Clinical trials: Transplant Donation
Brain Death, Organ Donation
Goal of Open Lung Ventilation in Donors
The primary goal of this study is to assess whether ventilation of deceased organ donors with an open lung protective ventilatory strategy will improve donor lung utilization rates and donor oxygenation compared to a conventional…
- Conditions
- Brain Death, Organ Donation, Organ Transplant Failure or Rejection
- Trial name
- GOLD (NCT03439995)
- Testing
- Open lung protective ventilation, Conventional ventilation
- Where
- 4 sites in United States
- Volunteers
- 154 people
- Sponsor
- Vanderbilt University Medical Center
Living Donor Liver Transplantation
The Correlation Between CT and MRCP Before Living Liver Donation for Liver Blood Vessel Assessment: an Ambidirectional Cohort Study
Living donor liver transplantation (LDLT) is a good solution to the donor liver shortage in the Netherlands. In cases of severe liver disease, LDLT has substantial survival benefits, fewer (future) complications, and an improved…
- Trial name
- BVLDLT (NCT06875232)
- Testing
- Living liver donors
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Erasmus Medical Center
Liver Transplant Infection
Evaluation of Procalcitonin (PCT) as a Marker of Infection Post Living Donated Liver Transplant
, the study aimed at assessing the frequency of rising procalcitonin associated with infectious complications in immunosuppressed LDLTRx.
- Trial name
- NCT03389360
- Testing
- procalcitonin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
End Stage Kidney Disease
Evaluation of a Website on Living Kidney Donation for Hispanics
The purpose of this study is to increase understanding about living kidney donation (LKD) among Hispanic/Latino patients and public by increasing knowledge and positive attitudes about LKD.
- Trial name
- NCT01859871
- Testing
- Website Intervention
- Where
- 2 sites in United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Liver Transplantation
Post-Static Cold Storage Hypothermic Oxygenated Perfusion in Bergamo Liver Transplant Program
In light of the widespread organ shortage, dynamic preservation by means of Machine Perfusion (MP) has been proposed as a strategy to increase the pool of suitable grafts for liver transplantation.
- Trial name
- NCT03098043
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Papa Giovanni XXIII Hospital
End Stage Renal Disease, Transplantation
Live Kidney Donor Study - Cross-Sectional and Historical Cohort Study
Kidney transplantation from living donors has been shown to carry many benefits over deceased donor transplantation. Because of benefits such as shorter waiting times and improved outcome for transplant recipients, living kidney…
- Trial name
- NCT00951977
- Where
- 3 sites in United States
- Volunteers
- 7,029 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Transplantation, Rituximab (RTx)
Impact of Rituximab (RTx) Induction and Living Donation on Immunoregulation and Virus Control in Renal Transplantation
This project comprises immunological and virological analyses within a prospective clinical study of Rituximab (Rtx)-treated blood group incompatible living donor (LD) renal transplant recipients compared to blood group…
- Conditions
- Kidney Transplantation, Rituximab (RTx), Living Donors, Immunology
- Trial name
- NCT01136395
- Testing
- Rituximab, living donor transplantation, deceased donor transplantation
- Where
- Germany
- Volunteers
- 85 people
- Sponsor
- University of Giessen
Renal Failure, Renal Transplantation
A Reduced 11-b-HSD Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?
Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation according to official guidelines.
- Conditions
- Renal Failure, Renal Transplantation, Living Donors
- Trial name
- NCT01009229
- Testing
- Low and high salt diets
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Kidney Disease, End-Stage Renal Disease
Increasing Kidney Transplant Among Blacks on the Transplant Waiting List
For most patients with kidney failure, living donor kidney transplant (LDKT) is their best treatment option. Unfortunately, Blacks (vs. non-Blacks) are more likely to have kidney failure but less likely to receive LDKTs.
- Trial name
- NCT02319447
- Testing
- Additional education
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- St. Barnabas Medical Center
End Stage Renal Disease, End Stage Liver Disease
Dissemination of the Donor Application: Utilizing Social Media to Identify Potential Live Organ Donors
This study utilizes a web-based application to help patients on the organ transplant waitlist communicate patient's need for a living donor via social media and provide interested potential donors the opportunity to engage with…
- Trial name
- NCT03803423
- Testing
- The Donor App
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
End Stage Renal Disease
Explore Transplant @Home Within Kaiser Permanente Southern California
Today, there are 25 million Americans with chronic kidney disease (CKD) and 660,000 patients in full kidney failure, the final CKD stage, known as end stage renal disease (ESRD).
- Trial name
- NCT03389932
- Testing
- Patient-Guided
- Where
- United States
- Volunteers
- 977 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Kidney Transplantation
Live Donors for Kidney Transplants
On a yearly basis there are approximately 12,000 kidney transplants in the United States. Presently there are approximately 40,000 patients awaiting a transplant with only 5,000 available donors.
- Trial name
- NCT00001856
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Manual Manipulation and Ex Vivo Flexible Ureteroscopic Lithotripsy to Salvage Deceased Donor Kidneys With Renal Stones:a New Method by
Manual Manipulation and Ex Vivo Flexible Ureteroscopic Lithotripsy to Salvage Deceased Donor Kidneys With Renal Stones: A Case Series
we report the manual manipulation and Ex Vivo Flexible Ureteroscopic Lithotripsy to Salvage Deceased Donor Kidneys with Renal Stones,including nine cases,Renal transplantation was performed with the treated kidney after removing…
- Trial name
- NCT06510101
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Yingxin FU.MD
Liver Transplantation, Kidney Transplantation
Enhancing Donated After Cardiac Death (DCD) Utilization With Thrombolytic Therapy
We hypothesize that delayed graft function and ITBS events may be related to small blood clots (microthrombi) that collect in the kidneys and liver after cardiac death.
- Trial name
- NCT01197573
- Testing
- rTPA Treatment, No TPA Treatment
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- The Cleveland Clinic
Living Donor Nephrectomy
Kidney Donor Outcomes Cohort (KDOC) Study
Live donor kidney transplantation (LDKT) is important because its outcomes for recipients are superior to those of deceased donor transplantation, and it yields significant cost savings to the healthcare system overall.
- Trial name
- KDOC (NCT01427452)
- Where
- 7 sites in United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Kidney Transplant; Complications, Kidney Failure
Normothermic Machine Perfusion (NMP) Versus Static Cold Storage (SCS) in Human Kidney Transplantation
Due to organ shortage in kidney transplantation (KT) several strategies have been implemented in an attempt to increase donor pool utilization, including transplantation of extended criteria donor (ECD) allografts.
- Conditions
- Kidney Transplant; Complications, Kidney Failure, Graft Dysfunction
- Trial name
- NMP-DBD (NCT05031052)
- Testing
- End-ischemic normothermic oxygenated machine perfusion, Static cold storage
- Where
- 4 sites in Germany
- Volunteers
- 194 people
- Sponsor
- Charite University, Berlin, Germany
Gastro-Intestinal Disorder
Healthy Stool Volunteer Donors for Fecal Microbiota Transplantation Trials
Currently, ANSM recommendations govern FMT (Fecal Microbiota Transplantation) in clinical trials. The collection and validation of these stool donations as part of the trials is complex and not very efficient.
- Trial name
- VIOLONSEL (NCT06478823)
- Testing
- Stools donation
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplant; Complications, Surgical Injury
Magnetic Spiderman for Preparation of Liver Donation
Due to many vascular branches on the supra-hepatic vena cava (SHVC) and infra-hepatic vena cava (IHVC), in the whole procedures of preparation of liver donation, preparation of hepatic vena cava (HVC) is the most key and…
- Trial name
- MSPLD (NCT04182256)
- Testing
- MS
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Brain Death, Renal Failure
Understanding Family Refusal
The investigators plan a secondary data analysis of an existing dataset to examine how individual decision-making differs from family decision-making in organ donation.
- Trial name
- NCT04303624
- Testing
- Health sciences survey
- Volunteers
- 1,007 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Delayed Function of Renal Transplant
A Study on SANGUINATE™ for the Reduction of Delayed Graft Function in Kidney Transplant Patients
Safety and efficacy study of SANGUINATE on reduction of delayed graft function (DGF) in patients who will be recipients of a donation after brain death (DBD) donor kidney.
- Trial name
- NCT02658162
- Testing
- SANGUINATE, Normal Saline
- Sponsor
- Prolong Pharmaceuticals