Clinical trials: Transplantation, Cornea
Corneal Transplantation
Safety and Efficacy of Corneal Preservation Solution for Corneal Transplantation
The goal of this clinical trial is to learn if a corneal preservation solution can safely and effectively preserve donor corneas for corneal transplantation in patients who need penetrating keratoplasty (PKP) or endothelial…
- Trial name
- NCT07874568
- Testing
- penetrating keratoplasty
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong Branden Med.Device Co.,Ltd
Corneal Dystrophies, Hereditary
Descemet Stripping (Automated) Endothelial Keratoplasty (DSEK or DSAEK)
To evaluate the transplantation of a posterior corneal disc for the management of corneal endothelial disorders in Descemet Stripping Endothelial Keratoplasty (DSEK) or Descemet Stripping Automated Endothelial Keratoplasty…
- Trial name
- DSAEK (NCT00543660)
- Testing
- Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Netherlands Institute for Innovative Ocular Surgery
Corneal Ulcers, Corneal Melting
Safety Study of a Sutureless Amniotic Membran Transplantation to Treat Ocular Surface Disorders (Expanded Access)
The investigators aimed at developing a technique to apply amniotic membrane to a diseased ocular surface without surgical intervention (sutureless amniotic membrane transplantation).
- Trial name
- AmnioClip (NCT02168790)
- Testing
- Amniotic membrane ring
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Klinikum Chemnitz gGmbH
Fuchs' Endothelial Corneal Dystrophy
Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology
Background Fuchs' Endothelial Dystrophy Fuchs' Endothelial Dystrophy (Fuchs' ED) is characterized by changes on the inside of the cornea, which leads to a substantial decline in visual acuity.
- Trial name
- NCT01979250
- Testing
- DSAEK surgery
- Where
- Denmark
- Volunteers
- 81 people
- Sponsor
- Aarhus University Hospital
Fuchs' Corneal Endothelial Dystrophy
Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)
This project compares the Neusidl Corneal Injector (NCI) device developed by Fischer Surgical, Inc. for the delivery of tissue into the eye in DSAEK surgery to the current standard forceps insertion DSAEK technique.
- Trial name
- NCT01357122
- Testing
- NCI Insertion, Standard Forceps Insertion
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Legacy Health System
Cataract, Corneal Graft
DMEK And Cataract Surgery: Comparison Of Sequential Versus Combined Procedure
The aim of this study is to describe the outcomes of phaco-DMEK (Descemet Membrane Endothelial Keratoplasty ) according to a sequential versus a combined procedure
- Trial name
- CISIPHE (NCT03355924)
- Volunteers
- 31 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Porcine Corneal Xenograph
Xenogenic Keratoplasty From Porcine Cornea
Acellular porcine cornea is a valid substitution for human cornea because of its similar biological structure, corneal superficial curvature and good histocompatibility toward human.
- Trial name
- XKFPC (NCT01443559)
- Testing
- Xenogenic cornea, homogenic cornea
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xiamen University
Unilateral Limbal Stem Cell Insufficiency
The Application of Cultured Cornea Stem Cells in Patients Suffering From Corneal Stem Cell Insufficiency
Name of the project：The application of cornea stem cells cultured on amniotic membrane in patients suffering from corneal stem cell insufficiency Purpose: To develop the technique of using ex vivo expansion of autologous limbal…
- Trial name
- NCT01377311
- Testing
- Transplant of cultured limbal stem cells on cornea
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Corneal Transplant Failure
ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty
The main objective of this study is to determine the safety of Ex Vivo Cross Linking (CXL) of donor corneal tissue in participants who have undergone high-risk penetrating keratoplasty.
- Trial name
- ExCrossV (NCT06753916)
- Testing
- Corneal Donor Tissue with Cross Linking, Corneal Donor Tissue without Cross Linking
- Where
- 12 sites in United States
- Volunteers
- 96 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Keratoconus
Donors Predisposed by Corneal Collagen Cross-linking in Deep Lamellar Keratoplasty for the Patients With Keratoconus
The Study was designed as a randomized controlled study with the following objectives: To investigate whether use of donors predisposed by corneal collagen cross-linking (CXL) reduced myopic refractive errors for keratoconic eyes…
- Trial name
- NCT05905978
- Testing
- Corneal donors predisposed by CXL, Corneal donors stored in corneal storage media
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Keratoconus
Treatment of Keratoconus With PALK Versus PK
The purpose of this study is to evaluate the visual results of patients with keratoconus treated with one of two techniques: penetrating keratoplasty (PK) vs. pachymetry and Excimer laser assisted lamellar keratoplasty (PALK).
- Trial name
- NCT02625467
- Testing
- Penetrating keratoplasty, Pachymetry and Excimer laser assisted lamellar keratoplasty, Treatment posterior to surgery
- Volunteers
- 28 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Meibomian Gland Dysfunction, Cataract
Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures
The development of optical coherence tomography (OCT) and its application for in vivo imaging has opened entirely new opportunities in ophthalmology.
- Conditions
- Meibomian Gland Dysfunction, Cataract, Glaucoma, Corneal Transplantation
- Trial name
- NCT03461978
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Corneal Endothelial Dystrophy, Corneal Edema
Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection
The purpose of this study is to assess off-label use of loteprednol etabonate 0.25% ophthalmic suspension (Eysuvis) for prevention of immunologic rejection in the first year after Descemet membrane endothelial keratoplasty…
- Trial name
- NCT05136443
- Testing
- loteprednol etabonate 0.25% ophthalmic suspension
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Price Vision Group
Limbal Stem-cell Deficiency
Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency
The study purpose is to evaluate the efficacy and safety of cultivated oral mucosal epithelial sheet transplantation as a novel therapy for limbal stem cell deficiency, for which no effective approaches has thus far been…
- Trial name
- NCT02415218
- Testing
- Mucosal cell sheet transplantation
- Where
- Thailand
- Volunteers
- 6 people
- Sponsor
- Siriraj Hospital
Keratoconus
Femtosecond Laser-Assisted Keratoplasty
The purpose of this study will be to determine optimal surgical technique for performing FLAK including laser parameters, keratoplasty shape and suture technique in order to standardize surgical technique and to collect safety…
- Trial name
- FLAK (NCT01695811)
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Corneal Transplantation
Pretreatment to Promote Graft Survival After Subsequent High-risk Corneal Transplantation [CrossCornealVision]
The trial evaluates the effect of corneal crosslinking as pre-treatment before corneal transplantation. The goal is to improve graft survival by reducing pathological vessels through pre-treatment.
- Trial name
- NCT05870566
- Testing
- Corneal Crosslinking
- Where
- 7 sites in Germany
- Volunteers
- 110 people
- Sponsor
- Claus Cursiefen
Keratitis
Efficacy of Mutilayered Fresh Amnoitic Membrane Transplantation in Resistant Fungal Keratitis
Corneal infection or infectious keratitis (IK) is the most common cause of corneal blindness worldwide, particu-larly in the developing countries1. The incidence was estimated at 2.5-799 per 100,000 population/year.
- Trial name
- NCT06070883
- Testing
- Amniotic membrane transplantation
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Al-Azhar University
Corneal Neovascularization
Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery
The primary purpose of this trial is to evaluate the safety and tolerability of ranibizumab given via subconjunctival injection in patients undergoing corneal transplantation.
- Trial name
- NCT00769145
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Miami
Corneal Edema, Corneal Defect
Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant Surgery
Assessing the efficacy and safety of DEXTENZA, sustained release dexamethasone 0.4 mg insert following corneal transplant surgery (PKP, DSEK, DMEK) as compared to topical prednisolone acetate 1%.
- Conditions
- Corneal Edema, Corneal Defect, Corneal Transplant, Penetrating KeratoPlasty
- Trial name
- NCT04521140
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Nicole Fram M.D.
Corneal Disease, Fuch's Dystrophy
Cornea Donor Study
The Cornea Donor Study (CDS) was designed as a prospective cohort study with the following objectives: To determine whether the graft-failure rate over a 5-year follow-up period following corneal transplantation is the same when…
- Conditions
- Corneal Disease, Fuch's Dystrophy, Pseudophakic Corneal Edema
- Trial name
- CDS (NCT00006411)
- Testing
- corneas assigned by donor age group
- Where
- United States
- Volunteers
- 1,090 people
- Sponsor
- National Eye Institute (NEI)