Clinical trials: Transmission
Sexually Transmitted Diseases
Comparing Specimen Collection Techniques to Screen for Sexually Transmitted Infections in Pregnant Women: A Pilot Study
The purpose of this research study is to compare two specimen collection techniques (vaginal vs. endocervical swab) to screen for sexually transmitted infections in pregnant women.
- Trial name
- NCT03877263
- Testing
- Endocervical swab for detection of STI, Vaginal swab for detection of STI
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- OhioHealth
Human Immunodeficiency Virus (HIV) Infection
Pharmacokinetics, Safety And Toleration Of Maraviroc Administered To Subjects With Various Degrees Of Renal Impaired And Normal Renal Function
The purpose of this study is to assess whether a dosing adjustment is needed in patients with renal impairment.
- Trial name
- NCT00717067
- Testing
- Maraviroc, Ritonavir, Saquinavir
- Where
- 2 sites in Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Genital Infection, Asymptomatic Infections
Evaluation of Vaginal Self-sampling Diagnostic Performances to Identify Genital Infections
Screening for genital infection (GI), sexually transmitted infection (STI) and asymptomatic carriage of group B streptococcus (GBS) in pregnant women is a common reason for medical appointments.
- Trial name
- NCT04039711
- Testing
- Vaginal self-sampling
- Where
- France
- Volunteers
- 1,028 people
- Sponsor
- Hôpital Européen Marseille
HIV Infections
Phase 2b, Open-label, Multicenter, Rollover Study to Assess Antiviral Activity and Safety of Long-acting (LA) Cabotegravir (CAB) Plus LA Rilpivirine (RPV), Administered Every 2 Months (Q2M), in Human Immunodeficiency Virus (HIV)-Positive Participants From the LATTE Study
This study (POLAR), is designed to assess the antiviral activity and safety of CAB LA plus RPV LA, administered Q2M, in approximately 100 adult HIV-1 infected, antiretroviral therapy (ART) experienced participants.
- Trial name
- NCT03639311
- Testing
- CAB LA, RPV LA, RPV
- Where
- 30 sites in United States, Canada
- Volunteers
- 97 people
- Sponsor
- ViiV Healthcare
HIV Infection
Safety and Efficacy Study of AGS-004 During Analytical Treatment Interruption
The purpose of this study is to determine the safety and effectiveness of AGS-004, an immune therapy, for HIV-infected individuals.
- Trial name
- NCT01069809
- Testing
- AGS-004
- Where
- 9 sites in United States, Canada
- Volunteers
- 53 people
- Sponsor
- Argos Therapeutics
Platelet Activation Testing Before/After Anti-platelet Therapy, Healthy
The Accuracy Of A Novel Platelet Activity Assay In Humans On Antiplatelet Agents: Pharmacodynamics And Comparison With Light Transmission Aggregometry
The purpose of this study is to test a novel diagnostic immunoassay of platelet function and compare it to the current gold standard platelet function assay by testing the response to aspirin and clopidogrel in a group of healthy…
- Trial name
- NCT04822363
- Testing
- Aspirin, Clopidogrel
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Chlamydia Infection, Contact Tracing
The Participant Agreement for Contact Tracing (PACT) Study: Enhancing Partner Notification Services.
Patients diagnosed with chlamydial infections (a sexually transmitted disease) are asked to notify their sex partners and tell them to seek medical evaluation.
- Trial name
- NCT00207493
- Testing
- Kit enhancement to referral, patient referral versus contract referral
- Where
- United States
- Volunteers
- 494 people
- Sponsor
- Centers for Disease Control and Prevention
SARS-CoV-2 Infection, Covid19
Prospective COVID-19 Cohort Study, Dominican Republic
This project will build on an existing CDC funded cooperative agreement in the Dominican Republic with the Brigham and Women's Hospital (2018-2023) that includes (i) prospective COVID-19 and AFI surveillance at two health…
- Trial name
- NCT04898738
- Testing
- Alcohol based hand sanitizer
- Where
- Dominican Republic
- Volunteers
- 1,043 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
HIV Infections, Human Immunodeficiency Virus
Effect of Bednets and a Water Purification Device on HIV Disease Progression Among ART naïve Patients in Kenya
In many areas of the world most severely affected by the HIV/AIDS pandemic, insect and water-borne diseases such as malaria and diarrheal disease are common causes of illness and death.
- Conditions
- HIV Infections, Human Immunodeficiency Virus, Malaria, Plasmodium Falciparum
- Trial name
- ITN (NCT00914225)
- Testing
- Bednets and Water Purification
- Where
- 2 sites in Kenya
- Volunteers
- 500 people
- Sponsor
- University of Washington
HIV Infections
Optimisation of Care in Vulnerable HIV Infected Individuals
Antiretroviral therapy is currently the only way to control HIV disease progression in HIV infected subjects and to prevent transmission.
- Trial name
- OPTICARE (NCT03799276)
- Testing
- Opticare study
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida
Human Immunodeficiency Virus
Use of the Shang Ring Circumcision Device in Boys Below 18 Years Old in Kenya
A proof of concept study to evaluate the feasibility of using the Shang Ring, a novel male circumcision device across all childhood age groups namely infants (under 1), 1-5 age group, 6-12 age group and the 13-17 age group.
- Trial name
- NCT01891409
- Testing
- Male circumcision using the Shang Ring device
- Where
- Kenya
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- EngenderHealth
HIV, Cardiovascular Disease
Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology
Background: Antiretroviral therapy has increased the lifespan of people with human immunodeficiency virus (HIV), but recent research suggests that people with HIV also have an increased risk of developing cardiovascular disease.
- Trial name
- NCT01089114
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, AIDS
Enhanced Access to HIV Care for Drug Users in San Juan, Puerto Rico
The overall goal of this project is to implement and evaluate a community-level, structured approach to enhance HIV care access and retention for drug users in San Juan, Puerto Rico.
- Conditions
- HIV, AIDS, Substance Abuse
- Trial name
- Proyecto PACTo (NCT01792752)
- Testing
- Enhanced HIV Care Access and Retention Intervention, HIV Testing Campaign, Treatment Re-engagement Campaign
- Where
- 2 sites in Puerto Rico
- Volunteers
- 2,082 people, healthy volunteers welcome
- Sponsor
- Columbia University
Spinal Cord Injury (SCI), Amyotrophic Lateral Sclerosis (ALS)
Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS
Most neurological injuries such as spinal cord injuries (SCI) and amyotrophic lateral sclerosis (ALS) spare a portion of nerve circuitry.
- Trial name
- NCT02469675
- Testing
- Transcranial magnetic stimulation, Median nerve stimulation, Cervical transcutaneous stimulation
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Bronx VA Medical Center
HIV Infections
Phase I Study of Safety and Persistence of UC-781 Vaginal Microbicide
Vaginal microbicides are compounds that may protect women from HIV and other sexually transmitted infections (STIs). This study will determine the safety of the microbicide UC-781 by comparing the effects of keeping the…
- Trial name
- NCT00441909
- Testing
- UC-781
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sexual Transmitted Disease, Vaginosis, Bacterial
Impact of Internal Menstrual Protections on Immunity and Vaginal Microbiota
The availability, effectiveness, and safety of menstrual protection represent a key public health issue. However, research on women's menstrual and sexual health remains extremely limited.
- Conditions
- Sexual Transmitted Disease, Vaginosis, Bacterial, Mycosis, Urogenital Disease
- Trial name
- CUPS2 (NCT07199998)
- Testing
- Samples collection (whole blood, urine, vaginal and cervical cells)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre National de la Recherche Scientifique, France
HIV Infections
To Assess the Relative Bioavailability (BA) of TRIUMEQ® and Dolutegravir and Lamivudine (DTG/3TC) Pediatric Dispersible Tablet Formulations in Healthy Volunteers
This is a 2-part, single-dose, open label, randomized 3-way cross-over study to compare BA of pediatric study drugs TRIUMEQ and (DTG/3TC) in healthy volunteers under fasted conditions. Study will be conducted in 2-parts.
- Trial name
- NCT03441984
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Infection
TransPrEP: Social Network-Based PrEP Adherence for Transgender Women in Peru
The investigators propose a social network-based PrEP adherence intervention as part of a comprehensive, context-specific approach to HIV prevention for TW in Lima, Peru.
- Trial name
- TransPrEP (NCT02710032)
- Testing
- Social Network-Based Adherence Intervention, Social Media Platform
- Where
- Peru
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hiv
CD4 CAR+ ZFN-modified T Cells in HIV Therapy
This research study is being carried out to study a new way to possibly treat HIV. As part of this study, doctors will take some of your own white blood cells, called T-cells, and modify them so that they can identify and target…
- Trial name
- NCT03617198
- Testing
- CD4 CAR+CCR5 ZFN T-cells
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Pennsylvania
HIV Infections, Depression
Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)
The primary purpose of this study was to test the whether high-risk, HIV-seronegative persons with mild-to-moderate depression would be more likely to adopt protective behavior change when provided with pharmacotherapy for their…
- Trial name
- NCT00285584
- Testing
- Bupropion
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- NYU Langone Health
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