Clinical trials: Transformed Migraine
Chronic Migraine
Intramuscular Electrical Stimulation for the Treatment of Trigger Points in Patients With Migraine
The goal of this single-case experimental study is to investigate the effects of intramuscular electrical stimulation for the treatment of trigger points on reducing the frequency of headaches in a small sample of patients with…
- Trial name
- NCT05893914
- Testing
- Dry Needling and intramuscular electrical stimulation to trigger points
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Thomas W. Perreault, PT
Migraine
A Study of Wearable Devices to Predict Migraines
The purpose of this research is to determine if data from smart devices, including heart rate and movement during sleep and wake times, will be able to track headaches and predict recurrence and exacerbations (make worse).
- Trial name
- NCT05755945
- Testing
- eHealth Application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Chronic Migraine, Pain
Anesthetic Blockades and Migraine
Greater occipital nerve (GON) anesthetic blockades are widely used for the treatment of headaches, yet its efficacy in migraine has hardly been assessed with controlled studies.
- Trial name
- NCT02188394
- Testing
- Anesthetic blockades with bupivacaine, Isotonic saline injection
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- César Fernández-de-las-Peñas
Chronic Migraine, Headache
Comparison of the Efficacy of Ultrasound-guided Greater Occipital Nerve Block and Pulsed Radiofrequency Therapy in Chronic Migraine Patients
Chronic migraine (CM) is related to headache-related disability and reduced quality of life. Therefore, patients with CM require preventive treatment.
- Trial name
- NCT05464212
- Testing
- USG Guided Greater Occipital Nerve Block, USG Guided Greater Occipital Nerve Block and Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Eskisehir Osmangazi University
Migraine Disorders
Evaluation of ALD403 (Eptinezumab) in the Prevention of Chronic Migraine
The purpose of this study is to assess the efficacy and safety of ALD403 in the prevention of migraine headache in chronic migraineurs.
- Trial name
- PROMISE 2 (NCT02974153)
- Testing
- ALD403 (Eptinezumab)
- Where
- 144 sites in United States, Belgium and 11 more
- Volunteers
- 1,121 people
- Sponsor
- Alder Biopharmaceuticals, Inc.
Migraine, Headache
Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache.
The purpose of this study is to determine whether Topiramate is effective in preventing the development of chronic daily headache among patients with episodic migraine headaches.
- Conditions
- Migraine, Headache, Classic Migraine, Common Migraine
- Trial name
- NCT00212810
- Testing
- Topiramate
- Volunteers
- 385 people
- Sponsor
- Ortho-McNeil Neurologics, Inc.
Migraine, Migraine With Aura
Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of atogepant as preventive migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- STAR (NCT06414044)
- Testing
- Atogepant 60 mg
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Migraine Disorders
An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine
A 6-month, observational, post authorization safety study for the collection and evaluation of additional safety data on topiramate as a prophylactic treatment for migraines in adult patients.
- Trial name
- NCT00297336
- Testing
- Topiramate
- Volunteers
- 80 people
- Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
Migraine, Migraine Disorders
Assessment of Prolonged Safety and tOLerability of in Migraine Patients in a Long-term OpeN-label Study
This is a 128-week open-label study to assess the long-term safety and tolerabilty of the monoclonal antibody erenumab in migraine patients.
- Conditions
- Migraine, Migraine Disorders, Migraine Headache
- Trial name
- APOLLON (NCT04084314)
- Testing
- Erenumab
- Where
- 75 sites in Germany
- Volunteers
- 701 people
- Sponsor
- Novartis Pharmaceuticals
Migraine
A Study of the Effectiveness and Safety of Topiramate Versus Placebo for Preventing Chronic Migraine Headaches
The purpose of this study is to assess the safety and effectiveness of topiramate as compared to placebo for the prevention of headaches in patients with chronic migraine.
- Trial name
- NCT00210912
- Testing
- topiramate
- Volunteers
- 328 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Migraine
Intra-Nasal Mechanical Stimulation (INMEST) as a Potential Preventative Treatment for Migraine
This is a prospective, randomized, open-label, delayed-start clinical investigation evaluating the safety and efficacy of the Walther System, a Class IIa investigational medical device delivering intra-nasal mechanical…
- Trial name
- A-MI-01 (NCT07279623)
- Testing
- INMEST-treatment
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Abilion Medical Systems AB
Migraine
The Effects of Transcutaneous Occipital Nerve Stimulation and Instrument-Assisted Soft Tissue Mobilization on Patients With Chronic Migraine
In this study, it was aimed to examine the effects of two different treatments applied to the neck region, which have been popular in recent years, on migraine.The study included 45 female patients aged 20-50 years with migraine…
- Trial name
- NCT05372796
- Testing
- IASTM, home exercise, Chattanooga direct Tens device (DJO UK Ltd, Guildford Surrey, United Kingdom)
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Emine Atıcı
Chronic Migraine Headache, Chronic Tension-type Headache
Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache
This multicenter, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the efficacy of repeated bilateral greater occipital nerve (GON) blockade in patients with chronic migraine and chronic tension-type…
- Trial name
- GONBLOCK-RCT (NCT07497646)
- Testing
- Bupivacaine, Normal Saline (0.9% NaCl), Greater occipital nerve blockade
- Where
- Turkey (Türkiye)
- Volunteers
- 290 people
- Sponsor
- Saglik Bilimleri Universitesi
Chronic Migraine, Headache
Comparison Between Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine
Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study
- Trial name
- NCT07512219
- Testing
- Greater occiptal nerve block, Pulsed radiofrequency
- Volunteers
- 70 people
- Sponsor
- Sohag University
Migraine, Chronic Migraine
Eptinezumab as an Adjunct to Standard of Care for Migraine in an Acute Emergency Context
The purpose of the study is to investigate how a medication called eptinezumab (Vyepti) given to patients in the Emergency Department (ED) might help prevent migraines from happening again.
- Trial name
- NCT06428838
- Testing
- Eptinezumab, Standard of Care
- Where
- 2 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Dr George Medvedev
Migraine
Middle Meningeal Artery Embolization for Chronic Migraine
The main goal of this study is to find out how well middle meningeal artery coil embolization works for patients with recurrent chronic migraines that are not resolved with medication.
- Trial name
- NCT07044648
- Testing
- Middle Meningeal Artery Embolization
- Sponsor
- Wake Forest University Health Sciences
Chronic Migraine, Episodic Migraine
A Study Evaluating Oral Atogepant for the Prevention of Migraine in Japanese Participants With Chronic or Episodic Migraine
This study will evaluate the long-term safety, efficacy and tolerability of atogepant 60 mg daily for the prevention of migraine in Japanese participants with chronic (CM) or episodic migraine (EM).
- Trial name
- JPN ATO OLE (NCT04437433)
- Testing
- Atogepant 60 mg
- Where
- 24 sites in Japan
- Volunteers
- 186 people
- Sponsor
- AbbVie
Myofascial Trigger Points, Cervicogenic Headache
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Chronic Cervicogenic Headache
Chronic cervicogenic headache is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life.
- Conditions
- Myofascial Trigger Points, Cervicogenic Headache, Dorsal Root Ganglion
- Trial name
- NCT07347730
- Testing
- MTrPs injection, C2 dorsal root ganglion blocks
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Migraine
Efficacy, Safety, and Tolerability of Atogepant for the Prevention of Chronic Migraine
This study evaluated the efficacy, safety and tolerability of atogepant in participants with chronic migraine. This study included a 12-week treatment period.
- Trial name
- NCT03855137
- Testing
- Atogepant 30 mg, Atogepant 60 mg
- Where
- 150 sites in United States, Australia and 15 more
- Volunteers
- 778 people
- Sponsor
- Allergan
Chronic Migraine
Tertiary Care With or Without Manual Therapy for Chronic Migraine
The aim of this study is to determine if adding manual therapy to care as usual reduces the discomfort from chronic migraine compared to care as usual alone
- Trial name
- NCT03395457
- Testing
- Care as usual, Manual Therapy
- Where
- United Kingdom
- Volunteers
- 67 people
- Sponsor
- Bournemouth University