Clinical trials: Trauma Prevention
Surgical Site Infection
Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery
The purpose of the study is to assess the effectiveness of a single dose of preoperative antibiotic in reducing surgical site infections in certain dermatological procedures.
- Trial name
- NCT04580472
- Testing
- Cephalexin
- Where
- United States
- Volunteers
- 574 people
- Sponsor
- Carilion Clinic
Contrast Induced Acute Kidney Injury
Early Hydration in Acute Myocardial Infarction
The purpose of this study is to determine whether hydration with sodium bicarbonate is more effective than hydration with sodium chloride to prevent contrast nephropathy in patients undergoing primary coronary intervention for…
- Trial name
- NCT01742130
- Testing
- sodium bicarbonate solution, Isotonic saline
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Ospedale Misericordia e Dolce
Osteoporosis Fracture
Osteoporosis and Fall Prevention With Multiple Interventions in the Metropolitan Area
OBJECTIVES To determine the effects of 3 exercise interventions on sarcopenic indices among community-dwelling older adults with high osteoporotic fracture risks.
- Trial name
- NCT02483286
- Testing
- ICG, MTG, XBG
- Where
- Taiwan
- Volunteers
- 139 people
- Sponsor
- National Taiwan University Hospital
Opioid Use, Substance Use
Preventing Opioid Use Among Justice-involved Youth as They Transition to Adulthood Leveraging Safe Adults (LeSA)
Across the US, substance use is a significant public health concern, with juvenile justice (JJ)-involved youth representing a particularly vulnerable population.
- Trial name
- LeSA (NCT04678960)
- Testing
- Trust-based Relational Intervention Training, Trust-based Relational Intervention In-Home Structured Coaching, Trust-based Relational Intervention In-Home Responsive Coaching
- Where
- 11 sites in United States
- Volunteers
- 250 people
- Sponsor
- Texas Christian University
Injuries, Flexibility
Effects of the FIFA 11+ on Physical Performance and Injury Prevention in Female Futsal Players
The FIFA 11 + is an injury prevention that has shown to improve physical performance and prevent injuries in male futsal players, however, this injury prevention program has not been tested in female futsal players.
- Conditions
- Injuries, Flexibility, Balance
- Trial name
- NCT05334082
- Testing
- FIFA 11+
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Head and Neck Squamous Cell Carcinoma
BH4 in the Prevention and Treatment of Radiation-induced Skin Reactions for Head and Neck Squamous Cell Carcinoma (Including Nasopharyngeal Carcinoma)
Head and neck squamous cell carcinoma (include nasopharyngeal carcinoma) is one of the most common malignant tumor in China, and radiotherapy is the main treatment method.
- Trial name
- NCT05299203
- Testing
- Sapropterin dihydrochloride tablets
- Volunteers
- 18 people
- Sponsor
- West China Hospital
Critically Ill, Acute Kidney Injury
Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury
The purpose of this study is to assess the efficacy of calcifediol (25-hydroxyvitamin D) and calcitriol (1,25-dihydroxyvitamin D) in preventing and reducing the severity of acute kidney injury (AKI) in critically ill patients.
- Trial name
- ACTIVATE-AKI (NCT02962102)
- Testing
- Calcifediol, Calcitriol
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- David Leaf
Head and Neck Cancer
A Ph2, Colchicine For Inflammatory Carotid Injury And Disease Evolution After Radiotherapy
The goal of this clinical research study is to find out if low-dose colchicine (an anti-inflammatory drug) lowers the rate of radiation-related side effects to the carotid artery in patients who have completed radiation therapy…
- Trial name
- NCT07856719
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Musculoskeletal Pain, Sexual Assault
Post-traumatic Estradiol Administration and Care Evaluation (PEACE)
This pilot randomized, double-blind, placebo-controlled trial evaluates the feasibility, acceptability, and tolerability of administering a single 6 mg oral dose of 17β-estradiol (E2) to individuals assigned female at birth who…
- Conditions
- Chronic Musculoskeletal Pain, Sexual Assault, Posttraumatic Stress Disorder (PTSD)
- Trial name
- PEACE (NCT07868536)
- Testing
- 17β-estradiol
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Surgical Site Infection, Surgery--Complications
Prophylaxis of Surgical Wound Infection With Topical Antibiotics
Surgical site infection (SSI) is the main complication of surgery. The prevention of superficial SSI by topical prophylaxis is controversial.
- Conditions
- Surgical Site Infection, Surgery--Complications, Colorectal Surgery, Cesarean Section; Infection
- Trial name
- NCT04476212
- Testing
- Topical antibiotic prophylaxis
- Where
- Spain
- Volunteers
- 560 people
- Sponsor
- Hospital de Granollers
Thrombopenia, Cervical Cancer
Herombopag for the Prevention of Radio-chemotherapy Induced Thrombocytopenia in Cervical Cancer
Exploring and evaluating the efficacy of herombopag in preventing thrombocytopenia due to radiotherapy for cervical cancer
- Conditions
- Thrombopenia, Cervical Cancer, Radiotherapy Side Effect, Chemotherapeutic Toxicity
- Trial name
- NCT06745219
- Testing
- herombopag
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Cancer Hospital & Institute
Spinal Cord Injuries (SCI), Osteoporosis
Osteoporosis Awareness in Chronic Spinal Cord Injury
Osteoporosis is a common and serious complication of spinal cord injury (SCI), substantially increasing the risk of fragility fractures.
- Conditions
- Spinal Cord Injuries (SCI), Osteoporosis, Health Knowledge, Attitudes
- Trial name
- NCT07725081
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Afyonkarahisar Health Sciences University
Spinal Cord Injuries
Evaluate the Incidence of Sacral and Heel Pressure Ulcers During Acute Care After SCI
This study evaluates the effect of the application of a five-layer foam dressing on the sacrum as well as a boot applied on the heels as preventive measures in the development of pressure ulcers in patients hospitalized with…
- Trial name
- NCT04165395
- Testing
- Five-layer foam dressing, Heelmedix boot
- Where
- Canada
- Volunteers
- 165 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Prevention of Surgical Site Infections
Tumescent Antibiotic Delivery Pharmacokinetics
Tumescent Antibiotic Delivery (TAD) is a technique for improving the prevention of surgical site infections (SSI). TAD involves the subcutaneous infiltration of tumescent local anesthesia (TLA) containing water soluble…
- Trial name
- NCT01046981
- Testing
- Tumescent Antibiotic Delivery of cefazolin with or without metronidazole, Intravenous Antibiotic Delivery
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Klein, Jeffrey A., M.D.
Mild Traumatic Brain Injury, Suicide Prevention
Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury
The study purpose is to test the effect of Crisis Response Planning (CRP) when used as the second method of suicide prevention in military service members who are at risk for suicide due to mild traumatic brain injury (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Suicide Prevention, Suicide Risk | Patient, Suicide Risk
- Trial name
- NCT07327567
- Testing
- Crisis Response Planning
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Surgical Wound Infection, Head and Neck Neoplasms
Prophylactic Antibiotic Duration in Head and Neck Cancer Surgery (PROTECT-HN Trial)
The goal of this clinical trial is to learn whether giving antibiotics for 7 days after surgery, instead of the usual 24 hours, lowers the chance of wound infection in adults having major surgery for mouth or throat cancer.
- Conditions
- Surgical Wound Infection, Head and Neck Neoplasms, Oral Cancer Neoplasms, Pharyngeal Neoplasms
- Trial name
- PROTECT-HN (NCT07851857)
- Testing
- Ampicillin/Sulbactam 24-Hour Postoperative Prophylaxis, Ampicillin/Sulbactam 7-Day Postoperative Prophylaxis
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- AC Camargo Cancer Center
Traumatic Brain Injury
A Pharmacokinetic Analysis of Levetiracetam Prophylaxis in Critically Ill Patients With Severe Traumatic Brain Injury
This study aims is to describe the pharmacokinetic properties of levetiracetam through measurement of serum concentrations in critically ill, severe traumatic brain injury patients.
- Trial name
- NCT04836481
- Testing
- Serum Sample Collection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Prevention and Control
Effects of a Neuromuscular Training Ankle Preventive Program in Soccer Player
Objetive:To determine the effects of a functional ankle instability prevention neuromuscular training (PENMT) program compared to the conventional FIFA 11+ program on the occurrence of ankle sprains, flexibility, balance and…
- Trial name
- PENT (NCT05688930)
- Testing
- PENMT (Experimental Group), FIFA 11+ (Control Group)
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autónoma de Manizales, Colombia
Post-traumatic Stress Disorder
Prevention of Post Traumatic Stress Disorder by Early Treatment
To prospectively evaluate the effect of early treatment (cognitive therapy (CT), cognitive-behavioral therapy (CBT) and escitalopram (SSRI) in preventing the occurrence of post-traumatic stress disorder in recent survivors of…
- Trial name
- NCT00146900
- Testing
- Cognitive Behavioral Therapy, Cognitive Therapy, Escitalopram
- Where
- Israel
- Volunteers
- 298 people
- Sponsor
- Hadassah Medical Organization
Colon Cancer, Cancer Pancreas
Frequency of Care for Peripherally Inserted Central Vascular Access In the Prevention of Marsi
This randomized controlled clinical trial evaluates the safety equivalence between weekly and biweekly dressing changes for peripherally inserted central catheters (PICC) in oncology patients receiving outpatient chemotherapy.
- Trial name
- ICO-MARSI (NCT07697170)
- Testing
- Weekly dressing for peripherally inserted central catheters, 15 days dressing change for peripherally inserted central catheters, peripherally inserted central catheters
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Institut Català d'Oncologia
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