Clinical trials: Transcriptomics
Healthy Volunteers
Investigating the Impact of Environmental Factors on the Transcriptomics Profile in Healthy Individuals
Changes in biology will be reflected by changes in the composition of Ribonucleic acid (RNA) in the blood. An example of that would be environmental changes, e.g. diet, acute illness, temperature.
- Trial name
- IMEN (NCT06040008)
- Testing
- blood collection
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- CENTOGENE GmbH Rostock
Obesity (BMI>30)
Exercise and Taurine Supplementation on Intramuscular Fat in Older Women With Obesity
This randomized clinical trial aims to investigate the effects of multicomponent concurrent exercise training associated or not with taurine supplementation on intramuscular fat infiltration, physical performance, transcriptomic…
- Trial name
- TAUMUSCLE (NCT07730255)
- Testing
- Concurrent Exercise Training, Taurine
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Peritoneal Metastases
Single-Cell Transcriptomics of the Peritoneal Microenvironment of Colorectal PC
Single cell transcriptomics of CRC PC samples
- Trial name
- SingleCell (NCT05676372)
- Testing
- CRC+HIPEC
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Ghent
Feasibility Study, Vaccine Immune Response
How Gut Health Affects Immune Responses to the Oral Rotavirus Vaccine in Adults in Zambia
The Rotavirus SpatioTrasncriptomics (Rota-Omics) study is a multidisciplinary research project aimed at understanding why oral rotavirus vaccines perform less effectively in some low- and middle-income countries, including…
- Conditions
- Feasibility Study, Vaccine Immune Response, Rota Virus Gastroenteritis, Transcriptomics
- Trial name
- Rota-Omics (NCT07626606)
- Testing
- Rotarix®,
- Where
- Zambia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Triple Negative Breast Cancer
Cellular Immune Responses in Triple-negative Breast Cancer - High Throughput Immunogenetic Studies
This project introduces a novel methodology for the in-depth immunogenetic characterization of the TR gene repertoire in solid tumors, holding the promise to offer unprecedented insights into the TR anti-tumor specificity and the…
- Trial name
- NCT06646263
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Institute of Applied Biosciences
Rejection; Transplant, Liver
Transcriptomics as an Aid in the Histological Diagnosis of Acute Rejection After Liver Transplantation
The primary objective of this exploratory study is to identify genes associated with acute rejection in liver transplant patients.
- Trial name
- NCT06734013
- Testing
- Molecular diagnostic
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cardiovascular Risk Factors
Beneficial Impact of Orange Juice Consumption on Risk Factors Associated With Cardiovascular Diseases
The primary aim is to examine both the acute and chronic effects of hesperidin consumption from 100% Florida orange juice in various doses on functional and systemic markers associated with cardiovascular disease (CVD) risks.
- Trial name
- CITRUS (NCT02479568)
- Testing
- Control, 100% Florida OJ, 100% Florida OJ-enriched
- Where
- Spain
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Asthma, Asthma Attack
Genomics and Metagenomics of Asthma Severity
The Genomics and Metagenomics of Asthma Severity (GEMAS) study aims to assess the role of genomics, the microbiome, and the interaction between them in the development of asthma exacerbations in European patients with asthma.
- Trial name
- GEMAS (NCT04501926)
- Where
- 6 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Maria Pino-Yanes
Psoriasis
Development of Predictive Psoriasis Response Endotypes Using Single Cell Transcriptomics
The investigators propose to improve the possibility of reaching skin resolution by identifying certain markers or gene patterns that may predict patient response to certain psoriasis drugs ahead of time, thus eliminating or…
- Trial name
- NCT05270733
- Testing
- Ustekinumab
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University Hospitals Cleveland Medical Center
Gastric Adenocarcinoma
Transcriptomic Signatures in Gastric Adenocarcinoma
Gastric Adenocarcinoma (GAC) accounting for the major percentage of all stomach malignancies is associated with a poor overall survival of 25-30% despite the advancement in treatment strategies.
- Trial name
- GAC (NCT05319392)
- Testing
- Observational study
- Where
- India
- Volunteers
- 48 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Respiratory Distress Syndrome, Adult, COVID-19
Coronavirus Studied by Metagenomics in ARDS COVID-19 Patients
Pandemic SARS-CoV-2 (COVID-19) respiratory infection is responsible for more than 4,000 deaths, mainly (67%) secondary to acute respiratory distress syndromes (ARDS).
- Trial name
- COMETS (NCT04516486)
- Testing
- retrospective metagenomics on clinical samples collected during hospitalization
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcohol Use Disorder
Hepatic Lipid Metabolism-Alcohol Use Disorder
Patients with hepatic steatosis due to alcohol will be offered liver biopsies when they enter a detoxification program. The first biopsy will occur in the first week of admission and the second in the fourth week when the…
- Trial name
- NCT07191561
- Testing
- Liver biopsy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiometabolic Disease
Metagenomics and Integrative Systems Medicine of Cardiometabolic Diseases
Supported by state-of-the-art systems medicine competences including integrative computational and functional genomics, the overarching goal of the trial is to investigate the impact of qualitative and quantitative changes in the…
- Trial name
- METACARDIS (NCT02059538)
- Testing
- Adipose tissue biopsies (omental and subcutaneous) liver, CT-scan, Stools sampling
- Where
- 3 sites in Denmark, France and 1 more
- Volunteers
- 2,350 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Complex Regional Pain Syndromes
Spatially Transcriptomics Reveals Molecular Signatures in CRPS
This observational study aims to understand phenotype-specific molecular signatures in patients with complex regional pain syndrome (CRPS).
- Trial name
- NCT05986461
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University
Soft Tissue Tumors of the Tongue, Squamous Cell Carcinoma
Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue
Squamous cell carcinoma (SCC) could be a very aggressive cancer and has a bad prognosis if not detected early and thus is associated with high mortality.
- Conditions
- Soft Tissue Tumors of the Tongue, Squamous Cell Carcinoma, Proton Magnetic Resonance Spectroscopy, Transcriptomics
- Trial name
- ClimaBio (NCT06450080)
- Testing
- MRI and MRS acquisitions
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Psoriatic Arthritis, Osteoarthitis
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry
CARTIZ is a prospective observational clinical registry of adults in Mexico receiving tirzepatide (a dual GLP-1/GIP receptor agonist) under an independent clinical indication - typically type 2 diabetes, insulin resistance…
- Conditions
- Psoriatic Arthritis, Osteoarthitis, Knee, Diabetes (DM)
- Trial name
- CARTIZ (NCT07567378)
- Testing
- Tirzepatide
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- JULIO GRANADOS MONTIEL