaptation Changes, and Extubation Success Rate in Stroke Patients With Tracheotomy at Different Altitudes
Patients with brain injuries caused by various reasons often need tracheotomy to improve breathing, but this procedure can cause the air to lose its nasal regulation, increase the risk of lung infections, and reduce their quality…
- Trial name
- NCT07014501
- Testing
- High altitude, Medium altitude, Low altitude group
- Where
- China
- Volunteers
- 717 people
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Dysphagia, Oropharyngeal Dysphagia
Incidence of Dysphagia in Intensive Care Patients With Tracheostomy
This study will inform the feasibility of the High Resolution Impedance Manometry (HRIM) system combined with Automated Impedance Manometry (AIM) analysis as a screening tool for dysphagia and aspiration for the intensive care…
- Trial name
- NCT02874352
- Testing
- high resolution impedance manometry with Automated Impedance Manometry analysis
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Respiratory Failure
Humidity Therapy for Spontaneously Breathing Tracheostomy Patients
The goal of the study is to compare the safety and efficacy of molecular water and bland aerosol therapy (particulate water) in providing adequate humidity to the inspired gas of spontaneously breathing tracheostomy patients.
- Trial name
- NCT02686489
- Testing
- Heated humidification, Cool bland aerosol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rush University Medical Center
Respiratory Complications, Pneumonia
Incidence and Complications of Post-extubation and Post-tracheostomy Dysphagia in Adult Patients in the Critical Care Unit
Acquired Swallowing Disorder in ICU (ICU-ASD), also known as postextubation dysphagia, is a multicausal problem experienced by survivors in intensive care units (ICUs) when the efficiency, safety of swallowing, or both are…
- Conditions
- Respiratory Complications, Pneumonia, Quality of Lifte, Death
- Trial name
- NCT06583824
- Volunteers
- 414 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
Long-term Tracheostomy Ventilated Patients
Effects of Vibrating Mesh Nebulisation in Patients on Long-term Tracheostomy Ventilation: a Pilot Randomised Crossover Trial
Assessment of the effects of vibrating mesh nebulisation versus jet nebulisation on respiratory function in patients with long-term tracheostomy ventilation: evaluating neural respiratory drive, breathing mechanics, cardiac…
- Trial name
- EVOLVE (NCT06834581)
- Testing
- Vibrating mesh nebuliser, Jet nebuliser
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Respiratory Distress Syndrome (RDS), Respiratory Ilness
Study on the Correlation Between Tracheotomy Tip Pressure and Esophageal Pressure in Patients Weaned from Tracheotomy
Whether the correlation between gas incision tip pressure fluctuations (ΔPtt) and esophageal pressure fluctuations (ΔPes) is a potential measure of spontaneous respiratory effort in patients undergoing gas incision offline.
- Trial name
- NCT06783777
- Testing
- Esophageal pressure monitoring, Tracheotomy tip pressure
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Shanghai Zhongshan Hospital
Stroke
Comparison of Speaking Valve Trial and Capping Trial for Tracheostomy Decannulation in Stroke Patients
This study aims to compare the efficacy and safety of the Speaking Valve trial versus the traditional Capping trial as indicators for tracheostomy decannulation in stroke patients.
- Trial name
- NCT07435727
- Testing
- Passy-Muir Speaking Valve, Tracheostomy tube capping
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hongying Jiang, MD
Tracheostomy, ICU
Determinants of Successful Decannulation in Difficult-to-wean Patients
The factors of success of decannulation are not well known in the literature and the decision to decannulate is mainly based on clinical judgment.
- Conditions
- Tracheostomy, ICU, Weaning Failure
- Trial name
- DESCATRON (NCT04841889)
- Testing
- Associated factors with decannulation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hopital Forcilles
Weaning Failure
Changes of Weaning Parameter in Weaning Failure Patient After Tracheostomy as a Predictor of Subsequent Weaning
Weaning from mechanical ventilator is an essential element in the care of critically ill intubated patients receiving mechanical ventilation.
- Trial name
- NCT01312142
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital