Clinical trials: Transplants
Multiple Myeloma, Acute Myeloid Leukemia
Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT
The purpose of this study is to see whether hematopoietic stem cell transplant (HSCT) patients can consistently eat a diet rich in prebiotics.
- Conditions
- Multiple Myeloma, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Non Hodgkin Lymphoma
- Trial name
- HCTDiet (NCT04629430)
- Testing
- Pre-biotic foods/drinks
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Hepatitis C, Kidney Transplant; Complications
A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients
This study is being done to determine the effectiveness of using a combination of two different drugs in preventing the transmission of HCV from a HCV positive donor to a HCV negative solid organ recipient.
- Conditions
- Hepatitis C, Kidney Transplant; Complications, Heart Transplant Infection
- Trial name
- NCT04508907
- Testing
- Mavyret
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- Mayo Clinic
Bone Marrow Transplant
Perspectives on Bone Marrow Donors Who Donate for Their Parent
The purpose of this pilot study is to explore the role of family function on decision-making for bone marrow donors who donated for their parent, and to assess the unique supportive care needs of these participants.
- Trial name
- NCT03758911
- Testing
- Semi-structured Interview
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Stress, Family Caregivers
Physical and Emotional Health of Caregivers for People Who Have Had Stem Cell Transplants
Background: Stem cell transplants are a complex treatment that can have serious side effects. Having a caregiver to help with the recovery is critical.
- Trial name
- NCT01468857
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Transplant Sensitization, Panel Reactive Antibody
An In-vitro Standardization of B Cell Elispot Assays
This study is being done because the study doctor is trying to develop a new test which will help transplant doctors monitor patients with high panel reactive antibodies (PRA).
- Conditions
- Transplant Sensitization, Panel Reactive Antibody, Sensitization to HLA Antigens
- Trial name
- NCT01334281
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Organ Transplant Rejection
Clinical Study of Microchimerism and cfDNA as Biomarkers for Acute Rejection After Organ Transplantation
Organ transplantation has become an effective therapy for patients with end-stage organ failure at present. Rejection is still the most common cause of early dysfunction after organ transplantation.
- Trial name
- CSMCDTITAROT (NCT03255265)
- Testing
- no interventions
- Where
- China
- Volunteers
- 950 people
- Sponsor
- Fuzhou General Hospital
Antibody-mediated Rejection
A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Kidney Transplants Who Have Antibody-Mediated Rejection (AMR)
In this study, researchers will learn more about the use of felzartamab in kidney transplant patients who have antibody-mediated rejection, also known as AMR. Kidney transplants can save lives for people with kidney failure.
- Trial name
- TRANSCEND (NCT06685757)
- Testing
- Felzartamab
- Where
- 56 sites in United States, Argentina and 10 more
- Volunteers
- 132 people
- Sponsor
- Biogen
Squamous Cell Carcinoma
Warning Signs of Squamous Cell Carcinoma and Prevention of SCC by at Risk Organ Transplant Recipients
Using focus group and cognitive interviews with organ transplant recipients, the investigators developed interactive workbooks: a) prevention by sun protection b) early detection by skin self-examination (SSE).
- Trial name
- SCCs in OTRs (NCT01127737)
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Northwestern University
Transplant Complication, Kidney Transplant
"A Privacy-protecting Environment for Child Transplants Health Related and Genomic Data Integration in the European Reference Network"
Protect_Child_101 is an observational study to be performed in children that have undergone a liver or renal transplant. The aim of this study is to analyse small variations in the genetic material (DNA) of transplanted children.
- Conditions
- Transplant Complication, Kidney Transplant, Liver Transplant
- Trial name
- Protect_Child (NCT07194057)
- Testing
- Whole genome sequencing, Polygenic Risk Score Calculation, Methylome and episignatures
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 200 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Kidney Transplant
Randomized Study to Reduce Calcineurininhibitor Toxicity in Pediatric and Adolescent Kidney Transplant Recipients
The purpose of this study is to determine if a safe reduction of cyclosporine A in pediatric and adolescent patients with stable renal graft function, reduces signs of calcineurin-inhibitor toxicity.
- Trial name
- Recaltox (NCT00663455)
- Testing
- Reduction of cyclosporine A (CSA)-dosing
- Where
- 10 sites in Germany
- Volunteers
- 50 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cancer, Hematopoietic System--Cancer
Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients
This study is being done because the investigators would like to learn more about how well the COVID-19 vaccine works in participants with cancer or those who have received a transplant or cellular therapy.
- Conditions
- Cancer, Hematopoietic System--Cancer, Transplant-Related Cancer, Solid Tumor Malignancy
- Trial name
- NCT05164016
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- St. Jude Children's Research Hospital
Varicella Zoster
Recombinant Zoster Vaccine in Young Adult Solid Organ Transplant Recipients
This goal of this study is to assess the safety and immunogenicity of recombinant zoster virus in young adult solid organ transplant recipients. In this study, participants will receive the recombinant zoster vaccine.
- Trial name
- NCT06162494
- Testing
- Recombinant Zoster Vaccine
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Kidney Transplantation, Liver Transplantation
Quality of Life in Pediatric Transplant Patients
The goal of this study is to compare parent and child perceptions of wellness and vulnerability in children who have undergone solid organ transplant.
- Conditions
- Kidney Transplantation, Liver Transplantation, Heart Transplantation
- Trial name
- NCT00678002
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Medical College of Wisconsin
Merkel Cell Carcinoma, Basal Cell Carcinoma
Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies
The purpose of this study is to assess the safety and efficacy of RP1 (administered into the tumor) in 90 patients who have received an organ transplant in the past and currently have skin cancer.
- Conditions
- Merkel Cell Carcinoma, Basal Cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma, Cancer
- Trial name
- ARTACUS (NCT04349436)
- Testing
- RP1, intra-tumoral injection, oncolytic virus
- Where
- 24 sites in United States
- Volunteers
- 69 people
- Sponsor
- Replimune, Inc.
Kidney Transplantation, Medication Adherence
Video Education and Behaviour Contract to Optimize Adherence in Renal Transplants
This study aims to test the effectiveness of an electronic-based video intervention and behavioral contract on improving medication adherence among kidney transplant recipients.
- Trial name
- VECTOR (NCT03540121)
- Testing
- Video education + adherence contract
- Where
- 3 sites in United States, Canada
- Volunteers
- 173 people
- Sponsor
- University of Saskatchewan
Kidney Transplantation, Liver Transplantation
Immunogenicity of 13-valent Pneumococcal Conjugate Vaccine Compared to the Pneumococcal Polysaccharide Vaccine in Adult Kidney and Liver Transplant Patients
Severe Pneumococcal disease, such as bacteremia, meningitis and pneumonia, cause significant morbidity and mortality in both otherwise healthy adult population and in the immunocompromised patients.
- Trial name
- SOT13 (NCT01781871)
- Testing
- Prevenar13, Pneumovax
- Where
- 2 sites in Finland
- Volunteers
- 182 people
- Sponsor
- Helsinki University Central Hospital
Multiple Myeloma
Carfilzomib Based Chemotherapy Mobilization for Autologous Stem Cell Transplants in Multiple Myeloma
This phase I study utilizes a 3+3 design with escalating cohorts of Carfilzomib at 20mg/m2, 27mg/m2, 36mg/m2, 45mg/m2, 56mg/m2, and 70mg/m2 to be administered concomitantly with Cyclophosphamide 2 gm/m2, Dexamethasone and…
- Trial name
- CarMob (NCT03909412)
- Testing
- Carfilzomib, Cyclophosphamide, Dexamethasone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Hackensack Meridian Health
Immunosuppression
Microfluidics and Transcriptomics in Post Solid Organ Transplant Patients
The field of genomics is an exciting new field being applied in medicine. Its use in treating some cancers, sepsis and burn patients has been very promising.
- Trial name
- NCT02776111
- Testing
- Blood Sample
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Florida
Infection in Solid Organ Transplant Recipients
T-SPOT.CMV and T-SPOT.PRT Diagnostic Assays
The T-SPOT assay quantifies the number of peripheral blood interferon-γ producing effector T cells [spot forming cells/million peripheral blood mononuclear cells - PBMC)].
- Trial name
- PROTECT (NCT02382211)
- Where
- 39 sites in United States, Canada and 1 more
- Volunteers
- 600 people
- Sponsor
- Oxford Immunotec
Extensive Photodamage, Actinic Keratosis
Treatment of Field Cancerization for Reduction in Tumor Burden - A Prospective Study
This project aims to treat field cancerization ( pre-skin cancers) in a manner that will reduce the future pre-skin cancers and non-melanoma skin cancers in patients with significant photodamage.
- Conditions
- Extensive Photodamage, Actinic Keratosis, History of Numerous Skin Cancers
- Trial name
- NCT02150863
- Testing
- Ultrapulse Carbon Dioxide Laser, Cellutome epidermal harvesting system
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital