Clinical trials: Trauma Prevention
Surgical Site Infection
Topical Antibiotic Irrigation (Gentamicin) in Prophylaxis of Midfacial Fracture Surgical Wounds
The purpose of this study is to evaluate the use of topical antibiotic irrigation (gentamycin) and its ability to reduce surgical site infections in midfacial fracture surgery compared to sterile normal saline (NS).
- Trial name
- NCT03483363
- Testing
- topical irrigation with gentamicin (80mg diluted in 1L 0.9% normal saline), topical irrigation with sterile normal saline (NS), intravenous (IV) prophylactic antibiotic
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- The University of Texas Health Science Center, Houston
Surgical Site Infection
Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study
This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections…
- Trial name
- CALIPSO (NCT05447559)
- Testing
- Cefazolin, Water for injection
- Where
- 27 sites in United States, Australia and 3 more
- Volunteers
- 9,180 people
- Sponsor
- Monash University
Post-traumatic Stress Disorder
Interest of Cardiac Coherence in the Prevention of Chronic Post-traumatic Stress Disorder: Pilot Study
ThThe aim of this study is to determinate the potential benefits of a respiratory training program (cardiac coherence, CC) in patients suffering from acute stress disorder, after a potentially traumatic event.
- Trial name
- COHEPS-P (NCT04701723)
- Testing
- cardiac coherence
- Where
- Reunion
- Volunteers
- 44 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Chronic Thromboembolic Pulmonary Hypertension, Acute Lung Injury
Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by unresolved thromboemboli in the pulmonary arteries, which lead to pulmonary hypertension and, left untreated, right heart failure.
- Trial name
- NCT00747045
- Testing
- Ventilation Strategy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of California, San Diego
Sport Injury
Effects of the Singapore Youth Shoulder Overuse Injury Prevention Program Among Youth Volleyball Athletes in Singapore
The Singapore Youth Shoulder Overuse Injury Prevention Program (YoSO-IPP) includes an exercise segment and an education segment.
- Trial name
- NCT06271902
- Testing
- Singapore Youth Shoulder Overuse Injury Prevention Program, Lower body stretching program
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Radiation-induced Dermatitis
Superoxide Dismutase Skin Spray for the Prevention of Acute Radiation Dermatitis in Head and Neck Cancer
To evaluate the efficacy and safety of superoxide dismutase skin spray for the reducing the acute radiation dermatitis in patients with head and neck malignancies undergoing radiotherapy.
- Trial name
- NCT07704372
- Testing
- A topical superoxide dismutase skin spray
- Where
- China
- Volunteers
- 140 people
- Sponsor
- West China Hospital
Accidental Falls, Falling Injury
The Emergency Department Stopping Elderly Accidents, Deaths and Injuries Program
This study aims to determine if a bedside decision aid used in the ED for mechanical fall prevention can increase patient participation in management options that decrease their fall risk.
- Conditions
- Accidental Falls, Falling Injury, Other and Unspecified Fall on Same Level
- Trial name
- ED-STEADI (NCT02167737)
- Testing
- Bedside Decision Aid, Control Arm
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Lehigh Valley Hospital
Distal Radius Fracture, Vitamine c
Vitamin c Supplementation in the Prevention of CRPS Following Distal Radius Fractures
Complex Regional Pain Syndrome type 1 is a pain syndrome that develops after a trauma, surgery, or idiopathically. The incidence after distal radius varies significantly in the literature.
- Conditions
- Distal Radius Fracture, Vitamine c, Prophylaxis
- Trial name
- NCT05842395
- Testing
- Vitamin C
- Where
- Syria
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Damascus University
Injury Prevention
Brief Child Safety Interventions in Emergency Departments (Safety in Seconds)
Safety in seconds is a randomized controlled trial of a computer tailored Injury Prevention program which was conducted in the waiting area of a level 1 pediatric trauma center.
- Trial name
- NCT01432041
- Testing
- tailored health education
- Volunteers
- 901 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
ARDS (Acute Respiratory Distress Syndrome), Invasive Mechanical Ventilation
Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury in Patients With ARDS - Pilot RCT
Acute Respiratory Distress Syndrome (ARDS) is a serious condition where the lungs become inflamed, leading to severe breathing difficulties.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Invasive Mechanical Ventilation, Patient-Self Inflicted Lung Injury
- Trial name
- OSIRIS-1 (NCT07588217)
- Testing
- Ondansetron hydrochloride 8 mg IV Q8H, 0.9 % Normal Saline 10 ml
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Posttraumatic Stress Disorders
Propranolol Administration and Prevention of Child PTSD in Child Trauma Victims
Twenty-nine pediatric injury patients (ages 10-18) at risk for PTSD were randomly assigned to receive either propranolol or placebo in a double-blind placebo controlled design.
- Trial name
- NCT00597389
- Testing
- Inderol (propranolol)
- Volunteers
- 29 people
- Sponsor
- Kent State University
Muscle Injury, Sprains and Strains
The Role of Periodic Health Examination in Determining Indirect Muscle Injury Risk in Elite Football (Soccer)
Preseason periodic health examination (PHE) is used routinely in elite football (soccer) and can be used to inform injury prevention strategies. Indirect muscle injuries (IMI) are a considerable burden to elite teams.
- Trial name
- NCT03782389
- Testing
- Preseason Periodic Health Examination Completion
- Volunteers
- 321 people
- Sponsor
- Manchester United Football Club
Ischemia-Reperfusion Injury, Kidney Diseases
Reparixin in Prevention of Delayed Graft Function After Kidney Transplantation
The chemokine CXCL8 plays a key role in the recruitment and activation of polymorphonuclear neutrophils in post-ischemia reperfusion injury after solid organ transplantation. Reparixin is a novel, specific inhibitor of CXCL8.
- Trial name
- NCT00248040
- Testing
- Reparixin continuous infusion, reparixin intermittent infusion
- Where
- 9 sites in United States, France and 2 more
- Volunteers
- 80 people
- Sponsor
- Dompé Farmaceutici S.p.A
Surgical Site Infection
Application of Powdered Vancomycin in the Surgical Wound in Haiti
Vancomycin, a tricyclic glycopeptide antibiotic, was originally indicated for the treatment of penicillin-resistant S. Aureus. It has a bactericidal action, inhibiting the biosynthesis of the cell wall of Gram-positive bacteria.
- Trial name
- NCT05535725
- Testing
- application of powdered vancomycin in the surgical wound as prophylaxis against the occurrence of surgical site infection
- Where
- Haiti
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Clinique Ortos
Gastrointestinal Ulcer (Peptic) or Erosion, Anti-Platelet Therapy
Proton Pump Inhibitor Preventing Upper Gastrointestinal Injury In Patients On Dual Antiplatelet Therapy After CABG
The purpose of this study is to compare the efficacy and safety for 12- vs. 1-month of pantoprazole treatment in preventing dual antiplatelet therapy (DAPT)-related upper gastrointestinal mucosal injury after coronary artery…
- Conditions
- Gastrointestinal Ulcer (Peptic) or Erosion, Anti-Platelet Therapy, Coronary Artery Bypass
- Trial name
- DACAB-GI-2 (NCT03908593)
- Testing
- Pantoprazole
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Ruijin Hospital
Acute Coronary Syndrome, Depressive Disorder
Comorbid Mental Disease and Heart Disease in Men
Mood disorders, anxiety disorders, and trauma-related stress (MD\AD\TRS) are common among men, particularly those suffering from heart disease (HD).
- Conditions
- Acute Coronary Syndrome, Depressive Disorder, Anxiety Disorders, Stress Disorders, Post-Traumatic
- Trial name
- MindTheHeart (NCT03354351)
- Testing
- Stepped-care model
- Volunteers
- 3,000 people
- Sponsor
- Universite de Moncton
Asthma, Respiratory Tract Infections
VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma
The overall aim of the study is to develop a nutritional preventive vitamin D supplementation strategy in pregnancy for early childhood asthma/persistent wheeze during the first three years of life as we hypothesize that…
- Conditions
- Asthma, Respiratory Tract Infections, Gastrointestinal Infection, Croup
- Trial name
- VICTORY (NCT06570889)
- Testing
- Cholecalciferol D3, Olive oil
- Where
- Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Professor Klaus Bønnelykke
Hip Fracture
Statin in Hip Fracture
Statins (or HMG-CoA reductase inhibitors) have largely proven their efficacy in the primary and secondary prevention of cardiovascular events.
- Trial name
- STAFF (NCT01494090)
- Testing
- Rosuvastatin
- Where
- 6 sites in France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Brest
Melanoma (Skin)
Pilot Study of Intervention to Reduce Sunburns in Melanoma Survivors
This project will pilot test whether a wearable device that tracks sun exposure and provides alerts regarding sun exposure and protection behaviors will reduce sunburns in melanoma survivors.
- Trial name
- NCT03518229
- Testing
- Microsoft Band 2 + UV messaging, Microsoft Band 2
- Sponsor
- University of Minnesota
Ankle Fracture
The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture
The use of prophylactic treatment with vitamin c may prevent complex regional pain syndrome (CRPS)
- Trial name
- CRPS (NCT01338129)
- Testing
- vitamin c
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
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