Clinical trials: Transplant; Failure, Kidney
Secondary Hyperparathyroidism, Tertiary Hyperparathyroidism
Intraoperative Parathyroid Hormone Monitoring to Guide Surgery in Renal hyperparathyroIdism
The goal of this pilot clinical is to determine the feasibility of a fully powered clinical trial to determine the effectiveness of intraoperative parathyroid hormone (IOPTH) criteria in guiding surgery for secondary and tertiary…
- Trial name
- PEREGRINE (NCT06542315)
- Testing
- Intraoperative parathyroid hormone (IOPTH) monitoring
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
End Stage Renal Disease
Rituximab Desensitization Therapy for Patients on the Waiting List for Kidney Transplant
This is a study of patients who have a high risk of kidney rejection before kidney transplant. The hypothesis is that treatment with a medication called rituximab will make it possible for them to receive a kidney transplant from…
- Trial name
- NCT00167791
- Testing
- rituximab
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
ESRD
Fabry Disease Screening in ESRD Patients in West of France
Screening of Fabry disease in end-stage renal disease (ESRD) patients on dialysis or transplant in west of France.
- Trial name
- SNOUFY (NCT02719249)
- Testing
- Dried blood spot test
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Rennes University Hospital
Heart Transplant Failure
Pilot Study: Interest of Belatacept as a Non-nephrotoxic Immunosuppressive Treatment in Cardiac Transplant Patients at Risk of Chronic Renal Failure (BELACOEUR)
Heart transplantation (TC) is the standard treatment for terminal heart failure. Chronic kidney disease (CKD) is a common complication responsible for increased mortality and morbidity.
- Trial name
- BELACOEUR (NCT04180085)
- Testing
- Belatacept Injection
- Where
- 4 sites in France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Multiple Myeloma, Renal Failure
High Dose Therapy Followed by Autologous Transplantation for Myeloma Patients With Severe Renal Impairment
Multiple myeloma (MM) is a malignant plasma cell disorder, characterized by the presence of more than 10 % of clonal plasma cells in the bone marrow.
- Trial name
- IRMYG (NCT03234335)
- Testing
- Data collection
- Where
- 33 sites in Algeria, Belgium and 2 more
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
End-Stage Renal Disease, Kidney Transplantation
A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant
The purpose of this study is to compare treatment with the new drug sirolimus (SRL) versus the standard treatment with cyclosporine (CsA) or tacrolimus in children who have received kidney transplants.
- Trial name
- NCT00005113
- Testing
- Cyclosporine, Sirolimus, Tacrolimus
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Boston Children's Hospital
Delayed Graft Function
Graft Acute Kidney Injury: Vitamin B3 to Facilitate Renal Recovery In the Early Life of a Transplant
Delayed graft function occurs in more than 20% of kidney transplantations. It is an episode of post-ischemic acute kidney injury with long-term consequences on the allograft's function.
- Trial name
- GABRIEL (NCT05513807)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Transplant Failure
SURGICAL EXPERIENCE ON RENAL TRANSPLANT COMPLICATIONS
Kidney transplantation (KT) failure could be due to surgery dependent factors and particularly surgeon's experience. Objective: To assess the impact of the surgeon's experience on the post-operative outcomes to know if it safe…
- Trial name
- IMPACT (NCT05200949)
- Testing
- Kidney transplant
- Where
- France
- Volunteers
- 303 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Vascular Calcification, Chronic Kidney Failure
Sclerostin and Vascular Calcification in CKD and Renal Transplant
the aim of the research is to determine the degree of vascular calcification in chronic kidney disease and post-transplant and whether there is a correlation with the level of serum sclerostin.
- Trial name
- NCT04066855
- Volunteers
- 36 people
- Sponsor
- Ahmed Faisal Mohamed Mohamed Saleh
Heart Transplantation, Acute Renal Failure
Metabolic Pattern of Cyclosporine A and Acute Renal Failure
Following heart transplantation many patients develop acute renal failure in the early posttransplant phase and some are in need of renal replacement therapy for shorter or longer time.
- Trial name
- NCT00264355
- Testing
- cyclosporine A
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University of Oslo School of Pharmacy
Kidney Transplant Rejection, End Stage Renal Disease
Safety & Tolerability Study of Chimeric Antigen Receptor T-Reg Cell Therapy in Living Donor Renal Transplant Recipients
The purpose of this study is to evaluate the safety and tolerability of TX200-TR101 and its effects on the donated kidney in living donor kidney transplant recipients.
- Trial name
- STEADFAST (NCT04817774)
- Testing
- TX200-TR101
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Volunteers
- 26 people
- Sponsor
- Sangamo Therapeutics
End Stage Renal Disease (ESRD)
A Safety Study of Tocilizumab to Improve Transplant Rates in Highly Sensitized Patients Awaiting Kidney Transplantation
In this Phase I/II trial, 10 highly sensitized patients will be entered after informed consent and will receive Intravenous Immunoglobulin (IVIG) at 2 gm/kg + Tocilizumab 8 mg/kg x 5 doses on days 15, 45, 75, 105, 119, 135, and…
- Trial name
- NCT01594424
- Testing
- Tocilizumab, Intravenous Immunoglobulin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cedars-Sinai Medical Center
Kidney Failure
Hepatitis C Virus (HCV) Positive Kidney Grafts in HCV Negative Recipients
To determine the efficacy and safety of transplanting HCV positive kidney allografts to HCV sero-negative patients who are on the waiting list.
- Trial name
- NCT04605679
- Testing
- Kidney Transplantation
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Loma Linda University
Renal Failure, Obesity
Use of the INAMED LAPBAND System to Reduce BMI's in Obese Renal Failure Patients
The purpose of this study is to assess the use of this Lap-Band system for the purpose of promoting weight loss in renal failure patients who do not qualify as transplant candidates because of excessive BMI's
- Trial name
- NCT00466882
- Testing
- Inamed Lap-Band System
- Where
- United States
- Sponsor
- Summa Health System
Cardiovascular Diseases, Kidney Transplant; Complications
Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation
Cardiovascular disease (for example, heart attack, stroke, heart failure) is the commonest complication of kidney failure. Kidney transplantation reduces cardiovascular risk but cardiovascular disease remains the commonest cause…
- Trial name
- CRAFT-CTCA (NCT06234410)
- Testing
- Computed tomography coronary angiography (CTCA)
- Where
- 2 sites in United Kingdom
- Volunteers
- 332 people
- Sponsor
- University of Edinburgh
Sepsis and Septic Shock, Acute Respiratory Failure
Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure
Kidney transplantation is the treatment of choice for end-stage chronic kidney disease. Kidney transplantation is at the first rank of solid organ transplantation in France, with 3,376 grafts performed in 2022.
- Conditions
- Sepsis and Septic Shock, Acute Respiratory Failure, Kidney Transplant Recipients, Immunosuppressive Agents
- Trial name
- REDIS (NCT06881927)
- Testing
- Hydrocortisone Hemisuccinate: 200 mg per day., reduction of the level of immunosuppression
- Where
- France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Renal Failure
MSC and Kidney Transplant Tolerance (Phase A)
The general aim of the present study is to test a cell therapy with third-party ex-vivo expanded bone marrow-derived mesenchymal stromal cells (MSCs) as a strategy to induce tolerance in kidney transplant recipients with a…
- Trial name
- NCT02565459
- Testing
- Mesenchymal Stromal Cells
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Monia Lorini
Renal Failure Chronic Requiring Hemodialysis
Hemodialysis Reliable Outflow (HeRO) Vascular Access Patency Study
Compare the HeRO Vascular Access Device to a conventional ePTFE graft.
- Trial name
- NCT00890045
- Testing
- HeRO Vascular Access Device, Conventional ePTFE hemodialysis graft
- Where
- 11 sites in United States
- Volunteers
- 72 people
- Sponsor
- Merit Medical Systems, Inc.
Acute Kidney Injury
Acute Kidney Injury After Cardiac Surgery Based on KDIGO Criteria
The aim of this study was to apply the acute kidney injury criteria based on KDIGO classification in a population of patients undergoing cardiac surgery [coronary artery bypass grafting (CABG) or cardiac valve surgery (CVS)] and…
- Trial name
- NCT00777465
- Where
- Brazil
- Volunteers
- 2,804 people
- Sponsor
- Hospital de Base
Cirrhosis, Food Preferences
Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation
This study evaluates the influence of the taste sensitivity, of food preferences and of the reward system on the energetic balance before and after liver transplantation in cirrhotic patients and after kidney transplantation in…
- Conditions
- Cirrhosis, Food Preferences, Taste Disorders, Protein-Energy Malnutrition
- Trial name
- GREFFE (NCT02931812)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Burgundy