Clinical trials: Trauma Prevention
Traumatic Brain Injury
Use of Biperiden for the Prevention of Post-traumatic Epilepsy
There is no AED or medication that has been demonstrated to affect the development of post-traumatic epilepsy. Biperiden is a cholinergic antagonist, acting in the muscarinic receptor, that is widely used as an anti Parkinson…
- Trial name
- NCT01048138
- Testing
- Biperiden Lactate
- Where
- Brazil
- Volunteers
- 123 people
- Sponsor
- Federal University of São Paulo
Peripheral Vascular Disease, Claudication
Oral Nutritional Supplement in Reducing Surgical Site Infections
The study aims to evaluate the efficacy of an arginine enriched oral nutritional supplement in the prevention of wound complications in the the wounds of patients post lower limb revascularization.
- Trial name
- NCT02475525
- Testing
- Arginine enriched oral nutritional supplement
- Where
- Ireland
- Volunteers
- 6 people
- Sponsor
- University of Limerick
Chronic Subdural Hematoma
Endovascular Embolization of Chronic Subdural Hematomas After Surgery
Chronic subdural hematomas (CSH) are one of the most frequent pathologies in emergency neurosurgical practice. Standard therapy for symptomatic CSH is surgical drainage.
- Trial name
- ENCLOSURE (NCT05220826)
- Testing
- Post surgical embolization of middle meningeal artery with liquid embolic agents (ethylene vinyl alcohol copolymers as Onix, Squid, Phil or Libro)
- Where
- Spain
- Volunteers
- 280 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Postural Stability, Dynamic Knee Valgus
The Effect Subtalar Joint Pronation on Postural Stability and Lower Extremity Alignment
The lower extremity consists of sequent columns. The deviation of one segment from its normal alignment in the lower extremity also affects the alignment of the other segments.
- Conditions
- Postural Stability, Dynamic Knee Valgus, Injury Prevention
- Trial name
- NCT05606835
- Testing
- Postural stability assessment, Frontal plan prjection angle, Foot and Ankle Ability Measure
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Colorectal Surgery
Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery
To determine the optimal prophylactic antibiotics administration method in elective colorectal surgery
- Trial name
- NCT00292708
- Testing
- Cefmetazole (drug)
- Where
- 7 sites in Japan
- Volunteers
- 500 people
- Sponsor
- National Cancer Center, Japan
Renal Failure
The Efficacy of "MediHoney" to Facilitate Catheter Exit-Site Surgical Wound Healing
To evaluate the efficacy of honey as a post surgical exit site care process to promote healing and prevent infectious bacterial colonization of newly created exit sites.
- Trial name
- NCT01230489
- Testing
- MediHoney
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Missouri-Columbia
Lumbar Hyperlordosis, Athletic Injuries
Effectiveness of Abdominal Muscle Strengthening and Pelvic Control in the Prevention of Dance Injuries
Introduction. After observing the lack of lumbo-pelvic control and the difficulty in identifying the musculature used when performing the different dance positions, it was decided to carry out an exercise intervention to…
- Trial name
- NCT05771233
- Testing
- Prevention
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Pressure Ulcer (PU), Pressure Injury Prevention
Effect of a Risk-Based Perioperative Pressure Injury Prevention Bundle in Elective Surgery Patients
This study evaluates whether a risk-based perioperative pressure injury prevention bundle reduces the development of pressure injuries in patients undergoing elective surgery lasting 3 hours or longer.
- Conditions
- Pressure Ulcer (PU), Pressure Injury Prevention, Perioperative Care, Braden Scale
- Trial name
- RiPPB (NCT07725068)
- Testing
- Risk-Based Perioperative Pressure Injury Prevention Bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Fall and Fractures Prevention
Prescribe Exercise for Prevention of Falls and Fractures: A Family Health Team Approach
Falls and fractures are a leading cause of death and disability in the older adult population. The consequences of falls and fractures contribute substantially to health care costs and can have a significant negative impact on…
- Trial name
- PEPTEAM (NCT01698463)
- Testing
- Identification of patients at risk, tailored exercise prescription, motivational interviewing, review of behavioural outcomes
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Waterloo
Surgical Site Infection
WHO Checklist- Based Infection Prevention Guidelines in Mulago Hospital
This prospective cohort study will assess all mothers undergoing elective and emergency caesarean delivery in the labour ward theatre at Mulago National Referral Hospital based temporarily at Kawempe Hospital.
- Trial name
- NCT03822039
- Where
- Uganda
- Volunteers
- 768 people
- Sponsor
- Makerere University
Diabetes Mellitus, Chronic Kidney Disease
Berberine Prevent Contrast-induced Nephropathy in Patients With Diabetes
The number of cardiac angiography and percutaneous coronary interventions (PCI) has increased steadily in recent years. This has resulted in the increasing incidence of contrast-induced nephropathy (CIN).
- Trial name
- NCT02808351
- Testing
- Berberine
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease, Acute Kidney Injury
Use of Flozins (Empagliflozin/Dapagliflozin) for Prevention of AKI
All consecutive patients hospitalized from 01.01.2020 to 30.09.2025 who underwent coronary angiography or PCI will be eligible for inclusion.
- Conditions
- Coronary Artery Disease, Acute Kidney Injury, Contrast-Induced Acute Kidney Injury, Percutaneous Coronary Intervention
- Trial name
- FLORENCE (NCT07231939)
- Testing
- Flozin
- Where
- Poland
- Volunteers
- 4,000 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Intrusive Thought, Psychological Trauma
Towards a Post-exposition Pharmacological Prophylaxis for Post-traumatic Stress Disorder
In this study, we investigate the role that deep sleep plays in the prevention of posttraumatic stress disorder after someone has been exposed to a trauma by boosting deep sleep with two drug conditions compared to placebo…
- Conditions
- Intrusive Thought, Psychological Trauma, Inflammatory Response, Physiological Stress
- Trial name
- TRAUMA-PRO (NCT04508166)
- Testing
- Dexmedetomidine, Gamma-Hydroxybutyrate, Experimental Model Trauma Film
- Where
- Switzerland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Endometritis, Cesarean Section; Infection
Two-drug Antibiotic Prophylaxis in Scheduled Cesarean Deliveries
Cesarean deliveries are the most common surgical procedure performed in the United States. A significant decrease in cesarean delivery associated maternal morbidity has been achieved with preoperative prophylactic single-dose…
- Conditions
- Endometritis, Cesarean Section; Infection, Wound Infection
- Trial name
- NCT03960970
- Testing
- Azithromycin 500 mg, Mefoxin 2g
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- RWJ Barnabas Health at Jersey City Medical Center
Chronic Lung Disease
Prevention of Chronic Lung Disease (CLD - Prevention Study)
Primary endpoint: prospectively identify potential biomarkers able to predict the severe course of pulmonary funcion in the first 12 months of life and realize a new profile to early identify hugh risk newborns Secondary…
- Trial name
- NCT06559670
- Testing
- Blood sampling
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Overuse Injuries
Overuse Injuries in Road Cyclists, Prevalence and Prevention
The purpose of this study is to investigate the prevalence of overload injuries to road cyclists in Sweden, and if it 's possible to prevent low back pain by a simple exercise program for two months of training .
- Trial name
- Cycle (NCT02106715)
- Testing
- Training
- Where
- Sweden
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Post Traumatic Stress Disorder, Sleep Deprivation
Explanation About Sleep in Post Trauma Patients
This study is designed to test the effect of an explanation about the first sleep following trauma exposure, on the development of Post Traumatic Stress Disorder (PTSD) in the months following the traumatic event.
- Trial name
- NCT01684085
- Testing
- Explanation encouraging sleep, Explanation discouraging sleep, Lorazepam
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Acute Kidney Injury
Prevention of Nephrotoxin-Induced Acute Kidney Injury Using Cilastatin
The goal of this clinical trial is to repurpose cilastatin for preventing acute kidney injury (AKI) in hospitalized patients receiving nephrotoxic medications. The trial will evaluate the efficacy of the re-purposed drug.
- Trial name
- PONTiAK (NCT06886464)
- Testing
- Cilastatin Sodium
- Where
- 2 sites in Canada
- Volunteers
- 698 people
- Sponsor
- Matthew James
Wound Infection, Wound Dehiscence
Honey Dressing - A Preventive Procedure for Post-Surgical Site Infection.
The goal of this clinical trial is to compare the wound healing in the participants who underwent the clean surgical procedure, by applying honey dressing and common Iodine solution dressing, participants will have no other…
- Conditions
- Wound Infection, Wound Dehiscence, Wound Bleeding, Wound Surgical
- Trial name
- NCT06220344
- Testing
- Honey Dressing, Iodine Dressing
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- HITEC-Institute of Medical Sciences
Delirium - Postoperative, Delirium Prevention
Dexmedetomidine for Prevention of Delirium After Hip Fracture Surgery
Postoperative delirium is common after hip fracture surgery and is associated with delayed recovery and serious postoperative complications.
- Conditions
- Delirium - Postoperative, Delirium Prevention, Dexmedetomidine, Dexmedetomidine Infusion
- Trial name
- DEXLIR (NCT07867899)
- Where
- Denmark
- Volunteers
- 242 people
- Sponsor
- Peter Gaarsdal Uhrbrand
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