Clinical trials: Transplant, Liver
Blood Concentration of Tacrolimus Metabolites
Dosage of Tacrolimus Metabolites in Blood and Bile for Prediction of Its Side Effects in Liver Transplant Recipients
The purpose of this study is to evaluate if concentration of tacrolimus metabolites is increased in patients presenting tacrolimus (TAC) side effects.
- Trial name
- STABILE 2 (NCT05277792)
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Rennes University Hospital
Autosomal Dominant Polycystic Kidney Disease
The Efficacy of Everolimus in Reducing Total Native Kidney Volume in Polycystic Kidney Disease Transplanted Recipients
The investigators multicenter randomized open-labelled study will investigate the efficacy of an everolimus based immunosuppression in reducing total native kidney volume in kidney recipients with autosomal dominant polycystic…
- Trial name
- EVERKYSTE (NCT02134899)
- Testing
- Everolimus, Calcineurin inhibitors maintenance
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplant; Complications, Ischemia Reperfusion Injury
Abdominal Regional Perfusion in Donation After Cardiac Death for Multi-Organ Transplantation
The main purpose of this study is to increase the pool of organs available for donation by performing ARP to recondition donation after cardiac death (DCD) organs prior to transplantation.
- Conditions
- Liver Transplant; Complications, Ischemia Reperfusion Injury, Cirrhosis, Liver Cancer
- Trial name
- NCT03946852
- Testing
- Abdominal Regional Perfusion
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre
Allogene Transplantation, Chronic Liver Diseases Patients
Allogene MSCs Transplantation in Liver for Patients With Chronic Liver Diseases Through Portal Vein by Ultrasound Guiding
Allogene MSCs transplantation will be performed in patients with chronic liver diseases through portal vein by ultrasound guiding and therapeutic effects including short-term effects and long-term follow-up will be compared and…
- Conditions
- Allogene Transplantation, Chronic Liver Diseases Patients, Through Portal Vein by Ultrasound Guiding
- Trial name
- NCT01256138
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Liver Transplant
Outflow Reconstruction in Right Lobe Living Donor Liver Transplantation
Modified Right Lobe Graft(MRLG) is one of the most common used graft in liver transplantation .Anterior sector of allograft in MRLG usually congested to decrease this congestion tributaries of middle hepatic vein should be…
- Trial name
- NCT03666689
- Testing
- surgical technique
- Volunteers
- 50 people
- Sponsor
- Assiut University
Polycystic Liver Disease
Polycystic Liver Disease in Kidney Transplant
The purpose of this study is to see if one kind of immunosuppressive drug has better effects for the patient's polycystic liver disease than another type.
- Trial name
- NCT00934791
- Testing
- Tacrolimus, Sirolimus, Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Hepatitis C, Renal Insufficiency, Chronic
HCV Treatment Immune Response With Grazoprevir/Elbasvir Before or After Renal Transplant
The purpose of this study is to determine whether patients treated for chronic hepatitis C (HCV) with zepatier (grazoprevir/elbasvir) prior to kidney transplant will have a stronger immune response compared to patients treated…
- Conditions
- Hepatitis C, Renal Insufficiency, Chronic, Disorder of Transplanted Kidney
- Trial name
- NCT02902120
- Testing
- Post-transplant Grazoprevir and Elbasvir
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Maryland, Baltimore
Liver Transplantation, Liver Transplant; Complications
EBD RCT Trial in Living Donor Liver Transplantation
This study was designed to demonstrate incidence of biliary complication rates after living donor liver transplantation according to the implantation of external biliary drainage throug duct-to-duct anastomosis site.
- Conditions
- Liver Transplantation, Liver Transplant; Complications, Bile Stricture, Bile Leakage From Biliary Anastomosis
- Trial name
- NCT04622540
- Testing
- External biliary drainage
- Where
- South Korea
- Volunteers
- 124 people
- Sponsor
- Seoul National University Hospital
Liver Transplanted Patients
Early Rehabilitation Program is Feasible and Safe in ICU in Liver Transplanted Patients
Liver transplantation is the last surgical treatment for patients with acute or chronic liver disease. Transplantation therapies technics are in constant evolution.
- Trial name
- NCT01960868
- Testing
- standard physiotherapy, experimental physical therapy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Mental Health Issue
Bioenergy, Depression, Anxiety and Stress After Liver Transplantation
In this study, the investigators aimed to examine the effect of bioenergy application on depression, anxiety and stress after liver transplantation.
- Trial name
- NCT06297018
- Testing
- Bioenergy application
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Liver Transplantation
REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy
The purpose of this study was, starting from the Italian clinical practice in liver transplantation, to optimize the immunosuppressive therapy, considering specific patient characteristics as alcoholic cirrhosis, hepatitis C…
- Trial name
- REFLECT (NCT02115113)
- Testing
- Everolimus, Tacrolimus
- Where
- 14 sites in Italy
- Volunteers
- 78 people
- Sponsor
- Novartis Pharmaceuticals
Liver Transplant
EVR and EPO for Liver Transplant Tolerance
This is an open label, single-arm, multicenter phase 1b study of stable adult liver transplant recipients on a tacrolimus (TAC)-based immunosuppression (IS) regimen who will transition from TAC to Everolimus (EVR), receive five…
- Trial name
- EVEREST (NCT06832189)
- Testing
- Everolimus, Epoetin alfa
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
End Stage Liver DIsease
SALT in Adolescents With End-stage Liver Disease
End-stage liver disease is synonymous with advanced liver disease, liver failure, and decompensated cirrhosis, and their disease progression is generally irreversible.
- Trial name
- NCT06069050
- Testing
- sequential adolesent left lateral lobe liver transplantation (SALT)
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Liver Transplant, Hepatocellular Carcinoma Recurrent
Safety of Atezolizumab-Bevacizumab in Liver Transplanted Patients With Advanced Hepatocellular Carcinoma
The prognosis of liver transplanted (LT) patients with recurrence of hepatocellular carcinoma (HCC), especially those with progression after locoregional treatment or advanced HCC, remains poor.
- Conditions
- Liver Transplant, Hepatocellular Carcinoma Recurrent, Systemic Treatment
- Trial name
- IMMUNO-TH (NCT06254248)
- Testing
- Systemic therapy
- Where
- 10 sites in France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Diseases+Liver Transplantation
Usefulness of Cardiopulmonary Exercise Testing for Cardiovascular Risk Estimation and Frailty Assessment in Liver Transplant Candidates
Patients undergoing liver transplantation (LT) have a high risk for cardiovascular disease (CVD). Frailty is a frequent condition among LT candidates.
- Trial name
- NCT04543825
- Testing
- Cardiopulmonary exercise testing
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Andres Duarte-Rojo
End Stage Liver DIsease, Liver Transplant; Complications
Fibrinogen and Intraoperative Bleeding in Liver Transplant
Liver transplantation is the only treatment for end-stage liver disease. It is a high-risk surgery that can cause heavy intraoperative bleeding.
- Trial name
- FIB_TOF (NCT04925843)
- Where
- Canada
- Volunteers
- 612 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Liver Failure, Liver Transplant; Complications
Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors
Because of the insufficiency of cadaveric organs and increasing need for organs, the interest in living donor liver transplantation have been greatly increased.
- Conditions
- Liver Failure, Liver Transplant; Complications, Post Operative Pain
- Trial name
- NCT05441150
- Testing
- Low dose ketamine infusion, 0.9% NaCl infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inonu University
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Bone marrow transplantation may allow doctors to give higher doses of chemotherapy and kill more tumor cells.
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Head and Neck Cancer, Kidney Cancer
- Trial name
- NCT00002515
- Testing
- filgrastim, carboplatin, thiotepa
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Immunosuppression, Hyperlipidemias
Cholesterol and Fatty Acid Synthesis in Islet and Liver Transplant Patients and Effect of Dietary Intervention
The purpose is to investigate possible mechanisms of increased blood lipid levels following transplantation, and also to see if a comprehensive dietary intervention is effective in reducing blood lipid levels in post-transplant…
- Conditions
- Immunosuppression, Hyperlipidemias, Diabetes Mellitus, Type 1
- Trial name
- NCT00947635
- Testing
- Dietary intervention - supplements
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Cirrhosis, Liver Failure
Comparative Analysis of Different Tests to Evaluate Prognosis of Patients on Liver Transplant Waiting List
It is a cohort to evaluate the power of different diagnostic tests in predicting the prognosis of patients with severe liver disease.
- Conditions
- Cirrhosis, Liver Failure, Portal Hypertension
- Trial name
- NCT01774617
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Guilherme Rezende
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