Clinical trials: Transcutaneous Vagal Nerve Stimulation
Premature Ventricular Complexes, Ventricular Tachycardia (VT)
Transcutaneous Vagus Nerve Stimulation for Ventricular Arrhythmias
Ventricular arrhythmias are abnormal heart rhythms that arise from the bottom chambers of the heart. They can cause debilitating symptoms when they occur intermittently (these are called premature ventricular ectopics or PVCs)…
- Conditions
- Premature Ventricular Complexes, Ventricular Tachycardia (VT), Ventricular Arrhythmias
- Trial name
- TREAT-VT (NCT07026695)
- Testing
- transcutaenous vagal nerve stimulation
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- University College, London
Autonomic Nervous System Imbalance
Vagus Nerve Stimulation for Autonomic Nervous System Activity
There are no generally accepted values for transcutaneous vagus nerve stimulation (taVSS application parameters (amplitude, frequency, intensity, duration, side) yet, therefore there are heterogeneous applications in studies.
- Trial name
- NCT05906940
- Testing
- Transcutaneous Vagus Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Infertility Assisted Reproductive Technology
The Feasibility of taVNS on Pregnancy Outcomes of Infertility Patients Undergoing IVF
To assess the feasibility of taVNS on pregnancy outcomes of infertility subjects undergoing IVF, the primary aim of this trial will focus on encompassing recruitment, compliance, and preliminary engagement outcomes.
- Trial name
- NCT06742788
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Subarachnoid Hemorrhage
Auricular VNS Following Subarachnoid Hemorrhage
This study will evaluate whether non-invasive auricular vagal nerve stimulation lowers inflammatory markers, and improves outcomes following spontaneous subarachnoid hemorrhage.
- Trial name
- NCT04557618
- Testing
- Auricular Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Anna Huguenard
Intracerebral Hemorrhage
TaVNS for Acute Intracerebral Hemorrhage
This study aims to evaluate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with acute intracerebral hemorrhage (ICH).
- Trial name
- TAVANS-ICH (NCT06918964)
- Testing
- transcutaneous auricular vagus nerve stimulation device
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Palsy
Non Invasive Vagus Nerve Stimulation in Cerebral Palsy (BOOSTTVNS)
The present study aims to assess, through a randomized controlled trial (RCT), the efficacy of transcutaneous Vagus Nerve Stimulation (tVNS) in enhancing the functional changes due to an intensive motor training in children and…
- Trial name
- (BOOSTTVNS) (NCT06372028)
- Testing
- transcutaneous vagus nerve stimulation (tVNS)
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- IRCCS Eugenio Medea
Atrial Fibrillation
Transcutaneous (Tragus) Vagal Nerve Stimulation for Post-op Afib
Patients undergoing cardiac surgery are at high risk of developing atrial fibrillation (AF), with estimated rates of 30-50% and occurs at approximately 2-4 days after surgery.
- Trial name
- STOP_AF (NCT04514757)
- Testing
- active tVNS
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- University of California, Los Angeles
Overweight, Obesity
Transcutaneous Auricular Vagus Nerve Stimulation Combined With Lifestyle Intervention for Visceral Fat Reduction in Adults With Overweight or Obesity
This is a single-center, randomized, open-label controlled trial with blinded outcome assessment and data analysis. Fifty adults with overweight or obesity (body mass index [BMI] >= 24 kg/m2) and a sedentary lifestyle will be…
- Trial name
- taVNS (NCT07907029)
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS), Standardized lifestyle program (calorie-restricted diet plus aerobic exercise)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Parkinson Disease, Apathy
Respiratory-gated Transcutaneous Auricular Vagus Nerve Stimulation for Improving Apathy in Parkinson's Disease
The goal of this clinical trial is to learn whether 100HZ respiratory-gated vagus nerve stimulation (RAVANS) can improve the non-motor symptoms in people with Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Apathy, Non-motor Symptoms, Vagus Nerve Stimulation
- Trial name
- NCT07118956
- Testing
- Active RAVANS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Stroke, Cerebrovascular Accident
Effects of tVNS and mCIMT in Chronic Stroke
Stroke is a leading cause of death and disability worldwide, resulting in significant physical and cognitive impairments. Arm weakness is most common after stroke and its treatment is recognized as an area of considerable need.
- Trial name
- NCT07272239
- Testing
- Transcutaneous Vagus Nerve Stimulation, Modified Constraint Induced Movement Therapy with Routine Physical Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Atrial Fibrillation, Postoperative, Postoperative Complications
Transcutaneous Autonomic Modulation in Thoracic Surgery
In this study, the investigators aim to determine whether non-invasive autonomic modulation decreases inflammation and complications after thoracic surgery.
- Conditions
- Atrial Fibrillation, Postoperative, Postoperative Complications, Inflammation
- Trial name
- TON-POINTS (NCT02783157)
- Testing
- Transcutaneous Low-Level Vagal Nerve Stimulation (LLVNS)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Duke University
Postoperative Pain, Postoperative Pain in Orthopaedics
Effects of taVNS on Postoperative Pain in Complex Spinal Surgery
Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive, novel neuromodulation technique. Previous studies have demonstrated its safety and efficacy in chronic pain, mental disorders, and other diseases, but…
- Conditions
- Postoperative Pain, Postoperative Pain in Orthopaedics, Postoperative Pain Management
- Trial name
- taVNS-cSSPain (NCT07330973)
- Testing
- transauricular auricular vagus nerve stimulation
- Volunteers
- 98 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Delirium
TaVNS for Delirium
The goal of this clinical trial is to test whether a non-invasive device called transauricular vagus nerve stimulation (taVNS) is safe, practical, and potentially helpful for patients in the hospital who develop delirium.
- Trial name
- NCT07258082
- Testing
- Transauricular Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stony Brook University
Mental Fatigue, Mental Stress
tAN for First Responders
This study is designed as an open label, single arm, decentralized clinical study in which first responders will receive transcutaneous auricular neurostimulation (tAN), which targets the auricular branch of the vagus nerve…
- Trial name
- NCT07109349
- Testing
- Sparrow Link
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Spark Biomedical, Inc.
Healthy Adults
Does Transcutaneous Vagal Nerve Stimulation Improves Fear Extinction in Humans
A recent study with rats showed that electrical stimulation of the vagus nerve (VNS) facilitates extinction of fear (Pena, Engineer, \& McIntyre, Biological Psychiatry, 2013).
- Trial name
- t-VNSext (NCT02113306)
- Testing
- t-VNS
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Feeding Delays, Neonates and Term Infants
BabySTrong II taVNS Feeding Trial
The long-term goal of this project is to develop a therapy to assist pre-term and term infants with brain injury overcome difficulties in learning to feed so that infants may be discharged home with their families and avoid the…
- Trial name
- BabySTrong II (NCT07049952)
- Testing
- taVNS, NAC and taVNS, inactive taVNS
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Medical University of South Carolina
Aphasia, Chronic Stroke
Transcutaneous Vagus Nerve Stimulation in Aphasia After Stroke
Aphasia is an acquired language disorder. Stroke is the most common cause of aphasia, which affects 30% of stroke survivors. Speech and Language Therapy (SLT) can help people with aphasia but it may not be provided at the…
- Trial name
- TRANSLATE (NCT06403475)
- Testing
- Transcutaneous Vagus Nerve Stimulation, Computer Based Speech and Language Therapy (Step by Step)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Cognition, Healthy Volunteers
Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Cognition, Dual-Task Performance, and Interoceptive Accuracy
This study aims to determine the simultaneous effects of transcutaneous auricular vagus nerve stimulation (taVNS) at two frequencies (30 Hz and 100 Hz) compared to sham stimulation on cognitive functions, dual-task performance…
- Trial name
- NCT07897175
- Testing
- taVNS 30 Hz, taVNS 100 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Toros University
Stroke, Stroke, Ischemic
At-Home taVNS - Stroke Rehab
Early evidence suggests the benefits of post-stroke motor rehabilitation may be enhanced by applying electrical stimulation to the ear.
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- NCT06616831
- Testing
- Remote Transcutaneous Auricular Vagal Nerve Stimulation Paired with Task-Specific Training
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Prader-Willi Syndrome, Social Behavior
tVNS in Children With Prader-Willi Syndrome
The purpose of the current project is to test the impact of transcutaneous vagus nerve stimulation (tVNS) on social ability in children with Prader-Willi Syndrome (PWS).
- Trial name
- NCT04396470
- Testing
- tVNS
- Sponsor
- Stanford University