Clinical trials: Transplants
Hepatitis C, Kidney Transplant; Complications
A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients
This study is being done to determine the effectiveness of using a combination of two different drugs in preventing the transmission of HCV from a HCV positive donor to a HCV negative solid organ recipient.
- Conditions
- Hepatitis C, Kidney Transplant; Complications, Heart Transplant Infection
- Trial name
- NCT04508907
- Testing
- Mavyret
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- Mayo Clinic
Atherosclerosis
Biologically Modified Saphenous Vein Transplants for Improved CABG Outcomes
The purpose of this study is to study the effects of polyarginine treated vein grafts on graft patency for patients undergoing coronary artery bypass surgery.
- Trial name
- NCT01313533
- Testing
- Polyarginine, Vein soak treated with Lactated Ringers Solution
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- St. Luke's Hospital, Chesterfield, Missouri
Renal Failure
Dexmedetomidine and Renal Transplants
Investigators aim to retrospectively research patients undergoing renal transplants that received dexmedetomidine perioperatively to see if dexmedetomidine use protects renal function.
- Trial name
- NCT02019121
- Where
- United States
- Volunteers
- 797 people
- Sponsor
- University of California, Davis
Transplant
Cell Mediated Immunity and the Prediction of CMV Infection In Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut, and the liver.
- Trial name
- NCT00436384
- Testing
- Monitoring-blood samples drawn for CMV testing
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Frailty, Liver Transplants
Frailty in Liver Transplant Exercise (FLEX) Trial
Frailty is common in patients with end-stage liver disease. It's characterized by reduced strength, low endurance and reduced physical function.
- Trial name
- FLEX (NCT04200846)
- Testing
- Exercise intervention
- Sponsor
- Milton S. Hershey Medical Center
Organ Transplant
DCD IIT: Evaluating the Safety of Utilizing Donor Hearts From Donation After Circulatory Death (DCD) Donors
The purpose the research is to evaluate whether patients who receive a Donation after Circulatory Death (DCD) heart for cardiac transplantation using either normothermic regional perfusion (NRP) or direct procurement and…
- Trial name
- NCT05462041
- Testing
- DBD Donor Heart Transplantation, DCD Donor Heart Transplantation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Hepatitis E
Seroprevalence of Hepatitis E in People With an Organ Transplant
Background: The hepatitis E virus causes an acute hepatitis that usually goes away by itself. Researchers in France studied people who received a liver or kidney transplant.
- Trial name
- NCT02190253
- Where
- 3 sites in United States
- Volunteers
- 447 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Solid Organ Transplant, Heart Transplant
REmote moBile Outpatient mOnitoring in Transplant 2.0
This study is designed to determine if an innovative mobile health intervention designed to improve patient-provider communication can reduce unscheduled hospitalizations, and visits to the emergency department and ambulatory…
- Conditions
- Solid Organ Transplant, Heart Transplant, Liver Transplant, Kidney Transplant
- Trial name
- Reboot (NCT04721288)
- Testing
- Active communication through Reboot application, Generic communication through Reboot application
- Volunteers
- 400 people
- Sponsor
- University Health Network, Toronto
Bacteriuria, Urinary Tract Infections
Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants
The goal of this research program is to understand the natural history of asymptomatic bacteriuria in the renal transplant patients, to determine if screening for asymptomatic bacteriuria and identification of key host…
- Conditions
- Bacteriuria, Urinary Tract Infections, Asymptomatic Infections, Transplantation Infection
- Trial name
- ASB (NCT01349738)
- Testing
- Antibiotic
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rice, James C., M.D.
Transplant;Failure,Kidney, Transplant; Failure, Heart
EASE-SOT Pilot Study
Many transplant recipients may experience physical and emotional symptoms, such as anxiety, fatigue, sleep problems, pain, etc. Often, these symptoms are not reported or managed well, and can affect a patient's quality-of-life.
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Heart, Transplant; Failure, Liver, Transplant; Failure, Pancreas
- Trial name
- NCT06396702
- Testing
- EASE-SOT
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Liver Disease, Liver Transplantation
Peripheral Immunologic Response of Solid Organ Transplant Recipients to Depletion Versus Non-depletion Protocols
Rejection and infection are primary causes of morbidity and mortality in solid organ transplant recipients. Current clinical practice relies on immunosuppressive drug levels measured in plasma to reflect the peripheral immune…
- Trial name
- NCT00839709
- Testing
- blood sampling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Graft-versus-leukemia, Graft vs Host Disease
Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell Transplants
This study will provide follow-up evaluation and care of patients who have undergone allogeneic (donor) stem cell transplantation at the NIH Clinical Center.
- Conditions
- Graft-versus-leukemia, Graft vs Host Disease, Graft Rejection
- Trial name
- NCT00106925
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Late Complication From Kidney Transplant, Complication of Transplanted Liver
Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients
The human papilloma virus (HPV) is known to be an important cause of cervical and anal cancers. Studies on patients who have received a solid organ transplant (such as a liver or kidney transplant) have suggested the risk of…
- Conditions
- Late Complication From Kidney Transplant, Complication of Transplanted Liver, Human Papillomavirus-Related Carcinoma
- Trial name
- NCT02624349
- Testing
- Quadravalent human papillomavirus vaccine
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Contraception, Contraception Behavior
Contraception for Solid Organ Transplant Patients: Utilizing Social Media
The purpose of this study is to use an electronic survey to explore Solid Organ Transplant patients' contraceptive knowledge and counseling.
- Conditions
- Contraception, Contraception Behavior, Contraceptive Usage, Reproductive Health
- Trial name
- NCT03979950
- Testing
- Survey
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cytomegalovirus Viraemia
Cell Mediated Immunity for Secondary Prophylaxis in CMV SOT Patients
This study will evaluate whether a test for Cytomegalovirus (CMV) specific cell-mediated immunity can be used to determine whether patients who complete a course of therapy for CMV viremia need secondary antiviral prophylaxis.
- Trial name
- Q-CMV (NCT02370758)
- Testing
- Valganciclovir or Ganciclovir
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University Health Network, Toronto
Human Papillomavirus Infection, Anal HPV Infection
Epidemiology of Anal Human Papillomavirus Carriage in Female Solid Organ Transplant Recipients With More Than 10 Years of Immunosuppression
Anal canal cancer is primarily associated with persistent infection by high-risk human papillomavirus (HR-HPV), particularly HPV-16.
- Conditions
- Human Papillomavirus Infection, Anal HPV Infection, Human Papillomavirus 16 Infection
- Trial name
- EPAHTOS (NCT07858201)
- Testing
- Anal Self-Sampling for High-Risk HPV Detection
- Volunteers
- 190 people
- Sponsor
- University Hospital, Montpellier
Organ Transplants
Immune Status in Solid Organ Transplantation
Immunosuppressive therapy protocols in solid organ transplantation are rudimentary, differ by transplant center and no practical strategies are available to guide an individuals' response to immune suppression.
- Trial name
- NCT01070901
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Renal Transplant
Elastographic Imaging of Renal Transplants
The study was developed to acquire images of normal, then abnormal, then unknown diagnosis for transplanted kidneys in order to determine whether the elastography imaging modality, a type of ultrasound imaging, can provide data…
- Trial name
- Elastorenal (NCT00935727)
- Testing
- Elastographic imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Fanconi Anemia, Anemia, Hypoplastic, Congenital
Prenatal Transplantation for Fetuses With Fanconi Anemia
The investigators aim to evaluate the safety and efficacy of in utero hematopoietic stem cell transplantation (IUHSCT) for the treatment of fetuses diagnosed with Fanconi anemia (FA) during pregnancy.
- Conditions
- Fanconi Anemia, Anemia, Hypoplastic, Congenital, Congenital Bone Marrow Failure Syndromes, Bone Marrow Failure Disorders
- Trial name
- NCT07408583
- Testing
- IUHSCT for FA-affected fetuses
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Agnieszka Czechowicz
Kidney Transplantation
Safety and Tolerability Study of Inhaled Carbon Monoxide in Kidney Transplant Patients
The purpose of this study is to evaluate the safety and tolerability of two carbon monoxide doses when administered as an inhaled gas for 1 hour in patients receiving kidney transplants.
- Trial name
- NCT00531856
- Testing
- Inhaled carbon monoxide
- Where
- 3 sites in United States
- Sponsor
- Mallinckrodt