Clinical trials: Transplant, Liver
Liver Dysfunction
Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation
INTERLIVER is a prospective observational study of the relationship of the molecular phenotype of 300 liver transplant biopsies to the histologic phenotype and the clinical features and outcomes.
- Trial name
- INTERLIVER (NCT03193151)
- Testing
- liver biopsy
- Where
- 15 sites in United States, Australia and 3 more
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Liver Failure, Mesenchymal Stem Cell
MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver Transplantation
Acute liver failure (ALF) refers to a potentially reversible disorder that was the result of severe liver injury, with an onset of encephalopathy within 8 weeks of symptom appearance and in the absence of pre-existing liver…
- Conditions
- Liver Failure, Mesenchymal Stem Cell, Extracellular Vesicles
- Trial name
- NCT06825572
- Testing
- MSC-EVs
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Liver Transplant
Hepato-duodenal Ligament Occlusion and Classic Technique in Liver Transplant
Liver transplantation was historically associated with massive blood loss. Many factors have contributed to the decline in bleeding and transfusion in the past two decades including refinement of surgical techniques, anesthetics…
- Trial name
- NCT04265157
- Testing
- Surgical technique surgical occlusion
- Volunteers
- 50 people
- Sponsor
- Assiut University
Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome
Ultrasound Elastography to Predict Development of SOS
The long-term goal of our research is to accurately identify SOS patients who would benefit from defibrotide treatment using US SWE. The overall objective of this study is to validate SWE as an early diagnostic marker for SOS.
- Conditions
- Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome, Veno-occlusive Disease, Stem Cell Transplant Complications
- Trial name
- NCT03858530
- Testing
- Ultrasound Examination
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Mercy Hospital Kansas City
Reperfusion Injury
Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)
The purpose of this study is to establish the effectiveness of the combined drug approach (anti-thrombin III, infliximab, apotransferrin, human recombinant erythropoietin beta, C1-inhibitor, glutathione, alfa-tocopherol…
- Trial name
- CAPITL (NCT02251041)
- Testing
- Antithrombin-III, Infliximab, Apotransferrin
- Where
- Belgium
- Volunteers
- 143 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Transplantation
The Validity of Central Venous to Arterial Co2 Difference During Living Donor Liver Transplantation
Study will be conducted on 20 patients ASA III-IV undergoing orthotopic liver transplantation. Blood samples will be obtained simultaneously from arterial line, pulmonary artery catheter and central venous catheter at 4 specific…
- Trial name
- NCT03123172
- Testing
- arterial and central venous blood gases
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Kasr El Aini Hospital
Hepatocellular Carcinoma
A Study of TCR-Redirected T Cell Infusion to Prevent Hepatocellular Carcinoma Recurrence Post Liver Transplantation
Hepatocellular Carcinoma (HCC) recurrence rate is high among liver transplant patients, while treatment measures are limited. This study plans to recruit 39 subjects with Hepatitis B virus (HBV) related HCC after liver…
- Trial name
- NCT02686372
- Testing
- TCR-T, No intervention and TCR-T (at crossover)
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Lion TCR Pte. Ltd.
Liver Transplantation, MRI
Exploring the Application Value of New Magnetic Resonance Imaging Technologies in Non-invasive Quantitative Assessment of Graft Function After Liver Transplantation
Title: Exploring the Application Value of New Magnetic Resonance Imaging Technologies in Non-invasive Quantitative Assessment of Graft Function after Liver Transplantation Purpose of the Study: This study aims to investigate the…
- Conditions
- Liver Transplantation, MRI, Graft Function
- Trial name
- NCT06994429
- Testing
- MRI Techniques for Graft Function Assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Zhen Li
Hepatitis C, Human Immunodeficiency Virus
Efficacy and Safety of Sofosbuvir Plus Ribavirin in Chronic Genotype 1, 2 and 3 Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Co-infected Adults
This study will evaluate the efficacy, safety, and tolerability of sofosbuvir (SOF; GS-7977) plus ribavirin (RBV) in adults with chronic genotypes 1, 2, and 3 HCV infection who are coinfected with HIV-1.
- Trial name
- NCT01667731
- Testing
- SOF, RBV
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 224 people
- Sponsor
- Gilead Sciences
Liver Transplantation
The Effects of Glucose/Ischemic Preconditioning on Reperfusion Injury in Deceased-Donor Liver Transplantation
Standard liver retrieval procedures for transplantation from a deceased donor inevitably result in a "reperfusion injury" to the liver tissue.
- Trial name
- NCT00718575
- Testing
- Glucose/Ischemic Preconditioning Pre-treatment
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Focus : To Study the Differences in Patient Compliance to Immunosuppressive Treatments and Patient Preference.
Adherence to Immunosuppressive Therapy Liver Transplant Recipients
Immunosuppressive therapy is fundamental in post-liver transplant patients to prevent and reduce the incidence of acute cellular rejection. Non-compliance to treatment leading to graft rejection is a well-recognized event.
- Trial name
- AIM (NCT01959308)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Venous Thromboembolism, Liver Transplantation
Risk Factors and a nOmogram of Venous thromboEmbolism in Patients After liveR Transplantation(ROVER Study)
Liver transplantation is currently an effective treatment for end-stage liver disease. The high incidence of thrombotic related complications in the early postoperative period after orthotopic liver transplantation(OLT) has been…
- Trial name
- NCT05209048
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Late Complication From Kidney Transplant, Complication of Transplanted Liver
Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients
The human papilloma virus (HPV) is known to be an important cause of cervical and anal cancers. Studies on patients who have received a solid organ transplant (such as a liver or kidney transplant) have suggested the risk of…
- Conditions
- Late Complication From Kidney Transplant, Complication of Transplanted Liver, Human Papillomavirus-Related Carcinoma
- Trial name
- NCT02624349
- Testing
- Quadravalent human papillomavirus vaccine
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Liver Disease, Liver Transplant
Pediatric Liver Database
The purpose of this study is to collect data to examine and characterize the clinical outcomes of pediatric patients diagnosed with any liver disease at Children's Hospital of Wisconsin.
- Trial name
- NCT00677625
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- Medical College of Wisconsin
Diabetes, Liver Transplant; Complications
Optimal A1c Control in Post Liver or Combined Liver and Kidney Transplant Recipients Who Have Diabetes Mellitus
Major cardiovascular events are greatest in liver transplant recipients with sustained post-transplantation diabetes1. However, the optimal A1c target after transplantation has not been studied.
- Conditions
- Diabetes, Liver Transplant; Complications, Kidney Transplant Failure
- Trial name
- NCT04216303
- Testing
- hemoglobin A1c
- Where
- United States
- Sponsor
- Methodist Health System
Hepatocellular Injury
Hypothermic Oxygenated Perfusion (HOPE) of Human Liver Grafts
The purpose of this study is, in a randomized trial, to test a newly developed machine perfusion technique of human liver allografts before transplantation.
- Trial name
- NCT01317342
- Testing
- Hypothermic oxygenated perfusion (HOPE)
- Where
- 2 sites in Switzerland
- Volunteers
- 179 people
- Sponsor
- University of Zurich
Rejection; Transplant, Liver
Transcriptomics as an Aid in the Histological Diagnosis of Acute Rejection After Liver Transplantation
The primary objective of this exploratory study is to identify genes associated with acute rejection in liver transplant patients.
- Trial name
- NCT06734013
- Testing
- Molecular diagnostic
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
End Stage Renal Disease, Chronic Hepatitis c
Single Patient Protocol for Donor HCV-positive to Recipient HCV-negative Kidney Transplant in a Patient at Risk for Loss of Dialysis Access
This is a single patient, single center study evaluating if administration of pan-genotypic DAA therapy on day 3 (+/- 2 days) post-kidney transplant prevents the transmission of hepatitis C virus infection from an HCV-positive…
- Trial name
- NCT04614142
- Testing
- Glecaprevir / Pibrentasvir Oral Tablet [Mavyret]
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Cancer Metastatic to the Liver, Hepatocellular Carcinoma
A Study to Assess PV-10 Chemoablation of Cancer of the Liver
This open-label study will evaluate the safety, tolerability, pharmacokinetics and effect on tumor growth following a single intralesional injection of PV-10 in subjects with either (a) hepatocellular carcinoma (HCC) that is not…
- Conditions
- Cancer Metastatic to the Liver, Hepatocellular Carcinoma, Metastatic Melanoma, Metastatic Ocular Melanoma
- Trial name
- NCT00986661
- Testing
- PV-10 (10% rose bengal disodium)
- Where
- 5 sites in United States
- Volunteers
- 78 people
- Sponsor
- Provectus Biopharmaceuticals, Inc.
Liver Transplant Rejection
Graft Rejection or Tolerance Affected by Serial Change of Anti-donor Lymphocyte Antibody After Liver Transplantation
Liver is an organ that is well-known for its immune tolerant capacity. However, there were still controversial issues about the impact of immunologic challenge after liver transplantation on the graft function.
- Trial name
- NCT01444079
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yonsei University
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