Clinical trials: Transplant, Liver
Kidney Failure, Kidney Diseases
Direct Acting Antiviral Therapy in Donor HCV-positive to Recipient HCV-negative Kidney Transplant
This is a proof of concept, single center study for the donation of HCV-positive kidney to HCV negative recipient patients, with preemptive, interventional treatment with 12 weeks of commercially available DAA therapy to prevent…
- Conditions
- Kidney Failure, Kidney Diseases, Hepatitis C
- Trial name
- NCT03623568
- Testing
- glecaprevir/pibrentasvir tablets
- Where
- United States
- Sponsor
- Raymond T. Chung, MD
Liver Cirrhoses
Developing Viability Index for Machine Perfused Livers
Machine perfusion technology is nearing the point of rescuing discarded liver grafts in the hope of proving them to be or improving them to the point of being transplantable.
- Trial name
- NCT03694691
- Testing
- Liver Biopsy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Liver Transplantation, Metabolic Syndrome X
Mediterranean Diet and Protein-Sparing Modified Diet for Metabolic Syndrome in Liver Transplant Recipients
Many metabolic complications can develop after liver transplant including: diabetes, high blood pressure, obesity, heart attacks and stroke.
- Conditions
- Liver Transplantation, Metabolic Syndrome X, Obesity
- Trial name
- NCT02174783
- Testing
- Control group, Mediterranean diet, Protein-Sparing Modified Fast (PSMF)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Liver Transplant
Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates
This is a multi-center clinical trial in Cytomegalovirus (CMV) seronegative prospective liver transplant recipients to determine the efficacy of two doses of Cytomegalovirus-Modified Vaccinia Ankara (CMV-MVA) Triplex CMV vaccine…
- Trial name
- COLT (NCT06075745)
- Testing
- CMV-MVA Triplex
- Where
- 18 sites in United States
- Volunteers
- 416 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatocellular Carcinoma
SBRT as Bridging Therapy for Hepatocellular Carcinoma Patients on Transplant Waitlist
This is a single center, prospective study to assess the efficacy and safety of using stereotactic body radiation therapy (SBRT) as bridging treatment for hepatocellular carcinoma (HCC) patients on transplant waitlist.
- Trial name
- NCT03950102
- Testing
- SBRT
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Liver Transplant Rejection, Liver Transplant; Complications
Safety of DNP007 in Healthy Subjects
This clinical trial evaluated the safety, tolerability, pharmacokinetic properties, and immunogenicity of DNP007 when administered as a single dose.
- Conditions
- Liver Transplant Rejection, Liver Transplant; Complications, Steatohepatitis, Nonalcoholic
- Trial name
- NCT06400771
- Testing
- DNP007
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Living Donor Liver Transplantation
Impact of Splenic Artery Ligation in LDLT for Patients With Portal Hypertension
In this study, the investigators aim to prove that performing splenic artery ligation in living donor liver transplantation for patients with portal hypertension is beneficial for early graft function postoperatively.
- Trial name
- NCT04988100
- Testing
- splenic artery ligation, No intervention
- Volunteers
- 30 people
- Sponsor
- Assiut University
Liver Diseases, Liver Cirrhosis
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial.
- Conditions
- Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
- Trial name
- CHANCE (NCT04613921)
- Testing
- Observational Protocol
- Where
- 106 sites in United States, Argentina and 25 more
- Volunteers
- 3,000 people
- Sponsor
- European Foundation for Study of Chronic Liver Failure
Chronic Hepatitis C-virus Infection, Renal Transplantation
Hepatitis C in Renal Transplant Recipients
The aim of the present trial is to evaluate whether the conversion of immunosuppression from tacrolimus to cyclosporine A induces changes in (i) hepatitis C-virus load, (ii) parameters of hepatic function and (iii) parameters of…
- Trial name
- NCT02108301
- Testing
- tacrolimus-cyclosporine A
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Prof. Dr. Alice Schmidt
Primary Sclerosing Cholangitis, Post- Orthotopic Liver Transplantation
Vancomycin Treatment in Recurrent PSC in Liver Transplant Patients
The purpose of the study is to investigate the safety and efficacy of oral vancomycin in patients with recurrent Primary Sclerosing Cholangitis (PSC) after liver transplantation.
- Trial name
- NCT03046901
- Testing
- Vancomycin
- Where
- United States
- Sponsor
- Ochsner Health System
Iron Overload, Hemosiderosis
Impact of Iron Overload on the Incidence of Liver Complications in Long-Term Survivors (≥10 Years) of Allogeneic Hematopoietic Stem-Cell Transplantation.
This single-center, non interventional cohort study investigates whether chronic iron overload influences the incidence of liver complications in adults who are at least 10 years beyond allogeneic hematopoietic stem cell…
- Conditions
- Iron Overload, Hemosiderosis, Liver Diseases, Hematopoietic Stem Cell Transplantation (HSCT)
- Trial name
- AlloFer (NCT07028112)
- Testing
- Cohort
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatitis C, Hepatitis C Virus Infection, Response to Therapy of
Prevention of Transmission of Hepatitis C Virus (HCV) From HCV-Viremic Organ Donor
This trial will be done in participants who undergo transplantation of heart, kidney or lung at University of California, San Diego (UCSD) and receive a hepatitis C infected donor organ.
- Trial name
- NCT04596475
- Testing
- glecaprevir/pibrentasvir (GLE/PIB)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Acute-On-Chronic Liver Failure
Mesenchymal Stem Cell Transplantation for Acute-on-chronic Liver Failure
Mesenchymal stem cells (MSC) has been reported to improved outcomes of acute-on-chronic liver failure(ACLF). More randomization controlled studies are needed to confirm the effect of MSC treatment for ACLF.
- Trial name
- NCT03668171
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Hemophilia, Hemophilia B
Study Evaluating Liver Transplantation in Haemophilia Patients in Spain
This study will analyze survival and outcome of patients with severe haemophilia who undergo liver transplantation in Spain
- Trial name
- NCT00927992
- Testing
- Epidemiological Non interventional
- Volunteers
- 11 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Hepatitis B, Hepatitis C
Observational Study on Prevalence of Host and Viral Genotypes in Chronic Hepatitis B and Hepatitis C Patients in India
This study will define the substantial disease burden associated with viral hepatitis in India, and provide a foundation to understand the host and viral determinants of disease pathogenesis that may ultimately impact treatment…
- Trial name
- NCT01772121
- Where
- 19 sites in India
- Volunteers
- 1,000 people
- Sponsor
- Gilead Sciences
Acute-On-Chronic Liver Failure
Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure
This study is a randomized double-blind placebo-controlled multicenter clinical trial to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell (UC-MSC) transplantation for the treatment of…
- Trial name
- NCT05985863
- Testing
- standard medical treatment, hUC-MSC, hUC-MSC_Prolonged
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing 302 Hospital
Living Donor Liver Transplantation Recipients
Pressure Controlled Versus Volume Controlled Mechanical Ventilation During Anesthesia for Living Donor Liver Transplantation Recipients
pressure controlled ventilation will improve oxygenation indices , hemodynamics during anesthesia for living donor liver transplantation recipients ,improving postoperative graft function and decreasing postoperative pulmonary…
- Trial name
- NCT01865019
- Testing
- mechanical ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Liver Failure Acute
Hepatocyte Transplantation for Acute Decompensated Liver Failure
The purpose of this research study is to determine whether liver cell transplantation can provide help for patients with liver failure who are unlikely to survive without some form of liver support.
- Trial name
- NCT01345565
- Testing
- human hepatocytes
- Where
- United States
- Sponsor
- Ira Fox
Incisional Hernia of Anterior Abdominal Wall
Study on the Efficacy of Prophylactic on Lay Mesh in Preventing Post-operative Hernia in Liver Transplant Patients
Study Design: Single-blinded, randomized, prospective clinical trial. Study Population: End-stage liver disease patients' candidates for liver transplantation.
- Trial name
- NCT04512469
- Testing
- Low molecular weight mesh
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Organ Failure, Multiple, LIVER TRANSPLANTATION
Electronic Archive of Internal Medicine for the Treatment of Severe Organ Failure and Liver Transplantation-MITIGO
ELECTRONIC ARCHIVE OF INTERNAL MEDICINE FOR THE TREATMENT OF SERIOUS ORGAN FAILURES AND LIVER TRANSPLANTATION
- Trial name
- NCT06781502
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
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