Clinical trials: Transplant Failure
Renal Transplant Failure
" SAVE Study (Switch AdVagraf® to Envarsus®) for Fast Metabolizers Kidney Transplant Recipients"
The use of calcineurin inhibitors (CNIs) in kidney transplantation is the gold standard treatment to prevent episodes of rejection. Nevertheless, CNIs have side effects and are in particular nephrotoxic for the kidney transplant.
- Trial name
- SAVE (NCT04945785)
- Testing
- No intervention
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Nantes University Hospital
Fanconi Anemia
TBI Dose De-escalation for Fanconi Anemia
This is a single arm, total body irradiation (TBI) trial. All patients will be prescribed TBI 300 cGy with the goal of evaluating secondary endpoints.
- Trial name
- NCT00352976
- Testing
- Cyclophosphamide, Fludarabine, Total Body Irradiation
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Coronary Artery Disease, Postoperative Pain
Pectointercostal Fascial Plane Block (PIFB) Alone Versus PIFB With Rectus Sheath Block (RSB) in Cardiac Surgery
The purpose of this study is to determine if ultrasound-guided bilateral pectointercostal fascial plane blocks with bilateral rectus sheath blocks block decrease pain scores, decrease opioid consumption, improve respiratory…
- Conditions
- Coronary Artery Disease, Postoperative Pain, Respiratory Failure
- Trial name
- NCT04908449
- Testing
- Rectus sheath block with bupivacaine
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical College of Wisconsin
Burns, Skin Graft (Allograft)(Autograft) Failure
Prospective Randomized International Study on the Reactivation of Burn Injuries
This clinical trial will be a multi-centric prospective, randomized controlled study with the commercial objective of evaluating the clinical efficacy of a battery-powered portable device that uses blue LEDs.
- Trial name
- SPRINT (NCT04951934)
- Testing
- EmoLED, Standard treatment
- Where
- 6 sites in Austria, Italy
- Sponsor
- Emoled
Transplant; Complication, Failure
Evaluation at 5 and 10 Years of Renal Transplant Patients
5 and 10 years follow-up of the oxyop study.
- Trial name
- OXYOP 5 and 10 (NCT05469906)
- Where
- France
- Volunteers
- 116 people
- Sponsor
- University Hospital, Brest
Liver Failure, Liver Transplantation
Autoregulation Assessment During Liver Transplantation
Patients with liver failure undergoing liver transplantation often have clinical or sub-clinical encephalopathy that may lead to increased intracranial pressure.
- Conditions
- Liver Failure, Liver Transplantation, Encephalopathy
- Trial name
- NCT01425385
- Testing
- Near infrared spectroscopy monitoring, Autoregulation monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
ESRD, Hemodialysis
Use of a Lifeline Graft in the A-V Shunt Model
This study will assess the safety and efficacy of a completely autologous and completely biological tissue engineered blood vessel (TEBV) called Lifeline™ used as an arteriovenous fistula for dialysis access.
- Trial name
- NCT00850252
- Testing
- Lifeline
- Where
- 2 sites in Argentina, Poland
- Sponsor
- Cytograft Tissue Engineering
End Stage Kidney Disease, Kidney Transplantion
The Response of the Immune System of Patients With End Stage Kidney Disease on Dialysis and Kidney Transplant Recipients Vaccinated for COVID-19
Observational study of patients with End Stage Kidney Disease on dialysis and Kidney Transplant Recipients, before and after vaccination for SARS-COV 2, after written consent, with the aim of laboratory efficacy of the vaccine…
- Conditions
- End Stage Kidney Disease, Kidney Transplantion, Covid19, Vaccination
- Trial name
- NCT04932876
- Testing
- SARS - COV 2 VACCINE
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Ioannina
Renal Failure
Expanded Access Study for Renal Transplant Patients With Envarsus XR ™
Open label, multi-center, expanded access study for renal transplant patients with once daily Envarsus XR (Tacrolimus).
- Trial name
- NCT02411604
- Testing
- Tacrolimus
- Sponsor
- Veloxis Pharmaceuticals
Chronic Renal Failure, Polycystic Kidney Disease
Mesenchymal Stem Cells Transplantation in Patients With Chronic Renal Failure Due to Polycystic Kidney Disease
This study was designed to provide confirmation of safety of mesenchymal stem cells (MSCs) therapy in chronic renal failure due to autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT02166489
- Testing
- Intravenous injection autologous mesenchymal stem cells
- Where
- Iran
- Volunteers
- 6 people
- Sponsor
- Royan Institute
Heart Failure, Myocardial Infarction
Combined CABG and Stem-Cell Transplantation for Heart Failure
This is a prospective double blind trial of intraoperative transmyocardial bone marrow-derived mesenchymal cell transplantation vs placebo in patients with low left ventricular ejection fraction scheduled to coronary bypass…
- Conditions
- Heart Failure, Myocardial Infarction, Coronary Artery Disease
- Trial name
- NCT00418418
- Testing
- Coronary bypass operation, Bone marrow aspiration (crista iliaca), Intramyocardial mesenchymal stem cell transplantation
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- University of Helsinki
Advanced Heart Failure, Acquired Heart Disease
TORCH-LATAM-004: Regional Advanced-Therapy Pathways for Adults With Acquired or Structural Heart Disease
TORCH-LATAM-004 is a pragmatic stepped-wedge cluster randomized trial evaluating a regional pathway for adults with advanced heart failure secondary to acquired or structural heart disease who may require heart or combined…
- Conditions
- Advanced Heart Failure, Acquired Heart Disease, Structural Heart Disease, Heart Transplantation
- Trial name
- TORCH-004 (NCT07826078)
- Testing
- TORCH Adult Advanced Therapies Pathway (TORCH-AATP)
- Volunteers
- 360 people
- Sponsor
- CardioVision International Tech, S.A.S. de C.V.
Acute Transplant Rejection in Patients Receiving Allogeneic Renal Transplant
Generic Mycophenolate Mofetil Safety Study for Prophylaxis in de Novo Renal Transplant Patients in Jordan
The purpose of this observational study was to assess the safety and efficacy of generic mycophenolate mofetil in de novo renal transplant patients in Jordan where no visits or intervention(s) additional to the daily practice…
- Trial name
- MyOra-PASS (NCT03517982)
- Testing
- Mycophenolate Mofetil
- Where
- Jordan
- Volunteers
- 12 people
- Sponsor
- Hikma Pharmaceuticals LLC
Graft Failure, Dialysis
Factors for Impairment of Renal Graft Function in Intensive Care
hypothesis = hospitalization in the intensive care unit (ICU) has an impact on the outcome of the renal graft, due to the therapeutic and exploratory procedures performed.
- Conditions
- Graft Failure, Dialysis, Chronic Kidney Failure
- Trial name
- RENAGRAF (NCT06191146)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Neoplasms, Kidney Failure
Post-transplant Cancer Incidence and Survival in Patients With or Without Pre-transplant Cancer
Patients with previous malignancies have increasingly been accepted for renal transplantation. However, post-transplant malignancy risk and survival rates of these patients are unknown.
- Trial name
- NCT02491580
- Where
- Sweden
- Volunteers
- 2,370 people
- Sponsor
- Uppsala University
Renal Failure
Randomized Fistula Study
The primary objective of this study is to compare two treatment strategies for establishing dialysis access in patients with unsuitable forearm veins for the standard forearm primary radio-cephalic arteriovenous fistula also…
- Trial name
- NCT00808561
- Testing
- Group 1: Alternative Fistula, Group 2: Forearm AV Graft
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Renal Transplant Failure
PDE5i Use in Renal Transplant Recipients
Ischemia-reperfusion (IRI) injuries are common in renal transplantation and cause poor patient outcomes. Ischemia occurs after the donor's death and reperfusion occurs after kidney implantation.
- Trial name
- NCT04122105
- Testing
- Sildenafil
- Where
- Canada
- Sponsor
- University of British Columbia
Hemodialysis Access Failure
Prospective, Multicenter, Non-randomized, Single Arm Clinical Trial to Evaluate the Safety and Efficacy of e-PTFE Grafts Inner Surface-treated With Paclitaxel as an Access for Hemodialysis in Patients With End-stage Renal Disease.
This prospective, multicenter, non-randomized, single-arm Clinical trial aims to evaluate the safety and effectiveness of the use of paclitaxel-coated arteriovenous graft (AVG) on the inner wall of ePTFE graft, which is designed…
- Trial name
- NCT04285073
- Testing
- Paclitaxel-eluting graft
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Samsung Medical Center
Liver Cirrhosis, Hemophilia
Alterations in Coagulation Factor Levels in Patients With End Stage Liver Disease
The goal of this observational study is to learn about the changes in coagulation factor VIII and IX levels in patients undergoing liver transplantation to help guide future management of coagulation factor replacement in…
- Conditions
- Liver Cirrhosis, Hemophilia, Hemophilia A, Hemophilia B
- Trial name
- NCT06014320
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Renal Transplant Failure
Major Cations Targeted Fluid Therapy In Renal Transplantation.
English Summary And Abstract The overall anesthetic goal for the newly transplanted kidney is to maintain intravascular volume and avoid decreased perfusion by maintaining main arterial blood pressure (MAP).
- Trial name
- NCT03846869
- Testing
- major cations
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
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