Clinical trials: Transpulmonary Pressure
Open Abdomen, Mechanical Ventilation
Effects of AbClo Fascial Approximation Device in Patients With Open Abdomen on Respiratory Mechanics
Patients who underwent an abdominal surgery and had the abdomen remain open are called to have an "open abdomen". To limit the risk of further widening of their wounds, surgeons can use AbClo, which is a non-invasive abdominal…
- Trial name
- AbClo-Resp (NCT07154589)
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593717
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Anesthesia
Influence of Xenon Anaesthesia on Transpulmonary Pressure and Tidal Volume Distribution
The influence of xenon anaesthesia on transpulmonary pressure and tidal volume distribution will be investigated in a prospective cohort study in 10 patients of normal weight and 10 obese patients undergoing routine xenon-based…
- Trial name
- NCT02682758
- Testing
- Xenon
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Intra-abdominal Hypertension, Acute Respiratory Distress Syndrome (ARDS)
End-expiratory Transpulmonary Pressure-guided vs Electrical Impedance Tomography-guided PEEP Titration Methods in Patients With Intra-abdominal Hypertension Combined With Acute Respiratory Distress Syndrome: a Randomized Crossover Controlled Study
This study aims to adopt a randomized crossover design to compare the effects of end-expiratory transpulmonary pressure-guided PEEP titration and EIT-guided PEEP titration on local lung ventilation, shunt, dead space, and…
- Trial name
- NCT06697717
- Testing
- Transpulmonary Pressure-Guided PEEP Titration in IAH and ARDS Patients, EIT-Guided PEEP Titration in IAH and ARDS Patients
- Where
- China
- Volunteers
- 15 people
- Sponsor
- XiaoJing Zou,MD
Anesthesia, General/Methods, Laparoscopy
Transpulmonary Driving Pressure and Intra-abdominal Pressure Relationship During Laparoscopic Surgery
Objective: The aim of this project is to evaluate how intra-abdominal pressure paired coupled with different ventilatory positive end-expiratory pressure levels affects the transpulmonary driving pressure during pneumoperiteneum…
- Conditions
- Anesthesia, General/Methods, Laparoscopy, Respiration, Artificial, Positive-Pressure Respiration
- Trial name
- NCT03435913
- Testing
- Standard PEEP ventilation, Matched PEEP ventilation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario La Fe
Mechanical Ventilation, Acute Respiratory Distress Syndrome
Comparison of Esophageal and Central Venous Pressure for Estimating Transpulmonary Pressure Changes
Central venous pressure (CVP) is characterized by a low-frequency pleural-dependent as well as a high-frequency cardiac pulsatile component.
- Trial name
- PPLproject (NCT04443491)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Siena
ARDS, Human, Obesity, Morbid
Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.
The goal of this clinical trial is to test a personalized intervention aiming to optimize the mechanical ventilator settings in morbidly obese patients suffering from moderate to severe Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- TGV-MOA (NCT06119516)
- Testing
- Esophageal pressure-guided strategy,
- Where
- 5 sites in France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Artificial Respiration, Surgery
Effects of Mechanical Ventilation Guided by Transpulmonary Pressure on Gas Exchange During Robotic Surgery: a Pilot Study
Laparoscopy and robotic techniques are widespread procedures for pelvic gynecologic, urologic and abdominal surgery often performed in Trendelenburg position, with the application of pneumoperitoneum by inflating carbon dioxide.
- Conditions
- Artificial Respiration, Surgery, Atelectasis
- Trial name
- Vetrapo (NCT03153592)
- Testing
- Transpulmonary pressure driven ventilation strategy, Conventional ventilation strategy
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Acute Lung Injury
Transpulmonary Pressure Gradients in High Frequency Oscillation
Patients with severe lung conditions occasionally require support with a special ventilator (breathing machine) called the High Frequency Oscillator (HFO).
- Trial name
- TPG in HFO (NCT01321398)
- Testing
- Esophageal Pressure Monitoring
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University of British Columbia
Respiratory Distress Syndrome, Adult
New Lung Ventilation Strategies Guided by Transpulmonary Pressure in VV-ECMO for Severe ARDS
Extracorporeal membrane oxygenation (ECMO) has been widely used in patients with severe acute respiratory distress syndrome (ARDS).
- Trial name
- NCT02439151
- Testing
- New lung ventilation strategy, Conventional ventilation strategy
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Rui Wang
Anesthesia
Intraoperative Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods.
Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations i esophagus pressure divided by the tidal volume.
- Trial name
- Lungbaro (NCT02830516)
- Testing
- Measurement of lung elastance by two methods
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Stefan Lundin
ARDS, Ventilator-Induced Lung Injury
Assisted or Controlled Ventilation in Ards (Ascovent)
The present pilot randomized controlled clinical trial will test the hypothesis that in patients with ARDS, fixing ventilator settings to the conventional protective ventilatory strategy (VT 6 ml/kg ideal body weight and Pplat ≤…
- Conditions
- ARDS, Ventilator-Induced Lung Injury, Mechanical Ventilation Complication, Inflammatory Response
- Trial name
- ASCOVENT (NCT03245684)
- Testing
- assessment of inflammatory response during PSV
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Respiratory Failure
Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients
This protocol describes a randomized controlled feasibility vanguard study designed to investigate the implementation and effects of esophageal pressure-guided positive end-expiratory pressure (PEEP) titration in patients with…
- Trial name
- TAILOR-PEEP (NCT07359261)
- Testing
- Esophageal pressure-guided PEEP titration, Standard care PEEP management
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
ARDS (Moderate or Severe)
Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With ARDS
To verify whether the transpulmonary pressure-guided mechanical ventilation strategy can reduce right ventricular involvement, especially the incidence of acute cor pulmonale (ACP), in patients with moderate to severe ARDS…
- Trial name
- NCT07490925
- Testing
- Transpulmonary pressure guided mechanical ventilation strategy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing Chao Yang Hospital
Mechanical Ventilation Complication, Respiratory Insufficiency
Transpulmonary Pressures in Mechanical Ventilated Patients With Morbid Obesity
The study consists in determine the transpulmonary pressure in morbidly obesity patients that require mechanical ventilation. both gender only adults Medical intensive care patients.
- Trial name
- NCT02309190
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Acute Respiratory Distress Syndrome, Acute Cor Pulmonale
Transpulmonary Pressure in Right Ventricle Protection of ARDS
To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.
- Trial name
- NCT05629832
- Testing
- mechanical ventilation strategy guided by transpulmonary pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Chao Yang Hospital
Surgery
Esophageal Balloon Measurements to Better Characterize Thoraco-abdominal Interrelationship Mechanics.
Esophageal pressure measurements in surgical patients requiring mechanical ventilation during abdominal laparoscopic or robotic surgeries requiring intra-abdominal insufflation.
- Trial name
- NCT03624491
- Testing
- Esophageal pressure measurement guided ventilation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Respiratory Distress Syndrome
Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS)
Mortality in Acute Respiratory Distress Syndrome is high (40 to 60 %). Protective mechanical ventilation, until 2010, was the cornerstone of the ARDS therapeutic strategies.
- Trial name
- NCT01573715
- Testing
- NIMBEX, WITHOUT NIMBEX
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Respiratory Distress Syndrome
EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures
This phase II multi-centered, randomized controlled trial of mechanical ventilation directed by esophageal pressure measurement will test the primary hypothesis that using a strategy of maintaining a minimal but positive…
- Trial name
- EPVent2 (NCT01681225)
- Testing
- Esophageal-pressure guided mechanical ventilation, High PEEP mechanical ventilation
- Where
- 14 sites in United States, Canada
- Volunteers
- 202 people
- Sponsor
- Beth Israel Deaconess Medical Center
ARDS
Effects of Sedation on Transpulmonary Pressure and Lung Homogenous
The acute respiratory distress syndrome (ARDS) is characterized by severe respiratory failure. Open Lung and Lung Protective Strategy have been proved to improve mortality of ARDS patients.
- Trial name
- ARDS (NCT03237806)
- Testing
- Deep sedated, Light sedated
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Southeast University, China