Clinical trials: Trauma and Stress Related Disorders
Dementia, Traumatic Brain Injury (TBI)
Clinical Characteristics of Dementias That Occur Remotely After Traumatic Brain Injury in Retired Military Personnel
The objective of this study is to measure the frequency and clinical types of mild cognitive impairment (MCI) or dementia that occur among up to 150 military retirees with and without a history of traumatic brain injury (TBI)…
- Conditions
- Dementia, Traumatic Brain Injury (TBI), Mild Cognitive Impairment (MCI), Chronic Traumatic Encephalopathy (CTE)
- Trial name
- NCT01891383
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Posttraumatic Stress Disorder, Substance Use Disorders
Treating Violence-related PTSD and Substance Risk in Low-income, Urban Adolescents
This project will provide initial feasibility and efficacy data for the implementation of Narrative Exposure Therapy (NET) to urban, at-risk youth.
- Trial name
- POWER-NET (NCT03737383)
- Testing
- Narrative Exposure Therapy
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Posttraumatic Stress Disorder, Substance Use Disorders
Emotional Regulation in People With Co-occurring Posttraumatic Stress Disorder and Substance Use Disorder
The aim of this project is to look at emotional regulation in people with posttraumatic stress disorder (PTSD) and substance use disorder (SUD).
- Conditions
- Posttraumatic Stress Disorder, Substance Use Disorders, Emotional Regulation
- Trial name
- NCT05531318
- Testing
- Qualitative Interview
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- King's College London
Post Traumatic Stress Disorder
Clonazepam and Paroxetine for Rapid Treatment of Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder (PTSD) is an anxiety disorder that follows exposure to an extremely traumatic stressors. PTSD is associated with serious symptoms.
- Trial name
- NCT00025740
- Testing
- clonazepam and paroxetine
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- National Institute of Mental Health (NIMH)
Nightmare
Nightmare Deconstruction and Reprocessing vs. NightWare Wristband
The overall goal of this Phase IIa randomized controlled pilot trial is to assess the potential efficacy of two emerging treatments for post-trauma nightmares and to test the feasibility of study design and methods.
- Trial name
- NDR/NW (NCT06399874)
- Testing
- Nightmare Deconstruction and Reprocessing, NightWare
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Uniformed Services University of the Health Sciences
Moral Injury, Distress, Emotional
Digital Interventions for Detection and Reduction of Moral Distress
Stress, anxiety, distress and depression are exceptionally high among healthcare workers at the frontline of the COVID-19 pandemic.
- Trial name
- VR (NCT05001542)
- Testing
- Educational moral injury video
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Post Traumatic Stress Disorder, Traumatic Brain Injury
TMS-fNIRS Personalized Dosing
The intent of this study is to establish technical feasibility in a clinical population (PTSD, with or without mild TBI) of personalized TMS-fNIRS technology.
- Trial name
- NCT05916417
- Testing
- TMS-fNIRS over the dl-PFC
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Florida State University
Post Traumatic Stress Disorder
Intensive Treatment Versus Standard Weekly Prolonged Exposure for Adults With Post-Traumatic Stress Disorder
The goal of this clinical trial is to compare a novel, massed treatment format of prolonged exposure to gold standard trauma focused cognitive behavioral therapy (weekly delivered prolonged exposure) for post-traumatic stress…
- Trial name
- NCT05934175
- Testing
- Intensive treatment with prolonged exposure, Weekly delivered prolonged exposure
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Karolinska Institutet
Alcohol Use Disorder, Mild Traumatic Brain Injury
Pilot rTMS for AUD+mTBI
This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder.
- Conditions
- Alcohol Use Disorder, Mild Traumatic Brain Injury, Post-traumatic Stress Disorder
- Trial name
- TMS_AUD+mTBI (NCT03995173)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation
This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD).
- Trial name
- NCT06234969
- Testing
- Continuous Theta Burst Stimulation to the Intraparietal Sulcus
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
OCD, Major Depressive Disorder (MDD)
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic…
- Conditions
- OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer
- Trial name
- NCT06624137
- Testing
- Serotonergic Psychedelic
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Posttraumatic Stress Disorder
Using Wearable Technology to Detect Symptoms of Posttraumatic Stress Disorder
The aim of the project is to advance our understanding of how individuals with Posttraumatic Stress Disorder (PTSD) experience symptoms in their every-day lives when they are in their home environment.
- Trial name
- NCT05534100
- Testing
- Biostrap EVO Wristband
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
PTSD, Trauma
Neuroendocrine Risk for PTSD in Women
This study will test for effects of estradiol (E2) on PTSD symptoms and functional magnetic resonance imaging (fMRI) indicators of stress vulnerability, in naturally-cycling women who are not using hormonal birth control.
- Trial name
- NCT03973229
- Testing
- Estradiol patch
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Emory University
Post-traumatic Stress Disorder (PTSD), Emotional Contagion
Attachment and Post-Traumatic Stress Disorder in Military Personnel: Characterization of the French Military Population, Exploration of Biopsychosocial Factors, and Study of the Impact of Security Priming on Emotional Contagion Capacities
Post-traumatic stress disorder (PTSD) is a pathology that impairs the quality of life of sufferers. In military personnel, it can lead to military incapacity.
- Trial name
- AT-HOME (NCT06996275)
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Stress Disorders, Post-Traumatic
Comparing Effects of a Holistic Yoga Program and a Wellness Program on PTSD Symptoms
Given the limited effectiveness of current treatments and the burden PTSD places on Veterans, civilians and clinicians, this research aims to compare the effects of a standardized, traditional, holistic yoga intervention…
- Trial name
- RELIEVE (NCT02234622)
- Testing
- Holistic Yoga Program, Wellness Lifestyle Program
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- VA Office of Research and Development
PTSD
Brief Treatment for Posttraumatic Stress Disorder
The primary goal of this study is to examine whether a brief treatment approach for PTSD is equally efficacious in the treatment of active duty service members relative to a first line treatment approach that requires much…
- Trial name
- NCT03033602
- Testing
- written exposure therapy, CPT, cognitive only
- Where
- 2 sites in United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Boston VA Research Institute, Inc.
Posttraumatic Stress Disorder
Treating Nightmares in Posttraumatic Stress Disorder With Clonidine and Doxazosin
This randomized controlled trial will test the hypothesis that oral Clonidine or Doxazosin improves nightmares (primary outcome), other PTSD symptoms and psychopathology (secondary outcomes) to a greater extent than placebo over…
- Trial name
- NCT05360953
- Testing
- Clonidine, Doxazosin
- Where
- 5 sites in Germany
- Volunteers
- 53 people
- Sponsor
- Charite University, Berlin, Germany
Mental Health, Physical Health
Parental Well-being After Childbirth in Switzerland
Improving maternal and child health is a global priority, with increasing emphasis on ensuring women and their families not only survive but also thrive after childbirth.
- Conditions
- Mental Health, Physical Health, Postpartum, Parents
- Trial name
- SOCRATES (NCT06886841)
- Where
- 2 sites in Switzerland
- Volunteers
- 4,200 people
- Sponsor
- Laurent Gaucher
PTSD, Chronic Musculoskeletal Pain
Mission Reconnect-Veterans and Their Partners to Manage Pain and PTSD (MR)
This project is responsive to Rehabilitation Research and Development's (RR\&D) current special areas of interest for non-pharmacological activity-based interventions for chronic pain impacting pain reduction, function and…
- Trial name
- MR (NCT03593772)
- Testing
- Mission Reconnect
- Where
- 3 sites in United States
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Psychological Trauma, Posttraumatic Stress Disorder PTSD
Psychometric and Patholinguistic Assessment of Psychotrauma Related to Natural Hazards in the Commune of "Le Prêcheur"
The project is to study the evolution of mental health in a little town of the French Martinique (Le Prêcheur) by using an innovative method of analysis that combines patholinguistic and psychometric indications for patients who…
- Conditions
- Psychological Trauma, Posttraumatic Stress Disorder PTSD, Mass Casualty Incidents
- Trial name
- EP3LAN (NCT04479670)
- Where
- Martinique
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique