Clinical trials: Transplantation, Kidney
Renal Transplantation
Belatacept Early Steroid Withdrawal Trial
The study purpose is to determine the safety and efficacy of a belatacept-based immunosuppressive regimen (calcineurin inhibitor free) with alemtuzumab or rabbit antithymocyte globulin (rATG) induction and early glucocorticoid…
- Trial name
- NCT01729494
- Testing
- Alemtuzumab, rabbit antithymocyte globulin, Belatacept
- Where
- 8 sites in United States
- Volunteers
- 316 people
- Sponsor
- University of Cincinnati
Invasive Fungal Infections, Lung Transplantation
Isavuconazole Therapeutic Drug Monitoring in Transplant Recipients
Isavuconazole is an antifungal medicine used to prevent or treat serious fungal infections in people who have received a solid organ transplant (mainly lung, and also kidney or liver) or a hematopoietic stem cell (bone marrow)…
- Conditions
- Invasive Fungal Infections, Lung Transplantation, Hematopoietic Stem Cell Transplantation (HSCT), Kidney Transplantation
- Trial name
- TRIM-1 (NCT07716878)
- Testing
- Isavuconazole
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhibin Xu
Kidney Transplantation, Antibody-mediated Rejection
CD38 mAb Induction + Azathioprine Maintenance for Chronic Active AMR in Kidney Transplant Recipients
This multicenter, prospective, single-arm exploratory study evaluates the efficacy and safety of a novel sequential regimen for chronic active antibody-mediated rejection (caABMR) in kidney transplant recipients: single-dose CD38…
- Trial name
- CAZA (NCT07718308)
- Testing
- CD38, Azathioprine (AZA), Standard Triple Immunosuppression Maintenance
- Volunteers
- 20 people
- Sponsor
- wujianyong
ABO Blood Type Incompatible Kidney Transplantation
Safety and Efficacy of the Bispecific T-Cell Engager (BiTE) as Conditioning Regimen for ABO-incompatible Living Donor Kidney Transplantation
The goal of this clinical trial was to determine whether the Bites drugs (Blinatumomab and Teclistamab) can reduce blood group antibodies in recipients of living donor blood-incompatible kidney transplants for pretransplant…
- Trial name
- NCT07706205
- Testing
- Blinatumomab Treatment, Teclistamab treat
- Volunteers
- 20 people
- Sponsor
- West China Hospital
Kidney Transplantation
Digital Application-Based Nursing Intervention
The purpose of this study is to evaluate the effect of a digital application-based nursing intervention on improving health outcomes among kidney transplant recipients.
- Trial name
- NCT07701057
- Testing
- Digital Application-Based Nursing Intervention
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Kidney Transplantation
A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PERSPECTIVE)
The purpose of this study is to evaluate if TCD601 can induce allogeneic tolerance in living donor renal transplant recipients
- Trial name
- PERSPECTIVE (NCT04803058)
- Testing
- TCD601
- Where
- 3 sites in United States, South Korea
- Volunteers
- 7 people
- Sponsor
- ITB-Med LLC
Disorder Related to Renal Transplantation
Curcumin in Kidney Transplant Recipients
The primary goal of this study is to investigate if curcumin is beneficial for kidney transplant recipients, a population with extensive baseline vascular dysfunction and cognitive impairment who have few treatment options.
- Trial name
- NCT03935958
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Illinois at Chicago
Kidney Transplantation Recipients, HLA Sensitization
Safety and Efficacy of BiTE in Desensitization Therapy for Highly Sensitized Kidney Transplant Candidates With cPRA ≥ 90%
This study is a prospective, open-label, two-arm exploratory clinical trial aimed at evaluating the safety and efficacy of Bispecific T-cell Engager (BiTE) therapies in refractory, highly sensitized kidney transplant candidates.
- Trial name
- NCT07689149
- Testing
- BiTE (CD19 x CD3 Bispecific Antibody), BiTE (BCMA x CD3 Bispecific Antibody)
- Volunteers
- 20 people
- Sponsor
- West China Hospital
Cardiovascular Diseases, End Stage Renal Disease
Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates
The Canadian Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK) will test the hypothesis that eliminating the regular use of non-invasive screening tests for CAD AFTER…
- Conditions
- Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication
- Trial name
- CARSK (NCT03674307)
- Testing
- No screening, Regular Screening
- Where
- 22 sites in United States, Canada and 2 more
- Volunteers
- 3,306 people
- Sponsor
- University of British Columbia
Living Donor Kidney Transplantation
TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation
This study will determine whether a preparatory regimen including total lymphoid irradiation (TLI), total body irradiation (TBI), anti-thymocyte globulin (ATG) and infusion of the donor hematopoietic stem cells when given along…
- Trial name
- NCT03943238
- Testing
- Infusion of Donor Hematopoetic Stem Cells and Recipient Tregs
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Stanford University
Hyperparathyroidism, Kidney Transplantation Recipients
Parathyroidectomy After Kidney Transplantation
This study aims to clarify whether surgical treatment of persistent hyperparathyroidism after kidney transplantation offers clinically meaningful benefits compared with a conservative treatment strategy.
- Trial name
- Para-KiT (NCT07415421)
- Testing
- Subtotal Parathyroidectomy, Conservative Management
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- Aarhus University Hospital
Polymorphism, VEGF
Study of the Impact of VEGF Polymorphism on the Development of Renal Carcinoma in Renal Transplant Patients
Renal transplant patients have on average 3-5 times more risk of developing cancer than the general population. This rate can be increased up to 10 to 15 times in some type of cancer like kidney cancer.
- Conditions
- Polymorphism, VEGF, Renal Carcinoma, Renal Transplantation
- Trial name
- VE-CART (NCT03114826)
- Testing
- To study the polymorphism of the gene encoding VEGF (rs699947) as a predictive marker
- Where
- France
- Volunteers
- 272 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
BK Virus Nephropathy, Risk Factor
Evaluation of Renal Pretransplant Serology for BK Virus on the Risk of Post-transplant Viral Reactivation
Due to the increasing importance of BKV infection on the survival of kidney transplants, a better knowledge, in the pretransplant phase, of the risk factors leading to viral reactivation could allow the follow-up physician to be…
- Conditions
- BK Virus Nephropathy, Risk Factor, Kidney Transplantation
- Trial name
- BKSEREIN (NCT04506060)
- Testing
- serum withdrawal
- Where
- France
- Volunteers
- 378 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Liver Transplantation, Acute Kidney Injury
Influence of Human Albumin Supplementation on Kidney Dysfunction After Liver Transplantation
To verify whether albumin administration to achieve serum concentration above 30g/L (treated group) and its maintenance within plasmatic physiologic range (above 30 g/L) for five days diminishes rate of AKI at Day 7 after liver…
- Trial name
- HALT (NCT06535945)
- Testing
- Albumin administration
- Where
- 8 sites in France
- Volunteers
- 400 people
- Sponsor
- Rennes University Hospital
Kidney Transplantation (Status Post), Preoperative Anxiety
Animated Video Versus Written Leaflet for Preoperative Kidney Transplant Education
This randomized comparative trial evaluated whether an animated educational video, added to standard verbal counselling, differs from a content-matched written information leaflet, also added to standard verbal counselling, in…
- Conditions
- Kidney Transplantation (Status Post), Preoperative Anxiety, Patient Education
- Trial name
- NCT07651384
- Testing
- Animated educational video, Written information leaflet
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Humoral Rejection in Kidney Transplantation
Impact of Treatment With Rituximab on the Progression of Humoral Acute Rejection After Renal Transplantation
Assessing the impact of J12 curative treatment with rituximab (375 mg / m² on J5) based on a composite "TREATMENT FAILURE"
- Trial name
- RITUX-ERAH (NCT01350882)
- Testing
- MabThera, Physiological serum : sodium chloride, sodium citrate
- Where
- 30 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Tours
Hypophosphatemia, Kidney Transplantation
Evaluation of Dipyridamole in Preventing Post-Transplant Hypophosphatemia in Kidney Transplant Recipients
The primary goal is to determine if Dipyridamole can improve serum phosphate levels and reduce the need for phosphate supplementation.
- Trial name
- NCT06824454
- Testing
- Dipyridamole 75 MG
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Kidney Transplantation
Safety and Tolerance of Increased Doses of SHR-2106 Injection in Healthy Subjects
This is a randomized, double-blind, placebo-controlled phase I clinical study with the primary objective of evaluating the safety and tolerability of SHR-2106 in healthy subjects after a single intravenous or subcutaneous…
- Trial name
- NCT05948059
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Kidney Disease, Chronic Kidney Disease (Stages 4 and 5)
The Adaptive Platform Trial for Kidney Disease
Background: Randomized clinical trials (RCTs) are essential for evaluating intervention effects but are often challenged by regulatory and logistical burdens, high costs, and extended timelines.
- Conditions
- Kidney Disease, Chronic Kidney Disease (Stages 4 and 5), End-Stage Kidney Disease (ESKD), Dialysis
- Trial name
- APT-KIDNEY (NCT07595952)
- Testing
- APT-KIDNEY platform participation
- Volunteers
- 5,000 people
- Sponsor
- Nicholas Carlson
Renal Transplantation
The Effect of Emotion-Focused Intervention on Emotion Regulation and Well-Being of Individuals With Transplantation
The study was designed to evaluate the effects of an emotion-focused intervention based on the Human-to-Human Relationship Model on emotion regulation skills and well-being in individuals who have undergone renal transplantation.
- Trial name
- NCT07294183
- Testing
- Emotion-Focused Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Akdeniz University