Clinical trials: Transcutaneous Vagus Nerve Stimulation
Major Depressive Disorder
Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression
This study will identify the sex-dependent impact of expiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry and associated physiology in major depressive disorder (MDD).
- Trial name
- tVNS_MDD_Sex (NCT04448327)
- Testing
- active tVNS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Neuropathic Pain
Addressing Disparities in Neuromodulation for Rehabilitation: A Mixed Methods Approach to Optimize Access for Underrepresented Racial Minorities
The purpose of this study is to: 1. Development of culturally sensitive videos for enhance informed consent with neurostimulation and determination of factors that influence minority interest in participating in neurostimulation…
- Trial name
- NCT05896202
- Testing
- taVNS Video, Educational materials, TMS Video
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Miami
Stroke
taVNS for Upper Limb Rehabilitation
This study explores the use of a new form of neuromodulation known as transcutaneous auricular vagus nerve stimulation (taVNS) which stimulates the ear.
- Trial name
- NCT04129242
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) + Task Specifc Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Major Depressive Disorder
Vagus Nerve Stimulation: Integration of Behavior and Cardiac Modulation
This study characterized the impact of respiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry, vagal tone and depressed mood in patients with major depressive disorder…
- Trial name
- tVNS-MDD (NCT04467164)
- Testing
- exhalatory-gated transcutaneous vagus nerve stimulation (e-RAVANS), Inhalatory-gated transcutaneous vagus nerve stimulation (i-RAVANS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Healthy
How Does the Type of Waveform Affect Tolerability With Transcutaneous Auricular Vagus Nerve Stimulation?
The purpose of this research study is to investigate the effects of different forms of a gentle form of electrical stimulation applied to the ear, known as transcutaneous auricular vagus nerve stimulation (taVNS).
- Trial name
- NCT06614933
- Testing
- Biphasic transcutaneous auricular vagus nerve stimulation, Monophasic transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Healthy
Transcutaneous Vagus Nerve Stimulation (taVNS) Dosage Study 1
The purpose of this research study is to investigate the effects of different forms of a gentle form of electrical stimulation applied to the ear, known as transcutaneous auricular vagus nerve stimulation (taVNS).
- Trial name
- NCT06381102
- Testing
- transcutaneous auricular vagus nerve stimulation 30/30, transcutaneous auricular vagus nerve stimulation 10/10
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Miami
Parkinson Disease
taVNS in Mild to Moderate Parkinson's Disease
The purpose of this study is to find out whether a non-invasive form of nerve stimulation called transcutaneous vagus nerve stimulation (taVNS) is safe and effective in people with Parkinson's Disease.
- Trial name
- taVNS (NCT04157621)
- Testing
- Active taVNS
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Psychological Distress, Stress (Psychology)
tAVNS for Stress Reduction in University Students
The goal of this clinical trial is to learn if transcutaneous auricular vagus nerve stimulation (taVNS) works to reduce perceived stress and psychological distress in university students with high distress levels.
- Conditions
- Psychological Distress, Stress (Psychology), Perceived Stress
- Trial name
- tAVNS4HES (NCT07411846)
- Testing
- taVNS
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Stroke, Stroke, Ischemic
At-Home taVNS - Stroke Rehab
Early evidence suggests the benefits of post-stroke motor rehabilitation may be enhanced by applying electrical stimulation to the ear.
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- NCT06616831
- Testing
- Remote Transcutaneous Auricular Vagal Nerve Stimulation Paired with Task-Specific Training
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Stroke, Cerebrovascular Accident (CVA)
Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Arm Function After Stroke
The purpose of this study is to evaluate if multiple therapy sessions of Transcutaneous Vagus Nerve Stimulation (tVNS) combined with robotic arm therapy lead to a greater functional recovery in upper limb mobility after stroke…
- Conditions
- Stroke, Cerebrovascular Accident (CVA), Hemiparesis
- Trial name
- tVNS (NCT03592745)
- Testing
- Transcutaneous Vagus Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Northwell Health
Systemic Lupus Erythematosus
Transcutaneous Vagus Nerve Stimulation for the Treatment of Lupus
This is a 3-month double blinded randomized controlled study of transcutaneous electrical vagus nerve stimulation (tVNS) compared to a sham stimulation for the treatment of patients with active systemic lupus erythematosus (SLE).
- Trial name
- TRUST (NCT02917265)
- Testing
- TENS for vagus stimulation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Aikaterini Thanou
Infant Development, Hemiplegia
CIMT and taVNS for Hemiplegia in Infants
Newborns who are born premature or suffer brain injury at birth are at risk for motor problems that may cause weakness in reaching and grasping on one side of the body.
- Conditions
- Infant Development, Hemiplegia, Constraint Induced Movement Therapy
- Trial name
- NCT05101707
- Testing
- transcutaneous auricular vagus nerve stimulation, Constraint induced movement therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical University of South Carolina
Juvenile Idiopathic Arthritis (JIA)
Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) in JIA
The study is a multicenter, double-blind, sham-controlled trial to evaluate the safety and effectiveness of tcVNS on pain and inflammation associated with JIA.
- Trial name
- AJA01 (NCT05710640)
- Testing
- Active tcVNS
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mild Cognitive Impairment
Treatment of Mild Cognitive Impairment With Transcutaneous Vagal Nerve Stimulation
Patients with amnestic mild cognitive impairment (MCI) often have compromised quality of life (QOL). Cognitive impairment is a major contributor to decrements in QOL and progression of MCI often leads to loss of independence and…
- Trial name
- TVNS MCI (NCT03359902)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- 3 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stroke, Pain
Post-stroke Pain taVNS
The purpose of this study is to explore whether a non-invasive form of ear stimulation called transcutaneous auricular vagus nerve stimulation (taVNS) can change the way participants perceive pain.
- Trial name
- NCT06456385
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Atrial Fibrillation, Inflammation
Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia. In previous experimental studies, the investigators found that low-level vagus nerve (VN) stimulation (LLVNS), at voltages substantially below that which slowed the…
- Trial name
- TREAT-AF (NCT02548754)
- Testing
- Parasym device
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Oklahoma
Vagus Nerve Stimulation
Examining Transcutaneous Vagal Nerve Stimulation as a Facilitator of Social Bonding
This study aims to understand the role of the vagus nerve in promoting social bonding by using a non-invasive stimulation technique called transcutaneous vagal nerve stimulation (tVNS).
- Trial name
- CtVNS (NCT05899413)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Atrial Fibrillation
Transcutaneous (Tragus) Vagal Nerve Stimulation for Post-op Afib
Patients undergoing cardiac surgery are at high risk of developing atrial fibrillation (AF), with estimated rates of 30-50% and occurs at approximately 2-4 days after surgery.
- Trial name
- STOP_AF (NCT04514757)
- Testing
- active tVNS
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- University of California, Los Angeles
Stroke, Stroke Sequelae
Noninvasive VNS to Facilitate Excitability in Motor Cortex
Transcranial Magnetic Stimulation (TMS) positively influences motor rehabilitation in stroke recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown effects on cortical plasticity.
- Conditions
- Stroke, Stroke Sequelae, Motor Activity
- Trial name
- NCT04130646
- Testing
- Transcranial Magnetic Stimulation, transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Stress, Psychological, Sleep
Stress and Sleep Study
This between-subject, longitudinal pilot study in healthy college students aims to explore the acceptability and preliminary outcomes of two novel and complementary interventions that may improve stress and sleep: transcutaneous…
- Conditions
- Stress, Psychological, Sleep, Transcutaneous Electric Nerve Stimulation, Vagus Nerve Stimulation
- Trial name
- NCT05218109
- Testing
- tVNS, Mindfulness, Number Puzzle
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Florida