Clinical trials: Transplantation, Kidney
Kidney Tansplant, Secondary Hyperparathyroidism
Post Transplant Study
Retrospective chart review to gather information on Sensipar patterns of use and effects on biochemical parameters in renal transplant recipients
- Conditions
- Kidney Tansplant, Secondary Hyperparathyroidism, Hyperparathyroidism
- Trial name
- NCT00395902
- Testing
- Sensipar after Post Transplant
- Volunteers
- 50 people
- Sponsor
- Amgen
Kidney Disease, Proteinuria
Angiotensin II Blockade for Chronic Allograft Nephropathy
Chronic allograft nephropathy continues to be a major cause of kidney transplant loss and return to dialysis. Treatment options are limited and the course of the disease tends to be progressive.
- Trial name
- NCT00067990
- Testing
- Losartan 100mg
- Where
- 2 sites in United States
- Volunteers
- 153 people
- Sponsor
- University of Minnesota
HIV, Awaiting Organ Transplant
HIV-to-HIV Transplant at MGH
HIV-infected (HIV+) individuals who agree to accept and receive a solid organ transplant from an HIV+ deceased donor will be followed to determine the safety and efficacy of this practice.
- Trial name
- NCT02750397
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Pancreas-Kidney Transplantation
Simultaneous Pancreas-kidney Transplantation With Campath Protocol
The purpose of this study is to determine and compare the efficacy of Campath-1H/Tacrolimus versus ATG/Tacrolimus/MMF therapy in conjunction with initial short-term steroids in Type 1-diabetic patients undergoing simultaneous…
- Trial name
- NCT00316810
- Testing
- Alemtuzumab, Rabbit Anti-Human Thymocyte Globulin
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Dr. Claudia Bösmüller
Kidney Transplantation
Functional Non Specific Immunity Monitoring After Kidney Transplantation Using an Interferon Gamma Test
The best renal replacement therapy is kidney transplantation. It improves end-stage renal kidney disease (ESRD) patients quality of life and increases their survival, but still remains risky.
- Trial name
- QuantiFERON (NCT03572842)
- Testing
- quantiferon monitor test
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Kidney Transplantation
Kidney Allograft Recipients in England - an Observational Cohort Study
Kidney transplantation is the renal replacement therapy of choice for the majority of patients with end-stage kidney disease. Epidemiological studies of kidney allograft recipients can aid in the understanding of cause and effect…
- Trial name
- KARE (NCT01798524)
- Where
- United Kingdom
- Volunteers
- 19,688 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Urinary Tract Infections, Kidney Transplant; Complications
Double Voiding and Post-transplant UTI
Urinary tract infections (UTI) are common in kidney transplant recipients and are an important cause of illness and hospital admissions.
- Trial name
- NCT05711446
- Testing
- Double Voiding, Regular Voiding
- Where
- United States
- Volunteers
- 438 people
- Sponsor
- Weill Medical College of Cornell University
Fever, Chest Tightness
Sulfamethoxazole Prophylaxis Duration After Renal Transplantation
Renal transplantation is the most ideal and effective treatment for end-stage renal disease. Pneumocystis jirovecii pneumonia (PJP) is one of the most common pulmonary infections after renal transplantation, with high morbidity…
- Trial name
- SPDART (NCT07231770)
- Testing
- Time-driven dosing
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Anhui Provincial Hospital
Kidney Transplant Access, Obese Patients
Access to Kidney Transplant of Obese Patients Beginning Dialysis
Obesity is in constant increase all over the world and affects 35% of the global population according to the World Health Organisation.
- Conditions
- Kidney Transplant Access, Obese Patients, Dialysis, Comorbidities
- Trial name
- Transplantob (NCT04748770)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Renal Failure
Comparing Everolimus and Sirolimus in Renal Transplant Recipients
This study is being done to compare the effectiveness and safety of two different kidney transplant immunosuppression drugs, Zortress (the study drug) and Rapamune (which is used in the current standard immunosuppression regimen).
- Trial name
- NCT01976390
- Testing
- Everolimus, Sirolimus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Pediatric Kidney Transplantation
Study of Safety and Efficacy of a Basiliximab, Mycophenolate Mofetil, Cyclosporine Microemulsion and Prednisone Combination Treatment Regimen in Pediatric Renal Allograft Recipients
The aim of this study is assess the safety and efficacy of the treatment regimen of basiliximab ,cyclosporine microemulsion, MMF, and prednisone combined compared to cyclosporine microemulsion, MMF and prednisone in the time to…
- Trial name
- NCT00228020
- Testing
- basiliximab, MMF(mycophenolate mofetil), cyclosporine, prednisone (or equivalent), MMF, cyclosporine, steroids
- Volunteers
- 212 people
- Sponsor
- Novartis
Kidney Transplant; Complications, Frailty Syndrome
Comprehensive Geriatric Assessment in Kidney Transplantation
This observational study aims to analyze the results of comprehensive geriatric assessment and to monitor the development of functional status in geriatric kidney transplant candidates and recipients.
- Conditions
- Kidney Transplant; Complications, Frailty Syndrome, Depressive Syndrome
- Trial name
- CoGeriaTx (NCT06104696)
- Testing
- Functional geriatric assessment
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Kidney Transplantation
Genetic Factors on Outcomes of Kidney Transplant Patients With Tacrolimus-based Therapy
The purpose of this study is to identify the influence of genetic and clinical factors on the clinical outcomes of kidney transplant patients with tacrolimus (TAC) based immunosuppression in Taiwan.
- Trial name
- NCT03764670
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- National Taiwan University Hospital
Renal Transplantation
Efficacy and Safety of the Switch From Sirolimus to Everolimus in Stable Maintenance Renal Transplant Patients Receiving a Calcineurin Inhibitor Free Regimen
The purpose of this study is to assess if a combination of everolimus, steroids, and mycophenolate mofetil is associated with a better renal function than sirolimus.
- Trial name
- NCT00170820
- Testing
- Everolimus
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Transplantation
A Study to Assess the Safety and Efficacy of a Tacrolimus Based Immunosuppressive Regimen in Stable Kidney Transplant Recipients Converted From Cyclosporine Based Immunosuppressive Regimen
The objective of this study is to observe and evaluate the change in renal function following conversion from cyclosporine-based immunosuppressive regimen to tacrolimus-based one.
- Trial name
- NCT02963103
- Testing
- Tacrolimus
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Astellas Pharma Korea, Inc.
Transplant Dysfunction
Safety and Effect of Low-Energy Extracorporeal Shockwave Therapy (ESWT) on the Renal Allograft in Transplant Recipients.
The aim is to investigate the safety and potential effect of Low-energy Shockwave Therapy (ESWT) on the transplanted kidney. The treatment consist of ESWT two times a week for three weeks, six treatments in total.
- Trial name
- NCT03602807
- Testing
- Extracorporeal Shockwave Therapy
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Odense University Hospital
Kidney Transplant Recipient
Biomarker-Guided Mycophenolate Mofetil Elimination in Low-Risk Older Adult Kidney Transplant Recipients
Most kidney transplant recipients take a combination of anti-rejection medicines for the rest of their life. One of these is called mycophenolate mofetil (MMF), also known by the brand name CellCept.
- Trial name
- OPTIMA-KT (NCT07806136)
- Testing
- Tacrolimus (Kidney transplant maintenance immunosuppression), Mycophenoate Mofetil, Prednisone (SOC arm)
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
End-stage Renal Disease
Quality of Life Therapy for Adults With ESRD Awaiting Renal Transplantation
The purpose of this study is to determine whether psychological intervention is effective in improving quality of life, mood, and relationships among adults with end-stage renal disease who are awaiting kidney transplantation.
- Trial name
- NCT00428012
- Testing
- Quality of Life Therapy, Supportive Therapy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pre-kidney Transplant, Living Donor Kidney Transplantation
Proteinuria and Renal Perfusion in Renal Transplant Recipients
Cardiovascular disease remains one of the major cause of mortality in renal transplant recipients, with the rate of cardiac death 10-times higher than that of the general population.
- Conditions
- Pre-kidney Transplant, Living Donor Kidney Transplantation, Renal Perfusion, End Stage Renal Disease
- Trial name
- NCT06051812
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Kidney Transplantation, Rejection
Monitoring Concentration and Pharmacodynamic Effects of Tacrolimus in Peripheral Blood Lymphocytes of Kidney Transplant Recipients
Therapeutic drug monitoring (TDM) of immunosuppressive drugs is used to improve the immunosuppressive effect while minimizing the toxicity related to exposition to high serum levels.
- Trial name
- NCT03425071
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital