Clinical trials: Transplant; Complication, Rejection
Kidney Transplant, Renal Transplant Failure
Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients
The purpose of this study is to assess a new test to detect antibodies which may form following kidney transplant. These antibodies can be difficult to detect as they do not cause any symptoms but can lead to kidney damage.
- Conditions
- Kidney Transplant, Renal Transplant Failure, Kidney Transplant Rejection, Frailty
- Trial name
- HLA-AB (NCT06025240)
- Testing
- cf-DNA, Immunological Events following renal transplant in older age, Determining Predictive Models for Post-transplant HLA-specific Antibody Formation
- Where
- United Kingdom
- Volunteers
- 282 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Liver Transplant Rejection, Liver Transplant; Complications
Safety of DNP007 in Healthy Subjects
This clinical trial evaluated the safety, tolerability, pharmacokinetic properties, and immunogenicity of DNP007 when administered as a single dose.
- Conditions
- Liver Transplant Rejection, Liver Transplant; Complications, Steatohepatitis, Nonalcoholic
- Trial name
- NCT06400771
- Testing
- DNP007
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Kidney Transplant Failure and Rejection, Kidney Transplant; Complications
Cf-DNA Assay During Treatment of Acute Rejection
The objective of this study is to determine whether cell-free DNA (cf-DNA) measurement can be used as a biomarker for successful treatment of an acute rejection (AR) episode after kidney transplantation.
- Conditions
- Kidney Transplant Failure and Rejection, Kidney Transplant; Complications, Kidney Transplant Rejection, Transplant; Complication, Rejection
- Trial name
- NCT04019353
- Testing
- cf-DNA Collection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Kidney Diseases, Kidney Transplant; Complications
Immunological Safety and Effectiveness of the First Booster Dose of mRNA Vaccines Against COVID-19 in Kidney Transplant Recipients.
Prospective observational trial to assess immunological safety (anti-HLA antibodies, donor-derived cell-free DNA) and immunological effectiveness (anti-SARS-CoV-2 IgG) of the first booster dose of SARS-CoV-2 mRNA vaccines in…
- Conditions
- Kidney Diseases, Kidney Transplant; Complications, COVID-19, Vaccine Adverse Reaction
- Trial name
- NCT05483725
- Testing
- Booster dose of mRNA vaccine
- Where
- Czechia
- Volunteers
- 108 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Kidney Injury, Kidney Failure
Personalization of Immunosuppressive Treatment for Organ Transplant Recipients
Long-term graft failure rates continue to be unacceptably high despite the development of immunosuppressive drugs, underscoring the unmet need for robust prognostic biomarkers of allograft injury and failure.
- Conditions
- Kidney Injury, Kidney Failure, Kidney Failure, Chronic, Kidney Failure, Acute
- Trial name
- STAART (NCT05747053)
- Testing
- AlloSure, PAXGene
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- George Washington University
Kidney Transplant; Complications, Kidney Transplant Infection
Pediatric Kidney Transplantation, Ureteroneocystostomy Techniques
In this study the researchers want to retrospectively compare non-refluxing ureteroneocystostomy (UNC techniques to reflux UNC techniques in paediatric kidney recipients with regard to urinary tract infections and uteral…
- Conditions
- Kidney Transplant; Complications, Kidney Transplant Infection, Kidney Transplant Failure and Rejection
- Trial name
- TUIKIT (NCT05397821)
- Testing
- UNC technique
- Where
- Netherlands
- Volunteers
- 398 people
- Sponsor
- Radboud University Medical Center
Kidney Transplant; Complications, Kidney Transplant Rejection
Immunosuppression Reduction in Failed Allograft Guided by cfDNA
The optimal timing for immunosuppression tapering for patients with failed kidney transplant is not known. This pilot study would be to correlate rise in cf-DNA and increase in cPRA.
- Conditions
- Kidney Transplant; Complications, Kidney Transplant Rejection, Kidney Transplant Failure
- Trial name
- NCT04560582
- Testing
- Blood Draw
- Where
- United States
- Sponsor
- University of Minnesota
Liver Transplant; Complications, Transplant; Failure, Liver
Liver Transplantation After ex Vivo Liver Perfusion
Today, it is difficult to predict liver function after transplantation and therefore livers where poor function is assumed (marginal livers) become discarded.
- Conditions
- Liver Transplant; Complications, Transplant; Failure, Liver, Transplant Dysfunction, Transplant; Complication, Rejection
- Trial name
- EVOLVE (NCT05951231)
- Testing
- Liver transplantation
- Volunteers
- 22 people
- Sponsor
- Oslo University Hospital
Renal Transplant Rejection, Immune Repertoire
ALLoreactive T-Cell receptOr RePertoire in kidnEy tranSplantation
In this study, the investigators will establish a workflow to generate unique patterns of the donor-reactive T cell repertoire using mixed lymphocyte reactions to select alloreactive T cell clones prior to transplantation Tissue…
- Conditions
- Renal Transplant Rejection, Immune Repertoire, Transplant; Complication, Rejection, Alloreactivity
- Trial name
- ALL-T-COPIES (NCT03422224)
- Testing
- Mixed lymphocyte reaction
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Kidney Transplant; Complications, Kidney Transplant Failure and Rejection
Prospective Pilot Feasibility Study Comparing Envarsus Once-a-day to Tacrolimus Twice-a-day Immunosuppressive Regimen on Drug Bioavailability in Hispanic First Time Kidney Transplant Recipients
This investigator-initiated post-marketing study will evaluate the role of Hispanic ethnicity on drug dosing of Envarsus in first-time stable renal transplant recipients.
- Trial name
- NCT03438773
- Testing
- Envarsus, Tacrolimus
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- California Institute of Renal Research
Lung Transplant Rejection, Lung Transplant Failure
Diagnostic and Prognostic Biomarkers of Transplant Dysfunction in the Context of Lung Transplantation
Transplant results vary considerably from one organ to another. Lung transplantation has poorer long-term outcomes than other solid organ transplants, with a current median post-transplant survival of 6.0 years.
- Conditions
- Lung Transplant Rejection, Lung Transplant Failure, Lung Transplant; Complications, Lung Transplant Failure and Rejection
- Trial name
- DATACOL (NCT04837339)
- Testing
- Collection of biological samples
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Hopital Foch
Immunosuppression, Kidney Transplant Rejection
The New LC-MS/MS Method for Determination of Unbound Tacrolimus in Plasma
Tacrolimus (TAC) is characterized by a narrow therapeutic window, as well as high inter- and intra-individual variability in pharmacokinetics. Both under- and overexposure may lead to severe adverse effects.
- Conditions
- Immunosuppression, Kidney Transplant Rejection, Kidney Transplant; Complications, Liver Transplant Rejection
- Trial name
- FreeTAC (NCT04657562)
- Testing
- Tacrolimus, Unbound tacrolimus measurement, CYP3A4 and CYP3A5 genotyping
- Where
- Poland
- Volunteers
- 380 people
- Sponsor
- National Science Centre, Poland
Liver Transplant; Complications, Liver Transplant Rejection
Mortality, Morbidity and Risk Factors of Liver Retransplantation
This study aims to compare the short and long term outcomes of living donor and deceased donor liver retransplantation. Bearing that in mind, the investigators will retrospectively analyze the files of patients whom underwent a…
- Conditions
- Liver Transplant; Complications, Liver Transplant Rejection, Liver Transplant Failure, Liver Diseases
- Trial name
- NCT04789213
- Testing
- Liver Transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Memorial Bahçelievler Hospital
Intestinal Microbiota, Complication of Transplanted Liver
Human Microbiota and Liver Transplant
The microbiota represents the collections of microbial communities that colonize a host. In health, the microbiota protects against pathogens and maturation of the immune system.
- Conditions
- Intestinal Microbiota, Complication of Transplanted Liver, Acute Rejection of Liver Transplant, Infection
- Trial name
- NCT02223468
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Vall d'Hebron
Transplant; Complication, Rejection
Volatile Organic Compounds as Markers of Acute Rejection in Lung Transplant
The aim of research is to identify markers of acute rejection by VOC analysis in exhaled breath of bilateral-lung transplanted patients.
- Trial name
- VOC-TP (NCT03172091)
- Testing
- eNose (electronic nose), Spectrometry
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hopital Foch
Liver Transplant Rejection, Kidney Transplant; Complications
VOCs in Kidney and Liver Transplants
Kidney and liver trasplants represent very challenging lifesaving and effective surgical procedures for patients with end-stage kidney and/or liver disease.
- Trial name
- NCT04514666
- Testing
- Breath analysis
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Kidney Transplant; Complications, Immunosuppression
Efficacy of Single Dose Anti-thymocyte Globulin in the Modulation of T Lymphocytes in Kidney Transplantation
The use of polyclonal anti-T cell antibodies (ATG) has benefits in kidney transplantation, however, its use is associated mainly with hematological, infectious, and neoplastic complications.
- Trial name
- NCT04835948
- Testing
- single dose of Anti-thymocyte globulin
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Covid19, Kidney Transplant; Complications
Multicenter CTS Pre-and Post-Transplantation Covid-19 Serum Studies
The Covid-19 Serum Study is a prospective case-control study in 1. kidney or liver transplanted patients being hospitalized due to an infection with Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) after…
- Conditions
- Covid19, Kidney Transplant; Complications, Kidney Transplant Failure and Rejection, Liver Transplant; Complications
- Trial name
- NCT04694573
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Heidelberg University
Transplant; Complication, Rejection
Mechanistic Evaluation of Treatments for Acute Antibody-Mediated Rejection of the Kidney Transplant
The best treatment for kidney failure is a kidney transplant, but a transplanted kidney only works for about 10 to 15 years on average.
- Trial name
- MOT-AMR (NCT04496037)
- Testing
- Rituximab
- Volunteers
- 170 people
- Sponsor
- Imperial College London
Transplant; Intestine, Transplant; Complication, Rejection
The Endoscopic Assesment of Intestinal Grafts
The study validates prospectively a new endoscopic scoring system (Gothenburg Intestinal Transplant Endoscopy Score, GITES) designed to summarize and stratify the abnormal ileal endoscopic findings after intestinal…
- Conditions
- Transplant; Intestine, Transplant; Complication, Rejection, Transplant; Failure, Bowel, Enteritis
- Trial name
- INTEGRATE (NCT03444675)
- Where
- 4 sites in United States, Argentina and 2 more
- Volunteers
- 80 people
- Sponsor
- Sahlgrenska University Hospital