Clinical trials: Transpulmonary Pressure
COVID-19 Pneumonia
Breathing Effort in Covid-19 Pneumonia: Effects of Positive Pressure, Inspired Oxygen Fraction and Decubitus
The study investigates the role of positive pressure, inspired oxygen fraction and different decubiti (seated, supine, prone) on breathing effort (as assessed by esophageal pressure swings) in Covid-19 pneumonia (at different…
- Trial name
- NCT04885517
- Testing
- Esophageal catheter
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- San Luigi Gonzaga Hospital
Acute Respiratory Failure
Effects of a New Interface for NIV on Respiratory Drive
This pilot physiologic randomized cross-over study was designed to investigate if, in patients with hARF, a new device combining high-flow oxygen through nasal cannula (HFNC) and continuous positive airway pressure (CPAP) reduces…
- Trial name
- NCT04619667
- Testing
- High Flow Nasal Cannula (HFNC), Continuous Positive Airway Pressure (CPAP)
- Volunteers
- 22 people
- Sponsor
- University Magna Graecia
Respiratory Failure
Inspiratory Effort at Different Expiratory Cycling and Airway Resistance During Pressure Support Ventilation (CYCLOPES)
The goal of this prospective interventional crossover randomized physiological study is to investigate the reliability of Pressure Muscle Index (PMI) - as an estimation of inspiratory effort - at different levels of expiratory…
- Trial name
- CYCLOPES (NCT05952726)
- Testing
- Expiratory cycling change at different levels of pressure support ventilation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Mechanical Ventilation Complication
Effect of Position and Pneumoperitoneum on Respiratory Mechanics and Transpulmonary Pressure During Laparoscopic Surgery
This study is an observational study measuring the esophageal pressure in anesthetized surgical patient undergoing changes in posture and pneumoperitoneum
- Trial name
- NCT03526003
- Testing
- Measurement of esophageal pressure
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Mechanical Ventilation, Airway Patency
The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency.
- Conditions
- Mechanical Ventilation, Airway Patency, Respiratory Depression
- Trial name
- NCT01969227
- Testing
- Subanesthetic ketamine
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Acute Respiratory Failure, Ventilator-Induced Lung Injury
New Automated System for Continuous Real-time Monitoring of Transpulmonary Pressure
Patients admitted to Intensive Care Unit often are affected by acute respiratory failure at admission or during hospital stay, with a mortality of 30%.
- Trial name
- NCT03945409
- Testing
- OPTIVENT
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Obesity, Surgery
Effect of Transpulmonary Pressure Guided Ventilation on Intraoperative Right Heart Function
The purpose of this clinical trial is to determine whether different types of ventilator settings during surgery change the relationship between the pressures in the lungs and the function of the heart.
- Conditions
- Obesity, Surgery, Anesthesia, Echocardiography, Transesophageal
- Trial name
- NCT05709041
- Testing
- Individualized lung-protective ventilation, Standard lung-protective ventilation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Vermont Medical Center
Pulmonary Disease
Effects of Standing at Different Angles on Transpulmonary Pressure
Effects of standing at different angles on transpulmonary pressure
- Trial name
- NCT04451421
- Testing
- Change of standing Angle
- Volunteers
- 50 people
- Sponsor
- Chinese PLA General Hospital
Acute Lung Injury
Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods (Lungbarometry)
Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations i esophagus pressure divided by the tidal volume.
- Trial name
- NCT02948530
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Stefan Lundin
Respiratory Distress Syndrome
Evaluation of the Diagnostic Performance of Electrical Impedance Tomography to Detect Situations at Risk of Lesions Induced by Conventional Mechanical Ventilation in ARDS
Acute respiratory distress syndrome remains a serious condition, with a mortality rate of between 30 and 50%. The use of mechanical ventilation with small tidal volumes, and by limiting the plateau pressure in the respiratory…
- Trial name
- NCT02896673
- Testing
- ventilatory conditions and measures with scanner and EIT
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Hospices Civils de Lyon
Lung Diseases
Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.
During thoracic surgery, one-lung ventilation (OLV) is associated with hypoxemia, lung injury, and perioperative respiratory complications.
- Trial name
- I-PEEP-THO (NCT05525312)
- Testing
- "Open-lung" protective ventilation strategy, "Standard" protective ventilation strategy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Montpellier
Mechanical Ventilation, Ventilator-induced Lung Injury
Extrapulmonary Lung Protection Strategy for Patients With Mechanical Ventilation
As an important life sustaining support , mechanical ventilation has greatly promoted the development of modern intensive care units.
- Conditions
- Mechanical Ventilation, Ventilator-induced Lung Injury, Transpulmonary Pressure
- Trial name
- NCT03947476
- Testing
- thoracic band
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
ARDS, Human
Hemodynamic Effects of Changes in Transpulmonary Pressure During Recruitment Maneuver in Patients Under Pressure Supported Mechanical Ventilation
According to the anatomical proximity of the heart temporarily elevated intrathoracic pressures may have direct and indirect effects on the cardiovascular system.
- Trial name
- NCT04141293
- Testing
- alveolar recruitment
- Where
- Hungary
- Sponsor
- Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged
Weaning Failure
Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation
This project focuses on the analysis of the correlation between transpulmonary driving pressure and uneven lung ventilation and regional lung compliance in patients using prolonged mechanical ventilation (PMV), in order to…
- Trial name
- NCT07003672
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Pediatric Acute Respiratory Distress Syndrome (PARDS), Acute Respiratory Failure
Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement
Mechanical ventilation is a critical intervention in the management of pediatric patients with respiratory distress. During this process, accurate measurement of transpulmonary pressure (PL) is essential to ensure the safety and…
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Acute Respiratory Failure, Acute Respiratory Distress Syndrome
- Trial name
- DECFVTTPM (NCT06051292)
- Testing
- Fast method, Conventional method
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Mechanical Ventilation Complication
Neural Pressure Support and Non-invasive Estimation of Transpulmonary Pressure in Spontaneous Ventilation Modes
The transition from controlled mechanical ventilation to assisted ventilation is one of the most complex and compromised phases of the ventilatory management during mechanical ventilation, affected by factors such as…
- Trial name
- EADITRAP (NCT05574829)
- Testing
- Esophageal manometry and monitoring of electrical activity of the diaphragm
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
ARDS, Human
Feasabilty and Physiological Effects of a Ventilation Strategy Combining PEEP and Tidal Volume Titration According to Inspiratory and Expiratory Transpulmonary Pressures in ARDS Patients.
Expiratory or inspiratory transpulmonary pressures have been proposed to optimize ventilator settings in patients with ARDS. The aim of this study is to assess the feasibility and the physiological effects of a new method based…
- Trial name
- PULMOESO (NCT05337059)
- Testing
- PEEP and Tidal Volume Titration
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Angers