Clinical trials: Transplant Donation
Liver Transplant
A Study to Assess the Role of Fenofibrate in Preventing Ischemic Cholangiopathy After Liver Transplantation
The purpose of this study is to evaluate the safety and effectiveness of a once-daily medication, fenofibrate (Lofibra), to prevent ischemic cholangiography (IC) in persons who were transplanted with livers donated after…
- Trial name
- FICsDCD (NCT05514119)
- Testing
- Fenofibrate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Organ Donation, Liver Transplantation
EPI-STORM: Cytokine Storm in Organ Donors
Kidney and liver transplantation are the treatment of choice and are often the last therapeutic option offered to patients with chronic renal and liver failure.
- Conditions
- Organ Donation, Liver Transplantation, Kidney Transplantation, Graft Dysfunction
- Trial name
- EPI-STORM (NCT03786991)
- Testing
- No intervention
- Where
- 4 sites in Canada
- Volunteers
- 105 people
- Sponsor
- Université de Sherbrooke
Kidney Transplantation, Nephrectomy,Kidney Donation
A Qualitative Study on Gratitude and Recognition Toward Living Kidney Donors
Kidney transplantation is widely recognized as the best treatment for patients with end-stage renal disease. However, its development is limited by the persistent shortage of available organs.
- Trial name
- GRACE (NCT07254546)
- Testing
- Semi-structured qualitative interview
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Donation, Kidney Failure
Live Kidney Donor Study -Renal Function Study
Kidney transplantation from living donors has been shown to carry many benefits over deceased donor transplantation. Because of benefits such as shorter waiting times and improved outcome for transplant recipients, living kidney…
- Conditions
- Kidney Donation, Kidney Failure, Kidney Transplantation
- Trial name
- NCT01158742
- Testing
- Glomerular Filtration Rate with Iothalamate, Glomerular Filtration Rate with Iohexol
- Where
- 3 sites in United States
- Volunteers
- 402 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Organ Transplantation From Brain-dead Donors
Cooling to Optimize Organ Life in Donor Study
The purpose of this study is to assess the feasibility and safety of mild-to-moderate hypothermia as an in-vivo organ preservation strategy compared to normothermia in 60 brain-dead organ donors.
- Trial name
- COOLDonor (NCT01544530)
- Testing
- Cold isotonic fluid and central venous hypothermia catheter
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Pittsburgh
Lung Transplantation
Transplanting Lungs From Uncontrolled Donation After Circulatory Death
The study team developed an uncontrolled donation after circulatory death (uDCD) protocol that preserves lungs for just over 3 hours after death using positive end expiratory pressure (PEEP) and supplemental oxygen.
- Trial name
- NCT06327945
- Testing
- Lung uDCD Protocol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NYU Langone Health
Kidney Transplantation, Renal Transplantation
Attenuating Ischemia Reperfusion Injury After Living Donor Renal Transplantation
Patients undergoing living donor renal transplant will be asked to participate to determine whether pre-operative dosing of immunosuppressive medication, and the donor organ receiving an additional dose of antibody induction…
- Conditions
- Kidney Transplantation, Renal Transplantation, Reperfusion Injury
- Trial name
- NCT01149993
- Testing
- Myfortic (mycophenolic acid), Thymoglobulin (anti-thymocyte globulin)
- Sponsor
- Georgetown University
Organ Donation After Circulatory Death, Organ Donation
Improving Deceased Organ Donation and Transplantation Using the Donation Advisor Clinical Decision Support Tool
Every year, thousands of Canadians receive life-saving, cost-effective organ transplants, while thousands more still wait or die because not enough organs are available.
- Conditions
- Organ Donation After Circulatory Death, Organ Donation, Clinical Decision Support Tool
- Trial name
- DART (NCT07903428)
- Testing
- Donation Advisor clinical decision-support tool
- Volunteers
- 10 people
- Sponsor
- OBS Medical Ltd
Organ Transplant Failure or Rejection, Brain Death
Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY)
The investigators hypothesize that preconditioning neurologically deceased organ donors with the calcineurin inhibitor tacrolimus will improve short and long-term transplant survival without causing harm.
- Conditions
- Organ Transplant Failure or Rejection, Brain Death, Ischemic Reperfusion Injury
- Trial name
- CINERGY (NCT05148715)
- Testing
- Tacrolimus
- Where
- 9 sites in Canada
- Volunteers
- 414 people
- Sponsor
- Université de Sherbrooke
Uremia
Effect of SVF Derived MSC in DCD Renal Transplantation
The objective of this trial is to determine if autologous Stromal Vascular Fraction (SVF) derived Mesenchymal Stem Cell (MSC) infusion during and after kidney transplantation from Donation after Citizen Death (DCD) can…
- Trial name
- NCT02492490
- Testing
- SVFderived MSC transplantations, Basiliximab
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fuzhou General Hospital
Kidney Failure, Hypertension
Cardiovascular-Renal Consequences of Reducing Renal Mass After Living Kidney Donation
A reduce in renal mass may result in remnant single nephron hyperfiltration, with associated proteinuria and an accelerated loss of kidney function.
- Conditions
- Kidney Failure, Hypertension, Albuminuria, Renal Failure
- Trial name
- NCT01564966
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Istanbul University
Hepatocellular Injury
Hypothermic Oxygenated Perfusion (HOPE) of Human Liver Grafts
The purpose of this study is, in a randomized trial, to test a newly developed machine perfusion technique of human liver allografts before transplantation.
- Trial name
- NCT01317342
- Testing
- Hypothermic oxygenated perfusion (HOPE)
- Where
- 2 sites in Switzerland
- Volunteers
- 179 people
- Sponsor
- University of Zurich