Clinical trials: Transcranial Doppler Ultrasound
Sickle Cell Disease
Aspirin Prophylaxis in Sickle Cell Disease
Neurologic complications secondary to cerebrovascular damage are prevalent in children with sickle cell disease. These patients experience both clinically overt cerebrovascular accidents and "silent infarctions" demonstrated by…
- Trial name
- START (NCT00178464)
- Testing
- aspirin
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Carotid Occlusion Intolerance
Prediction of Carotid Occlusion Intolerance by Transcranial Doppler Evaluation in Patients Undergoing Carotid Artery Stenting With Proximal Flow Arrest Protection System.
The aim of this observational pilot study is to determine whether intolerance of carotid occlusion during carotid artery stenting can be predicted with preprocedural transcranial Doppler evaluation.
- Trial name
- NCT01922609
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital, Motol
Newborn
Descriptive Study of Brain Velocity in Transcranial Doppler in Newborns Over 35 Weeks of Gestational Age in the Maternity Ward
There are significant variations in blood circulation at birth with the transition from fetal to permanent circulation. These variations are particularly impacted by the closure of the arterial canal within the first 48 hours of…
- Trial name
- VELOCITE (NCT03553134)
- Testing
- transcranial doppler ultrasound scan, ultrasound scan centered on the arterial canal
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Right-to-left Shunt, Migraine
Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population
The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.
- Conditions
- Right-to-left Shunt, Migraine, Cerebral Infarction
- Trial name
- NCT02425696
- Where
- China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Yingqi Xing
Cerebral Perfusion Pressure, Trendelenburg
Transcranial Doppler and NIRS Monitoring of Cerebral Hemodynamics in Pediatric Laparoscopic Surgery
Laparoscopic surgery has become increasingly common in pediatric patients due to its minimally invasive nature and favorable postoperative outcomes.
- Conditions
- Cerebral Perfusion Pressure, Trendelenburg, Pediatric
- Trial name
- NCT07482514
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hanife Kabukcu
Head Injuries, Subarachnoid Haemorrhage
Impact of Cranioplasty On Cerebral Perfusion
The purpose of this study is to examine the impact of cranioplasty on cerebral hemodynamic and blood flow as prognostic factor in patients receiving decompressive craniectomy for Head injuries, Subarachnoid haemorrhage…
- Conditions
- Head Injuries, Subarachnoid Haemorrhage, Intra-cerebral Haemorrhage, Cerebral Thrombosis
- Trial name
- CCP (NCT01113645)
- Testing
- Cerebral perfusion evaluation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intraoperative Neurophysiological Monitoring
Multi Modal Brain Monitoring and Cardiac Surgery
Multimodal brain monitoring is feasible and can be used in formulating therapeutic strategies during cardiac surgery. Such monitoring may help to improve patient outcome and to reduce costs after cardiac surgery with CPB.
- Trial name
- NCT02916069
- Testing
- Nearinfrared Spectroscopy (NIRS), Transcranial Doppler (TCD), Bispectral index (BIS)
- Where
- Egypt
- Volunteers
- 1,200 people
- Sponsor
- Assiut University
Sickle Cell Disease
Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell Disease
Structural and functional changes in arteries are increasingly being recognized as significant features of sickle cell disease. This study aims to determine whether there are differences in arterial function parameters between…
- Trial name
- AFAT (NCT05748717)
- Where
- Jamaica
- Volunteers
- 34 people
- Sponsor
- The University of The West Indies
Infarction, Brain, Embolism
Microembolic Detection in Acute Ischemic Stroke Patients With Atrial Fibrillation and Outcome
This multicenter international prospective cohort study will include patients with AIS with a known or newly diagnosed anticoagulant-naïve AF.
- Conditions
- Infarction, Brain, Embolism, Atrial Fibrillation
- Trial name
- NCT06018090
- Testing
- The presence and rate of MES measured by TCD monitoring
- Where
- Portugal
- Volunteers
- 61 people
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Cerebral Infarction
Identification the Cause of Silent Cerebral infarctiON in Healthy Subjects (ICONS)
We hypothesized that paradoxical embolism may be one of the main mechanisms of silent cerebral infarction (SCI) located outside the perforating artery territory.
- Trial name
- ICONS (NCT01429948)
- Where
- South Korea
- Volunteers
- 581 people
- Sponsor
- Samsung Medical Center
Intracerebral Hemorrhage
Non-invasive Ultrasound and Hematoma Clearance After Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is one of the stroke subtypes with the highest global rates of disability and mortality, accounting for 15%-20% of all strokes.
- Trial name
- NOTICE (NCT07246473)
- Testing
- non-invasive ultrasonic scalpel
- Where
- 3 sites in China
- Volunteers
- 86 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Stenosis, Cerebral Hyperperfusion Syndrome
Accuracy of TCD Monitoring in Predicting Cerebral Hyperperfusion Syndrome After Carotid Endarterectomy
Background: Cerebral hyperperfusion syndrome (CHS) is a life threatening complication of carotid endarterectomy (CEA) and the changes of middle cerebral artery velocity are used to predict the occurrence of CHS but the accuracy…
- Conditions
- Carotid Stenosis, Cerebral Hyperperfusion Syndrome, Blood Pressure
- Trial name
- NCT01799070
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Sickle Cell Disease
A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary Stroke
The study will test a new medicine, etavopivat, for sickle cell disease and see if it is safe and help-ful for participants with sickle cell disease who are at an increased risk of stroke.
- Trial name
- HIBISCUS 3 (NCT05953584)
- Testing
- Etavopivat, Hydroxyurea
- Where
- 9 sites in India, Nigeria and 1 more
- Volunteers
- 27 people
- Sponsor
- Forma Therapeutics, Inc.
Brain Dead
Transcranial Doppler Ultrasonography and Brain Death
In France the diagnosis of brain death relies on electroencephalography (EEG) or cerebral angiography. Concerning the latter a time of 6 hours is mandatory between the clinical diagnosis and the realization of the cerebral…
- Trial name
- NCT01070563
- Testing
- Transcranial doppler
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Institut d'Anesthesiologie des Alpes Maritimes
Head Injury
Transcranial Doppler Measurement and Prognosis in Moderate Head Injury
The purpose of this study is to determine whether Transcranial Doppler measurements have correlation with neuropsychological test (Galvestone Orientation Amnesia Test), TC image (Marshall Scale) and prognosis (DRS and GOS) in…
- Trial name
- NCT00353444
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Sickle Cell Anemia in Children
Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE)
This study will 1) Evaluate the prevalence of elevated (conditional or abnormal) transcranial Doppler (TCD) velocities in a cross-sectional analysis of children with Sickle Cell Anemia (SCA) living in Tanzania; 2) Obtain…
- Trial name
- NCT03948867
- Testing
- Hydroxyurea, Elevated Arm TCD Examination, Normal Arm TCD Examination
- Where
- 2 sites in United States, Tanzania
- Volunteers
- 202 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pulmonary Disease, Chronic Obstructive, Heart Failure
Neuromuscular Fatigue During Exercise in COPD-HF Overlap
Rationale. Chronic obstructive pulmonary disease (COPD) and heart failure (HF) coexist in approximately one third of patients presenting with one of these conditions.
- Trial name
- FIBOX (NCT05235685)
- Testing
- Medical air, Hyperoxia
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Foramen Ovale, Patent, Migraine
Effectiveness and Safety of Transcatheter Patent Foramen Ovale Closure for Migraine
The purpose of the study is to evaluate effectiveness and safety of transcatheter patent foramen ovale closure for migraine.
- Trial name
- EASTFORM (NCT02127294)
- Testing
- transcatheter patent foreman ovale closure
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Yi Yang
Acute Renal Failure
Influence Continuous Veno-venous Hemodialysis the Autoregulation
The aim of the study is to characterize the influence of continuous veno-venous hemodialysis on the cerebrovascular autoregulation.
- Trial name
- dARICUCVVH (NCT01376531)
- Testing
- continuous veno-venous hemodialysis
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Johannes Gutenberg University Mainz
Idiopathic Intracranial Hypertension
Assessment of ICP in Idiopathic Intracranial Hypertension Using Transocular Ultrasound and Transcranial Doppler
Idiopathic Intracranial Hypertension (IIH) is a rare disease, primarily affecting overweight females of child-bearing age. Patients suffer from increased intracranial pressure (ICP), typically resulting in headaches, visual…
- Trial name
- NCT04314128
- Testing
- TOS and TCD
- Where
- Denmark
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center