Clinical trials: Transplant, Liver
Liver Transplantation, Transplantation Immunology
A Randomized Study to Assess the Safety and Efficacy of Prograf vs Prograf-XL in de Novo Liver Transplant Recipients.
The purpose of this study is to compare the efficacy and safety of Prograf extended release(XL) plus MMF with Prograf plus MMF and steroid withdrawal in de novo Liver transplant recipients
- Conditions
- Liver Transplantation, Transplantation Immunology, Host vs Graft Reaction
- Trial name
- NCT00720408
- Testing
- Prograf-XL, Prograf, MMF
- Where
- 4 sites in Taiwan
- Volunteers
- 48 people
- Sponsor
- Astellas Pharma Inc
Liver Transplantation, Metabolic Syndrome X
Mediterranean Diet and Protein-Sparing Modified Diet for Metabolic Syndrome in Liver Transplant Recipients
Many metabolic complications can develop after liver transplant including: diabetes, high blood pressure, obesity, heart attacks and stroke.
- Conditions
- Liver Transplantation, Metabolic Syndrome X, Obesity
- Trial name
- NCT02174783
- Testing
- Control group, Mediterranean diet, Protein-Sparing Modified Fast (PSMF)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Liver Transplant Disorder
Implementation of an Enhanced Rehabilitation Protocol After Liver Transplantation: Feasibility and Analysis of Results
Currently, there are no expert recommendations regarding enhanced rehabilitation after liver transplantation. The development of Enhanced Rehabilitation After Surgery (ERAS) protocols in major surgery, particularly cardiothoracic…
- Trial name
- IPRA (NCT05625139)
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Strasbourg, France
End Stage Liver Disease, Hepatitis C
Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection
The purpose of this study is to compare three treatment regimens in patients who have received a liver transplant for end-stage liver disease caused by Chronic Hepatitis C infection.
- Trial name
- NCT00163657
- Testing
- Daclizumub, Tacrolimus, Cyclosporine
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- Baylor Research Institute
Chronic Hepatitis c, Liver Transplant Infection
Grazoprevir/Elbasvir for Genotype 1b Chronic Hepatitis C After Liver or Kidney Transplantation
Grazoprevir/elbasvir combination therapy is highly effective in the treatment of genotype 1b chronic hepatitis C, and the drug-drug interaction with central immunosuppressant, such as tacrolimus, should be manageable.
- Conditions
- Chronic Hepatitis c, Liver Transplant Infection, Kidney Transplant Infection
- Trial name
- NCT03723824
- Testing
- grazoprevir 100 mg/ elbasvir 50 mg, Zepatier®
- Where
- 2 sites in Taiwan
- Volunteers
- 14 people
- Sponsor
- Taichung Veterans General Hospital
Cirrhosis, Liver, Diabetes Mellitus Risk
Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant
The goal of this observational study is to establish risk factors for post-transplant in adult individuals with cirrhosis without diabetes undergoing liver transplant evaluation.
- Conditions
- Cirrhosis, Liver, Diabetes Mellitus Risk, Transplant; Failure, Liver, Transplant-Related Disorder
- Trial name
- NCT06950788
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Chicago
Liver Transplant; Complications
Perioperative Hemostasis Management in Liver Transplantation
Liver transplantation (LT) is a surgery with risk of bleeding. Several risk factors have been identified: complex dissection, portal hypertension, history of ascites fluid infections, history of surgical procedures, pre-existing…
- Trial name
- HEMOTRANSPLANT (NCT06257407)
- Where
- 16 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Société Française d'Anesthésie et de Réanimation
Liver Cirrhosis, Biliary
Autologous Bone Marrow Mononuclear Stem Cell for Children Suffering From Liver Cirrhosis Due to Biliary Atresia
The aim of this study was to evaluate the safety and effectiveness of autologous bone marrow mononuclear stem cell transplantation for Children Suffering from Liver Cirrhosis Due to Biliary Atresia
- Trial name
- NCT03468699
- Testing
- Autologous BMMC transplantation
- Where
- 2 sites in Vietnam
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Transthyretin Amyloidosis, Transthyretin Amyloidosis With Cardiomyopathy
Long-term Safety of Eplontersen Treated aTTR Patients and in Liver Transplant and Severely Hepatic Impaired Subpopulations
The aim of this observational cohort study is to characterise use of eplontersen in patients with prior liver transplant or with pre-existing severe hepatic impairment, as well as to assess long-term safety among all new users of…
- Conditions
- Transthyretin Amyloidosis, Transthyretin Amyloidosis With Cardiomyopathy, Transthyretin Amyloidosis With Polyneuropathy
- Trial name
- sTTRing (NCT07654855)
- Testing
- None ( observational study )
- Where
- 6 sites in United States, Canada and 4 more
- Volunteers
- 320 people
- Sponsor
- AstraZeneca
Liver Failure
Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure
HBV-related liver failure (HBV-LF), a dramatic clinical syndrome, is characterized with massive necrosis of liver cells. Liver transplantation might be the most effective therapy for HBV-LF.
- Trial name
- NCT01844063
- Testing
- Conventional plus BM-MSC treatment, Conventional plus UC-MSC treatment, Conventional treatment
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Acute-On-Chronic Liver Failure
Mesenchymal Stem Cell Transplantation for Acute-on-chronic Liver Failure
Mesenchymal stem cells (MSC) has been reported to improved outcomes of acute-on-chronic liver failure(ACLF). More randomization controlled studies are needed to confirm the effect of MSC treatment for ACLF.
- Trial name
- NCT03668171
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Acute Kidney Injury, Acute Renal Injury
Renal and Cardiac Risk Factors of AKI After Liver Transplantation
Background: Liver transplantation (LT) is an extensive operation with various factors contributing to the development of acute kidney injury in the perioperative period.
- Conditions
- Acute Kidney Injury, Acute Renal Injury, Liver Transplant; Complications
- Trial name
- NCT05666232
- Testing
- renal resistive index and myocardial performance index
- Volunteers
- 105 people
- Sponsor
- Mansoura University
Hepatocellular Carcinoma
Impact of Preoperative Serum Albumin Level on Postoperative Outcomes in Chinese HCC Patients Treated With Surgery
This is an observational and retrospective cohort study to evaluate the impact of the preoperative serum albumin concentration on postoperative outcomes among hepatocellular carcinoma (HCC) patients who received hepatectomy or…
- Trial name
- REAL (NCT05970159)
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shanghai Zhongshan Hospital
Primary Biliary Cholangitis, Heart Failure
Evidence Based Mental Wellness Programming Online for Adults Across Chronic Physical Conditions
Chronic physical conditions are defined as conditions that require ongoing management and treatment over extended periods of time.
- Conditions
- Primary Biliary Cholangitis, Heart Failure, Digestive Diseases, Women Who Have Experienced a Cardiac Event
- Trial name
- EMPOwer (NCT05786482)
- Testing
- Online mind-body wellness program, Online mind-body wellness program + Weekly Check-ins
- Where
- Canada
- Volunteers
- 825 people
- Sponsor
- University of Alberta
Liver Transplantation, Donor
External Oblique Intercostal Plane Block for Liver Transplantation Donors
Postoperative pain management is one of the important factors to improve rehabilitation and enhance recovery. External oblique intercostal plane block may be used for abdominal wall analgesia to provide effective analgesia for…
- Conditions
- Liver Transplantation, Donor, Postoperative Pain
- Trial name
- NCT05890079
- Testing
- Subcostal transversus abdominis plane block, External oblique intercostal plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istinye University
Pediatric Liver Transplanted Recipients
Health Advocate for Children After Liver Transplant
The HEAL-Tx is a 90-day intervention, in which a Health Advocate works with eligible families to identify and apply for community-based resources, alert healthcare providers to challenges the family is encountering, and guide…
- Trial name
- HEAL-Tx:RCT (NCT07279350)
- Testing
- Health advocate, Enhanced Control
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of California, San Francisco
The Recipients Undergoing Liver Transplantation
Identification of Genetic Polymorphism Related to Acute Kidney Injury After Liver Transplantation Through Genome-wide Association Study (GWAS) in Korean Population
Some of the liver transplantation recipients experience postoperative acute kidney injury due to various causes including genetic factors.
- Trial name
- NCT03344380
- Where
- South Korea
- Volunteers
- 330 people
- Sponsor
- Yonsei University
Immunosuppression, Kidney Transplant Rejection
The New LC-MS/MS Method for Determination of Unbound Tacrolimus in Plasma
Tacrolimus (TAC) is characterized by a narrow therapeutic window, as well as high inter- and intra-individual variability in pharmacokinetics. Both under- and overexposure may lead to severe adverse effects.
- Conditions
- Immunosuppression, Kidney Transplant Rejection, Kidney Transplant; Complications, Liver Transplant Rejection
- Trial name
- FreeTAC (NCT04657562)
- Testing
- Tacrolimus, Unbound tacrolimus measurement, CYP3A4 and CYP3A5 genotyping
- Where
- Poland
- Volunteers
- 380 people
- Sponsor
- National Science Centre, Poland
Liver Transplant
Efficacy and Safety of CertiroBell® Tablet Plus Tacrolimus in Primary Living Donor Liver Transplant Recipients
To evaluate the efficacy and safety of CertiroBell® tablet plus tacrolimus
- Trial name
- STELLA (NCT04867720)
- Testing
- Everolimus
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Cytomegalovirus (CMV) Infections Among Children and Adult Liver Transplantation Patients in China
A Study of Cytomegalovirus Disease Epidemiology in Pediatric and Adult Liver Transplant Recipients in China
The goal of this observational study is to learn about cytomegalovirus disease epidemiology in pediatric and adult liver transplant recipients in China.
- Trial name
- NCT05958186
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Lin Zhong
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.