Clinical trials: Transplant; Failure, Heart
Heart Failure, Heart Failure, Systolic
Apple-CPET Ted Rogers Understanding Exacerbations of Heart Failure
Heart Failure (HF) is a complex disease associated with the highest burden of cost to the healthcare system. The cardiopulmonary exercise test (CPET) is instrumental in determining the prognosis of patients with HF.
- Conditions
- Heart Failure, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Transplantation
- Trial name
- TRUE-HF (NCT05008692)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Heart Failure
Assessment and Monitoring of Patients in Medium-term Heart Transplant Candidates Undergoing Low-intensity Exercise
Objectives: To study the behavior and cardiovascular safety protocol to the front low-intensity exercise in patients with heart failure (HF) severe, awaiting heart transplantation.
- Trial name
- NCT01160939
- Testing
- low intensity exercise
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- Federal University of São Paulo
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio
Heart Failure
ICMNC-HF. IntraCoronary Bone Marrow MonoNuclear Cells in Heart Failure (HF) Patients
This is a prospective, randomised double blind, controlled, parallel-group phase I and II study. Its aim is to assess that a single intracoronary infusion of autologous bone marrow-mononuclear cells is safe and effective in hear…
- Trial name
- ICMNC-HF (NCT03145402)
- Testing
- Intracoronary injection of stem cell
- Where
- Iran
- Volunteers
- 5 people
- Sponsor
- SCARM Institute, Tabriz, Iran
Coronary Artery Bypass Graft Surgery (CABG), Radial Artery Grafts
Effect of Oral Isosorbide Mononitrate Plus Amlodipine Antispasm Therapy on Outcomes of Radial Artery Grafts After CABG
The goal of this clinical trial is to to evaluate the effect of oral isosorbide mononitrate plus amlodipine antispasm therapy on outcomes of radial artery grafts in patients underwent primary isolated CABG.
- Conditions
- Coronary Artery Bypass Graft Surgery (CABG), Radial Artery Grafts, Graft Failure
- Trial name
- ASRAB (NCT06730945)
- Testing
- Oral isosorbide mononitrate 4+ amlodipine
- Where
- China
- Sponsor
- Ruijin Hospital
Heart Failure, Transplant; Failure, Heart
Assessing the Effects of Mechanical Unloading on Repair Version-1
The mechanism by which heart failure initiates and progresses and the mechanisms of heart repair remain unclear. The left ventricular assist device (LVAD) is a therapy to stabilise patients while they await their transplant.
- Trial name
- NCT06026215
- Volunteers
- 23 people
- Sponsor
- Manchester University NHS Foundation Trust
Advanced Heart Failure
Carmat Total Artificial Heart as a Bridge to Transplant in Patients With Advanced Heart Failure
The objective of this clinical investigation is to evaluate the efficacy and the safety of the Carmat Total Artificial Heart for the treatment of refractory advanced heart failure in transplant eligible patients.
- Trial name
- EFICAS (NCT04475393)
- Testing
- Carmat Total Artificial Heart, Standard therapy for heart failure
- Where
- 10 sites in France
- Volunteers
- 104 people
- Sponsor
- Carmat SAS
Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction
Chronic Exogenous Ketosis in HFpEF
The goal of this clinical research study is to test what effects a ketone drink will have in people with heart failure with preserved ejection fraction (HFpEF), including on exercise and heart function.
- Conditions
- Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction, Heart Failure, Diastolic
- Trial name
- NCT06937320
- Testing
- Exogenous Ketone Drink
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Congenital Heart Disease, Heart Failure
The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)
Advances in surgical and medical care have led to improved outcomes in patients with congenital heart disease (CHD). As a consequence, the majority of patients nowadays survives to adulthood (adults with CHD, that is, adult CHD…
- Conditions
- Congenital Heart Disease, Heart Failure, Transplant; Complication, Failure, Arrythmia
- Trial name
- ARTORIA-R (NCT04848844)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heart Failure
Study of Anginera in Adults With a Left Ventricular Assist Device (LVAD) as Bridge to Transplant
The purpose of this study is to obtain human heart tissue after treatment with Anginera to determine its effect on a variety of things that might indicate improvement in heart function.
- Trial name
- NCT00364598
- Testing
- Anginera, a human tissue replacement therapy
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Theregen, Inc.
COPD, Interstitial Pneumonia
Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results.
- Conditions
- COPD, Interstitial Pneumonia, Bronchiectasis, Respiratory Failure
- Trial name
- NCT06922916
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhejiang University
Heart Failure, Congestive, Ventricular Dysfunction
Thoratec HeartMate II Left Ventricular Assist System (LVAS) for Bridge to Cardiac Transplantation
The purpose of this study is to determine the safety and effectiveness of the Thoratec HeartMate II Left Ventricular Assist System (LVAS) as a bridge to cardiac transplantation in end-stage heart failure patients who are listed…
- Conditions
- Heart Failure, Congestive, Ventricular Dysfunction, Cardiomyopathies
- Trial name
- NCT00121472
- Testing
- Thoratec HeartMate II Left Ventricular Assist System (LVAS)
- Where
- 36 sites in United States, Canada
- Volunteers
- 194 people
- Sponsor
- Abbott Medical Devices
Congestive Heart Failure
The Epidemiology of Bleeding and Clotting in Patients Undergoing Heart Transplantation, Coronary Artery Bypass Graft Surgery,or Implantation of Left Ventricular Assist Devices
The purpose of this study is to obtain data or information on how blood clotting factors are activated during open heart surgery.
- Trial name
- NCT01481012
- Where
- 13 sites in United States
- Volunteers
- 94 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
End-stage Heart Failure
Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
In the DAPA-HF trial, the use of dapagliflozin, an inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduced significantly the risk of worsening heart failure or death from cardiovascular causes compared to placebo among…
- Trial name
- ARCADIA-HF (NCT04782245)
- Testing
- Dapagliflozin 10mg
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Heart Failure, Coronary Arterial Disease
Effect of Dapagliflozin on Right Ventricular-Pulmonary Artery Coupling After Off-Pump Coronary Atery Bypass Grafting
This prospective, single-center observational study evaluates the effect of dapagliflozin 10 mg/day on right ventricular-pulmonary artery coupling measured by the TAPSE/PASP ratio in 72 patients with left ventricular ejection…
- Trial name
- DAPA-RV-CABG (NCT07601867)
- Where
- Russia
- Volunteers
- 72 people
- Sponsor
- Pyatigorsk City Clinical Hospital Number 1
Vasculopathy, Heart Transplant Failure
The Role of CD34 + Stem Cells and Biomarkers in the Development of CAV in HTX Patients
Coronary allograft vasculopathy represents one of the major limiting factors of long-term survival in heart transplant recipients.
- Trial name
- NCT05485467
- Testing
- coronary CT angiography
- Where
- Slovenia
- Volunteers
- 55 people
- Sponsor
- University Medical Centre Ljubljana
Heart Failure
Evaluation of Myocardial Improvement in Patients Supported by Ventricular Assist Device Under Optimal Pharmacological Therapy
Cardiac function may improve in patients with end-stage heart failure who receive long-term support with ventricular assist devices (VAD).
- Trial name
- NCT00402376
- Testing
- Pravastatin, Carvedilol, Perindopril, Biventricular assist device (Thoratec paracorporeal assist device)
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Cardiovascular Diseases, Heart Failure
Randomized Study of Coronary Revascularization Surgery With Injection of WJ-MSCs and Placement of an Epicardial Extracellular Matrix
Ischemic heart disease is one of the most important causes of mortality and morbidity in the Western world and is a public health problem.
- Conditions
- Cardiovascular Diseases, Heart Failure, Coronary Artery Disease, Mesenchymal Stem Cell Transplantation
- Trial name
- scorem-cells (NCT04011059)
- Testing
- Wharton's jelly-derived mesenchymal cells
- Where
- Colombia
- Volunteers
- 40 people
- Sponsor
- Hospital San Vicente Fundación
Cardiomyopathies, Amyloidosis Cardiac
Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation
The study aims to identify new diagnostic and prognostic markers for CMP that can help predict disease progression. In particular, the study will focus on microRNAs (miRNAs) and spatial transcriptomics, which are emerging…
- Conditions
- Cardiomyopathies, Amyloidosis Cardiac, Fabry Disease, Arrhythmogenic Cardiomyopathy
- Trial name
- CMPMIRNA (NCT06813443)
- Where
- 3 sites in Italy
- Volunteers
- 700 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Heart Failure
Cardiovascular Prehabilitation in Patients Awaiting Heart Transplantation (PREHAB HTx Study)
This study evaluates the addition of high-intensity interval training to the standard pre-heart transplantation clinical care. Participants will be randomised into 2 arms: one arm will receive high-intensity interval training…
- Trial name
- PREHAB (NCT02957955)
- Testing
- High-Intensity Interval Training
- Where
- 2 sites in Canada
- Volunteers
- 6 people
- Sponsor
- Ottawa Heart Institute Research Corporation