Clinical trials: Transgenderism
Transsexualism, Surgery
Use of an External Erectile Device in Transgender Man Following Phalloplasty
The purpose of this study is to test whether an external erectile prosthesis (The Elator™) is a feasible alternative to internal erectile prostheses for transgender men who have undergone a phalloplasty with glansplasty and wish…
- Conditions
- Transsexualism, Surgery, Sex Behavior, Erectile Dysfunction
- Trial name
- ProstHEsis (NCT03823014)
- Testing
- Elator
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Transgenderism
Sociological Study of the Life Courses of Young TRANSgender Patients
The number of people consulting for a request related to trans identity is increasing sharply. The study monocentric qualitative study of discursive material aims to describe the diversity of practices and discourses mobilized by…
- Trial name
- ParTransRep (NCT06221163)
- Testing
- collection of biographical and sociological data
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Transsexualism
A Common Polymorphism of the SRD5A2 Gene is Not Associated With Male-to-Female and Female-to-Male Transsexualism
Genetic variations, i.e. polymorphisms, may be associated with gender dysphoria, e.g. transsexualism. This study aims to identify such variations.
- Trial name
- NCT00435513
- Where
- Austria
- Volunteers
- 1,770 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Gender Dysphoria, Gender Identity Disorder
Sexuality in Transmen During Hormone and Operative Treatment
With this analysis the investigators aim at discovering a difference in sexuality between transmen, cissexual women and cissexual men. A potential impact of body satisfaction will also be explored.
- Conditions
- Gender Dysphoria, Gender Identity Disorder, Transsexualism, Body Image
- Trial name
- Transmann (NCT03637920)
- Where
- Austria
- Volunteers
- 160 people
- Sponsor
- Medical University of Graz
Gender Incongruence, Transgenderism
Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors
The purpose of this research is to find out if hormone therapy in transgender subjects' changes hormone receptors in blood, muscle and fat; fat production; muscle production; and inflammation processes.
- Trial name
- NCT04551144
- Testing
- testosterone cypionate, Estradiol Valerate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- St. Louis University
Transgenderism, Gender Dysphoria
Effectiveness of Speech Therapy in Trans Women.
One of the greatest hurdles in the transition of transgender persons is that voice, speech and communication are not congruent with the desired gender.
- Conditions
- Transgenderism, Gender Dysphoria, Speech Therapy, Voice Disorder Due to Transsexualism
- Trial name
- NCT04708600
- Testing
- Pitch Elevation Therapy, Articulation Resonance Therapy
- Where
- Belgium
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University Ghent
Transsexualism, Transgenderism
Effects of Cross-sex Hormone Therapy on Eating Behavior, Metabolism, Energy Balance and Cardiovascular System
Current study aims to characterize five highly interconnected physiological systems in patients undergoing cross-sex hormone therapy - namely glucose and lipid metabolism, energy balance, eating behavior, functional brain…
- Conditions
- Transsexualism, Transgenderism, Adiposity, Eating Behavior
- Trial name
- HHS (NCT04838249)
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Transgenderism
Prospective Imaging Assessment of Perineo-pelvic Static's Evolution After Sexual Reassignment Surgery in MtF Transgender Patient, by Peno-scrotal Inversion Vaginoplasty Technique (TRANSPELV)
The research consists of adding to the usual MtF transgender patient undergoing vaginoplasty care course, static and dynamic perineo-pelvic MRI before, and at 6 and 24 months.
- Trial name
- TRANSPELV (NCT06093724)
- Testing
- Static and dynamic perineo-pelvic MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Limoges
Gender Dysphoria, Gender Identity Disorder
i2TransHealth: Interdisciplinary, Internet-based Trans Health Care
i2TransHealth is a randomized controlled trial that investigates the outcomes of an internet-based health care approach for transgender and gender diverse (TGD) people.
- Conditions
- Gender Dysphoria, Gender Identity Disorder, Transsexualism, Gender Identity
- Trial name
- NCT04290286
- Testing
- i2TransHealth
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Surgery, Larynx
Voice Outcome of Glottoplasty, Cricothyroid Approximation, Thyroplasty, and Chondrolaryngoplasty
The purpose of this study is to measure the short- and long-term voice outcome and outcome predictors of glottoplasty, cricothyroid approximation, thyroplasty, and chondrolaryngoplasty using a prospective non-randomized…
- Conditions
- Surgery, Larynx, Transgenderism, Gender Dysphoria
- Trial name
- NCT06439290
- Testing
- Phonosurgery, Mastectomy/breast augmentation
- Where
- 2 sites in Belgium
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University Ghent
Gender Dysphoria, Gender Identity Disorder
TransCare - Genital Surgery for Trans Women in Centralized vs. Decentralized Health Care Delivery Settings
Trans (i.e., transgender, transsexual) individuals experience a gender that does not match their sex assigned at birth (Gender Incongruence), which can lead to distress called gender dysphoria (formerly known as transsexualism).
- Conditions
- Gender Dysphoria, Gender Identity Disorder, Transsexualism, Gender Identity
- Trial name
- NCT03872648
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Transgenderism, Hypogonadism
Effects of Testosterone Plus Dutasteride or Placebo on Muscle Strength, Body Composition and Metabolism in Transmen
To compare the effects on body composition and muscle strengthof 54-weeks treatment with of testosterone undecanoate combined with placebo or with the 5a-reductase inhibitor dutasteride
- Trial name
- DUTMUSCLE-20 (NCT04545450)
- Testing
- dutasteride 5 mg/day, Testosterone Undecanoate
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Unita Complessa di Ostetricia e Ginecologia
Transgenderism, Fertility Issues
Transgender Caregivers' and Patients' Representations of Parenthood as Part of a Fertility Preservation Pathway
This research aims to understand the impact of fertility preservation consultation on transgender patients' projection and how the possibility of preserving gametes influences transgender people's transition paths, parenthood…
- Trial name
- TransFert (NCT06218446)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Transgenderism
Feminizing Treatment in Transgender Women and Non-binary Persons
Cohort study in 100 transgender women treated with gender affirming hormone treatment. Follow up affter 1year, 3 years, 5 years and 10 years, Outcomes regarding cardiovascular effects of hormone treatment.
- Trial name
- BIC-Estrogen (NCT05169762)
- Testing
- standard treatment
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Transgenderism
Evaluation of an Adaptative, Multidisciplinary, Reach-out Program, Facilitating Pre Exposition HIV Prophylaxis (PrEP) Prescription and Retention in Care, in a Group of Trans Womens (TW) at High Risk of HIV Infection.
Evaluation of an adaptative, multidisciplinary, reach-out program, facilitating pre exposition HIV prophylaxis (PrEP) prescription and retention in care, in a group of trans womens (TW) at high risk of HIV infection.
- Trial name
- PrEP à porter (NCT05415930)
- Testing
- Psychosocial assistance, Medical care, Legal-Administrative Assistance
- Volunteers
- 100 people
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Papillomavirus Infection, Transsexualism
HPV Prevalence in Transpersons - a Prospective Study
In this study, Human Papilloma Virus (HPV) prevalence will be determined once in the urine of 200 trans people. In addition, subjects will be asked to complete a questionnaire about their sexual orientation, which is adapted from…
- Trial name
- NCT04864951
- Testing
- Colli-Pee urine collection device, Survey
- Where
- 2 sites in Austria, Slovenia
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Sophie Pils
Transsexualism
Testosterone and Its Metabolites in GID
The purposes of this study are: to determine the role of testosterone versus dihydrotestosterone with respect to the following physiological functions: bone metabolism, body composition, insulin resistance and lipid profile to…
- Trial name
- NCT00146146
- Testing
- testosterone undecanoate alone, testosterone undecanoate plus letrozole, testosterone undecanoate plus dutasteride
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unita Complessa di Ostetricia e Ginecologia
Transgenderism, Reproductive Issues
Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version
This research study investigates whether male-level exogenous androgens inhibit the reproductive neuroendocrine axis in otherwise healthy (non-PCOS) females.
- Trial name
- NCT07092527
- Testing
- Testosterone Cypionate 50 milligrams per millileter (mg/mL) Injectable Solution
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Stigmatization, Sex Work
An Education Initiative to Reduce Stigma Towards Sex Workers and Sexual Minorities Among Nursing Students
Background: Sex workers and sexual minorities (SWSM) often encounter barriers when accessing healthcare services due to social stigma and discrimination.
- Conditions
- Stigmatization, Sex Work, Homosexuality, Transgenderism
- Trial name
- NCT06434805
- Testing
- sex workers and sexual minorities education workshop
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- Hong Kong Metropolitan University
Transgender, Transgenderism
Cardiometabolic Health in Transgender Males
Transgender individuals are those with a gender identity opposite the sex they were assigned at birth. Approximately 1% of the population is transgender, equating to ~60,000 transgender Wisconsinites.
- Trial name
- NCT04977765
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin