Clinical trials: Transplant Failure
Heart Failure, Heart Transplantation
Pericoronary Adipocyte Size Gradient
Evaluation of pericoronary adipocyte gradient (PCAT) in relationship with local atherosclerotic changes in a patient undergoing heart transplantation.
- Trial name
- AdipoCor (NCT07360925)
- Testing
- Heart transplantation for the final stage of heart failure
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Institute for Clinical and Experimental Medicine
End Stage Liver DIsease, Obesity
Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients
This study is being conducted to assess the safety of Direct Peritoneal Resuscitation (DPR) in high-risk liver transplant patients.
- Conditions
- End Stage Liver DIsease, Obesity, Acute Kidney Injury
- Trial name
- NCT05195125
- Testing
- Direct Peritoneal Resuscitation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Chronic Myeloproliferative Disorders, Leukemia
Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer
RATIONALE: Collecting and storing samples of tissue, blood, and body fluid from patients with cancer to study in the laboratory may help the study of cancer in the future.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT01137643
- Testing
- biologic sample preservation procedure, cytology specimen collection procedure
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Vascular Calcification, Chronic Kidney Failure
Sclerostin and Vascular Calcification in CKD and Renal Transplant
the aim of the research is to determine the degree of vascular calcification in chronic kidney disease and post-transplant and whether there is a correlation with the level of serum sclerostin.
- Trial name
- NCT04066855
- Volunteers
- 36 people
- Sponsor
- Ahmed Faisal Mohamed Mohamed Saleh
Hepatic Encephalopathy
Fecal Microbiota Transplantation (FMT) in the Management of Hepatic Encephalopathy (HE): a Pilot Study
The purpose of this study is to determine if FMT can reverse Hepatic Encephlopathy (HE) in cirrhotic patients who continue to have breakthrough episodes of HE despite maintenance therapy with lactulose and/or rifaximin or…
- Trial name
- NCT02255617
- Testing
- Fecal Microbiota Transplant
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta
Premature Ovarian Failure
Pregnancy After Stem Cell Transplantation in Premature Ovarian Failure
Out of 112 high risk patients for Premature Ovarian Failure (POF), diagnosis was established in 10 cases. ESS cut off point for menstruation and pregnancy was 6.
- Trial name
- POF (NCT02151890)
- Testing
- Stem Cell
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Al-Azhar University
Premature Ovarian Failure，
Stem Cell Therapy Combined Hormone Replacement Therapy in Patients With Premature Ovarian Failure
Premature ovarian failure (POF) refers the occurrence of amenorrhoea, elevated serum gonadotrophins and hypoestrogenism levels in female before the age of 40.
- Trial name
- NCT01742533
- Testing
- human umbilical cord mesenchymal stem cells, hUCMSCs and hCBMNCs, human cord blood mononuclear cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shenzhen Beike Bio-Technology Co., Ltd.
ESRD (End-Stage Renal Disease), Kidney Transplantation
Study to Evaluate the Safety and Efficacy of the GGTA1 KO Thymokidney in Patients With ESRD
The purpose of this study is to evaluate the safety and efficacy of the GGTA1 KO Thymokidney in patients with end-stage renal disease (ESRD) who are either not eligible for conventional allogeneic kidney transplantation (Group 1)…
- Conditions
- ESRD (End-Stage Renal Disease), Kidney Transplantation, Xenotransplantation
- Trial name
- EXTEND (NCT07224763)
- Testing
- GGTA1 KO Thymokidney
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- United Therapeutics
Heart Failure
Spinal Cord Stimulation in Hypotensive Heart Failure Patients: Hemodynamic Assessment
This is a prospective single-center study that aims to evaluate the effects of non-invasive transcutaneous spinal cord stimulation on systemic and pulmonary hemodynamics, assessed during right heart catheterization in patients…
- Trial name
- NCT05288387
- Testing
- Spinal cord stimulation
- Where
- Russia
- Volunteers
- 6 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Percutaneous Coronary Intervention, Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery
Cardiac Rehabilitation Peer Mentorship
The current study is a randomized controlled trial, being conducted at two hospitals in Toronto, Ontario, Canada, involving the randomization of cardiac inpatients into an intervention group, in which they will receive mentorship…
- Conditions
- Percutaneous Coronary Intervention, Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery, Acute Coronary Syndrome, Chronic Stable Heart Failure
- Trial name
- NCT02204449
- Testing
- Cardiac Rehabilitation Peer Mentorship
- Where
- 2 sites in Canada
- Volunteers
- 94 people
- Sponsor
- University Health Network, Toronto
Heart Failure
HCV Positive Heart Donors
Study subjects active on the waiting list for a heart transplant at the NYU Langone Transplant Institute who are hepatitis C (HCV) negative will receive a heart transplant from a donor who tests positive for HCV.
- Trial name
- NCT03382847
- Testing
- Transplant with HCV positive donor, followed by surveillance and treatment of viremia
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- NYU Langone Health
Ovarian Failure, Ovarian Insufficiency
Ovarian Tissue Allo-transplantation
Premature ovarian failure, also known as primary ovarian insufficiency (POI), or premature menopause, affects 1-2% of women under 40.
- Conditions
- Ovarian Failure, Ovarian Insufficiency, Menopause Ovarian Failure, Menopause, Premature
- Trial name
- NCT06673004
- Testing
- Ovarian tissue allo-transplantation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Kidney Transplant; Complications, Kidney Failure
Normothermic Machine Perfusion (NMP) Versus Static Cold Storage (SCS) in Human Kidney Transplantation
Due to organ shortage in kidney transplantation (KT) several strategies have been implemented in an attempt to increase donor pool utilization, including transplantation of extended criteria donor (ECD) allografts.
- Conditions
- Kidney Transplant; Complications, Kidney Failure, Graft Dysfunction
- Trial name
- NMP-DBD (NCT05031052)
- Testing
- End-ischemic normothermic oxygenated machine perfusion, Static cold storage
- Where
- 4 sites in Germany
- Volunteers
- 194 people
- Sponsor
- Charite University, Berlin, Germany
Liver Failure, Renal Failure
Assessment of Renal Function in Cirrhotic Patients
The purpose of this study is to help determine whether cystatin C is a more sensitive laboratory measurement for renal function in cirrhotic patients.
- Trial name
- NCT01895114
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Baylor Research Institute
PAD - Peripheral Arterial Disease, AAA - Abdominal Aortic Aneurysm
Retrospective Post-Market Clinical Follow-Up Study of GORE-TEX® Vascular Grafts and GORE® PROPATEN® Vascular Graft in Peripheral Artery Disease, Aortic Aneurysms, and Dialysis Access
This multicenter, single-arm retrospective registry (chart review) is being conducted to confirm the clinical performance and safety of GORE-TEX® Vascular Grafts and GORE® PROPATEN® Vascular Graft throughout the device functional…
- Conditions
- PAD - Peripheral Arterial Disease, AAA - Abdominal Aortic Aneurysm, End-Stage Renal Disease
- Trial name
- NCT05124184
- Testing
- GORE® PROPATEN® Vascular Graft, GORE-TEX® Vascular Grafts
- Where
- 8 sites in France, Italy and 1 more
- Volunteers
- 356 people
- Sponsor
- W.L.Gore & Associates
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Graft Failure, Poor Graft Function
CD34+ Selected Stem Cell for Poor Graft Function or Graft Failure
The proposed trial is a single arm, non-randomized, single center pilot study utilizing CliniMACS CD34 Reagent System for patients following allogeneic hematopoietic stem cell transplant (HSCT) requiring treatment of graft…
- Trial name
- NCT06569082
- Testing
- CD34+ Selected Donor Cell Boost, Blood Stem Cell Infusion
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- NYU Langone Health
Leukemia, Lymphoma
Dexamethasone, Intravenous Injection of Human Immunoglobulin, and Increased Infusion of Mononuclear Cells to Reduce Donor Specific Antibodies in Haploidentical Hematopoietic Stem Cell Transplantation
This study tests whether a combination of three treatments - dexamethasone (a steroid), intravenous immunoglobulin (IVIG, a protein that helps the immune system), and an extra dose of donor mononuclear cells - can safely lower…
- Conditions
- Leukemia, Lymphoma, Thalassemia, Aplastic Anemia
- Trial name
- NCT07698080
- Testing
- Intravenous Immunoglobulin, Dexamethasone, Mononuclear Cells
- Volunteers
- 60 people
- Sponsor
- Hematology department of the 920th hospital
Kidney Transplant Failure and Rejection, Kidney Transplant; Complications
ECP-DL Cell Infusion for Induction in Living Donor Kidney (LDK) Transplants
This is a phase 1 trial, 36 month duration for subjects with end-stage renal disease (ESRD). The objectives of the trail are1) Determine the safety of ECP-DL cell infusion in living donor renal transplant recipients.
- Trial name
- ECP (NCT07083830)
- Testing
- ECP-DL treated mononuclear cell infusion
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Advanced Heart Failure, Heart Transplantation
Registry of Patients Referred for Heart Transplantation
Main goal of the study is the risk stratification of patients with advanced heart failure referred for orthotopic heart transplantation (OHT) according to HFSS score, other risk factors and biological markers and verification of…
- Trial name
- POLKARD HF (NCT00690157)
- Where
- 5 sites in Poland
- Volunteers
- 999 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
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