Clinical trials: Transplants
Chronic Kidney Disease, Autoimmune Diseases
Capillary Sampling in Clinical Populations Undergoing Monitoring
Many people with long-term health conditions require regular blood tests to monitor their disease or medications. These blood tests are usually performed by taking blood from a vein during a hospital or clinic appointment.
- Conditions
- Chronic Kidney Disease, Autoimmune Diseases, Solid Organ Transplant Recipients
- Trial name
- CAPSICUM (NCT07802665)
- Testing
- Blood sampling with capillary sampling device(s)
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Graft Versus Host Disease
Efficacy of Low-dose PT-Cy for Prevention of GVHD in Ambulatory Allogeneic HSCT
Low-dose post-transplant cyclophosphamide have demonstrated therapeutic efficacy in allogeneic stem cell transplants which is comparable with the standard dose and also facilitates early hematological recovery.
- Trial name
- NCT07319000
- Testing
- Cyclophosphamide
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Actinic Keratosis
Fractional Laser-assisted Daylight Photodynamic Therapy Versus Daylight Photodynamic for Treatment of Actinic Keratoses
Organ transplant recipients (OTR) have an increased risk of non-melanoma skin cancer, in particular squamous cell carcinoma (SCC), often developing in areas of field cancerization, areas with multiple precancerous actinic…
- Trial name
- NCT01898936
- Testing
- Pretreatment with CO2 laser before photodynamic therapy, Only photodynamic therapy
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Oslo University Hospital
Viral Infections
Virus Surveillance in Pediatric Solid Organ Transplant Recipients
Viral infections are an important complication of transplantation. Immunosuppressive therapy interferes with T cell immunity resulting in a high incidence of viral infection.
- Trial name
- NCT00886158
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Seattle Children's Hospital
Kidney Transplantation
Safety and Tolerability Study of Inhaled Carbon Monoxide in Kidney Transplant Patients
The purpose of this study is to evaluate the safety and tolerability of two carbon monoxide doses when administered as an inhaled gas for 1 hour in patients receiving kidney transplants.
- Trial name
- NCT00531856
- Testing
- Inhaled carbon monoxide
- Where
- 3 sites in United States
- Sponsor
- Mallinckrodt
Iron Overload
Safety and Efficacy of Iron Reduction by Phlebotomy
Hypothesis: The reduction of total body iron by phlebotomy will be safe and feasible in the post-HSCT setting Iron overload is common after hematopoietic stem cell transplantation.
- Trial name
- NCT00689182
- Testing
- monthly phlebotomy x 12 months
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Andrea Kew
Human Papilloma Virus, Hiv
Study of Safety, Tolerability and Immunogenicity of Gardasil®9 in Immunocompromised Patients
Patients with immunodeficiencies are at increased risk of developing persistent HPV infection and as such HPV-related disease (genital warts and cancer).
- Conditions
- Human Papilloma Virus, Hiv, Organ Transplants
- Trial name
- NCT03525210
- Testing
- 9-valent HPV vaccine
- Where
- Belgium
- Volunteers
- 271 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Kidney Transplant Rejection
The TOGETHER Project - Kidney
Researchers are trying to develop a way to customize immunosuppression treatment, based on the results of a blood test that measures the risk of rejection.
- Trial name
- TOGETHER (NCT03873623)
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- Mayo Clinic
Hematologic Diseases, Stem Cell Transplants
A Multiple Ascending Dose Study of PUL-042 in Stem Cell Transplant Recipients
Subjects with hematologic malignancies or recipients of a first allogenic or autologus hematopoietic stem cell transplant, without any evidence or respiratory infection, will receive 4 doses of PUL-042 Inhalation Solution over a…
- Trial name
- NCT03097796
- Testing
- PUL-042
- Where
- United States
- Sponsor
- Pulmotect, Inc.
Liver Transplantation
Continued Access Study to Evaluate Performance of the Organ Recovery Systems _LifePort® Liver Transporter System, a Machine Perfusion System, for Liver Transplant (PILOT™_CA)
To provide continued access for the LLT system to provide additional safety data in support of the PILOT pivotal efficacy and safety trial
- Trial name
- PILOT™_CA (NCT05574361)
- Testing
- Hypothermic Machine Perfusion
- Where
- 5 sites in United States
- Volunteers
- 385 people
- Sponsor
- Organ Recovery Systems, Inc.
Chronic Renal Failure
MSC and Kidney Transplant Tolerance (Phase A)
The general aim of the present study is to test a cell therapy with third-party ex-vivo expanded bone marrow-derived mesenchymal stromal cells (MSCs) as a strategy to induce tolerance in kidney transplant recipients with a…
- Trial name
- NCT02565459
- Testing
- Mesenchymal Stromal Cells
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Monia Lorini
Heart Transplant Rejection, Immune Suppression
Mobile Video Directly Observed Therapy (DOT) for Immunosuppression Medication Adherence in Adolescent Heart Transplant Recipients
We will conduct a two-group randomized controlled trial to examine the eMocha DOT intervention with pediatric HT recipients.In this population, medication nonadherence remains a primary cause of late acute rejection (LAR)…
- Conditions
- Heart Transplant Rejection, Immune Suppression, Pediatric Heart Transplant, Medication Nonadherence
- Trial name
- NCT05732779
- Testing
- DOT intervention
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Complications of Organ Transplant Stem Cells, Gram-Negative Bacterial Infections
Survey of Severe Infections by Gram Negative Bacteria in Patients Submitted to Stem Cell Transplant
All patients undergoing autologous or allogeneic stem cell transplant (SCT) for any underlying disease will be monitored for severe infections by gram negative bacteria (SIGNB) during the engraftment period.
- Trial name
- GITMO-SIGNB (NCT02088840)
- Where
- 54 sites in Italy
- Volunteers
- 2,769 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Liver Transplant Rejection
The TOGETHER Project - Liver
To validate the use of a RNAseq-based peripheral blood assay in liver transplant recipients when correlated to liver biopsy results.
- Trial name
- TOGETHER (NCT03874286)
- Testing
- Liver Transplant
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- Mayo Clinic
Organ Transplant
DCD IIT: Evaluating the Safety of Utilizing Donor Hearts From Donation After Circulatory Death (DCD) Donors
The purpose the research is to evaluate whether patients who receive a Donation after Circulatory Death (DCD) heart for cardiac transplantation using either normothermic regional perfusion (NRP) or direct procurement and…
- Trial name
- NCT05462041
- Testing
- DBD Donor Heart Transplantation, DCD Donor Heart Transplantation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Solid Organ Transplant Complications
Microbiota Transplantation in Solid Organ Transplantation
Solid organ transplantation (SOT), an alternative therapy for end-stage diseases, offers increased longevity and better quantity of life.
- Trial name
- NCT06730451
- Testing
- Washed Microbiota Transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Solid Organ Transplant
Feeding the Flame, One Day at a Time: Design and Acceptability of a Serious Game to Support Medication Adherence and Education for Pediatric Solid Organ Transplant Patients
Children and teenagers who receive a solid organ transplant (such as a kidney, liver, or heart) must take medications every day to keep their new organ healthy.
- Trial name
- Mystic Wizard (NCT07609303)
- Testing
- Mystic Wizard
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Transplant
Parents of Pediatric Solid Organ Transplant Recipients: Transition to Home and Chronic Illness Care
The overall long term objective of this research is to improve health care utilization and quality of life of pediatric solid organ transplant recipients and family.
- Trial name
- NCT01389804
- Where
- 5 sites in United States
- Volunteers
- 51 people
- Sponsor
- Medical College of Wisconsin
End Stage Kidney Disease, Immunological Tolerance
Immunological Tolerance in Patients With Mismatched Kidney Transplants
This study seeks to determine if administration of the drug belumosudil (KD025) will be safe and improve transplant tolerance in subjects undergoing combined Human Leukocyte Antigen (HLA) single haplotype-matched related or 0-3…
- Conditions
- End Stage Kidney Disease, Immunological Tolerance, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases
- Trial name
- NCT05806749
- Testing
- Donor CD34+, CD3+. and belumosudil
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, Los Angeles
Kidney Transplantation, Cytomegalovirus
Comparison Between Two Tacrolimus-based Immunosuppressant Regimens and Induction With Thymoglobulin in Kidney Transplants From Deceased Donors With Expanded Criteria
The disparity between supply and demand for organs has stimulated the development of strategies to increase the availability of kidney grafts. Such strategy involves the use of kidneys with expanded donor criteria (EDC).
- Trial name
- NCT01895049
- Testing
- Induction therapy with Thymoglobulin, prednisone, everolimus and late introduction of tacrolimus, Induction therapy with Thymoglobulin, prednisone, mycophenolate sodium and late introduction of tacrolimus
- Where
- Brazil
- Volunteers
- 171 people
- Sponsor
- Helio Tedesco Silva Junior