Clinical trials: Transplant Dysfunction
Irritable Bowel Syndrome
Donor Versus Autologous Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Many patients with irritable bowel syndrome (IBS) do not experience adequate symptom relief with current treatments. The pathophysiology of IBS is diverse, controversial and not completely understood.
- Trial name
- NCT04691544
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Norway
- Volunteers
- 450 people
- Sponsor
- University Hospital of North Norway
Sexual Dysfunction
A Multimodal Intervention to Address Sexual Dysfunction in Hematopoietic Stem Cell Transplant Survivors
This research study is evaluating the feasibility and impact of an intervention to improve sexual function in stem cell transplant survivors on participants' sexual function, quality of life, and mood.
- Trial name
- NCT02492100
- Testing
- Multi-modality sexual dysfunction intervention
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Massachusetts General Hospital
Thrombocytopathy
Platelet Function in Minimal Extracorporeal Circulation in CABG
Rationale: Cardiac surgery with extracorporeal circulation (ECC) triggers platelets. Minimal extracorporeal circulation system (minimal-ECC) has several advantages compared with conventional ECC amongst less platelet activation.
- Trial name
- ECCTEG (NCT01935245)
- Testing
- Mini extracorporeal circulation, Conventional extracorporeal circulation
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC
This is a data collection study that will examine the general diagnostic and treatment data associated with the reduced-intensity chemotherapy-based regimen paired with simple alemtuzumab dosing strata designed to prevented graft…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- PRO-RIC (NCT04528355)
- Testing
- data collection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Paul Szabolcs
Anaemia, Renal Transplantation
Correction of Anaemia and Progression of Renal Failure on Transplanted Patients
The purpose of this study is to evaluate, on renal transplanted patients with CGD, the effect of two levels of haemoglobin on quality of life at 6 months and the speed of progression of renal function degradation at 24 months.
- Conditions
- Anaemia, Renal Transplantation, Kidney Failure
- Trial name
- NCT00396435
- Testing
- Neorecormon
- Where
- 20 sites in France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Peripheral Vascular Disease
Lower Extremity Regional Anesthesia and Infrainguinal Bypass Grafting
In this investigation, the investigators will attempt to demonstrate that patients who have received nerve blocks (regional anesthesia) prior to open surgical vascular bypass of the lower extremities (infrainguinal bypass…
- Trial name
- NCT01803165
- Testing
- Single shot femoral and sciatic nerve block
- Sponsor
- University of Nebraska
Diastolic Dysfunction, Coronary Artery Disease
Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index
The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.
- Conditions
- Diastolic Dysfunction, Coronary Artery Disease, General Anesthesia
- Trial name
- NCT00907439
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Sinusoidal Obstruction Syndrome, Veno-occlusive Disease
Defibrotide Dose-escalation for SOS Post-HSCT
This research study is being done to determine the safety and tolerability of increasing doses of defibrotide within a single patient with sinusoidal obstructive syndrome (SOS)/veno-occlusive disease (VOD) after hematopoietic…
- Trial name
- NCT05987124
- Testing
- Defibrotide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York Medical College
HSCT, Pediatric Cancer
Neurocognitive Deficit After Paediatric Transplantation: Understanding the Role of Environment and Physical Function
Hematopoietic stem cell transplantation (HSCT) is a potentially life-saving treatment for children with relapsed or resistant leukemia and other life-threatening hematological and hereditary disorders.
- Conditions
- HSCT, Pediatric Cancer, Pediatric Patients, Late Effect
- Trial name
- NATURE (NCT07408713)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cognitive Impairment, Hematologic Neoplasms
Cognitive Training Intervention and Attitudes Towards Genetics
A pilot study to evaluate feasibility of enrollment of patients in an intervention to improve neurocognitive function in hematopoietic cell transplantation (HCT) survivors using the cognitive training Lumosity program.
- Conditions
- Cognitive Impairment, Hematologic Neoplasms, Hematopoietic Cell Transplant
- Trial name
- cTAG (NCT03094026)
- Testing
- Lumosity, Lumosity (waitlist control)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Allografts, Rejection; Transplant, Kidney
A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant
The purpose of this study is to evaluate the efficacy, safety and tolerability of dual costimulation blockade with VIB4920 in combination of belatacept in adult male or female recipients of a renal allograft from a deceased…
- Conditions
- Allografts, Rejection; Transplant, Kidney, Transplant Rejection, Kidney Transplantation
- Trial name
- NCT04046549
- Testing
- Belatacept, VIB4920, Thymoglobulin
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Amgen
Primary Graft Dysfunction, Lung Transplant; Complications
Perioperative Vitamin C Lung Transplant
This study is being done to determine if parenterally administered ascorbic acid (Vitamin C) given at the time of lung transplant is safe. Vitamin C may be an effective intervention towards primary graft dysfunction (PGD).
- Trial name
- NCT04505878
- Testing
- Vitamin C
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cognitive Dysfunctions
Neurological Complications - Pulmonary Transplant
A monocentric prospective open study to evaluate the frequency and nature of cognitive complications in the 3rd month post pulmonary transplant.
- Trial name
- NCT01818193
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hopital Foch
Disorder Related to Lung Transplantation, Brain Death
Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation
The recent introduction of ex-vivo lung perfusion (EVLP) as a tool to evaluate and recondition lungs from marginal donors has opened a new era in the field of lung transplantation.
- Conditions
- Disorder Related to Lung Transplantation, Brain Death, Graft Failure, Primary Graft Dysfunction
- Trial name
- EVLP_MI (NCT01967953)
- Testing
- EVLP Group
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- Policlinico Hospital
Dry Eye, Ocular Graft vs Host Disease
Brimonidine Eye Drops for Treatment of Ocular Graft-vs-Host Disease (oGVHD)
The objective of this study is to establish whether patients with dry eye disease (DED) are able to tolerate receiving Brimonidine: 0.15% eye drops two times a day for twelve weeks (primary tolerability objective) and to…
- Conditions
- Dry Eye, Ocular Graft vs Host Disease, Meibomian Gland Dysfunction
- Trial name
- NCT02975557
- Testing
- Brimonidine 0.15%, Brimonidine 0.075%
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Sandeep Jain, MD
Semilunar Heart Valve Replacement
Partial Heart Transplantation for Severe Pediatric Semilunar Valve Dysfunction
The long-term goal of this research initiative is to develop a new valve replacement option for neonates, infants and young children.
- Trial name
- NCT05372757
- Testing
- Partial Heart Transplantation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Cardiovascular Disease, Mitral Valve Repair
Carbon Dioxide Insufflation on Cerebral Microemboli
The purpose of this study is to determine if blowing carbon dioxide into the surgical field during open-heart surgery to displace retained chest cavity air from the atmosphere will decrease the number of microembolic being…
- Conditions
- Cardiovascular Disease, Mitral Valve Repair, Cerebral Microemboli, Cognitive Decline
- Trial name
- NCT00715845
- Testing
- Carbon dioxide insufflation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Kidney Transplantation, Graft Rejection
A Study on a New Staining Method (C4d Staining) of Transplanted Kidney Biopsies
Patients who had received kidney transplantation may suffer from rejection. Recently, positive staining for C4d in kidney biopsies of malfunctioning transplant kidney is increasingly recognized as an important prognostic…
- Trial name
- NCT00498095
- Testing
- Renal biopsy
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Hospital Authority, Hong Kong
Liver Cirrhosis
A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis
A feasibility trial called PROFIT has previously shown that FMT administered endoscopically into the jejunum in patients with cirrhosis is safe and feasible and have identified some potential mechanisms of action that warrant…
- Trial name
- PROMISE (NCT06461208)
- Testing
- Encapsulated FMT
- Where
- 23 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- King's College London
Renal Transplant Recipients
Sexual Function in Male Renal Transplant Patients
Sexual dysfunction is common in male patients with chronic renal failure on dialysis and after renal trasnplantation. Multiple factors play a role in this important clinical problem.
- Trial name
- NCT00271830
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Montefiore Medical Center