Clinical trials: Transfusion
Chikungunya Virus Infection, Neonatal
Against Chikungunya Virus and Neonatal Infection
The goal of this clinical trial is to learn if administration of plasma, from a whole blood donation from an individual who has declared a Chikungunya infection for less than 6 months , to a newborn, whose mother has a peripartum…
- Conditions
- Chikungunya Virus Infection, Neonatal, Transfusion, Encephalopathy
- Trial name
- ConvictionCHIK (NCT07190560)
- Testing
- plasma transfusion : PC-CHIK-V
- Where
- 3 sites in France, French Guiana and 1 more
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Intraoperative Complications, Intraoperative Bleeding
Ostene in Thoracolumbar Decompression and Fusion Evaluated With VIBE
In spine surgery, it is important to try to minimize bleeding. In particular, spine surgery often involves inserting hardware into bone, and/or removing bone in the spine.
- Conditions
- Intraoperative Complications, Intraoperative Bleeding, Intraoperative Blood Loss, Hemostasis
- Trial name
- Ostene VIBe (NCT06450834)
- Testing
- Ostene
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- University of Maryland, Baltimore
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries
The investigators will conduct a study on non-vigorous infants at birth to determine if umbilical cord milking (UCM) results in lower rate of moderate to severe hypoxic ischemic encephalopathy (HIE) or death than early clamping…
- Trial name
- CORDMILK (NCT03657394)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Coronary Artery Disease, Blood Transfusion Complication
Re-infusion of Unwashed Shed Blood During Off-pump Surgery
To assess the efficacy and side-effects of re-infusion of unwashed shed blood during off-pump coronary artery surgery using a novel cardiotomy circuit.
- Conditions
- Coronary Artery Disease, Blood Transfusion Complication, Cardiovascular Complication
- Trial name
- NCT06358079
- Testing
- Re-infusion of unwashed shed blood
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University
Thalassemia Particularly Transfusion Dependent Thalassemia
Clinical, Economic,and Psychosocial Burden of Thalassemia in Sohag
This study aims to assess the clinical, economic, and psychosocial burden of thalassemia among affected children in Sohag. Clinically, the study will evaluate disease severity, transfusion requirements, iron overload…
- Trial name
- HBT-sohag (NCT07796022)
- Volunteers
- 100 people
- Sponsor
- Randa Elham Hamam
Iron Overload Due to Repeated Red Blood Cell Transfusions, Thalassemia Majors (Beta-Thalassemia Major)
Evaluate the Efficacy and Safety of Irochel for the Management of Iron Overload in Thalassemia Patients in Comparison With Deferoxamine
This research study was an experimental, randomized, controlled clinical trial to evaluate the safety and efficacy of coded Unani formulation Irochel for the management of IOL due to repetitive blood transfusion in comparison…
- Trial name
- NCT07782931
- Testing
- Irochel, Deferoxamine
- Where
- Pakistan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hamdard University
Anemia, Post ICU Syndrome
Iron Deficiency at ICU Discharge
IRON-RECOVERY is a prospective, multicenter, observational cohort study designed to determine the prevalence of iron deficiency at intensive care unit (ICU) discharge and to evaluate its association with post-ICU clinical…
- Conditions
- Anemia, Post ICU Syndrome, Red Blood Cell Transfusions, Iron Deficiencies
- Trial name
- IRON-ICU (NCT07781540)
- Testing
- transferrin saturation
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 462 people
- Sponsor
- Università degli Studi di Ferrara
Transfusion, Red Blood Cell
Restrictive Versus Liberal Thresholds for RBC Transfusion in ECMO
Rationale: In patients supported with extracorporeal membrane oxygenation (ECMO), transfusion of red blood cells (RBC) is very common.
- Conditions
- Transfusion, Red Blood Cell, Extracorporeal Membrane Oxygenation, Anemia
- Trial name
- TREC (NCT06560164)
- Testing
- Red Blood Cell transfusion
- Where
- 14 sites in Austria, Belgium and 2 more
- Volunteers
- 526 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Critical Illness, Multiple Organ Dysfunction Syndrome
AI-Based Precision Transfusion Prediction Model in Critically Ill Patients
This multicenter observational study aims to develop and validate an artificial intelligence-based precision transfusion prediction model for critically ill patients.
- Conditions
- Critical Illness, Multiple Organ Dysfunction Syndrome, Blood Transfusion
- Trial name
- NCT07762131
- Testing
- Red Blood Cell Transfusion Exposure
- Volunteers
- 2,598 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Transfusion Adverse Reaction, Major Trauma
Blood Storage Related Mortality and Adverse Effects in Trauma Patients
The purpose of this retrospective study is to examine the following factors related to blood storage time in severely injured trauma patients who received large blood transfusions: 1.
- Conditions
- Transfusion Adverse Reaction, Major Trauma, Blood Product Transfusion for All Conditions
- Trial name
- NCT07341139
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Kocaeli City Hospital
Blood Transfusion
Oxygen Extraction-guided Transfusion
In critically ill patients, optimized strategies for red blood cells transfusion (RBCT) are still controversial. Most recent guidelines suggest that clinical practice in ICU setting should follow a restrictive approach to RBCT…
- Trial name
- OXYTRIP (NCT06102590)
- Testing
- Individualized red blood cell transfusion strategy, European guidelines red blood cell transfusion strategy
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 324 people
- Sponsor
- Università degli Studi di Ferrara
Transfusion-dependent Beta-Thalassemia
Gene-Modified Stem Cell Therapy for Subjects With Transfusion-dependent Beta-thalassemia
This is a prospective, dual-centre, single dose, Phase IIb, single arm, open label study. The proposed clinical trial involves a single infusion of autologous HSPCs genetically modified with the GLOBE lentiviral vector, using an…
- Trial name
- NCT07680803
- Testing
- FT007
- Where
- 2 sites in Italy
- Volunteers
- 9 people
- Sponsor
- Fondazione Telethon
Beta Thalassemia Transfusion Dependent
Gene Therapy for Patients With Transfusion-Dependent β-Thalassemia
Thalassemia is a group of recessively inherited hemoglobin disorders characterized by reduced or no production of hemoglobin and chronic anemia of varying severity.
- Trial name
- NCT07721480
- Testing
- HGI-001 Injection
- Volunteers
- 6 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Transfusion-dependent Anemia, Surgery
Liberal Transfusion Strategy in Elderly Patients
In this prospective, multicentre, open, randomised, controlled clinical trial elderly patients (≥ 70 years) undergoing intermediate- or high-risk non-cardiac surgery will be randomised either to a liberal group (patients receive…
- Conditions
- Transfusion-dependent Anemia, Surgery, Anemia
- Trial name
- LIBERAL (NCT03369210)
- Testing
- red blood cell transfusion trigger
- Where
- 17 sites in Germany
- Volunteers
- 4,456 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up
An extension of the CORDMILK trial, the CORDMILK follow-up trial will evaluate the neurodevelopmental outcomes at 22-26 months age of term/late preterm infants who were non-vigorous at birth and received umbilical cord milking…
- Trial name
- CORDMILK-FU (NCT03682042)
- Testing
- Umbilical Cord Milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Preterm, Infant Death
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries- PreTerm
The goal of this multicenter, cluster-randomized, crossover trial is to determine if umbilical cord milking compared to early cord clamping will reduce in-hospital mortality in non-vigorous preterm infants born between 30 weeks…
- Trial name
- CORDMILK-PT (NCT06240715)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 800 people
- Sponsor
- Nemours Children's Clinic
Preterm Birth Complication, Neonatal Morbidity and Mortality
Delayed Versus Immediate Cord Clamping in Preterm Birth
The goal of this study is to evaluate whether delayed cord clamping improves early neonatal outcomes compared with immediate clamping in preterm birth.
- Conditions
- Preterm Birth Complication, Neonatal Morbidity and Mortality, Cord Clamping, Delayed Cord Clamping
- Trial name
- PREM-CORD (NCT07699666)
- Testing
- Delayed Umbilical Cord Clamping, Immediate Umbilical Cord Clamping
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Faculty of Medicine of Tunis
RBCs Transfusion in Critically-ill Patients
Red Blood Cell Transfusion to Optimize Extubation
In comparison with a liberal transfusion strategy (high haemoglobin threshold), a restrictive transfusion strategy leads to around 50% decrease in the total number of transfused red blood cells (RBC) units and 30% to 40% fewer…
- Trial name
- TEXT (NCT07499492)
- Testing
- Transfusion of a single unit of RBC and standard of care
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion
Trial of Indication-Based Transfusion of Red Blood Cells in ECMO
TITRE - Trial of Indication-based Transfusion of Red Blood Cells in ECMO, is a multicenter, prospective, randomized clinical trial.
- Conditions
- Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion, Organ Failure, Multiple
- Trial name
- TITRE (NCT05405426)
- Testing
- Red blood cell transfusion
- Where
- 22 sites in United States, Australia and 1 more
- Volunteers
- 228 people
- Sponsor
- Boston Children's Hospital
Thrombocytopenia, Prophylactic Platelet Transfusion
EFFECT OF PLATELET CONCENTRATE TRANSFUSION ON MICROCIRCULATORY ENDOTHELIAL FUNCTION IN INTENSIVE CARE UNIT
This study aims to investigate the impact of platelet concentrate (PC) transfusions on endothelial function and the systemic inflammatory response in thrombopenic patients admitted to intensive care who require prophylactic…
- Conditions
- Thrombocytopenia, Prophylactic Platelet Transfusion, Platelet Transfusion, Endothelial Function
- Trial name
- PLATOMIR (NCT07682246)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris