Clinical trials: Transdiagnostic, open to volunteers
Healthy Participants Study
ACT-based EMI in College Students
This study aims to evaluate the acceptability and effectiveness of a transdiagnostic, Acceptance and Commitment Therapy (ACT)-based ecological momentary intervention (EMI) among college students.
- Trial name
- NCT06843395
- Testing
- ACT-based ecological momentary intervention, Mood monitoring
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Type 1 Diabetes, T1D
DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions
This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with…
- Conditions
- Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- DASH-Obesity (NCT07638345)
- Testing
- Adhera Caring Digital Program-Obesity (ACDP-O)
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Pain, Depression
Transdiagnostic Cognitive Biomarkers
The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across…
- Trial name
- NCT04864080
- Testing
- Computer game/task, Health surveys online
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Transdiagnostic Psychopathology, Attrition
Digital Rewards and Retention in a M-health App
Attrition and user engagement are two challenges that eHealth interventions struggle with. Attempts to address this have been previously made through gamification, instructional design and using different types of incentives.
- Conditions
- Transdiagnostic Psychopathology, Attrition, Engagement, Depression, Anxiety
- Trial name
- DIGITALRCT (NCT06883773)
- Testing
- Multipurpose Online Tool, No intervention
- Where
- Romania
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- University of Bucharest
TBI, Suicide Prevention
A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans
Risk of Veteran suicide is elevated during the first year of transition from military service to civilian life. Most Veteran suicides occur among Veterans who are not connected to VA healthcare.
- Conditions
- TBI, Suicide Prevention, Veterans, PTSD
- Trial name
- SH-SP (NCT05995678)
- Testing
- STEP-Home-SP, Transition Assistance Program, VA Solid Start
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Sleep Disorder, Circadian Dysregulation
NIA_Improving Function and Well-being by Improving Patient Memory: Transdiagnostic Sleep and Circadian Treatment
Mental illness is often chronic, severe, and difficult to treat. Though there has been significant progress towards establishing effective and efficient interventions for psychological health problems, many individuals do not…
- Conditions
- Sleep Disorder, Circadian Dysregulation, Memory Impairment
- Trial name
- NCT05986604
- Testing
- Memory Support Intervention, Transdiagnostic Intervention for Sleep and Circadian Dysfunction
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Sleep Disturbance, Sleep Problems
Transdiagnostic Sleep Intervention to Improve Mental Health in Adolescents
This cluster randomized controlled trial will evaluate whether a brief, school-based group adaptation of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) improves sleep and mental health in…
- Conditions
- Sleep Disturbance, Sleep Problems, Substance Use (Drugs, Alcohol), Anxiety
- Trial name
- SLEEP-TEEN (NCT07865728)
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction, Healthy habits psychoeducation
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Neurologic Disorders, Schizophrenia
Characterization of High-Level Cognitive Impairments in Patients With Neuropsychiatric Disorders
Neuropsychiatric disorders are extremely common, severe, and disabling conditions. In the field of psychiatry, they notably include schizophrenia, mood disorders (depressive and bipolar disorders), autism spectrum or…
- Conditions
- Neurologic Disorders, Schizophrenia, Bipolar Disorder (BD), Depressive Disorder
- Trial name
- COGPSY (NCT07295652)
- Testing
- Cognitive assessment, Brain MRI (optional), Electroencephalography (optional)
- Where
- 3 sites in France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Transdiagnostic, Depression - Major Depressive Disorder
Open-Label Psilocybin Study in Transdiagnostic Population
The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms.
- Conditions
- Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms
- Trial name
- NCT06442423
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Depression Disorders, Affective Disorders
Prevention of Mental Disorders Through Self-efficacy Interventions
Low self-efficacy is a transdiagnostic risk factor for several mental disorders. Self-efficacy refers to one's belief that one is capable of performing a behavior necessary to successfully complete a task or achieve a goal.
- Conditions
- Depression Disorders, Affective Disorders, Prevention, Substance Use Disorders
- Trial name
- SELFTIE (NCT06738953)
- Testing
- Cognitive-Behavioral Intervention to increase Self Efficacy
- Where
- Germany
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Health and Medical University Potsdam
The Focus is the Prevention and Promotion of Mental Well-being and is a Universal Delivery Intervention
Promotion of Mental Health in Adolescents: A School-Based Preventive Version of the Unified Protocol (UP-A Kind)
The goal of this clinical trial is to assess the efficacy of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders for Adolescents (UP-A; Ehrenreich-May et al., 2018) as a universal school-based preventive…
- Trial name
- UP-A Kind (NCT07021001)
- Testing
- UP-A, a cognitive-behavioral structured group intervention, was adapted as a universal preventive intervention to be delivered in school settings (UP-A Kind).
- Where
- Portugal
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Emotional Disorders, Anxiety
Unified Protocol Group Treatment in a University Outpatient Clinic
This clinical trial aims to evaluate the effectiveness and underlying processes of change of the Unified Protocol (UP) for treating emotional disorders in a university outpatient clinic.
- Conditions
- Emotional Disorders, Anxiety, Depression - Major Depressive Disorder
- Trial name
- NCT07129941
- Testing
- Unified Protocol
- Where
- Norway
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Death Anxiety, Depression
Death Anxiety, Depression and Anxiety: An Experimental Study
The goal of this experimental study is to investigate the transdiagnostic role of death anxiety in depression and anxiety symptoms in participants from the general population. The main questions it aims to answer are: 1.
- Conditions
- Death Anxiety, Depression, Anxiety
- Trial name
- NCT07201480
- Testing
- Mortality Salience Prompts, Dental Pain Prompts
- Where
- Romania
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Psychiatric Disorders
TORCH - Transdiagnostic Observation of Risk Factors, Craving and Health Behaviours in Psychiatric Patients
Mental disorders are often accompanied by health-risk behaviours, psychiatric comorbidity, and reduced functioning. TORCH investigates transdiagnostic mechanisms underlying multiple health behaviour change in adult psychiatric…
- Trial name
- TORCH (NCT07844798)
- Testing
- person-centred interventions
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Jacobs University Bremen gGmbH
Depression, Anxiety
Preliminary Testing and Development of a Short Digital Intervention for Patients on Waiting Lists for Psychological Treatment
The goal of this randomized pilot feasibility trial is to assess the feasibility and further develop a single-session digital mental health intervention for patients on waiting lists for psychological treatment.
- Trial name
- NCT07499219
- Testing
- Digital therapy program (short), Digital therapy program (long), Mental health advice
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Cancer Survivors
Improving Sleep, Fatigue, Activity & Quality of Life in Cancer Survivors Via a Transdiagnostic Intervention
Poor sleep affects over half of U.S. cancer survivors, contributing to daytime fatigue, reduced physical activity, and diminished quality of life.
- Trial name
- SLEEP-CARE (NCT07023783)
- Testing
- Transdiagnostic Sleep Health Intervention (TSHI)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Emotion Regulation, Relationship Conflict
Get Better Together: Relationship Education For Military Couples
This study is testing a program called Get Better Together, a relationship education program designed to help military couples effectively navigate life stressors as a team.
- Conditions
- Emotion Regulation, Relationship Conflict, Suicide Risk, Alcohol Use
- Trial name
- GBT RCT (NCT07096271)
- Testing
- Get Better Together (GBT)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Psychological Distress, Psychological Well-Being
Self-Help Plus for Distress in University Students
Prrospective, multi-center, randomized controlled trial of a brief, transdiagnostic, guided self-help intervention (Self-Help Plus) for university students who experience significant distress and are behind on their coursework.
- Conditions
- Psychological Distress, Psychological Well-Being, Depression, Anxiety
- Trial name
- SSH+ (NCT06606249)
- Testing
- Self-Help Plus (SH+), Psychological First Aid (PFA)
- Where
- 3 sites in Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Padova
Sexual Violence
Developing and Testing a Trauma-Informed Exercise Intervention for Women Veterans With Histories of Sexual Violence
Exposure to sexual violence disproportionally impacts women Veterans and can have profound negative impacts on daily functioning.
- Trial name
- NCT06746740
- Testing
- Exercise
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development