Clinical trials: Transplant, Liver
Hepatitis C Virus Infection, Liver Transplantation
Effect of Immunosuppression Drug Weaning on Hepatitis C Virus (HCV)-Induced Liver Damage After Liver Transplantation
Viral infections can profoundly influence alloimmune responses and hamper allograft tolerance induction. Persistent hepatitis C virus (HCV) infection occurs in 50% of liver and 20% of kidney transplant recipients, but the impact…
- Trial name
- NCT00668369
- Testing
- Gradual immunosuppression drug withdrawal.
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplantation
Assessment Of the Safety and Benefit of Prospective Immunosuppressive Drug Withdrawal in Liver Transplantation and Prediction of Operational Tolerance
In liver transplantation up to 20% of recipients can completely discontinue immunosuppressive therapy maintaining normal graft function, and are conventionally considered as operationally tolerant.
- Trial name
- NCT00647283
- Testing
- Gradual immunosuppression drug withdrawal
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplant; Complications
Effect of N_Acetylcysteine on Liver Functions in Donors in Living Liver Transplantation
our practice for the past 10 years we have noticed a transitional impairment of liver function (elevated liver enzymes, total and direct bilirubin, and elevated serum lactate levels) following donors' liver resection.
- Trial name
- NCT03634566
- Testing
- N-Acetylecysteine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Liver Transplant Disorder, Ischemic Cholangiopathy
Endoscopic Management of Non-anastomotic Biliary Strictures Following Liver Transplantation.
The study will evaluate the results of endoscopic treatment of NON-anastomotic biliary strictures following liver transplantation
- Conditions
- Liver Transplant Disorder, Ischemic Cholangiopathy, Non-anastomotic Biliary Stricture, Biliary Stricture
- Trial name
- STEBINANSIED (NCT05761483)
- Testing
- ERCP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cytomegalovirus Infections
An Observational Study of Valcyte (Valganciclovir) in D+/R- Liver Transplant Recipients
This retrospective review will evaluate the efficacy of Valcyte (valganciclovir) in preventing Cytomegalovirus (CMV) disease in D+/R- liver transplant recipients.
- Trial name
- NCT02062294
- Where
- 3 sites in Switzerland
- Volunteers
- 14 people
- Sponsor
- Hoffmann-La Roche
Pediatric Patients Who Need Liver Transplantation
Transfusion Strategies for Pediatric Liver Transplantation
The patients assigned to the restrictive group will receive transfusion once the hemoglobin concentration falls below 6.0 g per deciliter, with a target hemoglobin range of 7.5 to 8.0 g per deciliter.
- Trial name
- NCT02951013
- Testing
- restrictive transfusion, liberal transfusion
- Where
- China
- Volunteers
- 488 people
- Sponsor
- RenJi Hospital
Alcohol Associated Liver Disease, Liver Transplantation
ADDICTOlogical Intervention in LIVEr Transplantation Recipients
Transplantation for end-stage-liver disease (ESLD) in the context of Alcohol-Associated Liver Disease (AALD) has been increasing and represents the main indication for Liver Transplantation (LT) in the world.
- Trial name
- AddictoLIVE (NCT06472973)
- Testing
- Post-transplant addiction intervention
- Where
- 16 sites in France
- Volunteers
- 720 people
- Sponsor
- University Hospital, Montpellier
Non-alcoholic Fatty Liver Disease
Intestinal Microbiota Transplantation for Nonalcoholic Fatty Liver Disease
In China, with the improvement of living standards, there is a significant increase in the rate of prevalence of type 2 diabetes and hyperlipidemia, associated with Non-alcoholic fatty liver disease（NAFLD） which has gradually…
- Trial name
- NAFLD (NCT03648086)
- Testing
- intestinal microbiota transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhongshan Hospital Xiamen University
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability
The purpose of this research study is to perfect the technique of EVLP and learn about the safety of transplanting lungs that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and perfused…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01241942
- Testing
- Steen Solution™, Conventional Lung Transplant
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Carolina, Chapel Hill
Hepatocellular Carcinoma
Relationship Between 18FDG PET/MRI Patterns and ctDNA to Predict HCC Recurrence After Liver Transplantation
Liver transplantation is the standard treatment for patients with early-stage Hepatocellular Carcinoma (HCC). Currently, important treatment decisions, like the selection of patients for transplantation, are made on crude, static…
- Trial name
- PETMRIinHCC (NCT03839706)
- Testing
- PET MRI
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Acute-On-Chronic Liver Failure, Liver Cirrhosis
Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study
The definition and diagnostic criteria of acute-on chronic liver failure (ACLF) differed evidently between the East and the West due to the difference in the underlying etiology.
- Conditions
- Acute-On-Chronic Liver Failure, Liver Cirrhosis, Liver Transplant; Complications
- Trial name
- TEA-ACLF (NCT05036031)
- Volunteers
- 500 people
- Sponsor
- RenJi Hospital
Liver Transplant Infection, Surgical Site Infection
Pharmacological Study of Cefazolin Antibioprophylaxis in Liver Transplantation
This study describes Cefazolin pharmacokinetics variation to target levels during liver transplantation.
- Conditions
- Liver Transplant Infection, Surgical Site Infection, Antibiotic Prophylaxis, Cephazolin Adverse Reaction
- Trial name
- ProCeTH (NCT04280237)
- Testing
- Blood samples
- Where
- France
- Sponsor
- University Hospital, Tours
Liver Cirrhosis
Validation of the Bispectral Index Monitor During Living Donor Liver Transplantation
Bispectral index (BIS) monitoring during living donor liver transplantation (LDLT) may be influenced with several factors rather than the depth of anesthesia such as bradycardia, hypotension, hypothermia, and mixed venous oxygen…
- Trial name
- NCT01494220
- Testing
- Bispectral index monitoring (BIS)
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University
Living Donor Liver Transplantation, Hypotension
Hypotension Prediction Index in Living Donor Liver Transplantation
The Hypotension Prediction Index via the Edwards Hemosphere advanced monitoring system is monitored in living donor liver transplantation recipients.
- Trial name
- NCT05010941
- Testing
- Hypotension Prediction Index
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Liver Transplant; Complications, Vasoplegia
Angiotensin II in Liver Transplantation
The purpose of this study is to determine the efficacy and safety of Angiotensin II as a second-line vasopressor (drug that raises the blood pressure) during liver transplantation.
- Trial name
- AngLT-1 (NCT04901169)
- Testing
- Angiotensin II, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Organ Preservation Solutions
Peri-operative rATG-perfusion of Solid Transplants
The increasing demand for organ transplantation and the shortage of available organs limit the success of organ transplantation programs.
- Trial name
- ATG-perfusion (NCT03377283)
- Testing
- organ perfusion with rabbit anti-thymocyte globulin (rATG), organ perfusion with saline
- Volunteers
- 80 people
- Sponsor
- Medical University Innsbruck
Covid19, Liver Transplant
Liver Transplantation and Coronavirus Disease 2019 (COVID-19)
The COVID-19 pandemic together with the strategies that are applied to control it are generating high morbidity and mortality worldwide.
- Trial name
- NCT04695756
- Testing
- COVID-19 pandemic
- Where
- Argentina
- Volunteers
- 1,000 people
- Sponsor
- Hospital Italiano de Buenos Aires
Portal Vein Thrombosis, Liver Transplant; Complications
Living Donor Liver Transplantation to Patients With Portal Vein Thrombosis
Data of demographic, clinical, laboratory and imaging studies of living donor liver transplantation (LDLT) recipients from two transplant centers were collected.
- Trial name
- NCT05132192
- Testing
- living donor liver transplantation, Thrombectomy or interposition graft
- Volunteers
- 335 people
- Sponsor
- Elvan Onur Kirimker
Liver Transplantation
Physical Activity and Fatigue in Caregivers Before and After Liver Transplantation
Caregivers of liver transplant recipients often experience substantial physical and psychological demands during the transplantation process.
- Trial name
- NCT07468812
- Testing
- Observational assessment of caregivers without any intervention.
- Where
- Turkey (Türkiye)
- Volunteers
- 119 people
- Sponsor
- Hasan Kalyoncu University
Liver Transplantation, Portal Hypertension
Effects of Terlipressin and Somatostatin on Portal Pressure in Patients Undergoing Living Donor Liver Transplantation
The goal of this clinical trial is to compare the effects of somatostatin and terlipressin on lowering portal pressure in patients with portal hypertension undergoing liver transplantation, and to investigate whether there are…
- Trial name
- NCT07304466
- Testing
- Somatostatin, Terlipressin
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Medipol University Hospital
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