Clinical trials: Transplant Kidney
COVID-19
Homologous vs Heterologous Third Vaccination in Kidney Transplant Recipients Kidney Transplant Recipients
Randomized-controlled trial comparing homologous (mRNA vaccine) vs. heterologous (vector vaccine) for third SARS-CoV-2 vaccine dose in kidney transplant recipients not responding to initial prime-boost vaccination with an mRNA…
- Trial name
- BOOST_TX (NCT05324319)
- Testing
- Ad26COVS1, ChAdOx1 SARS2 Vaccine, BNT162B2
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Cancer of Kidney
Identification of Risk Factors Associated With Neoplastic Complications After Renal Transplantation in Nord-Pas de Calais , Normandy and Picardy Regions
Kidney transplantation is now the treatment of choice for end-stage renal disease (ESRD). Between 2800 and 3000 kidney transplants are performed each year in France and more than 33 000 patients are living with a functioning…
- Trial name
- FRISC (NCT02121730)
- Where
- 4 sites in France
- Volunteers
- 2,500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Kidney Injury, Hyperglycemia
Impact of Glycemic Control After Reperfusion on Acute Kidney Injury in Living Donor Liver Transplantation
This retrospective cohort study of patients classified by the blood glucose level after reperfusion in liver transplantation repicient.
- Conditions
- Acute Kidney Injury, Hyperglycemia, Hypoglycemia, End Stage Liver Disease
- Trial name
- NCT06320730
- Testing
- Observational study, records of blood glucose level after reperfusion
- Where
- South Korea
- Volunteers
- 3,790 people
- Sponsor
- Asan Medical Center
Chronic Kidney Disease, End-stage Renal Disease
A Randomized Trial to Reduce the Disparity in Live Donor Kidney Transplantation
The main purpose of this study is to learn which educational method is most helpful to patients and their family members when they consider whether to pursue live donor kidney transplantation.
- Trial name
- NCT00785265
- Testing
- Group-Based (GB) Intervention, Home-Based (HB) Intervention
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Beth Israel Deaconess Medical Center
Liver Transplantation, Postoperative Renal Complication
Postoperative Complications After Liver Transplantation
Incidence and risk factors for renal, cardiovascular and pulmonary complications after liver transplantation are not well defined.
- Conditions
- Liver Transplantation, Postoperative Renal Complication, Postoperative Pulmonary Complication, Postoperative Cardiovascular Complication
- Trial name
- NCT02761109
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Graft Rejection
A Pilot Study to Evaluate the Use of C1 Esterase Inhibitor (Human) in Patients With Acute Antibody-Mediated Rejection
The purpose of this research study is to evaluate the safety, effect, and pharmacology of C1 Esterase Inhibitor (human) in kidney transplant patients with acute Antibody-Mediated Rejection (AMR).
- Trial name
- NCT01147302
- Testing
- C1 Esterase Inhibitor (Human)
- Where
- 5 sites in United States, Germany
- Volunteers
- 18 people
- Sponsor
- Shire
Kidney Disease, Kidney Transplant
Strategies to Transform Kidney Care and Improve Pursuit of Transplant
Approximately 15% of the U.S. population has chronic kidney disease, and ~700,000 patients are in full kidney failure also called end-stage kidney disease (ESKD).
- Conditions
- Kidney Disease, Kidney Transplant, Deceased Donor Kidney Transplant, Living Donor Kidney Transplantation
- Trial name
- NCT07794631
- Testing
- Digital Health Integration, Training for Early Transplant Access and Support, Kidney Health Mobile Health (mHealth) Application
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
End Stage Renal Disease
CellCept/Iron Study: The Iron Ion-Mycophenolate Mofetil Chelation Complex Interaction in Renal Allograft Recipients
The objective of this study is to determine the extent and magnitude of the pharmacokinetic drug interaction between mycophenolate mofetil (MFF) (under Css conditions) in the presence of iron in renal transplant recipients.
- Trial name
- NCT00227045
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Kidney Transplant Failure and Rejection
Anti-Angiotensin II Type 1 Receptor Antibodies and Kidney Transplant Outcomes
Incompatibility between non-genetically identical donors and recipients has been increasingly recognized as the main contributing factor to solid allograft rejection and failure, through the triggering of donor-specific responses…
- Trial name
- NCT03466775
- Testing
- Anti-angiotensin II type 1 receptor antibody measurement, Measurement of ENDAT expression level allograft, Allograft survival
- Where
- 2 sites in France
- Volunteers
- 1,845 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Kidney Transplant; Complications, Metabolic Acidosis
Bicarbonate Administration in Kidney Transplant Recipients
Metabolic acidosis is associated with vascular endothelial dysfunction and is a common complication in patients who have received a kidney transplant.
- Trial name
- NCT03428464
- Testing
- Sodium Bicarbonate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Kidney Transplantation
Efficacy of Belatacept in Reducing DSA
The primary objective of this study is to demonstrate that administration of belatacept in maintenance kidney transplant recipients may cause a reduction in Donor Specific HLA Antibody (DSA).
- Trial name
- NCT02078193
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Cancer
Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection
RATIONALE: Heparin or M-EDTA may prevent catheter-related infections and blockages in patients at high risk for a catheter-related infection.
- Trial name
- NCT00378781
- Testing
- Heparin, Minocycline-EDTA
- Sponsor
- M.D. Anderson Cancer Center
Kidney Cancer
Allogeneic Stem Cell Transplant in Treating Patients With Metastatic Kidney Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplant may allow the doctor to give higher doses of…
- Trial name
- NCT00056095
- Testing
- therapeutic allogeneic lymphocytes, cyclophosphamide, cyclosporine
- Where
- 26 sites in France
- Volunteers
- 57 people
- Sponsor
- UNICANCER
Transplanted Kidney
The Effects of Synbiotic on Cardiovascular and Bone Metabolism Markers in Transplanted Kidney Patients
The aim of this double-blind randomized clinical trial is to determine the effects of synbiotic supplement on cardiovascular disease risk factors and bone metabolism markers and depression, in transplanted kidney patients on…
- Trial name
- NCT06160830
- Testing
- synbiotic
- Volunteers
- 44 people
- Sponsor
- National Nutrition and Food Technology Institute
Surgical Site Reaction
The Use of the Prevena Incision Management System (PIMS) on Closed Incisions in Renal Transplant Subjects
This study is being conducted to see how safe and effective the Prevena Incision Management System "Prevena" is when placed over a renal transplantation incision. Prevena provides negative pressure (suction) wound therapy.
- Trial name
- PIMS (NCT01341444)
- Testing
- Prevena Incision Management System, Standard of Care for Surgical Incisions
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- KCI USA, Inc
End Stage Renal Disease
Evaluation of the GORE® ACUSEAL Vascular Graft for Hemodialysis Access
This study is a prospective, non-randomized, multi-center evaluation of the performance of the GORE® ACUSEAL Vascular Graft. The study will enroll patients with End-Stage Renal Disease (ESRD), who are either currently receiving…
- Trial name
- ACUSEAL (NCT01173718)
- Testing
- GORE® ACUSEAL Vascular Graft
- Volunteers
- 138 people
- Sponsor
- W.L.Gore & Associates
Narcotic Use, Renal Transplant Donor of Left Kidney
Postoperative Pain Protocol Limiting Narcotics for Laparoscopic Hand-assisted Donor Nephrectomy
Kidney donors represent healthy patients and their anticipated postoperative course should be uncomplicated and brief. This study looks to optimize the perioperative pain regimen of laparoscopic donor nephrectomy patients by…
- Trial name
- NCT06458842
- Testing
- Ketamine
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Vascular Access Complication, Apheresis Related Complication
Vascular Access Complications for Therapeutic Apheresis in Nephrology
The aim of this study is to describe vascular access complications which are used for therapeutic apheresis in Nephrology.
- Trial name
- VACTANE (NCT05894317)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
End Stage Renal Disease
Evaluation of STARgraft-2 for Hemodialysis Access
This study is a single site, prospective, single arm evaluation of the safety and effectiveness of the Healionics STARgraft-2 hemodialysis access graft.
- Trial name
- NCT04783779
- Testing
- Implant of STARgraft-2 shunt in the upper arm and subsequent use for hemodialysis access
- Where
- Paraguay
- Volunteers
- 24 people
- Sponsor
- Healionics Corporation
KIDNEY TRANSPLANTATION
OPTImization of the Dose of tacroliMUS by Bayesian Prediction
The pharmacokinetics of tacrolimus (TAC) are characterized by high inter- and intra-individual variability with narrow therapeutic range.
- Trial name
- OPTIMUS (NCT03465410)
- Testing
- Standard dosage of Tacrolimus, Bayesian Prediction Tacrolimus dosage
- Where
- 2 sites in Spain
- Volunteers
- 96 people
- Sponsor
- NURIA LLOBERAS BLANCH