Clinical trials: Transcranial Doppler Ultrasound
Carotid Artery Stenosis, Ischemic Stroke
Platelet Reactivity and MES During CEA
The purpose of this study is to analyze the association between aspirin efficacy and general platelet reactivity in relation to microembolic signals (MES) during carotid endarterectomy (CEA).
- Conditions
- Carotid Artery Stenosis, Ischemic Stroke, Myocardial Infarction, Aspirin Resistance
- Trial name
- NCT01547039
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Sturge-Weber Syndrome
Biomarker Development in Sturge-Weber Syndrome
This is a study of 40 individuals with Sturge-Weber Syndrome (SWS) brain and/or eye involvement. It will examine the test-retest reliability of the following clinical tests: 1. Quantitative EEG 2. Transcranial Doppler 3.
- Trial name
- Pilot (NCT01345305)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Sickle Cell Anemia, Cerebrovascular Accident
Allogeneic Genoidentical Stem Cell Transplantation in Children With Sickle-cell Anemia and Cerebral Vasculopathy
The aim of this study is to demonstrate that cerebral velocities assessed by transcranial doppler (TCD) are more significantly decreased by SCT than by long-term transfusion program A multicenter, national, non-randomized…
- Trial name
- DREPAGREFFE (NCT01340404)
- Testing
- Stem cell transplantation, Transfusion program
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vasospasm
Comparing the Nautilus NeuroWaveTM to TCD or DSA for the Detection of Vasospasm
To determine the efficacy of using the Jan Medical NNW system as a diagnostic aid in detection of moderate and severe vasospasm for detection of vasospasm in patients with subarachnoid hemorrhage.
- Trial name
- NCT02071875
- Testing
- Nautilus NeuroWaveTM recording
- Where
- Germany
- Volunteers
- 43 people
- Sponsor
- Jan Medical, Inc.
Stenosis, Occlusion
Diagnostic Performance of the Resistance Index (RI) for the Assessment of Cerebral Vasoreactivity in Transcranial Doppler
Routine revascularization of asymptomatic carotid stenosis is questionable as optimal medical therapy has significantly reduced the risk of stroke.
- Trial name
- REVACEIR (NCT05780619)
- Testing
- Transcranial Doppler
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Aortic Valve Stenosis, Extracorporeal Circulation
Cerebral Embolic Load in Patients Undergoing Surgical Aortic Valve Replacement: A Comparison of the Conventional With the Minimized Extracorporeal Circulation Technique Using Transcranial Doppler Ultrasound
In this study, the investigators aim to compare cerebral embolic load in patients undergoing surgical aortic valve replacement using either the minimized extracorporeal circulation or the conventional extracorporeal circulation…
- Trial name
- AKE-MECC (NCT02308566)
- Testing
- Minimized Extracorporeal Circulation (MECC), Conventional Extracorporeal Circulation (CECC)
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stroke
Effects of Aerobic Exercise on the Cerebral Arterial System, Cognitive, and Motor Function in Post-stroke Patients.
Background: Stroke is the second leading cause of death and disability worldwide and in Hong Kong, 6.2% of all registered deaths in 2020 were due to cerebrovascular disease.
- Trial name
- NCT05706168
- Testing
- treadmill exercise, Cycle ergometer exercise
- Where
- Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Arterial Ischemic Stroke
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also…
- Trial name
- DOP-MOBILIZE (NCT07232498)
- Testing
- Doppler-guided early mobilization
- Where
- 7 sites in Croatia, Portugal
- Volunteers
- 1,300 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Sickle Cell Disease
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease
This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.
- Trial name
- HOPE Kids 2 (NCT04218084)
- Testing
- Voxelotor
- Where
- 35 sites in United States, Egypt and 7 more
- Volunteers
- 236 people
- Sponsor
- Pfizer
Postoperative Delirium After On-pump Cardiac Surgery
Preoperative Transcranial Doppler as a Predictor for Delirium Following On-pump Cardiac Surgery
Postoperative delirium is an important problem in patients undergoing major cardiac surgery and associated with more complicated hospital course, increased hospital length of stay and total postoperative cost.
- Trial name
- NCT02478736
- Testing
- No actual intervention
- Where
- South Korea
- Volunteers
- 175 people
- Sponsor
- Yonsei University
Blood Disease, Brain Injuries
Role of Transcranial Doppler and Magnetic Resonance Angiography for Future Management of Sickle Cell Anemia CNS.
This study aimed to determine the Predictive Value of Transcranial Doppler and Magnetic Resonance Angiography for Future Management of Sickle Cell Anemia.
- Trial name
- NCT06498726
- Testing
- transcranial doppler
- Volunteers
- 18 people
- Sponsor
- Eman Abdul-Hai
Ischemic Stroke, Carotid Stenosis
STAND: iSchemic sTroke evAluated at Bed Side With ultrasouND
Ischemic strokes account for more than 80% of strokes. Ischemic strokes are caused by the occlusion of an intracranial artery by a thrombus, responsible for tissue ischemia related to a decrease in local cerebral blood flow…
- Trial name
- STAND (NCT04180826)
- Testing
- Observational
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Post-Dural Puncture Headache
SGB in Management of Patients With PDPH Using TCD
This study aims to investigate the ability of SPGB in the management of PDPH. Transcranial Doppler is also used as an measure to assess the block success by detecting the variability in the cerebral hemodynamics before and after…
- Trial name
- NCT04401878
- Testing
- Sphenopalatine Ganglion Block using 2% lidocaine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Pre Eclampsia
Transcranial Doppler in Preeclampsia and Its Complications.
Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality. It is defined by new-onset hypertension after 20 weeks of gestation, often associated with proteinuria and/or systemic complications such as…
- Trial name
- DTC-PE (NCT07646561)
- Testing
- Transcranial doppler ultrasound
- Where
- Tunisia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Minimal Hepatic Encephalopathy
Transcranial Doppler Ultrasound and Minimal Hepatic Encephalopathy
Minimal hepatic encephalopathy (MHE) is a subclinical complication of liver cirrhosis with a relevant social impact. Thus, there is urgent need to implement easy to use diagnostic tools for the early identification of affected…
- Trial name
- NCT04077125
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Intracranial Pressure, Circulation System
The Effect of Arterial Carbon Dioxide Levels on Cerebral Blood Flow and Cerebral Autoregulation in the Steep Trendelenburg Position During Robot-assisted Prostatectomy, and Its Effect on Postoperative Cognition
Patients scheduled for robot-assisted prostatectomy will be randomized to either high or low concentrations of carbon dioxide in the blood.
- Conditions
- Intracranial Pressure, Circulation System, Cerebral Perfusion Pressure, Cognitive Function
- Trial name
- TILTDOWN-3 (NCT06865027)
- Testing
- Ventilation strategy
- Where
- Norway
- Volunteers
- 46 people
- Sponsor
- University Hospital, Akershus
Hemodynamics;In-stent Stenosis;Transcranial Doppler;Intracranial Aneurysm;Flow Diverter; Prospective Cohort Study
Hemodynamic Study of In-Stent Stenosis(I) After Flow Diverter(F) Based on 3D-DSA(D) Combined With TCCD(T)
DTFI is a single-center, prospective cohort study aimed at evaluating the hemodynamics of in-stent stenosis after flow diverter implantation, seeking to identify the threshold effect of blood flow in stenosis.
- Trial name
- DTFI (NCT06448949)
- Testing
- Flow Diverter Implantation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhujiang Hospital
Traumatic Brain Injury, Subarachnoid Hemorrhage
NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Liver Failure
- Trial name
- NOVEL ICP (NCT04548596)
- Testing
- Transcranial Doppler
- Where
- 3 sites in United States
- Volunteers
- 162 people
- Sponsor
- Emory University
Cerebral Autoregulation
Feasibility of Using NeuraSignal Transcranial Doppler Robot
The purpose of this study is to determine the feasibility of using the NeuraSignal transcranial doppler robot in a neuro ICU setting to measure cerebral blood flow correlated with arterial blood pressure to generate…
- Trial name
- NCT06565442
- Testing
- NeuraSignal transcranial doppler robot
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Acute Brain Injury, Mechanical Ventilation
Brain Monitoring During PEEP-Based Respiratory Therapy in Critically Ill Patients
Mechanical ventilation is commonly used in critically ill patients with acute brain injury. Positive end-expiratory pressure (PEEP) and lung recruitment maneuvers are important ventilator strategies for improving oxygenation, but…
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Neurocritical Care
- Trial name
- NCT07716787
- Testing
- Recruitment Maneuver, Positive End-Expiratory Pressure Adjustment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shengli Oilfield Hospital