Clinical trials: Trauma Exposure, active
PTSD
Psilocybin-Assisted Therapy
This pilot study will examine the safety, tolerability, acceptability, and efficacy of combination psilocybin + psychotherapy to decrease PTSD symptoms.
- Trial name
- NCT07332143
- Testing
- psilocybin, Supportive Therapy, Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Emory University
Coronary Heart Disease, Acute Myocardial Infarction
Twenty-year Follow-up of the Inter99 Cohort
Being born small increases your risk of developing Type 2 diabetes (T2D) with age. Furthermore, data even suggest that some of the diseases ("complications") in the eyes, kidneys, nerves, liver, blood vessels and heart often seen…
- Conditions
- Coronary Heart Disease, Acute Myocardial Infarction, Cardiovascular Diseases, Type 2 Diabetes
- Trial name
- NCT05166447
- Where
- Denmark
- Volunteers
- 4,000 people
- Sponsor
- Bispebjerg Hospital
Post Traumatic Stress Disorder
A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD
PTSD occurs in up to 17% of post-9/11 US Service Members and is associated with long-term functional impairment, family problems, unemployment, and suicidality.
- Trial name
- COOPERATE (NCT06990191)
- Testing
- Partnered Prolonged Exposure (PPE), Prolonged Exposure (PE)
- Where
- 4 sites in United States
- Volunteers
- 420 people
- Sponsor
- United States Department of Defense
Stress Disorders, Post-Traumatic
Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure
The goal of this clinical trial is to learn if receiving Trauma-Informed Guilt Reduction (TrIGR) Therapy is as effective as receiving Prolonged Exposure Therapy among veterans with PTSD and trauma related guilt.
- Trial name
- PORT (NCT06296589)
- Testing
- Trauma Informed Guilt Reduction Therapy, Prolonged Exposure Therapy
- Where
- 4 sites in United States
- Volunteers
- 158 people
- Sponsor
- Veterans Medical Research Foundation
Heat Stress
Heat Stress Exposure Among Low-Income Residents in Bangladesh and Evaluation of Indoor Interventions
The goal of this clinical trial is to learn if infrastructure and equipment installed to cool homes reduce adverse health outcomes.
- Trial name
- NCT06979258
- Testing
- Cooling intervention
- Where
- Bangladesh
- Volunteers
- 1,539 people
- Sponsor
- University of California, Berkeley
Stress Disorders, Post-Traumatic
Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication
The purpose of this clinical trial is to learn whether existing treatments for posttraumatic stress disorder (PTSD) can be improved.
- Trial name
- AWARE (NCT06088303)
- Testing
- Adjunctive writing to amplify response and engagement (AWARE), Cognitive processing therapy (CPT), Prolonged exposure (PE)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Boston University
REM Sleep Behavior Disorder, Concussion, Brain
The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls
The goal of this observational study is to investigate concussions and contact sports practices in REM sleep behaviour disorder (RBD).
- Trial name
- COSP-RBD (NCT06270290)
- Testing
- Exposure to contact sports or history of concussions
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Neonatal Respiratory Distress Related Conditions, Meconium
Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Meconium Exposure
Meconium in the amniotic fluid occurs in about one out of seven pregnancies and increases the chance that a newborn may have breathing problems after birth.
- Conditions
- Neonatal Respiratory Distress Related Conditions, Meconium, Perinatal Morbidity, Neonatal Acidosis
- Trial name
- PEARL (NCT07274527)
- Testing
- Intrauterine pressure catheter, Standard obstetric care at discretion of delivery provider
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Medical College of Wisconsin
Metabolic Diseases, Neurological and Mental Health Conditions
Growing Up in Singapore Towards Healthy Outcomes
This study aims to examine the role of genetic and epigenetic factors, maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of…
- Conditions
- Metabolic Diseases, Neurological and Mental Health Conditions, Genetic Predisposition, Skin Condition
- Trial name
- GUSTO (NCT01174875)
- Where
- Singapore
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Post Traumatic Stress Disorder, Written Exposure Therapy
Behavioral Health Technician Delivered Written Exposure Therapy
This study has two main goals. First, it aims to test a treatment called written exposure therapy to see if it can help military service members who have posttraumatic stress disorder (PTSD).
- Trial name
- NCT06789887
- Testing
- Written Exposure Therapy, Treatment as Usual (TAU)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Post Traumatic Stress Disorder
rTMS-augmented Written Exposure Therapy for PTSD
Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD.
- Trial name
- NCT05149534
- Testing
- Written Exposure Therapy, repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- VA Office of Research and Development
Spine Health, Spine Injuries and Disorders
Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain
Significance to VA: There is a lack of prospective longitudinal studies investigating the relationship between risk factors to Veterans and development and progression of musculoskeletal (MSK) spine injury and pain.
- Conditions
- Spine Health, Spine Injuries and Disorders, Spine Degeneration, Whole Body Vibration
- Trial name
- NCT07367139
- Testing
- Water
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Milwaukee VA Medical Center
Exposure to Pornography
Young Girls' Experiences of Exposure to Pornography: A Qualitative Study
This qualitative study aims to explore the experiences, meanings, and uses of pornography among female adolescents and young women receiving care in child and adolescent psychiatry services.
- Trial name
- ADO-X (NCT07812662)
- Testing
- Semi structured interview
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD)
Project COMET: Massed Prolonged Exposure for PTSD and SUD
The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD).
- Conditions
- Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD), Comorbidity, Trauma and Stressor Related Disorders
- Trial name
- PROJECT COMET (NCT06968832)
- Testing
- Massed Prolonged Exposure Therapy (M-PE), Standard outpatient SUD care
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Rutgers, The State University of New Jersey
PTSD
Treatment for Antepartum Posttraumatic Stress Disorder/PTSD Study
The majority of women with perinatal posttraumatic stress disorder (PTSD) do not receive mental health treatment despite the documented associations between PTSD and adverse pregnancy outcomes; this is likely due to workforce…
- Trial name
- TAPS (NCT05486793)
- Testing
- Written Exposure Therapy (WET), Emotion Focused Supportive Therapy (EFST)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Boston University
Concussions
COmmunities Aligned to Reduce Concussion and Head Impact Exposure
Head impacts in collision sports such as football are a public health concern, as repetitive head impacts, even if a concussion is not suspected, have negative effects on brain health.
- Trial name
- COACH (NCT06624202)
- Testing
- COmmunities Aligned to reduce Concussion and Head impact exposure (COACH) Intervention
- Where
- United States
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Post Traumatic Stress Disorder, PTSD
Effectiveness of Trauma Therapy Using Prolonged Exposure for Patients With PTSD and a Comorbid Psychotic Disorder
Psychosis patients with comorbid PTSD will be treated with trauma therapy.
- Conditions
- Post Traumatic Stress Disorder, PTSD, Psychosis
- Trial name
- TEP (NCT06048172)
- Testing
- Prolonged Exposure
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Medicalschool Hamburg
Blast or Combat Exposure, Head Injury Trauma
Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure
A Pre-post Study Evaluating the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans with Sequelae of Repeated Blast Exposure.
- Trial name
- NCT04313712
- Testing
- ibogaine with magnesium treatment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
PTSD, Substance Use Disorders
COPEWeb Training for Providers
Post-traumatic stress disorder (PTSD) and substance use disorders (SUD) are two of the most common and debilitating mental health conditions afflicting military Veterans.
- Trial name
- COPEWeb (NCT05812131)
- Testing
- COPEWeb online training, COPE In Person
- Where
- United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Psychiatric Disorder, Trauma, Psychological
Pedopsychiatric and Multidisciplinary Research Devoted to Children Exposed to the Attack in Nice on July 14, 2016
On July 14, 2016, in Nice, children and their families were attacked by the organization "EI". In Nice, 86 deaths, including 10 children, the youngest at 4, were recorded.
- Trial name
- Program14-7 (NCT03356028)
- Testing
- Child and adolescent psychiatry and Epidemiology, salivary biological collection, qualitative analysis of the discourse
- Where
- France
- Volunteers
- 728 people, healthy volunteers welcome
- Sponsor
- Fondation Lenval