Clinical trials: Transplantation, Kidney
Diabetes Mellitus, Type 1
Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation
The purpose of this study is to reverse hyperglycemia and insulin dependency, by islet cell transplantation, in patients with type 1 diabetes mellitus who have a stable kidney allograft.
- Trial name
- NCT00315588
- Testing
- Islet Transplantation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Rodolfo Alejandro
Kidney Disease, Proteinuria
Angiotensin II Blockade for Chronic Allograft Nephropathy
Chronic allograft nephropathy continues to be a major cause of kidney transplant loss and return to dialysis. Treatment options are limited and the course of the disease tends to be progressive.
- Trial name
- NCT00067990
- Testing
- Losartan 100mg
- Where
- 2 sites in United States
- Volunteers
- 153 people
- Sponsor
- University of Minnesota
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Disorder Related to Renal Transplantation
Efficacy of Certican® in Combination With Myfortic® in Renal
The primary objective is to demonstrate the superiority of everolimus plus Myfortic® plus corticosteroids following CNI withdrawal at week 16 compared to tacrolimus plus Myfortic® plus corticosteroids as measured by the change in…
- Trial name
- HUSJ1 (NCT01399242)
- Testing
- Certican
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Universitário São José
Renal Disease
Causes of Mortality in Kidney Transplant Recipients
The causes of mortality in kidney transplant patients and the risk factors for mortality have been widely published. However, there is a high variability according to geographical areas and time.
- Trial name
- Paradigme (NCT05529186)
- Where
- France
- Volunteers
- 7,000 people
- Sponsor
- University Hospital, Strasbourg, France
Hemodyalysis, Kidney Tansplant
Assessment of Mineral and Bone Disorders in Kidney Transplant Recipients
This study aims to integrate bone measurements (including bone turnover markers (BTM), bone mineral density (BMD) measurement, vertebral fracture assessment (VFA), trabecular bone score (TBS) ) commonly used in the general…
- Conditions
- Hemodyalysis, Kidney Tansplant, Osteoporosis, CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder
- Trial name
- NCT07141043
- Where
- Romania
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Aorto-Iliac Arterial Stenosis, Peripheral Arterial Disease
Aortoiliac Stenosis in Kidney Transplantation
The impact of aortoiliac stenosis on kidney transplant patients remains unclear. This study aims to investigate the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis.
- Conditions
- Aorto-Iliac Arterial Stenosis, Peripheral Arterial Disease, Kidney Transplant Failure
- Trial name
- TASC (NCT06020534)
- Where
- Netherlands
- Volunteers
- 655 people
- Sponsor
- Erasmus Medical Center
Renal Transplant Rejection
Efficacy and Safety of ATG-Fresenius Following a Renal Transplantation, Without Corticosteroids
The main objective of the study is the assessment of the overall graft rejection rate (acute, chronic and subclinical) between a treatment with ATG-Fresenius administered in addition to standard treatment consisting of CellCept®…
- Trial name
- IBERICA (NCT01324934)
- Testing
- ATG-Fresenius S
- Where
- 10 sites in Portugal, Spain
- Volunteers
- 40 people
- Sponsor
- Neovii Biotech
Renal Transplantation
Characterization of Immunological Profile of Renal Transplant Patients Undergoing Induction Treatment With Thymoglobulin vs. IL-2 Receptor Antagonist Basiliximab
The goal of the study is to find out the effects of two different drugs used at the beginning of organ transplantation on different populations of immune cells in the body of patients.
- Trial name
- NCT00842699
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Renal Transplantation
Contribution of Diffusion MRI in Renal Graft Transplantation
While renal graft outcomes were really improved for the last decade, long time outcomes remains stable. Indeed, at 10 years after transplantation, the renal graft survival rate reaches 50%.
- Trial name
- NCT02803684
- Testing
- MRI examination with tensor diffusion protocol acquisition. No injection needed.
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Chronic Kidney Diseases, Hyperparathyroidism, Secondary
Analysis of Bone Microarchitecture With HR-pQCT of Patients With Chronic Kidney Disease (CKD) Candidates for Renal Transplantation
While the duration of renal transplant function has increased over the last decade kidney transplanted patients (KTP) still exhibit a fracture risk 4 times higher than in the general population.
- Trial name
- TRANSBONE (NCT02523209)
- Testing
- HR-pQCT, DEXA
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Transplant;Failure,Kidney
Minimally Invasive Kidney Transplantation
This study aims to investigate the effect of robot-assisted laparoscopic kidney transplantation on kidney injury by measuring biomarkers of kidney injury which are found in blood and urine to establish if there is a significant…
- Trial name
- NCT03322709
- Testing
- kidney transplant
- Volunteers
- 90 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Kidney Transplantation
A Study of the Impact of an Early Biopsy in Patients Treated With CellCept (Mycophenolate Mofetil) After Kidney Transplantation
This 2 arm study will evaluate the impact on fibrosis at week 52 of an early biopsy, in patients who have received a kidney transplant from an expanded criteria donor.
- Trial name
- NCT00817687
- Testing
- mycophenolate mofetil [CellCept]
- Where
- 17 sites in France
- Volunteers
- 66 people
- Sponsor
- Hoffmann-La Roche
Renal Disease
Ides in Highly Sensitized (HS) Patients Awaiting Kidney Transplantation
This is a single center phase I/II open label, exploratory study assessing safety and efficacy of IdeS® (Hansa Medical, Lund, Sweden) given immediately prior to kidney transplantation.
- Trial name
- NCT02426684
- Testing
- IdeS® (Imlifidase)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Cedars-Sinai Medical Center
Vascular Diseases, Arterial Stiffness
Relation Between Renin-Angiotensin Gene Polymorphisms, Plasma Adiponectin and Arterial Stiffness in Renal Transplant Recipients
Relation between Renin-Angiotensin Gene Polymorphisms, Plasma Adiponectin and Arterial Stiffness in Renal Transplant Recipients
- Trial name
- NCT00221533
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- University Hospital, Ghent
Cytomegalovirus (CMV), Kidney Transplant; Complications
Kidney Transplant Preemptive Therapy or Prophylaxis for CMV Prevention in D+R Recipients
This is a prospective, randomized multicenter trial of preemptive therapy (PET) vs. antiviral prophylaxis (AP) for prevention of cytomegalovirus (CMV) disease in adult D+R- kidney transplant recipients (KTR).
- Conditions
- Cytomegalovirus (CMV), Kidney Transplant; Complications, Kidney Diseases
- Trial name
- KPoP (NCT06798909)
- Testing
- Valganciclovir (Pre-emptive CMV Therapy), Valganciclovir CMV Prophylaxis
- Where
- 8 sites in United States
- Volunteers
- 360 people
- Sponsor
- University of California, San Francisco
Delayed Graft Function
Renaparin® in Kidney Transplantation
This study evaluates the safety and tolerability of Renaparin in adult patients receiving a deceased donor kidney treated ex-vivo with Renaparin prior to transplantation.
- Trial name
- NCT03773211
- Testing
- Renaparin
- Where
- 3 sites in Sweden
- Volunteers
- 16 people
- Sponsor
- Corline Biomedical AB
End Stage Renal Disease, Kidney Transplantation
Bone Mass and Strength After Kidney Transplantation
The purpose of this study is to test whether active vitamin D (calcitriol) protects bones from weakening and protects blood vessels from calcium deposits over the first year of kidney transplantation.
- Conditions
- End Stage Renal Disease, Kidney Transplantation, Bone Loss, Fractures
- Trial name
- NCT02224144
- Testing
- Vitamin D3, Calcitriol
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Columbia University
Kidney Failure, Chronic, Multiple Myeloma
Combined Bone Marrow and Kidney Transplant for Multiple Myeloma With Kidney Failure
The purpose of this study is to determine whether a combined bone marrow and kidney transplant will be effective in treating stage II or greater multiple myeloma and associated kidney failure.
- Trial name
- NCT00062621
- Testing
- Combined bone marrow and kidney transplant
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Heart Transplantation, Kidney Transplantation
Effects of Donor and Recipient Genetic Expression on Heart, Lung, Liver, or Kidney Transplant Survival
Activity of genes in donor tissues that are involved in inflammation are thought to be involved with early organ dysfunction, increased immune responses in transplant recipients, and organ rejection.
- Conditions
- Heart Transplantation, Kidney Transplantation, Liver Transplantation, Lung Transplantation
- Trial name
- NCT00531921
- Where
- 5 sites in United States
- Volunteers
- 313 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)