Clinical trials: Transgender Persons, open to volunteers
Substance Abuse, Substance Addiction
The Trans-Led Care Study
This study is testing a new mutual-help group called "the TLC program" for transgender adults who use substances or are recently in recovery.
- Conditions
- Substance Abuse, Substance Addiction, Substance Use Disorder (SUD), Substance Use (Drugs, Alcohol)
- Trial name
- TLC (NCT06880705)
- Testing
- The TLC Program
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Illinois Institute of Technology
Obesity & Overweight, Eating Disorders
Lifestyle Intervention for Obesity and Eating Disorder Prevention in Transgender Adolescents
Transgender and gender-diverse adolescents are at increased risk for obesity, disordered eating behaviors, body dissatisfaction, and reduced quality of life due to minority stress and structural inequities.
- Conditions
- Obesity & Overweight, Eating Disorders, Body Image Disturbance, Gender Diverse Populations
- Trial name
- NCT07466069
- Testing
- TransForm Health Program
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Physical and Psychological Evaluation of Hormonal Therapy in Transsexual Persons
A European Network for the Investigation of Gender Incongruence
The physical and psychological effects of the hormonal treatment of transsexual persons are not sufficiently described. 'Transparency' wants to answer this question in a prospective manner, in a multicenter study to describe…
- Trial name
- ENIGI (NCT01072825)
- Testing
- questionnaires, blood sampling, clinical evaluation
- Where
- 4 sites in Belgium, Italy and 2 more
- Volunteers
- 125 people
- Sponsor
- University Hospital, Ghent
Transgender Persons
Research Participation With Transgender and Gender-Diverse Youth
Research has historically excluded the participation of transgender and gender-diverse people. The purpose of this research study is to find out about what goes into a transgender and gender-diverse youth's decision to…
- Trial name
- NCT05927350
- Testing
- Survey
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Virginia Commonwealth University
Surgery, Larynx
Voice Outcome of Glottoplasty, Cricothyroid Approximation, Thyroplasty, and Chondrolaryngoplasty
The purpose of this study is to measure the short- and long-term voice outcome and outcome predictors of glottoplasty, cricothyroid approximation, thyroplasty, and chondrolaryngoplasty using a prospective non-randomized…
- Conditions
- Surgery, Larynx, Transgenderism, Gender Dysphoria
- Trial name
- NCT06439290
- Testing
- Phonosurgery, Mastectomy/breast augmentation
- Where
- 2 sites in Belgium
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University Ghent
Gender Incongruence, Cardiovascular (CV) Risk
Cardiovascular Health of Transgender Individuals During the Gender-affirming Pathway
Gender incongruence, now classified in ICD-11 as a "marked and persistent incongruence between an individual's experienced gender and the gender assigned at birth," is managed in dedicated, multidisciplinary centres that…
- Conditions
- Gender Incongruence, Cardiovascular (CV) Risk, Cardiovascular Disease Risk Factor, Cardiovascular Disease Acute
- Trial name
- CV-TGD (NCT07187947)
- Testing
- Feminizing GAHT, Masculinizing GAHT
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cancer Screening, Transgender
Cervical and Endometrial Cancer Screening in Patients Seeking Gender-Affirming Hysterectomy
This study aims to quantify the rates of cervical cancer screening and endometrial sampling prior to gender-affirming hysterectomy, assess the need for these tests in TGD individuals, and explore patient-centered options for…
- Conditions
- Cancer Screening, Transgender, Gender Diverse Populations
- Trial name
- NCT07075731
- Testing
- No intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Psychological Distress, Stigma, Social
Behavioral Intervention to Reduce Stress Among Black Gender Minority Women
The research objectives of this study are to first, develop a culturally informed community-based intervention with guidance from community members (via focus groups and theater testing) to reduce the effect of chronic stigma…
- Trial name
- NCT05436106
- Testing
- Adaptive Intervention Approach
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Gender Affirmation Surgery, Perioperative Care
Support for Transgender and Non-Binary Individuals Seeking Vaginoplasty Study
The STRIVE study is the first national randomized trial to focus on improving well-being, access to surgical care and other health outcomes for transgender and nonbinary (referred to as trans) people seeking genital…
- Conditions
- Gender Affirmation Surgery, Perioperative Care, Transgender Health
- Trial name
- STRIVE (NCT06436560)
- Testing
- STRIVE Peer Support Intervention
- Where
- 9 sites in United States
- Volunteers
- 290 people
- Sponsor
- Oregon Health and Science University
HIV Prevention, HIV Pre-exposure Prophylaxis
Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP
The purpose of this project is to test a culturally-tailored, community-delivered long-acting injectable PrEP (lenacapavir) program for Latine gay and bisexual men (GBM) and transgender women (TGW).
- Conditions
- HIV Prevention, HIV Pre-exposure Prophylaxis, HIV Prevention Program, HIV Prevention and Care
- Trial name
- INCLUSION (NCT07218211)
- Testing
- Lenacapavir long-acting
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV
A Clinical Study of Alimatravir (MK-8527) in Transgender (Trans) and Gender Diverse Individuals on Gender-affirming Hormone Therapy and at Low Likelihood of Human Immunodeficiency Virus (HIV)-1 Exposure (MK-8527-018)
The goal of this study is to learn about the safety of alimatravir (MK-8527) in transgender and gender-diverse people and if they tolerate it.
- Trial name
- EXPrESSIVE-18 (NCT07850609)
- Testing
- Alimatravir
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Transgender Persons
Cohort Study on Factors Associated with the Evolution of Quality of Life Among Transgender Individuals in the French Population
This research focuses on identifying medical, social, and healthcare journey determinants associated with the evolution of quality of life in the transgender population at 12 months.
- Trial name
- TRANSPOSE (NCT06854965)
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- CNGE Conseil
HIV
Evaluation of a New Strategy to Approach the Transgender Sex Worker Populations and Their Clients for Access to a Preventive Sexual Health System Through the ORTIF Digital Teleconsultation Solution
The prevalence of HIV (Human Immunodeficiency Virus) and STIs (Sexually Transmitted Infections) is very high in the trans population, due to multifactorial components.
- Trial name
- E-PrevenT (NCT07516691)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypogonadism, Gender Identity Dysphoria
The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population
It has been known that both estrogen and testosterone are the major sex steroids regulating bone metabolism and other physiological changes in both male and female, respectively.
- Trial name
- NCT06247267
- Testing
- Fortesta, Estradiol
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Gender Identity, Gender Dysphoria in Adolescents and Adults
Puberty, Testosterone, and Brain Development
Transmasculine youth (female sex assigned at birth, male gender identity) who begin clinical gender affirming hormone therapy (GAHT) with testosterone (T) may experience changes in headache.
- Conditions
- Gender Identity, Gender Dysphoria in Adolescents and Adults, Headache, Transgender
- Trial name
- NCT06670053
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
HIV Prevention, Substance Use
The Implementation of a Trans-tailored Harm Reduction Service for Transgender Persons in Relation to chemsEX and Substance Use (iT-REX)
This study evaluates a comprehensive transgender-tailored harm reduction service for transgender women, transgender men, and non-binary individuals engaging in chemsex or substance use in Thailand, focusing on PrEP uptake…
- Conditions
- HIV Prevention, Substance Use, Mental Health Disorders, Sexually Transmitted Infections (STIs)
- Trial name
- NCT07512856
- Testing
- Transgender-tailored Harm Reduction Service
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
Gender Dysphoria, Gender Dysphoria, Adult
Metoidioplasty and Phalloplasty Surgery Decision Making
The goal of this clinical trial is to test a new online tool designed to provide clear and understandable information to help individuals considering Metoidioplasty and Phalloplasty Surgeries (MaPS) make informed decisions The…
- Conditions
- Gender Dysphoria, Gender Dysphoria, Adult, Gender Incongruence, Transgenderism
- Trial name
- MaPS (NCT06565663)
- Testing
- MaPS Decision Aid
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Self-Compassion
An "EmbraceMe" Self-compassion Intervention for Transgender and Gender-diverse People in Hong Kong
This proposed pilot study aims to evaluate the "EmbraceMe", a self-compassion intervention to improve positive body image and mental health among transgender and gender-diverse (TGD) people in Hong Kong.
- Trial name
- NCT07809529
- Testing
- "Embraceme" self-compassion intervention
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Hong Kong Metropolitan University
Substance Use, HIV Prevention
Pre-implementation Study to Develop Trans-tailored Services for Transgender Persons in Relation to chemsEX
The study is a pre-implementation cross-sectional study exploring chemsex behaviors among transgender persons and gathering perspectives from multiple stakeholders to inform the development of transgender-tailored harm reduction…
- Conditions
- Substance Use, HIV Prevention, Sexually Transmitted Infections (STIs)
- Trial name
- T-REX (NCT07505875)
- Testing
- Understanding of chemsex patterns, impacts, and service needs among transgender persons
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
Kidney Disease, Kidney Injury
Transgender Analysis of Nephrological Studies Focused on Renal Metrics
This study investigates how sex hormones affect kidney function in people undergoing gender-affirming hormone therapy (GAHT). We know men have a faster progression of kidney disease.
- Conditions
- Kidney Disease, Kidney Injury, Transgender Individuals
- Trial name
- TRANSFORM (NCT07542964)
- Testing
- P-aminohippurate clearance study, Iohexol infusion, Hyperinsulinemic clamp
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Amsterdam UMC, location VUmc