Clinical trials: Transplant, Liver
Liver Transplant; Complications, HLA Antigens
The Relationship Between HLA Tissue Compatibility and Biliary Complications in Patients With Liver Transplantation
Liver transplantation has become the accepted treatment option for advanced liver failure in recent years. In addition to the increase in the number of centers performing transplant and the decrease in complication rates…
- Trial name
- NCT04885582
- Testing
- HLA antigen results
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Inonu University
Pediatric Liver Transplantation
Incidence and Risk Factors of Prolonged Post-Operative Mechanical Ventilation
The primary goal of the study is to identify incidence and risk factors for PPMV in pediatric patients undergoing liver transplantation.
- Trial name
- NCT05825703
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hilar Cholangiocarcinoma
Safety Study of Liver Transplantation for Hilar Cholangiocarcinoma
Hilar cholangiocarcinoma is a highly malignant tumor. Surgical resection or simple liver transplantation leads to poor prognosis accompanied by high recurrence rate and low survival rate.
- Trial name
- NCT02178280
- Testing
- liver transplantation combined with neoadjuvant therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Liver Transplant Failure
Early Allograft Failure Simplified Estimation (EASE) in Liver Transplantation
A variety of clinical scores have been developed with the intent to predict early allograft failure after liver transplantation.
- Trial name
- EASE (NCT03858088)
- Testing
- Liver transplantation
- Where
- Italy
- Volunteers
- 2,350 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Liver Metastases, Colorectal Adenocarcinoma
Colorectal Metastasis and Liver Transplantation With Organs From Deceased Donors
MELODIC trial is an prospective, multicenter, non-randomized, open-label, parallel trial, aimed at assessing the efficacy (in terms of overall survival: OS) of liver transplantation (LT) in unresecable CRC liver-only metastases…
- Conditions
- Colorectal Liver Metastases, Colorectal Adenocarcinoma, Unresectable Malignant Neoplasm
- Trial name
- MELODIC (NCT04870879)
- Testing
- Liver Transplant, Chemotherapy
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Azienda Ospedaliera di Padova
Patients Suitable for a Liver Transplant
Survival and Quality of Life After Liver Transplantation in Patients Aged 65 and Over
The main objective of this non-interventional, single-center study is to assess survival and associated factors at 1 year in patients aged 65 and over who received liver transplantation
- Trial name
- LT 65+ (NCT04754503)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Gérond'if
Fulminant Liver Failure
Hepatocyte Transplantation as a Life Support Bridge
The purpose of this study is to gain knowledge about the result of infusing liver cells, carefully matched to blood type, into a subject's body.
- Trial name
- NCT00282542
- Testing
- Hepatocyte Infusion
- Sponsor
- Virginia Commonwealth University
Chronic Hepatitis B
A Study of Sequential Therapy With AHB-137 Injection Followed by TVAX-008 Injection in Participants Living With Chronic Hepatitis B (CHB)
This is a study of sequential therapy with AHB-137 injection followed by TVAX-008 injection in participants living with Chronic Hepatitis B (CHB).
- Trial name
- NCT07897448
- Testing
- AHB-137, TVAX-008
- Volunteers
- 105 people
- Sponsor
- Grand Theravac Life Sciences (Hangzhou) Co., Ltd.
Sinusoidal Obstruction Syndrome (SOS), Hematopoietic Stem Cell Transplant (HSCT)
Efficacy of N-acetylcysteine Versus Placebo as Prophylaxis of Sinusoidal Obstruction Syndrome in Patients Undergoing Hematopoietic Stem Cell Transplantation
Sinusoidal obstruction syndrome (SOS) or hepatic veno-occlusive disease (VOD) is a serious complication that occurs, most often occurring in patients undergoing hematopoietic stem cell transplantation (HSCT), especially in its…
- Trial name
- ALISON (NCT04712435)
- Testing
- N-acetylcysteine
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Instituto Brasileiro de Controle do Cancer
HCC, Liver Cirrhosis
SALT for Liver Cirrhosis With HCC
HCC is the third leading cause of cancer deaths worldwide. Although surgical treatment may be effective in patients with HCC, the five-year survival rate is only 50-70%.
- Trial name
- NCT06069947
- Testing
- sequential adult left lateral lobe liver transplantation (SALT)
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Complication, Postoperative, Regeneration Liver
Randomized Controlled Trial to Study the Outcome of Intravenous Phosphate Supplementation in Live Donors Undergoing Hepatectomy for Living Donor Liver Transplantation (LDLT)
In this study, we aim to analyse the effect of phosphate supplementation on donors undergoing partial hepatectomy for LDLT. In Group A, we are going to supplement phosphate in donors postoperatively from day 1 to day 5.
- Trial name
- NCT04026438
- Testing
- Potassium Phosphate Injection
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatic Encephalopathy, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation for the Treatment of Refractory Hepatic Encephalopathy After TIPS Surgery
This is a single-center, prospective, open-label, parallel-group exploratory clinical study designed to evaluate the safety and preliminary efficacy of fecal microbiota transplantation combined with standard medical therapy in…
- Conditions
- Hepatic Encephalopathy, Fecal Microbiota Transplantation, TIPS, Refractory Hepatic Encephalopathy
- Trial name
- NCT07683936
- Testing
- Fecal Microbiota Transplantation, Rifaximin、Lactulose, Dietary Fiber Prebiotic
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Esophageal and Gastric Varices, Child, Only
HEMOCC Study. Hemostasis in Cirrhotic Children.
Prospective investigations into the role of hemostatic factors in the risk of variceal bleeding among children with chronic liver disease (thromboelastometry e.g) is still required.
- Trial name
- HEMOCC (NCT03244332)
- Testing
- Collecting Clinical Data, Collecting laboratory data
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hepatitis C
Pre-Transplant Treatment to Prevent Recurrence of Hepatitis C After Liver Transplantation
The purpose of this study is to learn if pre-liver transplant treatment, using peginterferon plus ribavirin, will clear hepatitis C virus (HCV) RNA from the blood in HCV-infected recipients and reduce the risk of recurrent HCV…
- Trial name
- LADR (NCT00135798)
- Testing
- LADR Treatment
- Where
- 8 sites in United States
- Volunteers
- 79 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Liver Transplantation
A Study to Evaluate and Compare the Efficacy and Safety of FK506MR vs Prograf® in Stable Liver Transplantation Patients
This study aims to evaluate and to compare the efficacy and safety of FK506MR with Prograf® in stable liver transplantation patients.
- Trial name
- NCT00619398
- Testing
- Prograf, FK506MR capsule
- Where
- 6 sites in China
- Volunteers
- 172 people
- Sponsor
- Astellas Pharma Inc
Liver Cirrhosis
AI-SC Multi-center Study
To examined the opportunity for Artificial Intelligence (AI) agents to evaluate transplant candidacy objectively at LT-SC, with a large language models (LLM) representing the expertise of each individual specialist (hepatologist…
- Trial name
- NCT07885007
- Testing
- evaluate the alignment between AI-SC recommendations and LT-SC decisions, Multi AI-SC model
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- University Health Network, Toronto
Liver Diseases
YSPSL for Prevention of Delayed Graft Function in Cadaveric Liver Transplantation
The study is designed to assess the feasibility of evaluating YSPSL for the amelioration of ischemia reperfusion injury following liver transplantation by administering YSPSL into the liver graft directly ex vivo via the portal…
- Trial name
- NCT00450398
- Testing
- YSPSL
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Y's Therapeutics, Inc.
Liver Metastases, Colorectal Cancer Metastatic
Improving Outcome of Selected Patients With Non-resectable Hepatic Metastases From Colo-rectal Cancer With Liver Transplantation
The COLT trial is an investigator-driven, multicenter, non-randomized, open-label, controlled, prospective, parallel trial, aimed at assessing the efficacy (in terms of overall survival: OS) of liver transplantation (LT) in…
- Conditions
- Liver Metastases, Colorectal Cancer Metastatic, Liver Neoplasm, Neoplasms
- Trial name
- COLT (NCT03803436)
- Testing
- Liver transplant, Chemotherapy
- Where
- 12 sites in Italy
- Volunteers
- 38 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Hepatitis C, Liver Transplantation
Comparing Efficacy and Safety of Tacrolimus With Steroids or Monoclonal Anti-IL2R Antibody in Hepatitis C Virus (HCV) Positive Liver Transplant Patients
This is an exploratory study to evaluate the impact of eliminating steroid administration upon viral HCV load at 12 months measured by quantitative serum HCV-RNA determination in patients transplanted for HCV cirrhosis.
- Trial name
- CHASE (NCT00295607)
- Testing
- Tacrolimus, steroids, monoclonal anti-IL2R antibody
- Where
- 17 sites in Czechia, France and 6 more
- Volunteers
- 138 people
- Sponsor
- Astellas Pharma Inc
Kidney Transplant; Complications, Liver Transplant; Complications
Project LIFT - Promoting Healthy Behavior Through a Wearable Fitness Device and Financial Incentives
Project LIFT is a randomized, controlled trial that tests the effectiveness of a remotely-monitored, home-based exercise program utilizing wearable fitness trackers to monitor steps taken per day, health engagement questions, and…
- Conditions
- Kidney Transplant; Complications, Liver Transplant; Complications, Obesity
- Trial name
- LIFT (NCT03221465)
- Testing
- Self-monitoring of physical activity with incentives, Usual care and self-monitoring of physical activity
- Where
- 2 sites in United States
- Volunteers
- 127 people
- Sponsor
- University of Pennsylvania
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