Clinical trials: Transcutaneous Spinal Stimulation, open to volunteers
Chronic Spinal Cord Injury
Abdominal Electrical Stimulation for Bowel Dysfunction in SCI
Many people with spinal cord injury (SCI) have bowel problems resulting in constipation and need a long time to empty the bowel. Some people spend an hour or more to empty their bowel.
- Trial name
- NCT06948175
- Testing
- Abdominal transcutaneous electrical stimulation (TES)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Spinal Cord Injury, Acute
Transcutaneous Tibial Nerve Stimulation in Acute Spinal Cord Injury
Most patients with spinal cord injury (SCI) develop neurogenic lower urinary tract dysfunction (NLUTD), one of the most devastating sequelae of SCI which ultimately can lead to renal failure.
- Trial name
- TASCI (NCT03965299)
- Testing
- VERUM TTNS
- Where
- 4 sites in Switzerland
- Volunteers
- 114 people
- Sponsor
- University of Zurich
Respiratory Distress Syndrome
Spinal Cord Stimulation to Shorten Ventilator Dependence in ARDS Patients
This is an early phase, proof-of-concept clinical trial assessing the safety and feasibility of non-invasive spinal cord stimulation to prevent respiratory muscle atrophy in mechanically ventilated ARDS patients.
- Trial name
- NCT05928052
- Testing
- Transcutaneous Biopac Electrical Stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Secondary Osteoporosis, Sarcopenia
The Effect of Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation on Bone Strength.
Immobilization following spinal cord injury (SCI) results in muscle and bone loss below the level of injury, which ultimately predisposes to fracture at several sites throughout the legs and can lead to several medical…
- Trial name
- NCT07325149
- Testing
- Exoskeleton-Assisted Walking (EAW) + active Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Bronx VA Medical Center
Spinal Cord Injuries, Hypotension
Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury
The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury.
- Conditions
- Spinal Cord Injuries, Hypotension, Orthostatic Hypotension, Spinal Cord Diseases
- Trial name
- (SCI) (NCT07674511)
- Testing
- Tilt test with stimulation (real-time effects): Intervention 1, 20 sessions of stimulation (Intervention 2)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kessler Foundation
Spinal Cord Injury Cervical, Spinal Cord Injuries (SCI)
Transcutaneous Spinal Cord Stimulation for Blood Pressure Augmentation Immediately After Spinal Cord Injury
In the treatment of spinal cord injury (SCI) patients in the hyperacute setting, it is imperative to closely control mean arterial pressure (MAP) to ensure adequate spinal cord perfusion in the absence of properly functioning…
- Conditions
- Spinal Cord Injury Cervical, Spinal Cord Injuries (SCI), Spinal Cord Injury (SCI), Initial Encounter
- Trial name
- Stim for MAP (NCT07887373)
- Testing
- Spinal Cord Stimulation
- Volunteers
- 20 people
- Sponsor
- Markey Olson
Chronic Stroke Survivors, Chronic Stroke Patients
Walking and tSCS in Non-ambulatory Stroke Survivors
Rehabilitation interventions commonly used for stroke survivors include task-specific training, balance and strength exercises, and the use of assistive devices to enhance mobility and independence.
- Conditions
- Chronic Stroke Survivors, Chronic Stroke Patients, Stroke
- Trial name
- NCT07226518
- Testing
- Robot-assisted gait training and transcutaneous spinal cord stimulation in chronic non-ambulatory stroke survivors: pilot RCT trial, Robot assisted gait training alone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Spinal Cord Injuries
Treatment for Sexual Dysfunction in Women with Spinal Cord Injury
Women with spinal cord injury frequently experience sexual dysfunction such as disturbances during arousal and an increased time to orgasm. However, little evidence has been found on its therapeutic approach and low adherence.
- Trial name
- NCT05122325
- Testing
- Transcutaneous tibial nerve stimulation TENS® EMS NMS60 device, Genital vibration with Ferticare 2.0® vibrator
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Cristina Lirio
Stroke
Stimulating Postural Control to Augment Rehabilitation After Cerebral Stroke (SPARC): a Pilot Trial
People living with stroke have a high risk of falling and this risk increases as mobility improves over the first year post-stroke. Despite the high number of falls, there is a lack of interventions to prevent falls after stroke.
- Trial name
- NCT06987682
- Testing
- Balance training
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University Health Network, Toronto
Spinal Cord Injuries (SCI), Spinal Cord Injury
Transcutaneous Spinal Electrical Stimulation to Improve Exercise Function After Spinal Cord Injury.
Our overall objective is to decrease the prevalence of multiple sedentary-related diseases that are secondary consequences of spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Spinal Injury
- Trial name
- NCT07692191
- Testing
- Transcutaneous spinal electrical stimulation (TSES)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Cerebral Palsy, Spasticity
Spinal Cord Stimulation for Children With Cerebral Palsy
The goal of this clinical trial is to help understand spinal cord excitability in children with cerebral palsy compared to neurologically typical children.
- Trial name
- NCT07516067
- Testing
- Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Martin Piazza
Cerebral Palsy
tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy
This is an intervention study to investigate the impact of spinal stimulation on mobility outcomes in children with Cerebral Palsy.
- Trial name
- NCT07433023
- Testing
- tSCS, 5-Azacitidine, Mannitol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shirley Ryan AbilityLab
Myelomeningocele, Spina Bifida
Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida
A study to use transcutaneous spinal cord stimulation to characterize sensorimotor deficits in a pediatric population of individuals with spina bifida.
- Trial name
- NCT06918119
- Testing
- Transcutaneous stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Postoperative Pain, Postoperative Pain in Orthopaedics
Effects of taVNS on Postoperative Pain in Complex Spinal Surgery
Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive, novel neuromodulation technique. Previous studies have demonstrated its safety and efficacy in chronic pain, mental disorders, and other diseases, but…
- Conditions
- Postoperative Pain, Postoperative Pain in Orthopaedics, Postoperative Pain Management
- Trial name
- taVNS-cSSPain (NCT07330973)
- Testing
- transauricular auricular vagus nerve stimulation
- Volunteers
- 98 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Non Traumatic Spinal Cord Injury, Sub-Acute Rehabilitation
Functional Electrical Stimulation vs Transcutaneous Stimulation in Patients With Subacute Spinal Cord Injury
Cervical spinal cord injuries (SCI) are the most common form of spinal cord injuries within the veteran population. Losing arm function is a major concern with these injuries.
- Conditions
- Non Traumatic Spinal Cord Injury, Sub-Acute Rehabilitation, Spinal Cord Injury Cervical, Electric Stimulation Therapy
- Trial name
- NCT07911657
- Testing
- RTI Xcite, ExaStim
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Center for Veterans Research and Education
Acute Spinal Cord Injury, Blood Pressure
TSCS for Acute SCI
This project will focus on a novel approach to stabilizing blood pressure (BP) during inpatient rehabilitation after acute SCI. After SCI, people have unstable blood pressure, ranging from too low (orthostatic hypotension) to too…
- Conditions
- Acute Spinal Cord Injury, Blood Pressure, Hypotension
- Trial name
- NCT05305118
- Testing
- TSCS Mapping, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Inspiratory Strength Training (IST), Transcutaneous Spinal Stimulation
Rehab and Mechanical Ventilation
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness.
- Conditions
- Inspiratory Strength Training (IST), Transcutaneous Spinal Stimulation, Sham Spinal Stimulation
- Trial name
- REHAB-MV (NCT07427121)
- Testing
- Spinal cord stimulation, Inspiratory Strength Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Florida
Spinal Cord Injuries, Hypotension
The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)
This project will investigate the effect of spinal cord transcutaneous stimulation on blood pressure in individuals with a chronic spinal cord injury who experience blood pressure instability, specifically, orthostatic…
- Conditions
- Spinal Cord Injuries, Hypotension, Orthostatic Hypotension, Spinal Cord Diseases
- Trial name
- SCI (NCT05725499)
- Testing
- Biostim-5 transcutaneous spinal stimulator, Tilt-table orthostatic stress testing
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kessler Foundation
Perinatal Spinal Cord Injury
Understanding Perinatal Spinal Cord Injury
The purpose of this study is to deepen our understanding of children who have a cervical spinal cord injury obtained in utero or at birth and examine the effects of tailored activity-based recovery training (ABRT) in combination…
- Trial name
- NCT06808035
- Testing
- Activity-Based Recovery Training, Transcutaneous Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Louisville
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation Combined With 4-Aminopyridine and Intensive Rehabilitation in SCI
The purpose of this prospective, single-arm pilot feasibility study is to evaluate the safety, feasibility, and preliminary functional outcomes of combining transcutaneous spinal cord stimulation (TSS), dalfampridine…
- Trial name
- NCT07922122
- Testing
- Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- TryAbility LLC