Clinical trials: Transfusion Requirements
Blood Loss, Surgical
Study to Investigate the Effect of Aprotinin of Transfusion Requirements in Patients Undergoing Surgical Procedures for Lung or Esophageal Cancer
Study to Investigate the Effect of Aprotinin of Transfusion Requirements in Patients Undergoing Surgical Procedures for Lung or Esophageal Cancer.
- Trial name
- NCT00306137
- Testing
- Trasylol (Aprotinin, BAYA0128)
- Where
- 21 sites in United States, Australia and 8 more
- Volunteers
- 104 people
- Sponsor
- Bayer
Hepatectomy, Transfusion Requirements
Reducing Red Blood Cell Transfusion Requirements for Adults Undergoing Surgical Resection of the Liver - A Quality Improvement Project
The goal of this clinical trial is to determine if implementing a controlled blood removal protocol (i.e. hypovolemic phlebotomy [HP] where approximately 10% of the patient's blood is removed and reinfused following hepatic…
- Conditions
- Hepatectomy, Transfusion Requirements, Intraoperative Bleeding, Intraoperative Monitoring
- Trial name
- NCT07629648
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Dr. Glenio Mizubuti (MD, PhD, FRCPC)
Red Blood Cell Transfusion
The Effect of Retrograde Autologous Priming on Transfusion Requirements After Cardiac Surgery
The TheRAPy vanguard trial is a multicentre, multiple period randomized, cluster crossover vanguard trial testing the feasibility of a full-scale trial to evaluate whether a centre-based policy of routine use of RAP versus a…
- Trial name
- TheRAPy (NCT06230198)
- Testing
- retrograde autologous priming (RAP), Crystalloid priming
- Where
- 4 sites in Canada
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Fibrin Blood Clot
Impact of Two Guided Transfusion Strategies on Blood Product Requirements in Liver Transplantation.
It is a national multicentre clinical study, where 3 hospitals are involved: Bellvitge University Hospital, Clinic Hospital of Barcelona and Cruces Hospital of Bilbao).
- Trial name
- NCT04405518
- Testing
- Fibrinogen Concentrate (Human) 1 MG [RiaSTAP]
- Where
- 3 sites in Spain
- Volunteers
- 188 people
- Sponsor
- Antoni Sabaté Pes
Femoral Neck Fractures, Hemiarthroplasty
Efficacy of Intraoperative Periarticular Injections in Hip Fracture Hemiarthroplasty
The objective of this study was to assess the effectiveness of the intraoperative periarticular solution in reducing blood loss and minimizing transfusion requirements in patients with femoral neck fractures who underwent…
- Conditions
- Femoral Neck Fractures, Hemiarthroplasty, Blood Loss Requiring Transfusion
- Trial name
- NCT06701695
- Testing
- Periarticular Injection (PAI), Control (Standard treatment)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara City Hospital Bilkent
Hematologic Neoplasms
Platelet Transfusion Requirements in Hematopoietic Transplantation Pilot Study
It is hypothesized that a strategy using prophylactic oral Tranexamic Acid (TXA) with therapeutic platelet transfusions is safe and effective compared to prophylactic platelet transfusions in patients undergoing an autologous…
- Trial name
- PATH (NCT02650791)
- Testing
- Tranexamic Acid
- Where
- 5 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
E-Aminocaproic Acid, Bilateral Varus Rotational Osteotomy
The Effect of Intravenous EACA on Blood Loss and Transfusion Requirements After Bilateral VRO
E-Aminocaproic acid (EACA) is an anti-fibrinolytic agent that is used to decrease blood loss and transfusion requirements after several orthopedic procedures.
- Trial name
- NCT02257580
- Testing
- E-Aminocaproic acid
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Hospital for Special Surgery, New York
Hereditary Hemorrhagic Telangiectasia, Gastrointestinal Hemorrhage
Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber
The purpose of this study is to determine whether long-acting octreotide is safe and effective in the treatment of patients with Rendu-Osler-Weber (e.g. HHT).
- Conditions
- Hereditary Hemorrhagic Telangiectasia, Gastrointestinal Hemorrhage, Anemia
- Trial name
- ROW (NCT02874326)
- Testing
- Octreotide LAR
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Ewing Sarcoma of Bone, Osteosarcoma
Perioperative Use of Tranexamic (TXA) in Bone Tumor Surgery Will Change in Blood Loss and Transfusion Requirements.
The purpose of this trial is to investigate whether previously reported benefit of Tranexamic acid in pediatric orthopedic surgeries could be recapitulated in bone tumor surgeries or not through a double blinded randomized…
- Trial name
- NCT05024253
- Testing
- Tranexamic acid injection, Saline
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Total Hip or Knee Arthroplasty
Transfusion Requirements in Orthopedic Surgery (PHASE 2)
The objective of our research program is to determine the transfusion threshold required to maximize functional recovery after major orthopedic surgery (total hip/knee replacement) in these, most often, elderly patient with…
- Trial name
- TRIOS (NCT00726349)
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 305 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pediatric Cardiac Surgery, Transfusion
Is Redo Pediatric Cardiac Surgery a Risk Factor for Transfusion?
In pediatric cardiac surgery, transfusion requirements are associated with age, development status, pathology, type of surgical intervention and extracorporeal bypass.
- Trial name
- NCT04456751
- Testing
- Redo op
- Where
- Belgium
- Volunteers
- 2,439 people
- Sponsor
- Brugmann University Hospital
Transcatheter Aortic Valve Implantation (TAVI), Blood Transfusion
Transfusion Requirements in Transcatheter Aortic Valve Implantation (TRITAVI) Study
Periprocedural bleeding events are frequent during transcatheter aortic valve implantation (TAVI), mainly driven by vascular complications and are associated to a worse prognosis.
- Conditions
- Transcatheter Aortic Valve Implantation (TAVI), Blood Transfusion, AKI, Prognosis
- Trial name
- TRITAVI (NCT03740425)
- Testing
- Blood Transfusion
- Where
- Italy
- Volunteers
- 3,235 people
- Sponsor
- G. d'Annunzio University
Anemia, Multiple Myeloma
Epoetin Alfa in Treating Anemia in Patients Undergoing Chemotherapy for Multiple Myeloma
RATIONALE: Epoetin alfa may cause the body to make more red blood cells. It is used to treat anemia in patients with multiple myeloma.
- Conditions
- Anemia, Multiple Myeloma, Plasma Cell Neoplasm
- Trial name
- NCT00400686
- Testing
- epoetin alfa
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- The Cleveland Clinic
Blood Transfusion, Orthopedic Procedures
A Study to Determine the Safety of Epoetin Alfa and Whether Epoetin Alfa Can Reduce the Need for Blood Transfusions in Patients After Major Orthopedic Surgery.
The purpose of this study is to determine the safety of epoetin alfa and to determine the effectiveness of epoetin alfa in reducing the need for blood transfusions after major orthopedic surgery.
- Conditions
- Blood Transfusion, Orthopedic Procedures, Anemia
- Trial name
- NCT00270036
- Testing
- epoetin alfa
- Volunteers
- 1 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Anemia, Blood Transfusion
A Study to Determine Whether Epoetin Alfa Can Reduce the Need for Blood Transfusions in Patients During the Period of Time Around Major Orthopedic Surgery.
The purpose of this study is to evaluate the safety of epoetin alfa and to determine whether epoetin alfa will reduce the need for blood transfusions during the period of time around major orthopedic surgery.
- Conditions
- Anemia, Blood Transfusion, Orthopedic Procedures
- Trial name
- NCT00270088
- Testing
- epoetin alfa
- Volunteers
- 316 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Transfusion Requirements in Cardiac Surgery III
TRICS-III is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in high risk patients having cardiac surgery using a non-inferiority trial design.
- Trial name
- TRICS-III (NCT02042898)
- Testing
- Restrictive Transfusion Strategy, Liberal transfusion strategy
- Where
- 74 sites in United States, Australia and 17 more
- Volunteers
- 5,028 people
- Sponsor
- Unity Health Toronto
Coagulopathy, Rethoracotomy
Modified Ultrafiltration in Cardiac Surgery
The purpose of this study is to find out, whether filtration of the blood in patients undergoing cardiac surgery, beneficially influences the coagulation system.
- Conditions
- Coagulopathy, Rethoracotomy, Blood Loss, Transfusion Requirements
- Trial name
- NCT00998647
- Testing
- modified ultrafiltration using Maquet haemoconcentrator, BC 20 plus
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Goethe University
VV ECMO, Bleeding
Incidence of Bleeding, Thrombosis and Transfusion Requirements in ICU Patients With COVID-19 Supported With Veno-venous Extracorporeal Membrane Oxygenation
The investigators aim to assess the risk of bleeding and thrombo-embolic complications as well as benefit and harm of blood product transfusion and anticoagulation therapy in adult ICU patients with COVID-19 supported with V-V…
- Conditions
- VV ECMO, Bleeding, Thrombosis, Transfusion Adverse Reaction
- Trial name
- NCT07352072
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Upper Gastrointestinal Bleeding, Cirrhosis
Transfusion Requirements in Gastrointestinal (GI) Bleeding
Recently it has been suggested that a restrictive transfusion of units of Red Cells (URC) may improve the outcome of ICU patients with anemia.
- Conditions
- Upper Gastrointestinal Bleeding, Cirrhosis, Portal Hypertension
- Trial name
- NCT00414713
- Testing
- red blood cell transfusion
- Where
- Spain
- Volunteers
- 860 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Congenital Heart Disease
The Role of Tranexamic Acid in Reducing Blood Transfusion Requirements After Cardiopulmonary Bypass in Neonates
This is an observational, prospective study to evaluate the role of tranexamic acid in reducing blood transfusion in neonates undergoing cardiopulmonary bypass.
- Trial name
- NCT01914211
- Testing
- Tranexamic Acid, Acute Normovolemic Hemodilution
- Where
- United States
- Sponsor
- Aymen N Naguib