Clinical trials: Transplant, Liver
Coagulopathy, Endstage Liver Disease
Evaluation of the Safety of Octaplas™ Versus Plasma in Patients Undergoing Orthotopic Liver Transplantation
Post-Marketing Requirement study to evaluate the safety of octaplas™ versus plasma in patients undergoing orthotopic liver transplantation (OLT).
- Trial name
- NCT02037373
- Testing
- Octaplas™, Plasma
- Where
- 4 sites in United States
- Volunteers
- 43 people
- Sponsor
- Octapharma
Liver Diseases
Induction Treatment Followed by Immunosuppression Withdrawal in Liver Transplantation: A Comparative Trial
This is a randomized, controlled trial in liver transplantation in which conventional immunosuppressive treatment will be compared with a therapeutic strategy consisting in pre-transplant antibody-mediated T cell depletion…
- Trial name
- ATEGE-LIVER (NCT00436722)
- Testing
- ATG (Fresenius Biotech)
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Hospital Clinic of Barcelona
Medication Adherence, Liver Transplantation
mDOT for Immunosuppressant Adherence in Adolescent Liver Transplant Recipients
The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppression medication adherence among adolescent liver transplant recipients.
- Trial name
- NCT03781830
- Testing
- mHealth Intervention
- Where
- United States
- Sponsor
- Johns Hopkins University
Postoperative Acute Kidney Injury, Pediatric Liver Transplantation
Acute Kidney Injury and Recovery Mode in Pediatric Liver Transplantation
Acute kidney injury (AKI) is a common complication after pediatric liver transplantation (PLT), and renal impairment after LT has proven to be related with increased graft failure and mortality.
- Trial name
- NCT06598228
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Tianjin First Central Hospital
Amyloidosis, Familial, Transthyretin Amyloidosis
Patisiran in Patients With Hereditary Transthyretin-mediated Amyloidosis (hATTR Amyloidosis) Disease Progression Post-Liver Transplant
The purpose of this study is to evaluate the efficacy, safety and pharmacokinetics of patisiran in participants with hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) with disease progression after liver…
- Trial name
- NCT03862807
- Testing
- Patisiran
- Where
- 9 sites in France, Germany and 5 more
- Volunteers
- 24 people
- Sponsor
- Alnylam Pharmaceuticals
Liver Transplant
Serum Markers of Ischemia Reperfusion Injury in Liver Transplant Patients
This is an observational study examining serum markers in patients who are undergoing either a cadaveric liver transplant or a living related liver transplant.
- Trial name
- NCT00698399
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Evidence of Liver Transplantation
Reduction of Tacrolimus Dose in Association With Mycophenolate Mofetil After Liver Transplantation
The prevention of graft rejection after liver transplantation benefits nowadays from a variety of newly developed immunosuppressive agents.
- Trial name
- MMF-FK (NCT00151632)
- Testing
- Mycophenolate mofetil, Tacrolimus
- Where
- 8 sites in France
- Volunteers
- 195 people
- Sponsor
- Rennes University Hospital
Liver Transplant Disorder
Effect of Mannitol on Postreperfusion Syndrome During Living Donor Liver Transplant
Postreperfusion syndrome during living liver transplants remains a serious concern for transplant anesthesiologists. This syndrome is responsible for decreases in systemic blood pressure, systemic vascular resistance, and cardiac…
- Trial name
- NCT05277623
- Testing
- Mannitol, 0.9% normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Liver Transplant; Complications, Stress
Effects of Comedy Therapy on Anxiety and Vital Signs in Transplant Recipients
This study was conducted to investigate the effects of watching excerpts from classical Turkish comedy films on pre-transplant anxiety levels and vital signs in liver transplant recipients.
- Conditions
- Liver Transplant; Complications, Stress, Care Acceptor, Health
- Trial name
- NCT06919588
- Testing
- comedy therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bitlis Eren University
Living Donor Liver Transplantation
PRehab tO PreparE Living Liver Donors for Enhanced Recovery
1. to determine if a Phase III RCT of prehab vs usual care for LLDs is feasible (including rates of recruitment, adherence, adverse events, and attrition); 2.
- Trial name
- PROPELLER (NCT05431361)
- Testing
- Prehabilitation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Liver Failure
A Randomized Controlled Clinical Trial of Thymoglobulin® After Liver Transplantation
This is a 24-month, Phase II, multi-center, two-arm, randomized controlled study of adult patients receiving a single organ liver transplant from a deceased donor; the purpose being to determine the efficacy of Thymoglobulin®…
- Trial name
- NCT02544113
- Testing
- Thymoglobulin
- Where
- 4 sites in United States
- Volunteers
- 110 people
- Sponsor
- The Cleveland Clinic
Cholangiocarcinoma
Registry Study of Neoadjuvant Chemoradiation & Transplant for Cholangiocarcinoma Patients
This is an observational study intended to validate results of a previous study done at the Mayo Clinic. Patients are treated with combination chemotherapy and radiation and maintained on oral Xeloda until they can receive liver…
- Trial name
- NCT00301379
- Testing
- Observation data collection study.
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Washington University School of Medicine
Ileus
Interventions to Decrease the Impact of Post-OPerative Ileus After Liver Transplant or Resection Surgery
This is a randomized controlled trial to assess ways to address post-operative ileus (POI) in adult patients on the liver transplant service undergoing either liver transplant or resection surgery.
- Trial name
- NCT01156129
- Testing
- stool softener, Arm B: Acupressure bracelet, sugar free gum
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Nebraska
Hepatocellular Carcinoma
Effect of Adjuvant Therapy by Sorafenib, Oxaliplatin and S-1
The study is designed to investigate the effect of adjuvant therapy by Sorafenib, Oxaliplatin and S-1 to prevent the tumor recurrence for hepatocellular carcinoma after liver transplantation
- Trial name
- NCT02129322
- Testing
- Sorafenib, S-1, Oxaliplatin
- Where
- China
- Sponsor
- Zhejiang University
Hepatic and Hepatobiliary Disorders
Indocyanine Green Clearance Test in Liver Transplantation (LivInG)
The gap between patients awaiting and those undergoing liver transplantation (LT) continues to grow. Marginal organs carry higher risk of failure after LT however they are increasingly used to fill such gap.
- Trial name
- LivInG (NCT05228587)
- Testing
- Indocyanine green
- Where
- Italy
- Volunteers
- 162 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
End Stage Liver DIsease, Chronic Liver Failure
The Early Strength Training Program in Post-transplant Liver Cases
Liver transplantation (LT) is a current life-saving procedure performed as an open-abdominal surgery for patients with end-stage liver diseases (ESLD).
- Conditions
- End Stage Liver DIsease, Chronic Liver Failure, Liver Transplant Disorder, Muscle Loss
- Trial name
- NCT04546048
- Testing
- Strength Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Memorial Hospital Groups
Renal Function, Liver Transplant
Efficacy, Safety and Tolerability of Everolimus in Combination With Reduced Exposure Cyclosporine or Tacrolimus in Paediatric Liver Transplant Recipients.
This study was designed to assess the evolution of renal function and to collect efficacy, safety, and tolerability data of everolimus in co-exposure with reduced CNI in paediatric liver transplant recipients.
- Trial name
- NCT01598987
- Testing
- Introduction of everolimus with reduced cyclosporine or tacrolimus dose, the earliest 1 month and the latest 6 months after liver transplantation.
- Where
- 32 sites in United States, Australia and 10 more
- Volunteers
- 56 people
- Sponsor
- Novartis Pharmaceuticals
Liver Failure
Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure
HBV-related liver failure (HBV-LF), a dramatic clinical syndrome, is characterized with massive necrosis of liver cells. Liver transplantation might be the most effective therapy for HBV-LF.
- Trial name
- NCT01844063
- Testing
- Conventional plus BM-MSC treatment, Conventional plus UC-MSC treatment, Conventional treatment
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Liver Disease, Fungal Infection
Anidulafungin vs Amphotericin B Safety in High Risk Hepatic Transplant Recipients
The study is a randomized, open-label safety study comparing the use of anidulafungin (200 mg i.v. as initial dose and 100 mg/d i.v.
- Trial name
- AVALTRA (NCT01303549)
- Testing
- Anidulafungin, Liposomal amphotericin B
- Where
- 12 sites in Spain
- Volunteers
- 61 people
- Sponsor
- Fundacion SEIMC-GESIDA
Hepatitis C, Hepatocellular Carcinoma
Efficacy of Sofosbuvir With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant
The primary objective is to determine if the administration of a combination of sofosbuvir (SOF; GS-7977; PSI-7977) and ribavirin (RBV) to HCV-infected adults with hepatocellular carcinoma (HCC) meeting the MILAN criteria prior…
- Trial name
- NCT01559844
- Testing
- Sofosbuvir, Ribavirin
- Where
- 15 sites in United States, New Zealand and 1 more
- Volunteers
- 61 people
- Sponsor
- Gilead Sciences
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