Clinical trials: Transmission
HIV/AIDS, HIV Prevention
Helping Men Have Healthy Babies
Many men living with HIV (MLWH) want to have children. HIV-RNA suppression can minimize sexual HIV transmission risks while allowing for conception.
- Trial name
- NCT03818984
- Testing
- Safer Conception for Men with At Risk Partners
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Hiv
Systems Analysis and Improvement Approach to Improve Integration of HIV Prevention and Treatment Services
East and Southern Africa is home to 6.2% of the world's population but includes 54% of all people living with HIV (PLWH). In this region, three out of five PLWH are women, and there is a particularly high burden of HIV amongst…
- Trial name
- FP HIV SCALE (NCT05404958)
- Testing
- Systems Analysis and Improvement Approach (SAIA)
- Where
- Kenya
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV/AIDS
Safety, Tolerability and Immunogenicity of MVA.HTI and ChAdOx1.HTI With Vesatolimod in HIV-1 Positive Patients
AELIX-003 study aims to investigate the safety, tolerability, immunogenicity and efficacy of a regimen containing AELIX Therapeutics' HTI T-cell vaccines and Gilead´s Toll-Like Receptor 7 (TLR7) agonist vesatolimod in…
- Trial name
- AELIX-003 (NCT04364035)
- Testing
- ChAdOx1.HTI, MVA.HTI, GS-9620
- Where
- 9 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Aelix Therapeutics
HIV Infections
A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4-Immunoglobulin G (rCD4-IgG) Administered by Intravenous Bolus Injection in Combination With Oral Zidovudine in Patients With AIDS and AIDS-Related Complex
To determine the safety profile of recombinant human CD4-immunoglobulin G (CD4-IgG) and zidovudine (AZT) combination therapy in patients with AIDS or AIDS-related complex (ARC); to assess pharmacokinetic (blood level) properties…
- Trial name
- NCT00000976
- Testing
- CD4-IgG, Zidovudine
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Contraception
Acceptability of Depo-subQ in Uniject
This is an observational study to assess the experience of current depot medroxyprogesterone acetate (DMPA) intramuscular (IM) clients and providers when they try Depo-subQ in Uniject and offer recommendations for the…
- Trial name
- NCT01667276
- Where
- 2 sites in Senegal, Uganda
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- FHI 360
HPV, Cervical Cancer
Multimodality Treatments of HPV-related Lesions of the Female Genital Tract
Cervical cancer is one of the most preventable types of cancer, as it develops over an extended period, and its causative agent is well-known.
- Conditions
- HPV, Cervical Cancer, Cervix Lesion, Vagina Disease
- Trial name
- NCT05938192
- Testing
- vaccination
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
HIV Infection, Alcohol Use
Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV)
This study is a randomized controlled trial (RCT) to compare the effects of varenicline, cytisine, and nicotine replacement therapy (NRT) to reduce: 1) alcohol use and craving, 2) smoking; and 3) inflammation and risk for…
- Conditions
- HIV Infection, Alcohol Use, Smoking
- Trial name
- St PETER HIV (NCT02797587)
- Testing
- Varenicline, Cytisine, Nicotine Replacement Therapy
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Boston Medical Center
HIV Infection
Safety and Immunogenicity of a Plasmid HIV Vaccine in HIV Uninfected Adults
The purpose of this study is to determine the safety and immune response to a investigational DNA Plasmid HIV vaccine, ADVAX e/g + ADVAX p/n-t (ADVAX), at three different dosage levels, in adults who are not infected with HIV.
- Trial name
- C001 (NCT00249106)
- Testing
- ADVAX
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
HIV Infections
Sulforaphane Use to Effect Inflammatory and Metabolic Changes in Virally Suppressed HIV Patients
Assess the effects of Sulforaphane supplementation in HIV patients that have achieved viral suppression.
- Trial name
- NCT05224492
- Testing
- Sulforaphane
- Volunteers
- 20 people
- Sponsor
- Sunshine Specialty Health Care
Post-exposure Prophylaxis, Sexually Transmitted Diseases
Pharmacokinetic Characterization of a Single 200 mg Dose of Doxycycline in Post-exposure Prophylaxis (PEP) of Sexually Transmitted Infections in Different Biological Compartments
Post-exposure prophylaxis (PEP) using doxycycline 200 mg within 24 hours of unprotected sexual intercourse to prevent sexually transmitted infections has demonstrated a reduction in the incidence of chlamydial and syphilis…
- Conditions
- Post-exposure Prophylaxis, Sexually Transmitted Diseases, Doxycycline
- Trial name
- DOXY-PK (NCT06007534)
- Testing
- Samples
- Where
- 2 sites in France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infections
Implementation and Assessment of a Medication Therapy Management Program in HIV Patients at High Risk of Adverse Drug Events at Khartoum, Sudan
This clinical trial aims to evaluate the effectiveness and cost-effectiveness of two levels of a pharmacist-led Medication Therapy Management (MTM) program, Basic MTM and Enhanced MTM, compared with usual care for HIV patients at…
- Trial name
- HIV-MTM-SUDAN- (NCT07750834)
- Testing
- Basic MTM, Enhanced MTM
- Where
- Sudan
- Volunteers
- 1,149 people
- Sponsor
- Universiti Sains Malaysia
HIV Infections
A Peer-Driven Intervention to Increase PrEP Uptake Among Minority MSM
The objective of this study is to develop an effective peer-driven intervention (PDI) approach and assess its feasibility and efficacy on pre-exposure prophylaxis (PrEP) uptake among men who have sex with men.
- Trial name
- NCT05161663
- Testing
- Peer-driven intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
HIV Infections
Piloting At-birth Point of Care HIV Testing Strategies in Kenya
Innovative strategies to expedite HIV diagnosis among exposed infants, including at-birth testing and two portable point-of-care (POC) diagnostic systems, will be piloted using an implementation framework.
- Trial name
- NCT03435887
- Testing
- Alere q HIV-1/2 Detect for point of care infant testing, GeneXpert HIV-1 Qual for point of care infant testing, HIV DNA PCR testing (Standard of Care)
- Where
- 5 sites in United States, Kenya
- Volunteers
- 1,999 people
- Sponsor
- University of Kansas Medical Center
Heart Failure
Electronic Transmission of Laboratory and Adherence Records of Heart Failure Patients to General Practitioners Screen
Patients with heart failure (HF) need multiple guideline-directed medications to control the systolic and/or diastolic ventricular dysfunction.
- Trial name
- LabAdhDoc (NCT04326101)
- Testing
- Transmission of adherence records
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University Hospital, Basel, Switzerland
HIV
PrEP, Lube, and the Rectal Mucosa in MSM at Risk of HIV
The purpose of this study is to determine whether the use of rectal lubricants can affect how well the medication, Truvada, will work to prevent infection with HIV when someone is exposed to HIV in the rectum.
- Trial name
- NCT02401230
- Testing
- Truvada, Gel lubricant
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV Infections
Pharmacogenomic of Atazanavir/Efavirenz (ATV/EFV)
Objectives: To evaluate the impact of genetic polymorphism on ARV drug levels To evaluate the effect of genetic polymorphism/drug levels on long term immunologic and virologic response To correlate the genetic polymorphism/drug…
- Trial name
- NCT01138267
- Where
- Thailand
- Volunteers
- 450 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
HIV Infections
ADAPT-POL New Orleans: Adaptation of Prevention Techniques With Popular Opinion Leader
Adopting and Demonstrating the Adaptation of Prevention Techniques (ADAPT) is a supplement to the Centers for Disease Control and Prevention (CDC) Community Based Organization Program Announcement 04064 (PA 04064).
- Trial name
- NCT00252109
- Testing
- Popular Opinion Leader
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HIV Infections
Study to Evaluate the Influence of Nevirapine to Atazanavir in Steady State Equilibrium in HIV Patients
The purpose of this study is to evaluate the influence of nevirapine in exposure to atazanavir boosted with ritonavir, in steady state equilibrium, in HIV-infected adult patients.
- Trial name
- NCT00355719
- Testing
- Atazanavir (Reyataz), Ritonavir (Norvir), Nevirapine (Viramune)
- Where
- 2 sites in Spain
- Volunteers
- 14 people
- Sponsor
- Germans Trias i Pujol Hospital
HIV Infections
A Phase I/II Safety and Immunogenicity Trial of UBI Microparticulate Monovalent (HIV-1 MN) Branched Peptide Vaccine in HIV-1 Seronegative Human Subjects
To evaluate the safety and immunogenicity of a combination of microparticulate monovalent HIV-1 MN synthetic branched peptide candidate vaccine for oral administration and monovalent HIV-1 MN synthetic branched peptide vaccine in…
- Trial name
- NCT00002428
- Testing
- HIV-1 Peptide Vaccine, Microparticulate Monovalent, rgp120/HIV-1MN Monovalent Octameric V3 Peptide Vaccine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United Biomedical
HIV Infections
A Clinical Trial to Evaluate the Reversibility of Abacavir/Lamivudine/Dolutegravir CNS-Related Neurotoxicity After Switching to Tenofovir/Alafenamide/Emtricitabine/Darunavir/Cobicistat (TAF/FTC/DRV/c)
A phase IV, multicentre, randomised, open-label, pilot clinical trial to evaluate the Reversibility of abacavir/lamivudine/dolutegravir ( ABC/3TC/DTG) CNS-Related Neurotoxicity After Switching to tenofovir…
- Trial name
- DETOX (NCT03685500)
- Testing
- Symtuza® (TAF/FTC/DRV/c), ABC/3TC/DTG + Symtuza® (TAF/FTC/DRV/c)
- Where
- 6 sites in Spain
- Volunteers
- 78 people
- Sponsor
- Fundacion SEIMC-GESIDA
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